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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Six6
Z-value: 0.59
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Transcription factors associated with Six6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Six6 | rn6_v1_chr6_+_95816749_95816749 | 0.05 | 9.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_57516347 Show fit | 0.34 |
ENSRNOT00000082215
|
predicted gene 9949 |
|
| chr4_-_80395502 Show fit | 0.30 |
ENSRNOT00000014437
|
neuropeptide VF precursor |
|
| chr1_-_213650247 Show fit | 0.25 |
ENSRNOT00000019679
|
cytochrome c oxidase, subunit VIIIb |
|
| chr10_+_31647898 Show fit | 0.18 |
ENSRNOT00000066536
|
similar to kidney injury molecule 1 |
|
| chr8_+_69753373 Show fit | 0.17 |
ENSRNOT00000066973
|
timeless interacting protein |
|
| chr1_-_214252456 Show fit | 0.17 |
ENSRNOT00000023504
|
interferon regulatory factor 7 |
|
| chr3_-_40477754 Show fit | 0.16 |
ENSRNOT00000091168
|
|
|
| chr5_+_122508388 Show fit | 0.16 |
ENSRNOT00000038410
|
Tctex1 domain containing 1 |
|
| chr1_-_198104109 Show fit | 0.16 |
ENSRNOT00000026186
|
sulfotransferase family 1A member 1 |
|
| chr9_+_53440272 Show fit | 0.15 |
ENSRNOT00000059159
|
hypothetical protein LOC685203 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Six6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 0.1 | 0.2 | GO:0019626 | short-chain fatty acid catabolic process(GO:0019626) |
| 0.0 | 0.2 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.0 | 0.2 | GO:0034124 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) |
| 0.0 | 0.2 | GO:0050427 | flavonoid metabolic process(GO:0009812) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 0.0 | 0.2 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 0.0 | 0.2 | GO:0071688 | striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.1 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.0 | 0.1 | GO:1905133 | metaphase/anaphase transition of meiotic cell cycle(GO:0044785) regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902102) negative regulation of metaphase/anaphase transition of meiotic cell cycle(GO:1902103) regulation of meiotic chromosome separation(GO:1905132) negative regulation of meiotic chromosome separation(GO:1905133) |
| 0.0 | 0.1 | GO:0034441 | plasma lipoprotein particle oxidation(GO:0034441) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0031298 | replication fork protection complex(GO:0031298) |
| 0.0 | 0.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
| 0.0 | 0.2 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.1 | GO:0097058 | CRLF-CLCF1 complex(GO:0097058) |
| 0.0 | 0.1 | GO:0002189 | ribose phosphate diphosphokinase complex(GO:0002189) |
| 0.0 | 0.1 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.0 | 0.0 | GO:0035355 | Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0050294 | aryl sulfotransferase activity(GO:0004062) steroid sulfotransferase activity(GO:0050294) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.0 | 0.2 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.0 | 0.2 | GO:0097493 | structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.2 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.0 | 0.1 | GO:0004911 | interleukin-2 receptor activity(GO:0004911) |
| 0.0 | 0.1 | GO:0034437 | glycoprotein transporter activity(GO:0034437) |
| 0.0 | 0.1 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.1 | GO:0015272 | ATP-activated inward rectifier potassium channel activity(GO:0015272) |
| 0.0 | 0.1 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING | Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| 0.0 | 0.2 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 0.0 | REACTOME BETA DEFENSINS | Genes involved in Beta defensins |