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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Smad3

Z-value: 0.62

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Transcription factors associated with Smad3

Gene Symbol Gene ID Gene Info
Smad3
ENSRNOG00000008620 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Smad3rn6_v1_chr8_-_68678349_686783490.711.8e-01Click!

Activity profile of Smad3 motif

Sorted Z-values of Smad3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_142905758 0.41 ENSRNOT00000078663
Nr4a1
nuclear receptor subfamily 4, group A, member 1
chr3_-_94182714 0.30 ENSRNOT00000015073
LOC100362814
hypothetical protein LOC100362814
chr13_+_90723092 0.27 ENSRNOT00000010146
Kcnj10
ATP-sensitive inward rectifier potassium channel 10
chr10_+_106264434 0.24 ENSRNOT00000003891
Sept9
septin 9
chr9_-_65737538 0.24 ENSRNOT00000014939
Trak2
trafficking kinesin protein 2
chrX_+_80213332 0.24 ENSRNOT00000042827
Sh3bgrl
SH3 domain binding glutamate-rich protein like
chr12_-_44381289 0.22 ENSRNOT00000001493
Nos1
nitric oxide synthase 1
chr3_-_79282493 0.21 ENSRNOT00000049832
Ptprj
protein tyrosine phosphatase, receptor type, J
chr10_-_65066612 0.20 ENSRNOT00000043448
Myo18a
myosin XVIIIa
chr10_-_90393317 0.20 ENSRNOT00000028563
Fam171a2
family with sequence similarity 171, member A2
chr9_+_73319710 0.19 ENSRNOT00000092485
Map2
microtubule-associated protein 2
chr10_-_45297385 0.19 ENSRNOT00000041187
Hist3h2bb
histone cluster 3 H2B family member b
chr18_+_55797198 0.19 ENSRNOT00000026334
ENSRNOT00000026394
Dctn4
dynactin subunit 4
chr10_-_86554478 0.19 ENSRNOT00000049621
Ormdl3
ORMDL sphingolipid biosynthesis regulator 3
chr17_-_44527801 0.16 ENSRNOT00000089643
Hist1h2bk
histone cluster 1 H2B family member k
chr12_+_18074033 0.16 ENSRNOT00000001727
LOC103689975
integrator complex subunit 1-like
chr2_-_198360678 0.15 ENSRNOT00000051917
Hist2h2ac
histone cluster 2 H2A family member c
chr10_+_55687050 0.14 ENSRNOT00000057136
Per1
period circadian clock 1
chr1_+_167066516 0.14 ENSRNOT00000000474
Numa1
nuclear mitotic apparatus protein 1
chr3_-_80000091 0.13 ENSRNOT00000079394
Madd
MAP-kinase activating death domain
chr5_-_60559329 0.13 ENSRNOT00000017046
Zbtb5
zinc finger and BTB domain containing 5
chr12_+_16950728 0.12 ENSRNOT00000060370
Ints1
integrator complex subunit 1
chr6_-_115513354 0.12 ENSRNOT00000005881
Ston2
stonin 2
chr17_-_43770561 0.12 ENSRNOT00000088408
RGD1562378
histone H4 variant H4-v.1
chr7_+_123168811 0.12 ENSRNOT00000007091
Csdc2
cold shock domain containing C2
chr1_+_199037544 0.12 ENSRNOT00000025499
Rnf40
ring finger protein 40
chr1_+_217345545 0.12 ENSRNOT00000071741
Shank2
SH3 and multiple ankyrin repeat domains 2
chr8_+_117780891 0.11 ENSRNOT00000077236
Shisa5
shisa family member 5
chr7_-_116106368 0.10 ENSRNOT00000035678
Ly6k
lymphocyte antigen 6 complex, locus K
chr1_-_128695796 0.10 ENSRNOT00000076329
Synm
synemin
chr18_-_57114545 0.10 ENSRNOT00000026495
Afap1l1
actin filament associated protein 1-like 1
chr3_+_43255567 0.10 ENSRNOT00000044419
Gpd2
glycerol-3-phosphate dehydrogenase 2
chr17_-_43821536 0.10 ENSRNOT00000072286
RGD1562378
histone H4 variant H4-v.1
chr1_+_217345154 0.10 ENSRNOT00000092516
Shank2
SH3 and multiple ankyrin repeat domains 2
chr8_-_115358046 0.10 ENSRNOT00000017607
Grm2
glutamate metabotropic receptor 2
chr3_+_152752091 0.10 ENSRNOT00000037177
Dlgap4
DLG associated protein 4
chr1_+_259958310 0.09 ENSRNOT00000019751
LOC103689954
ectonucleoside triphosphate diphosphohydrolase 1
chr2_+_83393282 0.09 ENSRNOT00000044871
Ctnnd2
catenin delta 2
chr3_-_112676556 0.09 ENSRNOT00000014664
Cdan1
codanin 1
chr18_+_30398113 0.09 ENSRNOT00000027206
Pcdhb5
protocadherin beta 5
chr5_+_145257714 0.09 ENSRNOT00000019214
Dlgap3
DLG associated protein 3
chr1_+_185427736 0.09 ENSRNOT00000064706
Plekha7
pleckstrin homology domain containing A7
chr14_-_33677031 0.08 ENSRNOT00000002908
RGD1311575
hypothetical LOC289568
chr13_-_51076852 0.08 ENSRNOT00000078993
Adora1
adenosine A1 receptor
chr14_-_35149608 0.08 ENSRNOT00000003050
ENSRNOT00000090654
Kit
KIT proto-oncogene receptor tyrosine kinase
chr16_+_84465656 0.08 ENSRNOT00000043188
LOC689713
LRRGT00175
chr7_+_11054333 0.08 ENSRNOT00000007202
Gna15
guanine nucleotide binding protein, alpha 15
chr14_-_80355420 0.08 ENSRNOT00000049798
Acox3
acyl-CoA oxidase 3, pristanoyl
chr4_+_181315444 0.08 ENSRNOT00000044147
Ppfibp1
PPFIA binding protein 1
chr9_-_82410904 0.08 ENSRNOT00000026081
Glb1l
galactosidase, beta 1-like
chr5_+_122100099 0.08 ENSRNOT00000007738
Pde4b
phosphodiesterase 4B
chr2_+_185590986 0.07 ENSRNOT00000088807
ENSRNOT00000088188
Lrba
LPS responsive beige-like anchor protein
chr6_-_38228379 0.07 ENSRNOT00000084924
Mycn
v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr2_-_40386669 0.06 ENSRNOT00000014074
Elovl7
ELOVL fatty acid elongase 7
chr4_-_170117325 0.06 ENSRNOT00000074198
LOC100912564
histone H4-like
chr9_+_25410669 0.06 ENSRNOT00000030912
ENSRNOT00000090920
Tfap2b
transcription factor AP-2 beta
chr2_-_210282352 0.05 ENSRNOT00000075653
Slc6a17
solute carrier family 6 member 17
chr16_-_62241361 0.05 ENSRNOT00000090036
Gsr
glutathione-disulfide reductase
chr5_+_167141875 0.05 ENSRNOT00000089314
Slc2a5
solute carrier family 2 member 5
chr18_+_30424814 0.05 ENSRNOT00000073425
Pcdhb7
protocadherin beta 7
chr2_-_189254628 0.05 ENSRNOT00000028234
Il6r
interleukin 6 receptor
chr17_+_44520537 0.05 ENSRNOT00000077985
hist1h2ail2
histone cluster 1, H2ai-like2
chr1_-_80514728 0.05 ENSRNOT00000081565
Clasrp
CLK4-associating serine/arginine rich protein
chr11_-_84583542 0.04 ENSRNOT00000064212
Yeats2
YEATS domain containing 2
chr13_-_60496511 0.04 ENSRNOT00000004495
Cdc73
cell division cycle 73
chr4_-_7228675 0.04 ENSRNOT00000064386
Agap3
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
chr18_+_30474947 0.03 ENSRNOT00000027188
Pcdhb9
protocadherin beta 9
chr5_-_169499268 0.03 ENSRNOT00000046552
Rnf207
ring finger protein 207
chr1_-_57555048 0.03 ENSRNOT00000066370
Prdm9
PR/SET domain 9
chr5_+_48456757 0.03 ENSRNOT00000091482
Srsf12
serine and arginine rich splicing factor 12
chr18_+_867048 0.02 ENSRNOT00000065494
Colec12
collectin sub-family member 12
chr13_+_48287873 0.02 ENSRNOT00000068223
Fam72a
family with sequence similarity 72, member A
chr1_-_69743616 0.02 ENSRNOT00000030259
Zfp772
zinc finger protein 772
chr9_+_82411013 0.02 ENSRNOT00000026194
Stk16
serine/threonine kinase 16
chr8_-_72284852 0.02 ENSRNOT00000080319
ENSRNOT00000057739
Usp3
ubiquitin specific peptidase 3
chr16_+_54358471 0.02 ENSRNOT00000047314
Mtus1
microtubule associated tumor suppressor 1
chr7_-_93280009 0.02 ENSRNOT00000064877
Samd12
sterile alpha motif domain containing 12
chr16_+_70644474 0.02 ENSRNOT00000045955
LOC100359503
ribosomal protein S28-like
chr1_-_226791773 0.02 ENSRNOT00000082482
ENSRNOT00000065376
ENSRNOT00000054812
ENSRNOT00000086669
LOC100911215
T-cell surface glycoprotein CD5-like
chr10_+_45297937 0.02 ENSRNOT00000066367
Trim17
tripartite motif-containing 17
chr5_+_74941802 0.02 ENSRNOT00000015576
Akap2
A-kinase anchoring protein 2
chr2_+_209839299 0.02 ENSRNOT00000092450
Kcna2
potassium voltage-gated channel subfamily A member 2
chr10_+_104483042 0.02 ENSRNOT00000007362
Sap30bp
SAP30 binding protein
chr1_-_165997751 0.02 ENSRNOT00000050227
P2ry6
pyrimidinergic receptor P2Y6
chr2_+_198360998 0.02 ENSRNOT00000046129
Hist2h2be
histone cluster 2, H2be
chr7_-_117289961 0.01 ENSRNOT00000042642
Plec
plectin
chr20_-_6960481 0.01 ENSRNOT00000093172
Mtch1
mitochondrial carrier 1
chr18_+_3861539 0.01 ENSRNOT00000015363
Lama3
laminin subunit alpha 3
chr7_+_123482255 0.01 ENSRNOT00000064487
LOC688613
hypothetical protein LOC688613
chr4_+_79868442 0.01 ENSRNOT00000089973
Mpp6
membrane palmitoylated protein 6
chr7_+_115956276 0.01 ENSRNOT00000007773
Them6
thioesterase superfamily member 6
chr18_+_64008048 0.01 ENSRNOT00000083414
Ldlrad4
low density lipoprotein receptor class A domain containing 4
chr5_+_173288447 0.01 ENSRNOT00000091205
ENSRNOT00000067252
Mxra8
matrix remodeling associated 8
chr10_+_56453877 0.01 ENSRNOT00000031640
Plscr3
phospholipid scramblase 3
chr5_+_148923098 0.01 ENSRNOT00000048781
Sdc3
syndecan 3
chr2_-_59181863 0.00 ENSRNOT00000079636
Spef2
sperm flagellar 2
chr1_-_199037267 0.00 ENSRNOT00000078779
Ccdc189
coiled-coil domain containing 189
chr18_-_69780922 0.00 ENSRNOT00000079093
Me2
malic enzyme 2
chr1_+_192233910 0.00 ENSRNOT00000016418
ENSRNOT00000016442
Prkcb
protein kinase C, beta
chr20_+_7484800 0.00 ENSRNOT00000081604
Anks1a
ankyrin repeat and sterile alpha motif domain containing 1A

Network of associatons between targets according to the STRING database.

First level regulatory network of Smad3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.1 0.2 GO:0098939 dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972)
0.1 0.4 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.1 0.2 GO:0090164 asymmetric Golgi ribbon formation(GO:0090164)
0.1 0.2 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.1 0.2 GO:0098923 positive regulation of adrenergic receptor signaling pathway(GO:0071879) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0036395 pancreatic amylase secretion(GO:0036395) regulation of pancreatic amylase secretion(GO:1902276)
0.0 0.1 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0 0.3 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.1 GO:1900453 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0097324 Kit signaling pathway(GO:0038109) melanocyte migration(GO:0097324) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.1 GO:0019563 glycerol catabolic process(GO:0019563)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0015820 leucine transport(GO:0015820)
0.0 0.1 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0 0.2 GO:0099562 maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562)
0.0 0.2 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.2 GO:0007097 nuclear migration(GO:0007097)
0.0 0.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0097070 ductus arteriosus closure(GO:0097070)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.0 GO:1903116 positive regulation of actin filament-based movement(GO:1903116) regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.2 GO:0031105 septin complex(GO:0031105)
0.0 0.2 GO:0005869 dynactin complex(GO:0005869)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.1 GO:0060053 neurofilament cytoskeleton(GO:0060053)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.3 GO:0032039 integrator complex(GO:0032039)
0.0 0.0 GO:0070110 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.3 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.2 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.3 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0098919 structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919)
0.0 0.1 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.0 0.4 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.4 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling