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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Smad3
Z-value: 0.62
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Transcription factors associated with Smad3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad3 | rn6_v1_chr8_-_68678349_68678349 | 0.71 | 1.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_142905758 Show fit | 0.41 |
ENSRNOT00000078663
|
nuclear receptor subfamily 4, group A, member 1 |
|
| chr3_-_94182714 Show fit | 0.30 |
ENSRNOT00000015073
|
hypothetical protein LOC100362814 |
|
| chr13_+_90723092 Show fit | 0.27 |
ENSRNOT00000010146
|
ATP-sensitive inward rectifier potassium channel 10 |
|
| chr10_+_106264434 Show fit | 0.24 |
ENSRNOT00000003891
|
septin 9 |
|
| chr9_-_65737538 Show fit | 0.24 |
ENSRNOT00000014939
|
trafficking kinesin protein 2 |
|
| chrX_+_80213332 Show fit | 0.24 |
ENSRNOT00000042827
|
SH3 domain binding glutamate-rich protein like |
|
| chr12_-_44381289 Show fit | 0.22 |
ENSRNOT00000001493
|
nitric oxide synthase 1 |
|
| chr3_-_79282493 Show fit | 0.21 |
ENSRNOT00000049832
|
protein tyrosine phosphatase, receptor type, J |
|
| chr10_-_65066612 Show fit | 0.20 |
ENSRNOT00000043448
|
myosin XVIIIa |
|
| chr10_-_90393317 Show fit | 0.20 |
ENSRNOT00000028563
|
family with sequence similarity 171, member A2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.1 | 0.3 | GO:0051933 | amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935) |
| 0.0 | 0.3 | GO:0034472 | snRNA 3'-end processing(GO:0034472) |
| 0.1 | 0.2 | GO:0098939 | dendritic transport of mitochondrion(GO:0098939) anterograde dendritic transport of mitochondrion(GO:0098972) |
| 0.1 | 0.2 | GO:0090164 | asymmetric Golgi ribbon formation(GO:0090164) |
| 0.1 | 0.2 | GO:1900060 | negative regulation of ceramide biosynthetic process(GO:1900060) |
| 0.1 | 0.2 | GO:0098923 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) |
| 0.0 | 0.2 | GO:0010572 | positive regulation of platelet activation(GO:0010572) |
| 0.0 | 0.2 | GO:0099562 | maintenance of postsynaptic specialization structure(GO:0098880) maintenance of postsynaptic density structure(GO:0099562) |
| 0.0 | 0.2 | GO:1902857 | positive regulation of nonmotile primary cilium assembly(GO:1902857) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.3 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.0 | 0.2 | GO:0035339 | SPOTS complex(GO:0035339) |
| 0.0 | 0.2 | GO:0031105 | septin complex(GO:0031105) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.2 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.2 | GO:0042582 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.1 | GO:0061673 | mitotic spindle astral microtubule(GO:0061673) |
| 0.0 | 0.1 | GO:0033503 | HULC complex(GO:0033503) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.3 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 0.3 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.2 | GO:0004517 | nitric-oxide synthase activity(GO:0004517) |
| 0.0 | 0.2 | GO:0098919 | structural constituent of postsynaptic specialization(GO:0098879) structural constituent of postsynaptic density(GO:0098919) |
| 0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.1 | GO:0052591 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.0 | 0.1 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 0.4 | REACTOME PIP3 ACTIVATES AKT SIGNALING | Genes involved in PIP3 activates AKT signaling |
| 0.0 | 0.1 | REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES | Genes involved in Recruitment of NuMA to mitotic centrosomes |