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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Runx1

Z-value: 0.50

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Transcription factors associated with Runx1

Gene Symbol Gene ID Gene Info
Runx1
ENSRNOG00000001704 runt-related transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Runx1rn6_v1_chr11_-_33003021_330030210.484.1e-01Click!

Activity profile of Runx1 motif

Sorted Z-values of Runx1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_187742747 0.33 ENSRNOT00000026530
Bglap
bone gamma-carboxyglutamate protein
chr10_-_85435016 0.28 ENSRNOT00000079921
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr14_-_78902063 0.18 ENSRNOT00000088469
Ppp2r2c
protein phosphatase 2, regulatory subunit B, gamma
chr1_+_44311513 0.17 ENSRNOT00000065386
Tiam2
T-cell lymphoma invasion and metastasis 2
chr18_-_55916220 0.17 ENSRNOT00000025934
Synpo
synaptopodin
chr20_-_22459025 0.16 ENSRNOT00000000792
Egr2
early growth response 2
chr10_-_38985466 0.15 ENSRNOT00000010121
Il13
interleukin 13
chr13_-_83202864 0.13 ENSRNOT00000003976
Xcl1
X-C motif chemokine ligand 1
chr9_-_15700235 0.13 ENSRNOT00000088713
ENSRNOT00000035907
Trerf1
transcriptional regulating factor 1
chr1_+_100577056 0.12 ENSRNOT00000026992
Napsa
napsin A aspartic peptidase
chr4_-_117126822 0.12 ENSRNOT00000086720
Rab11fip5
RAB11 family interacting protein 5
chr10_+_104582955 0.11 ENSRNOT00000009733
Unk
unkempt family zinc finger
chr1_+_190666149 0.11 ENSRNOT00000089361
LOC102547219
uncharacterized LOC102547219
chr7_-_145450233 0.11 ENSRNOT00000092974
ENSRNOT00000021523
Calcoco1
calcium binding and coiled coil domain 1
chr16_+_46731403 0.11 ENSRNOT00000017624
Tenm3
teneurin transmembrane protein 3
chr1_-_226887156 0.11 ENSRNOT00000054809
ENSRNOT00000028347
Cd6
Cd6 molecule
chrX_-_159841072 0.10 ENSRNOT00000001158
Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor 6
chr1_-_82004538 0.10 ENSRNOT00000087572
Pou2f2
POU class 2 homeobox 2
chr14_-_6679878 0.10 ENSRNOT00000075989
ENSRNOT00000067875
Spp1
secreted phosphoprotein 1
chr14_-_81399353 0.10 ENSRNOT00000018340
Add1
adducin 1
chr1_-_82003691 0.10 ENSRNOT00000084569
Pou2f2
POU class 2 homeobox 2
chr9_+_118849302 0.10 ENSRNOT00000087592
Dlgap1
DLG associated protein 1
chr5_+_151362019 0.09 ENSRNOT00000077083
ENSRNOT00000067801
Wasf2
WAS protein family, member 2
chr6_+_52631092 0.09 ENSRNOT00000014054
Atxn7l1
ataxin 7-like 1
chr11_-_33003021 0.09 ENSRNOT00000084134
Runx1
runt-related transcription factor 1
chr13_+_70379346 0.09 ENSRNOT00000038183
Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr8_-_62987182 0.09 ENSRNOT00000070885
Islr2
immunoglobulin superfamily containing leucine-rich repeat 2
chr4_-_40036563 0.09 ENSRNOT00000084531
Tmem168
transmembrane protein 168
chr9_+_18564927 0.09 ENSRNOT00000061014
Runx2
runt-related transcription factor 2
chr5_+_25725683 0.08 ENSRNOT00000087602
LOC679087
similar to swan
chr4_-_155275161 0.08 ENSRNOT00000032690
Rimklb
ribosomal modification protein rimK-like family member B
chr9_+_71247781 0.07 ENSRNOT00000049654
Creb1
cAMP responsive element binding protein 1
chr8_-_47339343 0.07 ENSRNOT00000081007
Arhgef12
Rho guanine nucleotide exchange factor 12
chr14_-_55081551 0.07 ENSRNOT00000049245
Pcdh7
protocadherin 7
chr10_-_83655182 0.06 ENSRNOT00000007897
Abi3
ABI family, member 3
chr1_+_47032113 0.06 ENSRNOT00000024412
Tulp4
tubby like protein 4
chr10_+_75087892 0.06 ENSRNOT00000065910
Mpo
myeloperoxidase
chr8_-_96266342 0.06 ENSRNOT00000078891
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr20_-_4508197 0.06 ENSRNOT00000086027
ENSRNOT00000000514
C4a
complement component 4A (Rodgers blood group)
chr2_+_116032455 0.06 ENSRNOT00000066495
Phc3
polyhomeotic homolog 3
chr5_+_25253010 0.05 ENSRNOT00000061333
Rbm12b
RNA binding motif protein 12B
chr8_-_96132634 0.05 ENSRNOT00000041655
Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
chr14_+_86828355 0.05 ENSRNOT00000088611
Ccm2
CCM2 scaffolding protein
chr10_-_65200109 0.05 ENSRNOT00000030501
Nufip2
NUFIP2, FMR1 interacting protein 2
chr20_-_2678141 0.05 ENSRNOT00000072377
ENSRNOT00000083833
C4a
complement component 4A (Rodgers blood group)
chr20_-_4316715 0.05 ENSRNOT00000031704
C4b
complement C4B (Chido blood group)
chr16_+_83824430 0.05 ENSRNOT00000032918
Irs2
insulin receptor substrate 2
chr2_-_210550490 0.05 ENSRNOT00000081835
ENSRNOT00000025222
ENSRNOT00000086403
Csf1
colony stimulating factor 1
chr9_+_67546408 0.05 ENSRNOT00000013701
Cd28
Cd28 molecule
chr2_+_143475323 0.04 ENSRNOT00000044028
ENSRNOT00000015437
Trpc4
transient receptor potential cation channel, subfamily C, member 4
chr4_+_65637407 0.04 ENSRNOT00000047954
Trim24
tripartite motif-containing 24
chr1_-_219544328 0.04 ENSRNOT00000025847
Grk2
G protein-coupled receptor kinase 2
chr2_-_44981458 0.04 ENSRNOT00000014134
Gzma
granzyme A
chr17_-_87826421 0.04 ENSRNOT00000068156
Arhgap21
Rho GTPase activating protein 21
chr3_-_44177689 0.04 ENSRNOT00000006387
Cytip
cytohesin 1 interacting protein
chr1_+_79982639 0.04 ENSRNOT00000071916
Dmwd
dystrophia myotonica, WD repeat containing
chr1_+_5240180 0.03 ENSRNOT00000019893
ENSRNOT00000088292
Shprh
SNF2 histone linker PHD RING helicase
chr3_+_66673071 0.03 ENSRNOT00000034769
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr2_+_205553163 0.03 ENSRNOT00000039572
Nras
neuroblastoma RAS viral oncogene homolog
chr3_+_66673246 0.03 ENSRNOT00000081338
Ppp1r1c
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr9_-_81864202 0.03 ENSRNOT00000084964
Zfp142
zinc finger protein 142
chr15_-_42947656 0.03 ENSRNOT00000030007
Ptk2b
protein tyrosine kinase 2 beta
chr10_+_86950557 0.03 ENSRNOT00000014153
Igfbp4
insulin-like growth factor binding protein 4
chr2_-_203413124 0.03 ENSRNOT00000077898
ENSRNOT00000056140
Cd101
CD101 molecule
chr1_+_167522895 0.02 ENSRNOT00000092987
Stim1
stromal interaction molecule 1
chr15_-_27716008 0.02 ENSRNOT00000011741
Ttc5
tetratricopeptide repeat domain 5
chr3_+_104816987 0.02 ENSRNOT00000042103
ENSRNOT00000044625
Fmn1
formin 1
chr8_-_40137390 0.02 ENSRNOT00000042717
Panx3
pannexin 3
chr1_+_192233910 0.02 ENSRNOT00000016418
ENSRNOT00000016442
Prkcb
protein kinase C, beta
chr7_+_140464999 0.02 ENSRNOT00000090156
Wnt1
wingless-type MMTV integration site family, member 1
chr1_-_87825333 0.02 ENSRNOT00000072689
Zfp74
zinc finger protein 74
chr7_-_76294663 0.01 ENSRNOT00000064513
Ncald
neurocalcin delta
chr11_+_88122271 0.01 ENSRNOT00000002540
Sdf2l1
stromal cell-derived factor 2-like 1
chr11_+_44001579 0.01 ENSRNOT00000002258
Gpr15
G protein-coupled receptor 15
chr3_-_146491837 0.01 ENSRNOT00000061469
Vsx1
visual system homeobox 1
chr19_+_10024947 0.01 ENSRNOT00000061392
Cfap20
cilia and flagella associated protein 20
chr7_-_62162453 0.01 ENSRNOT00000010720
Cand1
cullin-associated and neddylation-dissociated 1
chr1_-_88240057 0.01 ENSRNOT00000073092
LOC103690038
zinc finger protein 569
chr3_+_170399302 0.01 ENSRNOT00000035245
Cass4
Cas scaffolding protein family member 4
chr3_+_79729739 0.01 ENSRNOT00000084833
Kbtbd4
kelch repeat and BTB domain containing 4
chr4_-_184096806 0.00 ENSRNOT00000055433
LOC100362344
mKIAA1238 protein-like
chr7_+_121930615 0.00 ENSRNOT00000091270
ENSRNOT00000033975
Tnrc6b
trinucleotide repeat containing 6B
chr6_+_109562587 0.00 ENSRNOT00000011563
Batf
basic leucine zipper ATF-like transcription factor
chr7_-_144880092 0.00 ENSRNOT00000055281
Nfe2
nuclear factor, erythroid 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Runx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.1 0.2 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0 0.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.2 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 0.3 GO:0032571 response to vitamin K(GO:0032571)
0.0 0.1 GO:0006710 androgen catabolic process(GO:0006710)
0.0 0.1 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.0 0.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.1 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.0 0.1 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)
0.0 0.1 GO:0002149 hypochlorous acid metabolic process(GO:0002148) hypochlorous acid biosynthetic process(GO:0002149)
0.0 0.1 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.0 0.1 GO:1901552 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 0.0 GO:1904139 regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972) microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.0 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.1 GO:0070842 aggresome assembly(GO:0070842)
0.0 0.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.2 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.1 GO:0097264 self proteolysis(GO:0097264)
0.0 0.0 GO:0051684 maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0097444 spine apparatus(GO:0097444)
0.0 0.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.1 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.0 0.1 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway