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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Sox21

Z-value: 0.36

Motif logo

Transcription factors associated with Sox21

Gene Symbol Gene ID Gene Info
ENSRNOG00000052579 Sox21

Activity profile of Sox21 motif

Sorted Z-values of Sox21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_135513650 0.19 ENSRNOT00000010676
REST corepressor 1
chr13_+_43850751 0.17 ENSRNOT00000004995
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
chr2_+_155555840 0.15 ENSRNOT00000080951

chrX_+_54062935 0.15 ENSRNOT00000004854
TGF-beta activated kinase 1/MAP3K7 binding protein 3
chr5_+_150787043 0.15 ENSRNOT00000082945
EYA transcriptional coactivator and phosphatase 3
chr6_+_12179227 0.13 ENSRNOT00000061693
forkhead box N2
chr4_-_155563249 0.12 ENSRNOT00000011298
solute carrier family 2 member 3
chr5_-_12526962 0.11 ENSRNOT00000092104
suppression of tumorigenicity 18
chr4_-_144869919 0.11 ENSRNOT00000009066
SLIT-ROBO Rho GTPase activating protein 3
chr4_-_168517177 0.11 ENSRNOT00000009151
dual specificity phosphatase 16
chr1_+_240355149 0.11 ENSRNOT00000018521
transient receptor potential cation channel, subfamily M, member 3
chr8_-_123829749 0.11 ENSRNOT00000090467

chr3_-_138683318 0.10 ENSRNOT00000029701
double zinc ribbon and ankyrin repeat domains 1
chr10_-_35187416 0.10 ENSRNOT00000084509
CCR4-NOT transcription complex, subunit 6
chr9_-_66019065 0.09 ENSRNOT00000088729
ALS2, alsin Rho guanine nucleotide exchange factor
chr14_+_104250617 0.09 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr1_-_67134827 0.09 ENSRNOT00000045214
vomeronasal 1 receptor 45
chr5_+_121952977 0.09 ENSRNOT00000008278
phosphodiesterase 4B
chr3_-_141411170 0.08 ENSRNOT00000017364
NK2 homeobox 2
chr16_+_50152008 0.08 ENSRNOT00000019237
kallikrein B1
chr7_+_48867664 0.08 ENSRNOT00000005862
PTPRF interacting protein alpha 2
chr19_-_37796089 0.08 ENSRNOT00000024891
RAN binding protein 10
chr3_+_171832500 0.08 ENSRNOT00000007554
VAMP associated protein B and C
chr10_-_58771908 0.07 ENSRNOT00000018808
similar to 4933427D14Rik protein
chr18_+_30895831 0.07 ENSRNOT00000026985
protocadherin gamma subfamily A, 10
chr2_+_251200686 0.07 ENSRNOT00000019210
collagen type XXIV alpha 1 chain
chrX_+_128409472 0.07 ENSRNOT00000078482
X-linked inhibitor of apoptosis
chr11_+_65743892 0.07 ENSRNOT00000085226

chr1_-_140262452 0.07 ENSRNOT00000046849
ENSRNOT00000045165
ENSRNOT00000025536
ENSRNOT00000041839
neurotrophic receptor tyrosine kinase 3
chr8_+_82037977 0.07 ENSRNOT00000082288
myosin VA
chr14_-_86333424 0.07 ENSRNOT00000083191
NudC domain containing 3
chr1_+_87563975 0.06 ENSRNOT00000088772
zinc finger protein 30
chr17_-_86657473 0.06 ENSRNOT00000078827

chr11_-_11213821 0.06 ENSRNOT00000093706
roundabout guidance receptor 2
chr4_+_153217782 0.06 ENSRNOT00000015499
CECR2, histone acetyl-lysine reader
chr5_+_167141875 0.06 ENSRNOT00000089314
solute carrier family 2 member 5
chr3_-_61488696 0.06 ENSRNOT00000083045
lunapark, ER junction formation factor
chr5_+_131380297 0.06 ENSRNOT00000010548
ATP/GTP binding protein-like 4
chr4_-_119131202 0.05 ENSRNOT00000011675
anthrax toxin receptor 1
chr16_-_9658484 0.05 ENSRNOT00000065216
mitogen-activated protein kinase 8
chr4_-_155275161 0.05 ENSRNOT00000032690
ribosomal modification protein rimK-like family member B
chr2_-_186480278 0.05 ENSRNOT00000031743
kin of IRRE like (Drosophila)
chr10_-_1461216 0.05 ENSRNOT00000083125
ENSRNOT00000084447
ENSRNOT00000078421
poly(A)-specific ribonuclease
chr1_-_219544328 0.05 ENSRNOT00000025847
G protein-coupled receptor kinase 2
chr2_-_27343998 0.05 ENSRNOT00000091418
DNA polymerase kappa
chr1_+_171797516 0.05 ENSRNOT00000088110
PPFIA binding protein 2
chr17_+_36691875 0.05 ENSRNOT00000074314
similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a)
chr4_-_49422824 0.05 ENSRNOT00000077889
family with sequence similarity 3, member C
chr12_+_38375416 0.05 ENSRNOT00000078530
CAP-GLY domain containing linker protein 1
chr12_-_52658275 0.05 ENSRNOT00000041981
zinc finger protein 605
chr3_+_94585873 0.05 ENSRNOT00000076762
cleavage stimulation factor subunit 3
chr11_-_72814253 0.05 ENSRNOT00000029842
UBX domain-containing protein 7-like
chr5_-_152589719 0.04 ENSRNOT00000022522
exostosin-like glycosyltransferase 1
chr5_+_156613741 0.04 ENSRNOT00000076031
SH2 domain containing 5
chr3_-_111587151 0.04 ENSRNOT00000007299
RNA polymerase II associated protein 1
chr5_-_39650894 0.04 ENSRNOT00000010421
ENSRNOT00000089522
Ufm1-specific ligase 1
chr3_+_17889972 0.04 ENSRNOT00000073021

chr6_+_99883959 0.04 ENSRNOT00000010588
farnesyltransferase, CAAX box, beta
chr10_-_52290657 0.04 ENSRNOT00000005293
mitogen activated protein kinase kinase 4
chr11_+_42259761 0.04 ENSRNOT00000047310
Eph receptor A6
chr7_-_104541392 0.04 ENSRNOT00000078116
family with sequence similarity 49, member B
chr4_-_50693869 0.04 ENSRNOT00000064228
ring finger protein 148
chr11_-_88374679 0.04 ENSRNOT00000002524
topoisomerase (DNA) III beta
chr1_+_204959174 0.04 ENSRNOT00000023257
zinc finger RANBP2-type containing 1
chr5_-_120083904 0.04 ENSRNOT00000064542
Janus kinase 1
chr20_+_4329811 0.04 ENSRNOT00000000513
notch 4
chr10_+_65552897 0.04 ENSRNOT00000056217
sperm associated antigen 5
chr13_-_83457888 0.04 ENSRNOT00000076289
ENSRNOT00000004065
SFT2 domain containing 2
chr17_-_2278613 0.03 ENSRNOT00000046525
contactin associated protein-like 3B
chr1_-_53152866 0.03 ENSRNOT00000085501
Fgfr1 oncogene partner
chr3_-_48831417 0.03 ENSRNOT00000009920
ENSRNOT00000085246
potassium voltage-gated channel subfamily H member 7
chr13_-_34251942 0.03 ENSRNOT00000044095
translin
chr3_-_132282879 0.03 ENSRNOT00000042040
high-mobility group nucleosomal binding domain 2-like
chr10_+_3170742 0.03 ENSRNOT00000093528
ENSRNOT00000004459
RRN3 homolog, RNA polymerase I transcription factor
chr2_-_38110567 0.03 ENSRNOT00000072212
importin 11
chr4_+_91373942 0.03 ENSRNOT00000043827
coiled-coil serine-rich protein 1
chr7_+_73273985 0.03 ENSRNOT00000077730
POP1 homolog, ribonuclease P/MRP subunit
chr7_+_28066635 0.03 ENSRNOT00000005844
phenylalanine hydroxylase
chr9_+_118842787 0.03 ENSRNOT00000090512
DLG associated protein 1
chrX_+_9956370 0.02 ENSRNOT00000082316
peripheral plasma membrane protein CASK-like
chr6_-_125723732 0.02 ENSRNOT00000084815
fibulin 5
chr4_-_55011415 0.02 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr2_-_3124543 0.02 ENSRNOT00000036547
family with sequence similarity 81, member B
chr10_-_87286387 0.02 ENSRNOT00000044206
keratin 28
chr1_-_87735308 0.02 ENSRNOT00000089385

chr9_+_10941613 0.02 ENSRNOT00000070794
semaphorin 6B
chr1_+_253221812 0.02 ENSRNOT00000085880
ENSRNOT00000054753
kinesin family member 20B
chr13_+_110372164 0.02 ENSRNOT00000049634
similar to ribosomal protein L37
chr3_+_158997834 0.02 ENSRNOT00000000211
von Willebrand factor A domain-containing protein 5A
chr1_-_102845083 0.02 ENSRNOT00000082289
serum amyloid A4
chr17_+_27492220 0.02 ENSRNOT00000084090
signal sequence receptor subunit 1
chr18_-_28017925 0.02 ENSRNOT00000075420
leucine rich repeat transmembrane neuronal 2
chr19_-_11669578 0.02 ENSRNOT00000026373
G protein subunit alpha o1
chr2_+_195684210 0.02 ENSRNOT00000028316
mitochondrial ribosomal protein L9
chr11_+_47061354 0.02 ENSRNOT00000039997
PEST proteolytic signal containing nuclear protein
chr3_+_43255567 0.02 ENSRNOT00000044419
glycerol-3-phosphate dehydrogenase 2
chr13_+_57243877 0.02 ENSRNOT00000083693
potassium sodium-activated channel subfamily T member 2
chr11_+_7265828 0.02 ENSRNOT00000084765
1,4-alpha-glucan branching enzyme 1
chr8_+_42443442 0.02 ENSRNOT00000015986
von Willebrand factor A domain containing 5A
chrM_+_9870 0.01 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr14_-_66771750 0.01 ENSRNOT00000005587
PARK2 co-regulated-like
chrX_-_40086870 0.01 ENSRNOT00000010027
small muscle protein, X-linked
chr2_+_164601586 0.01 ENSRNOT00000042079
ENSRNOT00000017608
G elongation factor, mitochondrial 1
chr13_-_52413681 0.01 ENSRNOT00000037100
ENSRNOT00000011801
neuron navigator 1
chr10_+_10457320 0.01 ENSRNOT00000003832
RNA binding motif protein 25-like 1
chr17_-_76281660 0.01 ENSRNOT00000058070
UPF2 regulator of nonsense transcripts homolog (yeast)
chr3_+_16846412 0.01 ENSRNOT00000074266

chr13_-_34251650 0.01 ENSRNOT00000068524
translin
chrX_+_84064427 0.01 ENSRNOT00000046364
zinc finger protein 711
chr5_+_6373583 0.01 ENSRNOT00000084749

chr7_+_37101391 0.01 ENSRNOT00000029764
early endosome antigen 1
chr9_+_42945358 0.01 ENSRNOT00000059806
fer-1-like family member 5
chr4_+_146598413 0.01 ENSRNOT00000067532
autophagy related 7
chr5_+_157222636 0.01 ENSRNOT00000022579
phospholipase A2, group IID
chr18_-_1828606 0.01 ENSRNOT00000033312
establishment of sister chromatid cohesion N-acetyltransferase 1
chr2_+_100677411 0.01 ENSRNOT00000067556
YTH N(6)-methyladenosine RNA binding protein 3
chrX_+_110016995 0.01 ENSRNOT00000093542
Nik related kinase
chr3_-_48604097 0.01 ENSRNOT00000009620
interferon induced with helicase C domain 1
chr2_+_196462554 0.00 ENSRNOT00000056380
family with sequence similarity 63, member A
chrX_-_10031167 0.00 ENSRNOT00000060988
G protein-coupled receptor 34
chr6_-_14523961 0.00 ENSRNOT00000071402
neurexin 1
chr11_-_54344615 0.00 ENSRNOT00000090307
myosin, heavy chain 15
chr1_+_281863918 0.00 ENSRNOT00000030108
SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
chr16_-_14382641 0.00 ENSRNOT00000018723
growth hormone inducible transmembrane protein
chr6_-_138249382 0.00 ENSRNOT00000085678
ENSRNOT00000006912
immunoglobulin heavy constant mu
chr10_-_63240332 0.00 ENSRNOT00000005125
bleomycin hydrolase
chr1_+_242959488 0.00 ENSRNOT00000015668
dedicator of cytokinesis 8
chr10_+_29033989 0.00 ENSRNOT00000088322
SLU7 homolog, splicing factor
chr6_+_29061618 0.00 ENSRNOT00000092223
ATPase family, AAA domain containing 2B

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.1 GO:0015755 fructose transport(GO:0015755)
0.0 0.1 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.1 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.1 GO:0051643 endoplasmic reticulum localization(GO:0051643)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.1 GO:0046725 negative regulation by virus of viral protein levels in host cell(GO:0046725)
0.0 0.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.0 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.0 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0051036 regulation of endosome size(GO:0051036)
0.0 0.0 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947) protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.0 GO:0072709 cellular response to sorbitol(GO:0072709)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042642 actomyosin, myosin complex part(GO:0042642)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.1 GO:0033222 xylose binding(GO:0033222)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0 0.1 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 0.0 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters