ISMARA results: Runx2

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Runx2_Bcl11a

Z-value: 0.90

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Transcription factors associated with Runx2_Bcl11a

Gene Symbol	Gene ID	Gene Info
Runx2 NCBI RGD Ensembl	ENSRNOG00000020193	runt-related transcription factor 2
Bcl11a NCBI RGD Ensembl	ENSRNOG00000007049	B-cell CLL/lymphoma 11A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Runx2	rn6_v1_chr9_+_18564927_18564927	0.57	3.2e-01	Click!
Bcl11a	rn6_v1_chr14_+_108826831_108826939	0.55	3.4e-01	Click!

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_14348046 Show fit	0.63	ENSRNOT00000018630	Cdhr1 NCBI RGD Ensembl Show fit	cadherin-related family member 1
chr11_-_33003021 Show fit	0.42	ENSRNOT00000084134	Runx1 NCBI RGD Ensembl Show fit	runt-related transcription factor 1
chr1_+_91152635 Show fit	0.36	ENSRNOT00000073438	LOC100912070 NCBI RGD Ensembl Show fit	dermokine-like
chr6_+_143938040 Show fit	0.33	ENSRNOT00000005876	Vipr2 NCBI RGD Ensembl Show fit	vasoactive intestinal peptide receptor 2
chr13_+_48455923 Show fit	0.32	ENSRNOT00000009280	Rab7b NCBI RGD Ensembl Show fit	Rab7b, member RAS oncogene family
chr10_+_73868943 Show fit	0.32	ENSRNOT00000081012	Tubd1 NCBI RGD Ensembl Show fit	tubulin, delta 1
chr2_-_187742747 Show fit	0.31	ENSRNOT00000026530	Bglap NCBI RGD Ensembl Show fit	bone gamma-carboxyglutamate protein
chr10_-_38985466 Show fit	0.30	ENSRNOT00000010121	Il13 NCBI RGD Ensembl Show fit	interleukin 13
chr2_+_210381829 Show fit	0.30	ENSRNOT00000024611	Alx3 NCBI RGD Ensembl Show fit	ALX homeobox 3
chr10_+_69423086 Show fit	0.30	ENSRNOT00000000256	Ccl7 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 7

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0045494	photoreceptor cell maintenance(GO:0045494)
0.1	0.4	GO:2000872	positive regulation of progesterone secretion(GO:2000872)
0.1	0.4	GO:0002380	immunoglobulin secretion involved in immune response(GO:0002380)
0.1	0.4	GO:1903575	cornified envelope assembly(GO:1903575)
0.0	0.4	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.1	0.3	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.1	0.3	GO:0033861	negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.3	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.3	GO:0032571	response to vitamin K(GO:0032571)
0.0	0.3	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)

Showing 1 to 10 of 113 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.6	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.4	GO:0032009	early phagosome(GO:0032009)
0.0	0.4	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	0.2	GO:0089717	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1	0.2	GO:0071149	TEAD-2-YAP complex(GO:0071149)
0.0	0.2	GO:1990584	cardiac Troponin complex(GO:1990584)
0.0	0.2	GO:0031501	mannosyltransferase complex(GO:0031501)
0.0	0.2	GO:0034657	GID complex(GO:0034657)
0.0	0.2	GO:0016589	NURF complex(GO:0016589)

Showing 1 to 10 of 27 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.4	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.1	0.3	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.3	GO:0035325	Toll-like receptor binding(GO:0035325)
0.1	0.2	GO:0071791	chemokine (C-C motif) ligand 5 binding(GO:0071791)
0.0	0.2	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.2	GO:0030172	troponin C binding(GO:0030172)
0.0	0.2	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.2	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)

Showing 1 to 10 of 58 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Total log-likelihood	Term	Description
0.9	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway

Showing 1 to 5 of 5 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME GLUCAGON TYPE LIGAND RECEPTORS	Genes involved in Glucagon-type ligand receptors
0.0	0.4	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.3	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	0.3	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	0.2	REACTOME DEFENSINS	Genes involved in Defensins
0.0	0.2	REACTOME SIGNALING BY FGFR	Genes involved in Signaling by FGFR
0.0	0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation

Showing 1 to 10 of 16 entries

Results for Runx2_Bcl11a

Z-value: 0.90

Motif logo

Transcription factors associated with Runx2_Bcl11a

Activity-expression correlation:

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: