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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Sp1
Z-value: 0.82
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Transcription factors associated with Sp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp1 | rn6_v1_chr7_+_144014173_144014173 | 0.54 | 3.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_5535432 Show fit | 0.89 |
ENSRNOT00000040859
|
synaptic Ras GTPase activating protein 1 |
|
| chr1_+_199196059 Show fit | 0.70 |
ENSRNOT00000090428
|
F-box and leucine-rich repeat protein 19 |
|
| chr13_+_52976507 Show fit | 0.70 |
ENSRNOT00000090599
ENSRNOT00000011324 |
kinesin family member 21B |
|
| chr7_+_70364813 Show fit | 0.65 |
ENSRNOT00000084012
ENSRNOT00000031230 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
|
| chr10_+_56546710 Show fit | 0.64 |
ENSRNOT00000023003
|
Y box binding protein 2 |
|
| chr2_+_34186091 Show fit | 0.61 |
ENSRNOT00000016129
|
small glutamine rich tetratricopeptide repeat containing beta |
|
| chr5_-_147375009 Show fit | 0.54 |
ENSRNOT00000009436
|
S100P binding protein |
|
| chr16_-_9709347 Show fit | 0.54 |
ENSRNOT00000083933
|
mitogen-activated protein kinase 8 |
|
| chr10_-_85684138 Show fit | 0.53 |
ENSRNOT00000017989
|
phosphatidylinositol-5-phosphate 4-kinase type 2 beta |
|
| chr3_-_164095878 Show fit | 0.52 |
ENSRNOT00000079414
|
beta-1,4-galactosyltransferase 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.0 | 0.9 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 0.8 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.0 | 0.8 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.8 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.2 | 0.7 | GO:0003430 | growth plate cartilage chondrocyte growth(GO:0003430) |
| 0.2 | 0.7 | GO:0035544 | negative regulation of SNARE complex assembly(GO:0035544) |
| 0.1 | 0.7 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.7 | GO:0045607 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.1 | 0.7 | GO:0007256 | activation of JNKK activity(GO:0007256) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.1 | 1.4 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 1.3 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.9 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.1 | 0.8 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.7 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.0 | 0.7 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 0.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.7 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 2.3 | GO:0004702 | receptor signaling protein serine/threonine kinase activity(GO:0004702) |
| 0.0 | 1.6 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 1.6 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 1.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 1.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.2 | 1.2 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 1.1 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 1.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.9 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.3 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 1.2 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 1.0 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 1.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.0 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 1.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 0.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.8 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.0 | 1.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.0 | 1.5 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 1.3 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 1.1 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.0 | 1.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.0 | 0.9 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.8 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.7 | REACTOME N GLYCAN ANTENNAE ELONGATION | Genes involved in N-Glycan antennae elongation |
| 0.0 | 0.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |