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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Sox18_Sox12
Z-value: 0.85
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Transcription factors associated with Sox18_Sox12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sox12 | rn6_v1_chr3_-_147865393_147865393 | 0.50 | 3.9e-01 | Click! |
| Sox18 | rn6_v1_chr3_-_177179127_177179127 | 0.37 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_155160481 Show fit | 0.67 |
ENSRNOT00000021133
|
protein phosphatase 1, regulatory subunit 16B |
|
| chr3_+_103773459 Show fit | 0.47 |
ENSRNOT00000079727
|
solute carrier family 12, member 6 |
|
| chr18_+_30562178 Show fit | 0.44 |
ENSRNOT00000040998
|
protocadherin beta-16-like |
|
| chr14_-_81399353 Show fit | 0.44 |
ENSRNOT00000018340
|
adducin 1 |
|
| chr1_-_128287151 Show fit | 0.43 |
ENSRNOT00000084946
ENSRNOT00000089723 |
myocyte enhancer factor 2a |
|
| chr10_+_14547172 Show fit | 0.41 |
ENSRNOT00000092043
|
unkempt family like zinc finger |
|
| chr18_+_30900291 Show fit | 0.34 |
ENSRNOT00000060461
|
protocadherin gamma subfamily B, 7 |
|
| chr2_+_22950018 Show fit | 0.32 |
ENSRNOT00000071804
|
homer scaffolding protein 1 |
|
| chr1_+_98627372 Show fit | 0.31 |
ENSRNOT00000030370
|
zinc finger protein 17 |
|
| chr8_+_109455786 Show fit | 0.30 |
ENSRNOT00000039593
|
male-specific lethal 2 homolog (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sox18_Sox12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 0.7 | GO:1902309 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) |
| 0.2 | 0.5 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.1 | 0.4 | GO:0055005 | ventricular cardiac myofibril assembly(GO:0055005) |
| 0.1 | 0.4 | GO:1901552 | positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142) |
| 0.0 | 0.4 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.4 | GO:0021860 | pyramidal neuron development(GO:0021860) |
| 0.1 | 0.3 | GO:1901421 | positive regulation of response to alcohol(GO:1901421) |
| 0.1 | 0.3 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.3 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.1 | 0.3 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 0.3 | GO:0097441 | basilar dendrite(GO:0097441) |
| 0.0 | 0.3 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.0 | 0.3 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.1 | 0.2 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.1 | 0.2 | GO:0033557 | Slx1-Slx4 complex(GO:0033557) |
| 0.0 | 0.2 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 0.2 | GO:0030991 | intraciliary transport particle A(GO:0030991) |
| 0.0 | 0.2 | GO:0031932 | TORC2 complex(GO:0031932) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.1 | 0.5 | GO:0035827 | rubidium ion transmembrane transporter activity(GO:0035827) |
| 0.0 | 0.4 | GO:0042608 | T cell receptor binding(GO:0042608) |
| 0.1 | 0.3 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.1 | 0.3 | GO:0031802 | type 5 metabotropic glutamate receptor binding(GO:0031802) |
| 0.1 | 0.3 | GO:0070139 | ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139) |
| 0.1 | 0.3 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 0.3 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.3 | GO:0034237 | protein kinase A catalytic subunit binding(GO:0034236) protein kinase A regulatory subunit binding(GO:0034237) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.4 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.0 | 0.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.0 | 0.2 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.2 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.0 | 0.2 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 0.2 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |