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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Runx2_Bcl11a

Z-value: 0.90

Motif logo

Transcription factors associated with Runx2_Bcl11a

Gene Symbol Gene ID Gene Info
ENSRNOG00000020193 runt-related transcription factor 2
ENSRNOG00000007049 B-cell CLL/lymphoma 11A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx2rn6_v1_chr9_+_18564927_185649270.573.2e-01Click!
Bcl11arn6_v1_chr14_+_108826831_1088269390.553.4e-01Click!

Activity profile of Runx2_Bcl11a motif

Sorted Z-values of Runx2_Bcl11a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_14348046 0.63 ENSRNOT00000018630
cadherin-related family member 1
chr11_-_33003021 0.42 ENSRNOT00000084134
runt-related transcription factor 1
chr1_+_91152635 0.36 ENSRNOT00000073438
dermokine-like
chr6_+_143938040 0.33 ENSRNOT00000005876
vasoactive intestinal peptide receptor 2
chr13_+_48455923 0.32 ENSRNOT00000009280
Rab7b, member RAS oncogene family
chr10_+_73868943 0.32 ENSRNOT00000081012
tubulin, delta 1
chr2_-_187742747 0.31 ENSRNOT00000026530
bone gamma-carboxyglutamate protein
chr10_-_38985466 0.30 ENSRNOT00000010121
interleukin 13
chr2_+_210381829 0.30 ENSRNOT00000024611
ALX homeobox 3
chr10_+_69423086 0.30 ENSRNOT00000000256
C-C motif chemokine ligand 7
chr1_-_82004538 0.29 ENSRNOT00000087572
POU class 2 homeobox 2
chr7_-_143967484 0.28 ENSRNOT00000081758
Sp7 transcription factor
chr1_-_178367828 0.27 ENSRNOT00000050823

chr19_-_43911057 0.27 ENSRNOT00000026017
chymotrypsinogen B1
chr1_+_219173002 0.26 ENSRNOT00000024018
unc-93 homolog B1 (C. elegans)
chr19_-_28751584 0.25 ENSRNOT00000079270

chr20_-_22459025 0.24 ENSRNOT00000000792
early growth response 2
chr18_-_37096132 0.24 ENSRNOT00000041188
protein phosphatase 2, regulatory subunit B, beta
chr8_-_133002201 0.24 ENSRNOT00000008772
C-C motif chemokine receptor 1
chr1_+_88875375 0.24 ENSRNOT00000028284
Tyro protein tyrosine kinase binding protein
chrX_-_138148967 0.23 ENSRNOT00000033968
FERM domain containing 7
chr11_+_88122271 0.23 ENSRNOT00000002540
stromal cell-derived factor 2-like 1
chr10_-_56270640 0.23 ENSRNOT00000056918
Cd68 molecule
chr16_-_75309176 0.23 ENSRNOT00000018427
defensin beta 1
chr3_-_6626284 0.22 ENSRNOT00000012494
ficolin B
chr5_-_151898022 0.22 ENSRNOT00000000133
phosphatidylinositol glycan anchor biosynthesis, class V
chr1_-_226887156 0.21 ENSRNOT00000054809
ENSRNOT00000028347
Cd6 molecule
chr15_-_34612432 0.21 ENSRNOT00000090206
mast cell protease 1-like 1
chr5_+_8459660 0.20 ENSRNOT00000007491
carboxypeptidase A6
chr1_-_37990007 0.20 ENSRNOT00000081054

chr2_+_195582781 0.20 ENSRNOT00000066020
thioesterase superfamily member 5
chr3_-_67668772 0.19 ENSRNOT00000010247
frizzled-related protein
chr10_-_83655182 0.19 ENSRNOT00000007897
ABI family, member 3
chr11_-_29710849 0.19 ENSRNOT00000029345
keratin associated protein 11-1
chr9_-_15700235 0.19 ENSRNOT00000088713
ENSRNOT00000035907
transcriptional regulating factor 1
chr1_+_44311513 0.19 ENSRNOT00000065386
T-cell lymphoma invasion and metastasis 2
chr1_-_169463760 0.18 ENSRNOT00000023100
tripartite motif-containing 30C
chr17_-_90315492 0.18 ENSRNOT00000070807
G protein subunit gamma 4
chr20_+_3189473 0.18 ENSRNOT00000047439
RT1 class I, locus T24, gene 4
chr16_-_75340360 0.18 ENSRNOT00000018501
defensin alpha 5
chr13_+_52662996 0.18 ENSRNOT00000047682
troponin T2, cardiac type
chr4_-_156276304 0.18 ENSRNOT00000078725
C-type lectin domain family 4, member E
chr17_+_49417067 0.18 ENSRNOT00000090024
POU domain, class 6, transcription factor 2
chr14_+_70780623 0.18 ENSRNOT00000083871
ENSRNOT00000058803
LIM domain binding 2
chr10_-_107376645 0.17 ENSRNOT00000046213
CEP295 N-terminal like
chr13_-_111917587 0.16 ENSRNOT00000007649
TRAF3 interacting protein 3
chr5_+_25253010 0.16 ENSRNOT00000061333
RNA binding motif protein 12B
chr9_+_18564927 0.16 ENSRNOT00000061014
runt-related transcription factor 2
chr1_+_101214593 0.16 ENSRNOT00000028086
TEA domain transcription factor 2
chr15_-_34693034 0.16 ENSRNOT00000083314
mast cell protease 8
chr16_+_2706428 0.16 ENSRNOT00000077117
interleukin 17 receptor D
chr14_-_18853315 0.16 ENSRNOT00000003794
pro-platelet basic protein
chr14_-_39112600 0.16 ENSRNOT00000003170
gamma-aminobutyric acid type A receptor beta 1 subunit
chr11_+_86520992 0.15 ENSRNOT00000040954
glycoprotein Ib platelet beta subunit
chr1_+_81208212 0.15 ENSRNOT00000026288
Ly6/Plaur domain containing 5
chrX_-_134719097 0.15 ENSRNOT00000068478
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr9_-_63641400 0.15 ENSRNOT00000087684
SATB homeobox 2
chr6_+_106039991 0.15 ENSRNOT00000088917
signal-induced proliferation-associated 1 like 1
chr1_+_98398660 0.15 ENSRNOT00000047473
CD33 molecule
chr4_+_66670618 0.15 ENSRNOT00000010796
thromboxane A synthase 1
chr1_-_261446570 0.15 ENSRNOT00000020182
secreted frizzled-related protein 5
chr5_+_25725683 0.14 ENSRNOT00000087602
similar to swan
chr3_+_67849966 0.14 ENSRNOT00000057826
dual specificity phosphatase 19
chr1_+_219199158 0.14 ENSRNOT00000024034
similar to fatty aldehyde dehydrogenase-like
chr7_+_12798868 0.14 ENSRNOT00000038553
protease, serine, 57
chr5_-_147784311 0.14 ENSRNOT00000074172
family with sequence similarity 167, member B
chr5_-_152423686 0.14 ENSRNOT00000056143
Uromoduilin-like
chr1_-_213818222 0.14 ENSRNOT00000054875
interferon induced transmembrane protein 6
chr2_+_86951776 0.14 ENSRNOT00000087275

chr9_+_67546408 0.14 ENSRNOT00000013701
Cd28 molecule
chr8_-_117237229 0.14 ENSRNOT00000071381
kelch domain containing 8B
chr8_+_2604962 0.13 ENSRNOT00000009993
caspase 1
chr13_+_75059927 0.13 ENSRNOT00000080801
hypothetical protein LOC680254
chr1_+_65576535 0.13 ENSRNOT00000026575
solute carrier family 27 member 5
chr3_+_110466790 0.13 ENSRNOT00000089434
p21 (RAC1) activated kinase 6
chr1_+_170242846 0.13 ENSRNOT00000023751
cyclic nucleotide gated channel alpha 4
chr3_+_137154086 0.13 ENSRNOT00000034252
otoraplin
chr10_+_75087892 0.13 ENSRNOT00000065910
myeloperoxidase
chrX_+_159081445 0.13 ENSRNOT00000056688

chr1_-_170175350 0.13 ENSRNOT00000023349
olfactory receptor 201
chr2_+_55835151 0.13 ENSRNOT00000018634
FYN binding protein
chr1_+_190462327 0.13 ENSRNOT00000030732
similar to ankyrin repeat domain 26
chr2_-_104955807 0.12 ENSRNOT00000014837
glycogenin 1
chr8_+_49621568 0.12 ENSRNOT00000021949
transmembrane protease, serine 13
chr4_+_96831880 0.12 ENSRNOT00000068400
RSA-14-44 protein
chr1_-_131460473 0.12 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr3_+_66673246 0.12 ENSRNOT00000081338
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_+_44096061 0.12 ENSRNOT00000018438
ankyrin repeat domain 55
chr1_-_169456098 0.12 ENSRNOT00000030827
tripartite motif-containing 30C
chr14_-_46054022 0.11 ENSRNOT00000002982
similar to RIKEN cDNA 0610040J01
chr4_-_78208767 0.11 ENSRNOT00000033918
retinoic acid receptor responder 2
chr2_-_106703401 0.11 ENSRNOT00000043933

chr9_+_74124016 0.11 ENSRNOT00000019023
carbamoyl-phosphate synthase 1
chr4_-_132171153 0.11 ENSRNOT00000015058
ENSRNOT00000015075
prokineticin 2
chr7_-_51515131 0.11 ENSRNOT00000006773
ENSRNOT00000041473
ENSRNOT00000050037
protein phosphatase 1, regulatory subunit 12A
chr18_+_55505993 0.11 ENSRNOT00000043736
similar to interferon-inducible GTPase
chr2_-_147392062 0.11 ENSRNOT00000021535
transmembrane 4 L six family member 1
chr18_-_28438654 0.11 ENSRNOT00000036301
marginal zone B and B1 cell-specific protein
chr5_-_57632177 0.11 ENSRNOT00000080787
ENSRNOT00000092581
ubiquitin-associated protein 2
chr14_+_10692764 0.11 ENSRNOT00000003012
uncharacterized LOC100910270
chr4_+_179398621 0.11 ENSRNOT00000049474
ENSRNOT00000067506
lymphoid-restricted membrane protein
chr5_-_135994848 0.11 ENSRNOT00000067675
BTB domain containing 19
chr11_-_81444375 0.11 ENSRNOT00000058479
ENSRNOT00000078131
ENSRNOT00000080949
ENSRNOT00000080562
ENSRNOT00000084867
kininogen 1
chr20_+_27129291 0.11 ENSRNOT00000031053

chr2_-_122949241 0.11 ENSRNOT00000039615
pyroglutamylated RFamide peptide receptor
chr4_-_84131030 0.11 ENSRNOT00000012196
carboxypeptidase, vitellogenic-like
chr2_-_250241590 0.11 ENSRNOT00000077221
ENSRNOT00000067502
LIM domain only 4
chr9_+_71247781 0.11 ENSRNOT00000049654
cAMP responsive element binding protein 1
chr1_-_167700332 0.11 ENSRNOT00000092890
tripartite motif-containing 21
chr1_+_1771710 0.11 ENSRNOT00000080138
ENSRNOT00000073528
nucleoporin 43
chr17_+_49714294 0.11 ENSRNOT00000018190
RAS like proto-oncogene A
chr7_-_143966863 0.10 ENSRNOT00000018828
Sp7 transcription factor
chr20_-_5806097 0.10 ENSRNOT00000000611
colipase
chr5_+_58661049 0.10 ENSRNOT00000078274
unc-13 homolog B
chr15_+_33074441 0.10 ENSRNOT00000075610
matrix metallopeptidase 14
chr5_+_135562034 0.10 ENSRNOT00000056967
coiled-coil domain containing 163
chr14_-_5378726 0.10 ENSRNOT00000002896
leucine rich repeat containing 8 family, member C
chr11_+_83868655 0.10 ENSRNOT00000072402
thrombopoietin
chr11_+_31694339 0.10 ENSRNOT00000002779
interferon gamma receptor 2
chr9_+_95161157 0.10 ENSRNOT00000071200
UDP glucuronosyltransferase family 1 member A5
chr2_+_198965685 0.10 ENSRNOT00000000107
ENSRNOT00000091578
PDZ domain containing 1
chr3_+_66673071 0.10 ENSRNOT00000034769
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr20_+_3156170 0.10 ENSRNOT00000082880
RT1 class Ib, locus S2
chr14_+_13192347 0.10 ENSRNOT00000000092
anthrax toxin receptor 2
chr7_-_145450233 0.10 ENSRNOT00000092974
ENSRNOT00000021523
calcium binding and coiled coil domain 1
chr1_+_212558257 0.10 ENSRNOT00000024912
proline-rich acidic protein 1
chr20_-_5805627 0.10 ENSRNOT00000085996
colipase
chr8_-_3272306 0.10 ENSRNOT00000040365

chr8_-_116531784 0.10 ENSRNOT00000024529
RNA binding motif protein 5
chr17_-_17872573 0.10 ENSRNOT00000082733
ring finger protein 144B
chr17_-_32783427 0.10 ENSRNOT00000059921
serine (or cysteine) peptidase inhibitor, clade B, member 6b
chr13_+_68785827 0.10 ENSRNOT00000003517
tRNA methyltransferase 1-like
chr13_-_80738634 0.10 ENSRNOT00000081551
flavin containing monooxygenase 1
chr8_-_40137390 0.10 ENSRNOT00000042717
pannexin 3
chr4_-_147505838 0.10 ENSRNOT00000086570
MKRN2 opposite strand
chr5_-_113532878 0.09 ENSRNOT00000010173
caspase activity and apoptosis inhibitor 1
chr10_-_34990943 0.09 ENSRNOT00000075555
required for meiotic nuclear division 5 homolog B
chr4_-_126071261 0.09 ENSRNOT00000080234
dynein light chain 1-like
chr2_+_185343883 0.09 ENSRNOT00000093640
SH3 domain containing 19
chr9_-_121725716 0.09 ENSRNOT00000087405
adenylate cyclase activating polypeptide 1
chrX_+_68891227 0.09 ENSRNOT00000009635
ephrin B1
chr9_-_30844199 0.09 ENSRNOT00000017169
collagen type XIX alpha 1 chain
chr8_-_45137893 0.09 ENSRNOT00000010743
similar to hypothetical protein FLJ23554
chr2_+_189454340 0.09 ENSRNOT00000087063
nucleoporin 210-like
chr20_+_10438444 0.09 ENSRNOT00000071248
ENSRNOT00000075545
crystallin, alpha A
chr13_-_91228901 0.09 ENSRNOT00000071728
ENSRNOT00000073643
ENSRNOT00000071897
low affinity immunoglobulin gamma Fc region receptor III-like
chr9_+_14560504 0.09 ENSRNOT00000091532
nuclear transcription factor Y subunit alpha
chr10_-_90151042 0.09 ENSRNOT00000055187
histone deacetylase 5
chr12_+_10255416 0.09 ENSRNOT00000092720
G protein-coupled receptor 12
chr12_-_46920952 0.09 ENSRNOT00000001532
musashi RNA-binding protein 1
chr2_+_198721724 0.09 ENSRNOT00000043535
ankyrin repeat domain 34A
chr12_-_17322608 0.09 ENSRNOT00000033038
uncharacterized LOC102546864
chr3_-_43119159 0.09 ENSRNOT00000041394
nuclear receptor subfamily 4, group A, member 2
chr11_+_43143882 0.09 ENSRNOT00000041445
olfactory receptor 1528
chr16_-_75481115 0.09 ENSRNOT00000035128
defensin alpha 7
chr4_-_165541314 0.09 ENSRNOT00000013833
serine/threonine/tyrosine kinase 1
chr4_+_5644260 0.09 ENSRNOT00000041876
ARP3 actin related protein 3 homolog B
chr4_-_113954272 0.09 ENSRNOT00000039966
ENSRNOT00000082996
WW domain-binding protein 1
chr7_-_76294663 0.09 ENSRNOT00000064513
neurocalcin delta
chr1_+_88113445 0.09 ENSRNOT00000056955
gametogenetin
chr9_-_103207190 0.09 ENSRNOT00000026010
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
chr1_-_81450094 0.09 ENSRNOT00000035356
zinc finger protein 575
chr6_-_115513354 0.09 ENSRNOT00000005881
stonin 2
chr11_+_37798370 0.09 ENSRNOT00000002679
beta-site APP-cleaving enzyme 2
chr18_+_30581530 0.08 ENSRNOT00000048166
protocadherin beta 20
chr20_-_4561062 0.08 ENSRNOT00000065044
ENSRNOT00000092698
ENSRNOT00000060607
complement factor B
complement C2
chr18_-_29611212 0.08 ENSRNOT00000022685
DND microRNA-mediated repression inhibitor 1
chr16_+_20521956 0.08 ENSRNOT00000026597
pyroglutamyl-peptidase I
chr13_-_110784209 0.08 ENSRNOT00000071698
TNF receptor-associated factor 5
chr7_-_120380200 0.08 ENSRNOT00000014878
similar to RIKEN cDNA 1700088E04
chr1_-_82003691 0.08 ENSRNOT00000084569
POU class 2 homeobox 2
chr10_-_75202030 0.08 ENSRNOT00000050349
olfactory receptor 1522
chrX_-_158261717 0.08 ENSRNOT00000086804
similar to RIKEN cDNA 1700001F22
chr7_-_29986163 0.08 ENSRNOT00000033123
growth arrest-specific 2 like 3
chr5_-_164927869 0.08 ENSRNOT00000012080
dorsal inhibitory axon guidance protein
chr5_-_155916893 0.08 ENSRNOT00000055947
low density lipoprotein receptor class A domain containing 2
chr10_+_72197977 0.08 ENSRNOT00000003886
myosin XIX
chr19_-_25378974 0.08 ENSRNOT00000011150
coiled-coil domain containing 130
chr11_+_57108956 0.08 ENSRNOT00000035485
CD96 molecule
chr1_-_169513537 0.08 ENSRNOT00000078058
tripartite motif-containing 30C
chr13_-_89661150 0.08 ENSRNOT00000058390
ubiquitin specific peptidase 21
chr4_-_114819848 0.08 ENSRNOT00000084381
WW domain binding protein 1
chr7_+_140829076 0.08 ENSRNOT00000086179
spermatogenesis associated, serine-rich 2
chr10_-_34361212 0.08 ENSRNOT00000072557
olfactory receptor 1385
chr7_+_140464999 0.08 ENSRNOT00000090156
wingless-type MMTV integration site family, member 1
chr14_-_22890958 0.08 ENSRNOT00000031916
lymphocyte antigen 6B-like
chr12_+_13323547 0.08 ENSRNOT00000074138
zinc finger protein 853
chr2_-_257864385 0.08 ENSRNOT00000072048
adenylate kinase 5
chr11_+_86903122 0.08 ENSRNOT00000048063
zinc finger, DHHC-type containing 8
chr7_+_12542713 0.08 ENSRNOT00000080089
mediator complex subunit 16
chr7_-_2712723 0.08 ENSRNOT00000004363
interleukin 23 subunit alpha
chr17_-_10364503 0.08 ENSRNOT00000086380
ENSRNOT00000041709
tetraspanin 17
chr13_-_89433815 0.08 ENSRNOT00000091541
Fc fragment of IgG receptor IIb
chr9_+_95202632 0.08 ENSRNOT00000025652
UDP glucuronosyltransferase family 1 member A5
chr13_-_61591139 0.08 ENSRNOT00000005324
regulator of G-protein signaling 18
chr8_-_119889661 0.08 ENSRNOT00000011780
SH3 and cysteine rich domain
chr18_+_44716226 0.08 ENSRNOT00000086431
TNF alpha induced protein 8
chr12_+_46989951 0.08 ENSRNOT00000001536
glutamyl-tRNA amidotransferase subunit C
chr1_-_241155537 0.08 ENSRNOT00000034216
ENSRNOT00000073493
MAM domain containing 2
chr13_-_90977734 0.08 ENSRNOT00000011869
SLAM family member 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.1 0.4 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.1 0.3 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.1 0.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.1 0.4 GO:1903575 cornified envelope assembly(GO:1903575)
0.1 0.2 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 0.2 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.2 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.1 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.2 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.1 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.0 0.2 GO:0032910 transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0 0.1 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.1 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.2 GO:0070366 regulation of hepatocyte differentiation(GO:0070366)
0.0 0.3 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.3 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.0 GO:0002536 respiratory burst involved in inflammatory response(GO:0002536)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.1 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0 0.1 GO:2001274 negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0060370 susceptibility to T cell mediated cytotoxicity(GO:0060370)
0.0 0.1 GO:0002877 regulation of acute inflammatory response to non-antigenic stimulus(GO:0002877)
0.0 0.2 GO:2001204 regulation of osteoclast development(GO:2001204)
0.0 0.1 GO:2000422 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
0.0 0.1 GO:1904954 Spemann organizer formation(GO:0060061) dermatome development(GO:0061054) regulation of dermatome development(GO:0061183) positive regulation of dermatome development(GO:0061184) Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904953) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:0046061 dATP catabolic process(GO:0046061)
0.0 0.2 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.0 0.1 GO:2000328 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142) regulation of T-helper 17 cell lineage commitment(GO:2000328)
0.0 0.1 GO:0002434 immune complex clearance(GO:0002434)
0.0 0.1 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0 0.1 GO:0015879 carnitine transport(GO:0015879)
0.0 0.1 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.0 0.2 GO:0021612 facial nerve structural organization(GO:0021612)
0.0 0.1 GO:0038027 apolipoprotein A-I-mediated signaling pathway(GO:0038027)
0.0 0.1 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.0 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.0 0.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.0 0.4 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.0 0.3 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.2 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.0 GO:0002277 myeloid dendritic cell activation involved in immune response(GO:0002277)
0.0 0.1 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.0 0.1 GO:0036265 RNA (guanine-N7)-methylation(GO:0036265)
0.0 0.1 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
0.0 0.1 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.0 GO:0051311 meiotic metaphase plate congression(GO:0051311)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.1 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
0.0 0.1 GO:0097394 post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.0 0.1 GO:0006574 valine catabolic process(GO:0006574)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.3 GO:0002076 osteoblast development(GO:0002076)
0.0 0.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0 0.0 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.2 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.0 0.1 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808) presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.3 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.0 GO:0006742 NADP catabolic process(GO:0006742)
0.0 0.0 GO:0002465 peripheral T cell tolerance induction(GO:0002458) peripheral tolerance induction(GO:0002465) negative regulation of interferon-gamma biosynthetic process(GO:0045077)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.1 GO:1902019 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.1 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.0 0.0 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.0 0.1 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0034214 protein hexamerization(GO:0034214)
0.0 0.2 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.0 0.1 GO:0060161 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0 0.1 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.0 0.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.0 0.0 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.1 GO:1904640 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.0 0.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.0 0.1 GO:0010759 positive regulation of macrophage chemotaxis(GO:0010759)
0.0 0.2 GO:0002283 neutrophil activation involved in immune response(GO:0002283)
0.0 0.1 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0 0.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.2 GO:1990834 response to odorant(GO:1990834)
0.0 0.1 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
0.0 0.0 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
0.0 0.0 GO:0046338 phosphatidylethanolamine catabolic process(GO:0046338)
0.0 0.0 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.1 GO:0002727 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.0 GO:1900224 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.0 0.1 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.0 GO:0019303 D-ribose catabolic process(GO:0019303)
0.0 0.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.0 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.0 0.1 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.0 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.0 0.1 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.0 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.0 GO:0090289 regulation of osteoclast proliferation(GO:0090289)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.1 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.1 GO:0034774 secretory granule lumen(GO:0034774)
0.0 0.6 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.2 GO:0031501 mannosyltransferase complex(GO:0031501)
0.0 0.2 GO:0034657 GID complex(GO:0034657)
0.0 0.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.4 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0097169 IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169)
0.0 0.1 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.1 GO:1990707 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.0 GO:0097444 spine apparatus(GO:0097444)
0.0 0.0 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.0 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.0 GO:1990879 CST complex(GO:1990879)
0.0 0.1 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.0 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.2 GO:0042612 MHC class I protein complex(GO:0042612)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.4 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.1 0.2 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
0.0 0.1 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0030172 troponin C binding(GO:0030172)
0.0 0.2 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.4 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.0 0.1 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.0 0.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.1 GO:0055077 gap junction hemi-channel activity(GO:0055077)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 0.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0030274 LIM domain binding(GO:0030274)
0.0 0.1 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.3 GO:0035325 Toll-like receptor binding(GO:0035325)
0.0 0.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.1 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.1 GO:0102345 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0 0.1 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.2 GO:0033691 sialic acid binding(GO:0033691)
0.0 0.0 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.0 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0 0.0 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
0.0 0.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0052813 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.0 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.1 GO:0015245 fatty acid transporter activity(GO:0015245) very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.1 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.1 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.1 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.1 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.0 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.0 0.2 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.0 GO:0004359 glutaminase activity(GO:0004359)
0.0 0.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.0 GO:0044715 8-oxo-dGDP phosphatase activity(GO:0044715)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.0 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
0.0 0.1 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.9 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.0 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 ST G ALPHA S PATHWAY G alpha s Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 0.2 REACTOME DEFENSINS Genes involved in Defensins
0.0 0.5 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.2 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.1 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.1 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression