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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Smad1
Z-value: 1.38
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Transcription factors associated with Smad1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smad1 | rn6_v1_chr19_+_32188267_32188267 | -0.85 | 6.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_66229311 Show fit | 1.10 |
ENSRNOT00000016897
|
lectin, galactose binding, soluble 5 |
|
| chr7_+_28654733 Show fit | 1.03 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
|
| chr17_+_78793336 Show fit | 0.86 |
ENSRNOT00000057898
|
metallothionein 1 |
|
| chr12_+_19714324 Show fit | 0.83 |
ENSRNOT00000072303
|
similar to cell surface receptor FDFACT |
|
| chr15_+_34584320 Show fit | 0.69 |
ENSRNOT00000048255
|
|
|
| chr2_-_257484587 Show fit | 0.65 |
ENSRNOT00000083344
|
nexilin (F actin binding protein) |
|
| chr1_-_216080287 Show fit | 0.63 |
ENSRNOT00000027682
|
tyrosine hydroxylase |
|
| chr14_+_43694183 Show fit | 0.63 |
ENSRNOT00000046342
|
similar to ribosomal protein S23 |
|
| chr10_-_44746549 Show fit | 0.58 |
ENSRNOT00000003841
|
family with sequence similarity 183, member B |
|
| chr2_+_190003223 Show fit | 0.57 |
ENSRNOT00000015712
|
S100 calcium binding protein A5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Smad1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.2 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.0 | 1.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.3 | 1.0 | GO:0060160 | negative regulation of dopamine receptor signaling pathway(GO:0060160) |
| 0.2 | 1.0 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.2 | 0.9 | GO:0052314 | phytoalexin metabolic process(GO:0052314) |
| 0.2 | 0.9 | GO:0046687 | response to chromate(GO:0046687) |
| 0.3 | 0.8 | GO:0051867 | general adaptation syndrome, behavioral process(GO:0051867) |
| 0.2 | 0.8 | GO:0010037 | response to carbon dioxide(GO:0010037) |
| 0.2 | 0.8 | GO:0061743 | motor learning(GO:0061743) |
| 0.1 | 0.8 | GO:0006068 | ethanol catabolic process(GO:0006068) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.4 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 1.3 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 1.0 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 1.0 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 0.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.9 | GO:0005840 | ribosome(GO:0005840) |
| 0.1 | 0.8 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 1.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 1.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 1.3 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 1.2 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 1.2 | GO:0005179 | hormone activity(GO:0005179) |
| 0.1 | 1.1 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.3 | 1.0 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.1 | 1.0 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 0.7 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 0.6 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.0 | 0.6 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 0.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 0.6 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.0 | 0.4 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.0 | 2.8 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.0 | 1.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 1.4 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 1.1 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.0 | 1.1 | REACTOME AMINE LIGAND BINDING RECEPTORS | Genes involved in Amine ligand-binding receptors |
| 0.0 | 1.1 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 1.0 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 0.0 | 1.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.9 | REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | Genes involved in Class A/1 (Rhodopsin-like receptors) |