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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Six3_Six1_Six2

Z-value: 0.29

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Transcription factors associated with Six3_Six1_Six2

Gene Symbol Gene ID Gene Info
ENSRNOG00000057031 SIX homeobox 3
ENSRNOG00000022777 SIX homeobox 1
ENSRNOG00000058827 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Six2rn6_v1_chr6_-_8956276_89562760.494.0e-01Click!
Six1rn6_v1_chr6_-_95934296_95934296-0.296.3e-01Click!
Six3rn6_v1_chr6_+_8886591_8886730-0.128.5e-01Click!

Activity profile of Six3_Six1_Six2 motif

Sorted Z-values of Six3_Six1_Six2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_111948753 0.24 ENSRNOT00000048074
hydroxysteroid 11-beta dehydrogenase 1
chr6_+_64224861 0.22 ENSRNOT00000093159
ENSRNOT00000093664
patatin-like phospholipase domain containing 8
chrX_+_19854836 0.20 ENSRNOT00000075010

chr5_+_173148884 0.16 ENSRNOT00000041753
hCG1994130-like
chr10_+_14492844 0.14 ENSRNOT00000023615
chloride voltage-gated channel 7
chrX_-_114232939 0.13 ENSRNOT00000042639
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr8_-_76940094 0.10 ENSRNOT00000082709
ENSRNOT00000084313
ring finger protein 111
chr10_-_36322356 0.09 ENSRNOT00000000248
zinc finger protein 354C
chr3_-_93789617 0.08 ENSRNOT00000078616
cell cycle associated protein 1
chr16_-_19544727 0.08 ENSRNOT00000074514
zinc finger protein 617
chr6_+_86823684 0.07 ENSRNOT00000086081
ENSRNOT00000006574
Fanconi anemia, complementation group M
chr5_+_124442293 0.07 ENSRNOT00000041922
similar to novel protein
chr5_+_9230984 0.06 ENSRNOT00000009136
valosin containing protein interacting protein 1
chr2_-_195935878 0.06 ENSRNOT00000028440
cingulin
chr1_+_201981357 0.05 ENSRNOT00000027999
acyl-CoA dehydrogenase, short/branched chain
chr10_+_71546977 0.05 ENSRNOT00000041140
acetyl-CoA carboxylase alpha
chr1_-_198104109 0.05 ENSRNOT00000026186
sulfotransferase family 1A member 1
chr2_-_187786700 0.04 ENSRNOT00000092257
ENSRNOT00000092612
ENSRNOT00000068360
solute carrier family 25, member 44
chr3_-_158328881 0.04 ENSRNOT00000044466
protein tyrosine phosphatase, receptor type, T
chr2_-_80667481 0.04 ENSRNOT00000016784
trio Rho guanine nucleotide exchange factor
chr1_+_57692836 0.04 ENSRNOT00000083968
ENSRNOT00000019358
chromodomain helicase DNA binding protein 1
chr4_+_170518673 0.04 ENSRNOT00000011803
activating transcription factor 7 interacting protein
chr4_-_150520363 0.04 ENSRNOT00000065579
zinc finger protein 9
chr6_+_96834525 0.04 ENSRNOT00000077935
hypoxia inducible factor 1 alpha subunit
chr8_+_115546712 0.03 ENSRNOT00000079801
DDB1 and CUL4 associated factor 1
chrX_+_156336450 0.03 ENSRNOT00000082124
solute carrier family 10, member 3
chr9_-_7891514 0.03 ENSRNOT00000072684
protection of telomeres 1B
chr10_+_70298519 0.03 ENSRNOT00000035730
ENSRNOT00000076233
ENSRNOT00000076445
ENSRNOT00000076133
schlafen family member 5
chr3_-_145641654 0.03 ENSRNOT00000008101
ENSRNOT00000008047
zinc finger protein 596-like
chr11_+_86903122 0.03 ENSRNOT00000048063
zinc finger, DHHC-type containing 8
chr7_-_60860990 0.03 ENSRNOT00000009511
RAP1B, member of RAS oncogene family
chr1_-_201981229 0.02 ENSRNOT00000077246
ENSRNOT00000035531
IKAROS family zinc finger 5
chr9_-_11108741 0.02 ENSRNOT00000072357
coiled-coil domain containing 94
chr10_+_62566732 0.02 ENSRNOT00000021368
TAO kinase 1
chr8_-_80631873 0.02 ENSRNOT00000091661
ENSRNOT00000080662
unc-13 homolog C
chr7_+_80750725 0.02 ENSRNOT00000079962
oxidation resistance 1
chr18_+_30856847 0.02 ENSRNOT00000027019

chr11_-_11585078 0.02 ENSRNOT00000088878
roundabout guidance receptor 2
chr16_-_81714346 0.02 ENSRNOT00000092552
lysosomal-associated membrane protein 1
chrX_-_56765893 0.02 ENSRNOT00000076283
interleukin 1 receptor accessory protein-like 1
chr7_+_117643206 0.02 ENSRNOT00000077588
aarF domain containing kinase 5
chr2_-_124047044 0.02 ENSRNOT00000065384
centrin 4
chr10_+_53713938 0.02 ENSRNOT00000004236
ENSRNOT00000086599
ENSRNOT00000085582
myosin heavy chain 2
chr1_-_189182306 0.02 ENSRNOT00000021249
glycoprotein 2
chr2_-_26011429 0.02 ENSRNOT00000065143
Rho guanine nucleotide exchange factor 28
chr13_+_56546021 0.02 ENSRNOT00000016797
abnormal spindle microtubule assembly
chr1_+_225899313 0.02 ENSRNOT00000031612
secretoglobin, family 2A, member 1
chr12_+_17253791 0.02 ENSRNOT00000083814
zinc finger AN1-type containing 2A
chr1_-_213650247 0.02 ENSRNOT00000019679
cytochrome c oxidase, subunit VIIIb
chrX_+_105575759 0.02 ENSRNOT00000088760
armadillo repeat containing, X-linked 3
chr10_-_13892997 0.02 ENSRNOT00000004192
TNF receptor associated factor 7
chr7_+_30699476 0.02 ENSRNOT00000059269
ankyrin repeat and sterile alpha motif domain containing 1B
chr13_-_34253910 0.02 ENSRNOT00000092847
translin
chr2_-_247446882 0.02 ENSRNOT00000021963
bone morphogenetic protein receptor type 1B
chr1_-_100530183 0.01 ENSRNOT00000067754
myosin binding protein C, fast-type
chr1_+_87045796 0.01 ENSRNOT00000027620
galectin 7
chr2_-_182846061 0.01 ENSRNOT00000013025
toll-like receptor 2
chr6_+_48452369 0.01 ENSRNOT00000044310
myelin transcription factor 1-like
chr12_-_16201632 0.01 ENSRNOT00000001688
carbohydrate sulfotransferase 12
chr11_+_73936750 0.01 ENSRNOT00000002350
ATPase 13A3
chr17_-_67945037 0.01 ENSRNOT00000023033
Kruppel-like factor 6
chr17_+_77195247 0.01 ENSRNOT00000081940
optineurin
chr8_+_133210473 0.01 ENSRNOT00000082774
chemokine (C-C motif) receptor 5
chr14_+_48726045 0.01 ENSRNOT00000086646
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr6_-_115352681 0.01 ENSRNOT00000005873
general transcription factor 2A subunit 1
chr8_-_21481735 0.01 ENSRNOT00000038069
zinc finger protein 426
chr5_+_146294030 0.01 ENSRNOT00000073637

chr1_-_167884690 0.01 ENSRNOT00000091372
olfactory receptor 61
chr3_+_119173818 0.01 ENSRNOT00000015124
ubiquitin specific peptidase 8
chr8_-_21453190 0.01 ENSRNOT00000078192
zinc finger protein 26
chr17_-_84249243 0.01 ENSRNOT00000082549
nebulette
chr13_+_113373578 0.01 ENSRNOT00000009900
plexin A2
chr1_-_167700332 0.01 ENSRNOT00000092890
tripartite motif-containing 21
chr4_+_56748494 0.01 ENSRNOT00000065747
uncharacterized LOC103692087
chr1_+_87045335 0.01 ENSRNOT00000084393
galectin 7
chr5_+_158090173 0.01 ENSRNOT00000088766
ENSRNOT00000079516
ENSRNOT00000092026
taste 1 receptor member 2
chr3_-_113091770 0.01 ENSRNOT00000068132
leucine carboxyl methyltransferase 2
chr1_-_189181901 0.01 ENSRNOT00000092022
glycoprotein 2
chr9_-_92524739 0.01 ENSRNOT00000089889
solute carrier family 16, member 14
chr20_-_4818568 0.01 ENSRNOT00000001115
DExD-box helicase 39B
chr8_+_115546893 0.01 ENSRNOT00000018932
DDB1 and CUL4 associated factor 1
chr1_-_77893509 0.01 ENSRNOT00000015059
glioma tumor suppressor candidate region gene 1
chr2_-_211690716 0.01 ENSRNOT00000027690
fibronectin type III domain containing 7
chrX_+_9956370 0.01 ENSRNOT00000082316
peripheral plasma membrane protein CASK-like
chr7_-_30274984 0.01 ENSRNOT00000092527
ENSRNOT00000010207
solute carrier family 17 member 8
chr4_-_115015965 0.01 ENSRNOT00000014603
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr1_-_226255886 0.01 ENSRNOT00000027842
flap structure-specific endonuclease 1
chr19_+_15195565 0.00 ENSRNOT00000090865
ENSRNOT00000078874
carboxylesterase 1D
chr8_+_69753373 0.00 ENSRNOT00000066973
timeless interacting protein
chr7_-_10430992 0.00 ENSRNOT00000047433
zinc finger protein 709-like 1
chr14_-_25585222 0.00 ENSRNOT00000042106
similar to 60S ribosomal protein L9
chr2_-_123851854 0.00 ENSRNOT00000023327
interleukin 2
chr8_+_91368111 0.00 ENSRNOT00000083151
Ttk protein kinase
chrX_+_77076106 0.00 ENSRNOT00000091527
ENSRNOT00000089381
ATPase copper transporting alpha
chr2_+_83393282 0.00 ENSRNOT00000044871
catenin delta 2
chr3_-_110828879 0.00 ENSRNOT00000013963
coiled-coil domain containing 32
chr11_+_73693814 0.00 ENSRNOT00000081081
ENSRNOT00000002354
ENSRNOT00000090940
large 60S subunit nuclear export GTPase 1
chr18_-_27452420 0.00 ENSRNOT00000037888
cell division cycle 23
chr1_-_212622537 0.00 ENSRNOT00000025609
shadow of prion protein homolog (zebrafish)
chr10_+_31813814 0.00 ENSRNOT00000009573
hepatitis A virus cellular receptor 1
chr8_-_46694613 0.00 ENSRNOT00000084514

chr19_+_38422164 0.00 ENSRNOT00000017174
NAD(P)H quinone dehydrogenase 1
chr4_+_72718458 0.00 ENSRNOT00000044780
Rho guanine nucleotide exchange factor 5
chr13_-_78521911 0.00 ENSRNOT00000087506
RAB GTPase activating protein 1-like
chr18_+_86071662 0.00 ENSRNOT00000064901
rotatin
chr2_+_26240385 0.00 ENSRNOT00000024292
coagulation factor II (thrombin) receptor-like 2
chr4_-_176528110 0.00 ENSRNOT00000049569
solute carrier organic anion transporter family, member 1A2
chr15_-_14737704 0.00 ENSRNOT00000011307
synaptoporin

Network of associatons between targets according to the STRING database.

First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0006713 glucocorticoid catabolic process(GO:0006713)
0.1 0.2 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268) malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.0 GO:1990164 histone H2A phosphorylation(GO:1990164)
0.0 0.0 GO:0071250 cellular response to carbon monoxide(GO:0071245) cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.0 GO:0050656 aryl sulfotransferase activity(GO:0004062) steroid sulfotransferase activity(GO:0050294) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)