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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Sox5_Sry

Z-value: 0.65

Motif logo

Transcription factors associated with Sox5_Sry

Gene Symbol Gene ID Gene Info
ENSRNOG00000027869 SRY box 5
ENSRNOG00000062090 sex determining region Y

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox5rn6_v1_chr4_-_178441547_178441547-0.884.9e-02Click!
Sryrn6_v1_chrY_+_327166_327166-0.089.0e-01Click!

Activity profile of Sox5_Sry motif

Sorted Z-values of Sox5_Sry motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_-_26211445 0.88 ENSRNOT00000027739
neuronal regeneration related protein
chr9_+_25410669 0.36 ENSRNOT00000030912
ENSRNOT00000090920
transcription factor AP-2 beta
chr6_-_125723944 0.33 ENSRNOT00000007004
fibulin 5
chr5_-_12563429 0.31 ENSRNOT00000059625
suppression of tumorigenicity 18
chr6_-_125723732 0.30 ENSRNOT00000084815
fibulin 5
chr4_+_44774741 0.26 ENSRNOT00000086902
MET proto-oncogene, receptor tyrosine kinase
chr4_-_99305812 0.24 ENSRNOT00000038912
required for meiotic nuclear division 5 homolog A
chr11_+_61083757 0.23 ENSRNOT00000002790
BOC cell adhesion associated, oncogene regulated
chr14_+_17492081 0.21 ENSRNOT00000003346
G3BP stress granule assembly factor 2
chr10_+_23661013 0.20 ENSRNOT00000076664
early B-cell factor 1
chr4_-_82133605 0.19 ENSRNOT00000008023
homeobox A2
chr10_-_18131562 0.19 ENSRNOT00000006676
T-cell leukemia, homeobox 3
chr17_-_57394985 0.17 ENSRNOT00000019968
enhancer of polycomb homolog 1
chr6_-_106971250 0.17 ENSRNOT00000010926
double PHD fingers 3
chr12_-_10335499 0.16 ENSRNOT00000071567
WAS protein family, member 3
chr18_-_5314511 0.16 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr13_+_95589668 0.16 ENSRNOT00000005849
zinc finger protein 238
chr10_+_86399827 0.15 ENSRNOT00000009299
growth factor receptor bound protein 7
chr20_+_5262946 0.15 ENSRNOT00000082900
bromodomain containing 2
chr16_-_19583386 0.14 ENSRNOT00000090131
zinc finger protein 617
chr10_+_14248399 0.13 ENSRNOT00000077689
splA/ryanodine receptor domain and SOCS box containing 3
chr10_-_35800120 0.13 ENSRNOT00000004361
mastermind-like transcriptional coactivator 1
chr10_-_46720907 0.13 ENSRNOT00000083093
ENSRNOT00000067866
target of myb1 like 2 membrane trafficking protein
chr15_-_24374753 0.13 ENSRNOT00000016274
autophagy related 14
chr7_-_81592206 0.12 ENSRNOT00000007979
angiopoietin 1
chr17_+_18151982 0.10 ENSRNOT00000066447
kinesin family member 13A
chr1_+_241594565 0.10 ENSRNOT00000020123
amyloid beta precursor protein binding family A member 1
chr20_+_46429222 0.10 ENSRNOT00000076818
forkhead box O3
chr13_+_90533365 0.10 ENSRNOT00000082469
DDB1 and CUL4 associated factor 8
chr4_-_123713319 0.10 ENSRNOT00000012875
ENSRNOT00000086982
solute carrier family 6 member 6
chr8_+_109455786 0.10 ENSRNOT00000039593
male-specific lethal 2 homolog (Drosophila)
chr10_+_72909550 0.09 ENSRNOT00000004540
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr18_+_27558089 0.09 ENSRNOT00000027499
family with sequence similarity 53, member C
chr2_-_187401786 0.09 ENSRNOT00000025624
hyaluronan and proteoglycan link protein 2
chr6_+_110624856 0.09 ENSRNOT00000014017
vasohibin 1
chr10_-_16046033 0.09 ENSRNOT00000089460
cytoplasmic polyadenylation element binding protein 4
chr10_-_16045835 0.09 ENSRNOT00000064832
cytoplasmic polyadenylation element binding protein 4
chr18_-_38088457 0.09 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr2_+_102685513 0.08 ENSRNOT00000033940
basic helix-loop-helix family, member e22
chrX_-_73778595 0.08 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
ring finger protein, LIM domain interacting
chr16_-_71319449 0.08 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr16_+_20740826 0.08 ENSRNOT00000038057
CREB regulated transcription coactivator 1
chr15_-_25505691 0.08 ENSRNOT00000074488
homeobox protein OTX2-like
chr1_+_154606490 0.08 ENSRNOT00000024095
coiled-coil domain containing 89
chr18_-_58097316 0.08 ENSRNOT00000088527

chr14_+_11198896 0.08 ENSRNOT00000079767
heterogeneous nuclear ribonucleoprotein D-like
chr10_+_35343189 0.08 ENSRNOT00000083688
mitogen-activated protein kinase 9
chr10_-_74298599 0.07 ENSRNOT00000007379
yippee-like 2
chr2_-_197935567 0.07 ENSRNOT00000085404
regulation of nuclear pre-mRNA domain containing 2
chr4_+_161696903 0.07 ENSRNOT00000055889
rCG30099-like
chr7_-_59547174 0.07 ENSRNOT00000085836
CCR4-NOT transcription complex, subunit 2
chr3_-_94833406 0.07 ENSRNOT00000049695
similar to Ac2-210
chr1_-_280338813 0.07 ENSRNOT00000011743
ventral anterior homeobox 1
chr3_+_80676820 0.07 ENSRNOT00000084809
autophagy and beclin 1 regulator 1
chr13_-_83425641 0.07 ENSRNOT00000063870
T-box 19
chr13_+_106463368 0.07 ENSRNOT00000003489
estrogen-related receptor gamma
chr19_-_26053762 0.06 ENSRNOT00000004646
microtubule associated serine/threonine kinase 1
chr9_+_16647922 0.06 ENSRNOT00000031625
kinesin light chain 4
chrX_+_63343724 0.06 ENSRNOT00000076530
ENSRNOT00000008558
kelch-like family member 15
chr1_-_261090437 0.06 ENSRNOT00000072055
FRAT2, WNT signaling pathway regulator
chrX_+_6273733 0.06 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr2_-_96509424 0.06 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chr4_+_152892388 0.06 ENSRNOT00000056198
ENSRNOT00000090218
ENSRNOT00000075895
lysine demethylase 5A
chr2_-_231521052 0.06 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr10_+_71536533 0.06 ENSRNOT00000088138
acetyl-CoA carboxylase alpha
chr6_-_67084234 0.06 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr11_+_9642365 0.05 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chr16_+_23668595 0.05 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr2_-_63166509 0.05 ENSRNOT00000018246
cadherin 6
chrX_-_73766885 0.05 ENSRNOT00000091325
ring finger protein, LIM domain interacting
chr9_+_16647598 0.05 ENSRNOT00000087413
kinesin light chain 4
chr16_+_46731403 0.05 ENSRNOT00000017624
teneurin transmembrane protein 3
chr7_-_129724303 0.05 ENSRNOT00000006034
bromodomain containing 1
chr3_+_116899878 0.05 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr6_+_147876237 0.05 ENSRNOT00000056649
transmembrane protein 196
chr9_-_43139870 0.05 ENSRNOT00000021956
semaphorin 4C
chr7_-_138483612 0.05 ENSRNOT00000085620
solute carrier family 38, member 4
chr13_+_98615287 0.05 ENSRNOT00000004032
inositol-trisphosphate 3-kinase B
chr13_+_76943633 0.05 ENSRNOT00000076908
ring finger and WD repeat domain 2
chr11_-_84633504 0.05 ENSRNOT00000052120
kelch-like family member 24
chr10_+_11206226 0.05 ENSRNOT00000006979
transcription factor AP-4
chr14_+_2613406 0.05 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr4_-_115516296 0.05 ENSRNOT00000019399
poly(A) binding protein interacting protein 2B
chr14_+_81819415 0.05 ENSRNOT00000018515
ENSRNOT00000075863
ENSRNOT00000077060
Max dimerization protein 4
chr14_+_11199404 0.05 ENSRNOT00000003106
heterogeneous nuclear ribonucleoprotein D-like
chr9_+_67234303 0.05 ENSRNOT00000050179
abl-interactor 2
chr17_-_18421861 0.05 ENSRNOT00000060500
ENSRNOT00000036560
family with sequence similarity 8, member A1
chr2_+_198006316 0.05 ENSRNOT00000081383
ENSRNOT00000056289
aph-1 homolog A, gamma secretase subunit
chr6_-_136436620 0.05 ENSRNOT00000067118
protein phosphatase 1, regulatory subunit 13B
chr1_-_126211439 0.05 ENSRNOT00000014988
tight junction protein 1
chr10_+_14248710 0.04 ENSRNOT00000020733
splA/ryanodine receptor domain and SOCS box containing 3
chr4_-_119131202 0.04 ENSRNOT00000011675
anthrax toxin receptor 1
chr6_-_136436818 0.04 ENSRNOT00000082600
protein phosphatase 1, regulatory subunit 13B
chr4_+_155321553 0.04 ENSRNOT00000089614
microfibrillar associated protein 5
chr4_+_62221011 0.04 ENSRNOT00000041264
caldesmon 1
chr3_+_14990652 0.04 ENSRNOT00000090735
DAB2 interacting protein
chr1_-_93949187 0.04 ENSRNOT00000018956
zinc finger protein 536
chr7_+_142776252 0.04 ENSRNOT00000008673
activin A receptor like type 1
chr20_+_34894419 0.04 ENSRNOT00000000471
anti-silencing function 1A histone chaperone
chr5_-_50684409 0.04 ENSRNOT00000013181
similar to RIKEN cDNA 3110043O21
chr7_+_59326518 0.04 ENSRNOT00000085231
protein tyrosine phosphatase, receptor type, B
chr2_-_172361779 0.04 ENSRNOT00000085876
schwannomin interacting protein 1
chr3_-_94418711 0.04 ENSRNOT00000089554
homeodomain interacting protein kinase 3
chrX_+_62727755 0.04 ENSRNOT00000077055
phosphate cytidylyltransferase 1, choline, beta
chr10_+_66732390 0.04 ENSRNOT00000089538
neurofibromin 1
chr1_-_40921508 0.04 ENSRNOT00000026433
zinc finger and BTB domain containing 2
chr16_-_71319052 0.04 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr8_+_119030875 0.04 ENSRNOT00000028458
myosin light chain 3
chr10_+_4945911 0.03 ENSRNOT00000003420
protamine 1
chr4_+_62220736 0.03 ENSRNOT00000086377
caldesmon 1
chr2_-_177924970 0.03 ENSRNOT00000029340
Rap guanine nucleotide exchange factor 2
chr8_+_128824508 0.03 ENSRNOT00000025343
myelin-associated oligodendrocyte basic protein
chr4_+_158088505 0.03 ENSRNOT00000026643
von Willebrand factor
chr1_-_156327352 0.03 ENSRNOT00000074282
coiled-coil domain-containing protein 89-like
chr9_+_62291809 0.03 ENSRNOT00000090621
phospholipase C-like 1
chr5_+_113725717 0.03 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr9_+_46657575 0.03 ENSRNOT00000083322
mitogen-activated protein kinase kinase kinase kinase 4
chr9_+_2190915 0.03 ENSRNOT00000077417
SATB homeobox 1
chr1_-_13395370 0.03 ENSRNOT00000085519
coiled-coil domain containing 28A
chr6_+_29061618 0.03 ENSRNOT00000092223
ATPase family, AAA domain containing 2B
chr15_+_83703791 0.03 ENSRNOT00000090637
Kruppel-like factor 5
chr14_+_10786399 0.03 ENSRNOT00000003006
lin-54 DREAM MuvB core complex component
chr3_+_148510779 0.03 ENSRNOT00000012156
XK related 7
chr7_+_59349745 0.03 ENSRNOT00000085334
protein tyrosine phosphatase, receptor type, B
chr8_+_94686938 0.03 ENSRNOT00000013285
ripply transcriptional repressor 2
chr4_+_157524423 0.03 ENSRNOT00000036654
zinc finger protein 384
chr3_-_91370167 0.03 ENSRNOT00000006291
proline rich 5 like
chr3_-_71845232 0.03 ENSRNOT00000078645
calcitonin receptor like receptor
chr4_-_168517177 0.03 ENSRNOT00000009151
dual specificity phosphatase 16
chr13_+_60435946 0.03 ENSRNOT00000004342
Beta-1,3-galactosyltransferase 2
chr7_+_142776580 0.03 ENSRNOT00000081047
activin A receptor like type 1
chr8_+_48925604 0.03 ENSRNOT00000077445
DEAD-box helicase 6
chr10_+_43768708 0.03 ENSRNOT00000086218
SH3 binding domain protein 5 like
chr6_-_105518725 0.02 ENSRNOT00000009693
ENSRNOT00000083488
mitogen-activated protein kinase kinase kinase 9
chr2_+_189615948 0.02 ENSRNOT00000092144
CREB regulated transcription coactivator 2
chr8_-_71337746 0.02 ENSRNOT00000021554
zinc finger protein 609
chr4_+_118207862 0.02 ENSRNOT00000085787
ENSRNOT00000023103
TIA1 cytotoxic granule-associated RNA binding protein
chr9_-_16647458 0.02 ENSRNOT00000024380
mitochondrial ribosomal protein L2
chr10_+_39850818 0.02 ENSRNOT00000012671
folliculin interacting protein 1
chr8_+_117574161 0.02 ENSRNOT00000077078
inositol hexakisphosphate kinase 2
chr14_+_8080565 0.02 ENSRNOT00000092395
mitogen activated protein kinase 10
chr13_+_89805962 0.02 ENSRNOT00000074035
thiosulfate sulfurtransferase like domain containing 1
chr10_+_67862054 0.02 ENSRNOT00000031746
cyclin-dependent kinase 5 regulatory subunit 1
chr2_+_257633425 0.02 ENSRNOT00000071770
zinc finger, ZZ-type containing 3
chr6_-_107080524 0.02 ENSRNOT00000011662
zinc finger FYVE-type containing 1
chr15_+_39779648 0.02 ENSRNOT00000084505
calcium binding protein 39-like
chr9_-_55256340 0.02 ENSRNOT00000028907
serum deprivation response
chr3_-_110324084 0.02 ENSRNOT00000010381
Bcl2 modifying factor
chrX_+_9436707 0.02 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr16_-_21274688 0.02 ENSRNOT00000027953
testis-specific serine kinase 6
chr3_-_168018410 0.02 ENSRNOT00000087579
breast carcinoma amplified sequence 1
chr10_+_95642640 0.01 ENSRNOT00000029782
Ribosomal_L22 domain containing protein RGD1359290
chr18_+_79406381 0.01 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr6_+_27768943 0.01 ENSRNOT00000015820
kinesin family member 3C
chr9_-_5329305 0.01 ENSRNOT00000078055
solute carrier family 5 member 7
chr18_+_3995921 0.01 ENSRNOT00000091424
tetratricopeptide repeat domain 39C
chr4_-_125929002 0.01 ENSRNOT00000083271
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_-_14247886 0.01 ENSRNOT00000020504
nucleotide binding protein 2
chr1_-_137359072 0.01 ENSRNOT00000014553
kelch-like family member 25
chr1_+_12823363 0.01 ENSRNOT00000086790
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr1_-_8885967 0.01 ENSRNOT00000016102
gap junction protein, epsilon 1
chr4_+_7122890 0.01 ENSRNOT00000076339
ENSRNOT00000076418
ENSRNOT00000014718
ATP binding cassette subfamily F member 2
chr1_+_174702373 0.01 ENSRNOT00000013733
zinc finger protein 143
chr18_+_3887419 0.01 ENSRNOT00000093089
laminin subunit alpha 3
chr5_-_48504511 0.01 ENSRNOT00000010271
proline-rich nuclear receptor coactivator 1
chrX_+_128493614 0.01 ENSRNOT00000044240
stromal antigen 2
chr3_-_147865393 0.01 ENSRNOT00000009852
SRY box 12
chr4_-_170117325 0.01 ENSRNOT00000074198
histone H4-like
chr4_-_87111025 0.01 ENSRNOT00000018442
kelch repeat and BTB domain containing 2
chr1_+_259926537 0.01 ENSRNOT00000073537
cyclin J
chr9_-_92405117 0.01 ENSRNOT00000079452
thyroid hormone receptor interactor 12
chr4_-_129569470 0.00 ENSRNOT00000008893
ubiquitin-like modifier activating enzyme 3
chrX_+_63343546 0.00 ENSRNOT00000076315
kelch-like family member 15
chrX_+_40363646 0.00 ENSRNOT00000010135
spermine synthase
chr10_+_35872619 0.00 ENSRNOT00000059190
heterogeneous nuclear ribonucleoprotein H1
chrX_-_62690806 0.00 ENSRNOT00000018147
DNA polymerase alpha 1, catalytic subunit
chr16_-_47535358 0.00 ENSRNOT00000040731
claudin 22
chr3_+_57286892 0.00 ENSRNOT00000039065
Golgi reassembly-stacking protein 2-like
chr2_+_77868412 0.00 ENSRNOT00000065897
ENSRNOT00000014022
myosin X
chr3_-_160038078 0.00 ENSRNOT00000013445
serine incorporator 3
chr13_-_68858781 0.00 ENSRNOT00000065944
ENSRNOT00000092053
ring finger protein 2
chr4_-_55398941 0.00 ENSRNOT00000075324
glutamate metabotropic receptor 8
chr1_+_260798239 0.00 ENSRNOT00000036791
ligand dependent nuclear receptor corepressor

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox5_Sry

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.4 GO:0097070 ductus arteriosus closure(GO:0097070)
0.1 0.2 GO:0048014 Tie signaling pathway(GO:0048014)
0.0 0.1 GO:1900095 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.1 GO:0060926 cardiac pacemaker cell development(GO:0060926)
0.0 0.1 GO:0016240 autophagosome docking(GO:0016240)
0.0 0.4 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.1 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.0 0.2 GO:1904646 cellular response to beta-amyloid(GO:1904646)
0.0 0.1 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.0 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.0 GO:1901726 negative regulation of histone deacetylase activity(GO:1901726)
0.0 0.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:2001295 multicellular organismal protein metabolic process(GO:0044268) malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.2 GO:0031643 positive regulation of myelination(GO:0031643)
0.0 0.9 GO:0031103 axon regeneration(GO:0031103)
0.0 0.1 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.2 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.0 0.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0071953 elastic fiber(GO:0071953)
0.1 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.0 GO:1990032 parallel fiber(GO:1990032)
0.0 0.1 GO:0030478 actin cap(GO:0030478)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.2 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)
0.0 0.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.3 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.2 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0098821 activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0043274 phospholipase binding(GO:0043274)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.1 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1