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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Sin3a
Z-value: 1.22
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Transcription factors associated with Sin3a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sin3a | rn6_v1_chr8_+_61762768_61762773 | 0.78 | 1.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr20_+_5535432 Show fit | 0.89 |
ENSRNOT00000040859
|
synaptic Ras GTPase activating protein 1 |
|
| chr9_-_63637677 Show fit | 0.66 |
ENSRNOT00000049259
|
SATB homeobox 2 |
|
| chr7_+_70364813 Show fit | 0.65 |
ENSRNOT00000084012
ENSRNOT00000031230 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
|
| chr7_+_130474279 Show fit | 0.62 |
ENSRNOT00000092388
|
SH3 and multiple ankyrin repeat domains 3 |
|
| chr3_-_59688692 Show fit | 0.61 |
ENSRNOT00000078752
|
Sp3 transcription factor |
|
| chr10_-_74679858 Show fit | 0.61 |
ENSRNOT00000003859
|
protein phosphatase, Mg2+/Mn2+ dependent, 1E |
|
| chr2_+_188253220 Show fit | 0.60 |
ENSRNOT00000027629
|
ASH1 like histone lysine methyltransferase |
|
| chr7_+_142877086 Show fit | 0.59 |
ENSRNOT00000088730
|
general receptor for phosphoinositides 1 associated scaffold protein |
|
| chr10_+_56546710 Show fit | 0.56 |
ENSRNOT00000023003
|
Y box binding protein 2 |
|
| chr4_-_67520356 Show fit | 0.56 |
ENSRNOT00000014604
|
B-Raf proto-oncogene, serine/threonine kinase |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sin3a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
| 0.2 | 1.1 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 0.0 | 1.0 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.9 | GO:0010663 | positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666) |
| 0.0 | 0.9 | GO:0048169 | regulation of long-term neuronal synaptic plasticity(GO:0048169) |
| 0.1 | 0.8 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.2 | 0.7 | GO:1903225 | negative regulation of endodermal cell differentiation(GO:1903225) |
| 0.1 | 0.7 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.2 | 0.6 | GO:0031632 | positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632) |
| 0.2 | 0.6 | GO:1903699 | tarsal gland development(GO:1903699) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 1.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 1.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.1 | 0.8 | GO:0098831 | presynaptic active zone cytoplasmic component(GO:0098831) |
| 0.2 | 0.7 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 0.7 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.7 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 0.6 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.1 | 0.5 | GO:0090576 | RNA polymerase III transcription factor complex(GO:0090576) |
| 0.1 | 0.5 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 1.6 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.2 | 1.3 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 1.1 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.0 | 1.0 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 1.0 | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) |
| 0.0 | 0.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.8 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.1 | 0.7 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 0.7 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.0 | 1.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 1.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 1.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 0.9 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 0.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.6 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 0.5 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 1.4 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.3 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 0.9 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.0 | 0.7 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 0.6 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.6 | REACTOME SPRY REGULATION OF FGF SIGNALING | Genes involved in Spry regulation of FGF signaling |
| 0.0 | 0.6 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.0 | 0.6 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.5 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |