Project
GSE49485: Hypoxia transcriptome sequencing of rat brain.
Navigation
Downloads
Results for Spi1
Z-value: 1.12
Motif logo
Transcription factors associated with Spi1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Spi1 | rn6_v1_chr3_+_79918969_79918969 | 0.67 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_43117337 Show fit | 0.47 |
ENSRNOT00000078001
|
nuclear receptor subfamily 4, group A, member 2 |
|
| chr8_+_96551245 Show fit | 0.41 |
ENSRNOT00000039850
|
BCL2-related protein A1 |
|
| chr12_-_19254527 Show fit | 0.40 |
ENSRNOT00000089349
|
|
|
| chr9_-_14599594 Show fit | 0.40 |
ENSRNOT00000018138
|
triggering receptor expressed on myeloid cells-like 1 |
|
| chr19_-_55510460 Show fit | 0.40 |
ENSRNOT00000019820
|
CBFA2/RUNX1 translocation partner 3 |
|
| chr7_+_119820537 Show fit | 0.38 |
ENSRNOT00000077256
ENSRNOT00000056221 |
cytohesin 4 |
|
| chr10_-_83655182 Show fit | 0.35 |
ENSRNOT00000007897
|
ABI family, member 3 |
|
| chr7_-_140245723 Show fit | 0.34 |
ENSRNOT00000088999
|
cyclin T1 |
|
| chr4_-_169999873 Show fit | 0.34 |
ENSRNOT00000011697
|
glutamate ionotropic receptor NMDA type subunit 2B |
|
| chr2_-_243224883 Show fit | 0.33 |
ENSRNOT00000014139
|
dual adaptor of phosphotyrosine and 3-phosphoinositides 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Spi1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) |
| 0.0 | 0.7 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.1 | 0.6 | GO:1900825 | regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825) |
| 0.1 | 0.6 | GO:1900017 | positive regulation of cytokine production involved in inflammatory response(GO:1900017) |
| 0.0 | 0.6 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.2 | 0.5 | GO:0043314 | negative regulation of neutrophil degranulation(GO:0043314) |
| 0.2 | 0.5 | GO:2000537 | regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538) |
| 0.1 | 0.5 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.1 | 0.5 | GO:1900364 | negative regulation of mRNA polyadenylation(GO:1900364) |
| 0.0 | 0.5 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.7 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.6 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.6 | GO:0008024 | cyclin/CDK positive transcription elongation factor complex(GO:0008024) |
| 0.0 | 0.6 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.4 | GO:1902710 | GABA receptor complex(GO:1902710) |
| 0.0 | 0.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.3 | GO:0089717 | spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.7 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.6 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.5 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.0 | 0.5 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.5 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 0.5 | GO:0032453 | histone demethylase activity (H3-K4 specific)(GO:0032453) |
| 0.0 | 0.5 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.5 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 1.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 0.8 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.8 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.7 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.0 | 0.7 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.0 | 0.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 0.5 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.5 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.0 | 1.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 0.9 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.0 | 0.7 | REACTOME G ALPHA1213 SIGNALLING EVENTS | Genes involved in G alpha (12/13) signalling events |
| 0.0 | 0.6 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.6 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.4 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.0 | 0.4 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |