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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Rhox4e_Rhox6_Vax2

Z-value: 0.29

Motif logo

Transcription factors associated with Rhox4e_Rhox6_Vax2

Gene Symbol Gene ID Gene Info
ENSRNOG00000013261 ventral anterior homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Vax2rn6_v1_chr4_+_115388839_1153888390.573.1e-01Click!

Activity profile of Rhox4e_Rhox6_Vax2 motif

Sorted Z-values of Rhox4e_Rhox6_Vax2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_88670430 0.45 ENSRNOT00000025547
hypocretin neuropeptide precursor
chr2_+_127525285 0.21 ENSRNOT00000093247
inturned planar cell polarity protein
chr10_+_61685645 0.17 ENSRNOT00000003933
MAX network transcriptional repressor
chr1_-_190370499 0.17 ENSRNOT00000084389

chrX_+_15113878 0.12 ENSRNOT00000007464
WD repeat domain 13
chr2_+_122877286 0.10 ENSRNOT00000033080
arylsulfatase E
chr9_+_71915421 0.10 ENSRNOT00000020447
phosphoinositide kinase, FYVE-type zinc finger containing
chr1_-_215284548 0.09 ENSRNOT00000090375
cortactin
chr2_-_33025271 0.09 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr12_-_35979193 0.09 ENSRNOT00000071104
transmembrane protein 132B
chr2_+_158097843 0.08 ENSRNOT00000016541
pentraxin 3
chr16_+_7035241 0.08 ENSRNOT00000084977
NIMA-related kinase 4
chr3_-_120076788 0.08 ENSRNOT00000047158
potassium voltage-gated channel interacting protein 3
chr12_+_49665282 0.08 ENSRNOT00000086397
G protein-coupled receptor kinase 3
chr14_+_34446616 0.08 ENSRNOT00000002976
clock circadian regulator
chr14_+_6221085 0.07 ENSRNOT00000068215

chr6_+_104291071 0.07 ENSRNOT00000006798
solute carrier family 39, member 9
chr10_-_10881844 0.07 ENSRNOT00000087118
ENSRNOT00000004416
mahogunin ring finger 1
chr19_+_25043680 0.07 ENSRNOT00000043971
adhesion G protein-coupled receptor L1
chr4_+_158088505 0.06 ENSRNOT00000026643
von Willebrand factor
chr4_+_148782479 0.06 ENSRNOT00000018133
similar to hypothetical protein MGC6835
chr10_-_106883423 0.06 ENSRNOT00000071406
similar to threonine aldolase 1
chr1_+_80279706 0.06 ENSRNOT00000047105
protein phosphatase 1, regulatory subunit 13 like
chr1_+_87224677 0.06 ENSRNOT00000028070
protein phosphatase 1, regulatory (inhibitor) subunit 14A
chr1_-_217631862 0.05 ENSRNOT00000078514
ENSRNOT00000079805
cortactin
chr2_-_185852759 0.05 ENSRNOT00000049461
mab-21 like 2
chr7_-_120770435 0.05 ENSRNOT00000077000
DEAD-box helicase 17
chrX_+_74200972 0.05 ENSRNOT00000076956
cysteine-rich hydrophobic domain 1
chr1_+_88113445 0.05 ENSRNOT00000056955
gametogenetin
chr18_-_55891710 0.05 ENSRNOT00000064686
synaptopodin
chr1_-_215033460 0.05 ENSRNOT00000044565
dual specificity phosphatase 8
chr5_+_139790395 0.04 ENSRNOT00000015033
regulating synaptic membrane exocytosis 3
chr10_-_65502936 0.04 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chrX_+_144994139 0.04 ENSRNOT00000071783
pre-mRNA-splicing factor CWC22 homolog
chr9_+_73378057 0.04 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr17_-_87826421 0.04 ENSRNOT00000068156
Rho GTPase activating protein 21
chr16_+_7035068 0.04 ENSRNOT00000024296
NIMA-related kinase 4
chr20_-_13994794 0.04 ENSRNOT00000093466
gamma-glutamyltransferase 5
chr1_+_141767940 0.03 ENSRNOT00000064034
zinc finger protein 710
chr10_-_91302155 0.03 ENSRNOT00000004371
spermatogenesis associated 32
chr8_+_16287804 0.03 ENSRNOT00000024691
vitamin K epoxide reductase complex, subunit 1-like 1
chr4_+_88694583 0.03 ENSRNOT00000009202
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr4_-_18396035 0.03 ENSRNOT00000034692
semaphorin 3A
chr10_+_43601689 0.03 ENSRNOT00000029238
mitochondrial ribosomal protein L22
chr10_-_67401836 0.03 ENSRNOT00000073071
cytokine receptor-like factor 3
chr8_+_40009691 0.03 ENSRNOT00000042679
V-set and immunoglobulin domain containing 2
chr4_+_155321553 0.03 ENSRNOT00000089614
microfibrillar associated protein 5
chr10_+_106264434 0.03 ENSRNOT00000003891
septin 9
chr4_+_180062799 0.03 ENSRNOT00000021623
Ras association domain family member 8
chr3_-_141411170 0.03 ENSRNOT00000017364
NK2 homeobox 2
chr1_+_8310577 0.03 ENSRNOT00000015131
human immunodeficiency virus type I enhancer binding protein 2
chr17_-_14627937 0.03 ENSRNOT00000020532
osteoglycin
chr20_-_32501722 0.03 ENSRNOT00000000448
zinc finger with UFM1-specific peptidase domain
chrX_+_6273733 0.03 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr4_-_168656673 0.03 ENSRNOT00000009341
G protein-coupled receptor 19
chr8_-_83280888 0.03 ENSRNOT00000052341
GDNF family receptor alpha like
chr3_+_56125924 0.03 ENSRNOT00000011380
ubiquitin protein ligase E3 component n-recognin 3
chr10_-_74679858 0.02 ENSRNOT00000003859
protein phosphatase, Mg2+/Mn2+ dependent, 1E
chr12_-_23727535 0.02 ENSRNOT00000085911
ENSRNOT00000001950
deltex E3 ubiquitin ligase 2
chr2_+_148765412 0.02 ENSRNOT00000018248
ENSRNOT00000084662
selenoprotein T
chr5_+_187312 0.02 ENSRNOT00000030857
zinc finger protein 120-like
chr5_-_147412705 0.02 ENSRNOT00000010688
similar to mKIAA1522 protein
chr6_+_104291340 0.02 ENSRNOT00000089313
solute carrier family 39, member 9
chr17_+_63635086 0.02 ENSRNOT00000020634
disco-interacting protein 2 homolog C
chr11_-_62067655 0.02 ENSRNOT00000093382
zinc finger and BTB domain containing 20
chr2_-_35870578 0.02 ENSRNOT00000066069
ring finger protein 180
chr10_+_29033989 0.02 ENSRNOT00000088322
SLU7 homolog, splicing factor
chr10_+_103206014 0.02 ENSRNOT00000004081
tweety family member 2
chr19_+_39229754 0.02 ENSRNOT00000050612
vacuolar protein sorting 4 homolog A
chr8_+_71914867 0.02 ENSRNOT00000023372
death-associated protein kinase 2
chr6_-_104290579 0.02 ENSRNOT00000066014
enhancer of rudimentary homolog (Drosophila)
chr5_-_22765429 0.02 ENSRNOT00000079432
aspartate-beta-hydroxylase
chr3_+_148654668 0.02 ENSRNOT00000081370
transmembrane 9 superfamily member 4
chrX_-_104932508 0.02 ENSRNOT00000075325
NADPH oxidase 1
chr8_-_7426611 0.02 ENSRNOT00000031492
Rho GTPase activating protein 42
chr2_+_145174876 0.02 ENSRNOT00000040631
mab-21 like 1
chr16_+_73584521 0.02 ENSRNOT00000024301
GINS complex subunit 4
chr18_+_14757679 0.02 ENSRNOT00000071364
microtubule-associated protein, RP/EB family, member 2
chr7_-_14364178 0.02 ENSRNOT00000090673
A-kinase anchoring protein 8 like
chr5_+_28485619 0.02 ENSRNOT00000093341
ENSRNOT00000093129
uncharacterized LOC100912373
chr7_+_12022285 0.02 ENSRNOT00000024080
RNA exonuclease 1 homolog
chr4_-_157304653 0.02 ENSRNOT00000051613
leucine rich repeat containing 23
chr9_+_20241062 0.02 ENSRNOT00000071593
leucine-rich repeat-containing protein 23-like
chr3_+_159368273 0.02 ENSRNOT00000041688
serum/glucocorticoid regulated kinase 2
chr17_-_22678253 0.02 ENSRNOT00000083122
LRRGT00112-like
chr18_+_87580424 0.02 ENSRNOT00000070984
thioredoxin-related transmembrane protein 3
chr1_-_198450047 0.02 ENSRNOT00000027360
major vault protein
chr18_-_43945273 0.02 ENSRNOT00000088900
DTW domain containing 2
chr7_-_15073052 0.02 ENSRNOT00000037708
zinc finger protein 799
chr10_-_47546345 0.01 ENSRNOT00000077461
aldehyde dehydrogenase 3 family, member A2
chr8_-_39460844 0.01 ENSRNOT00000048875
PBX/knotted 1 homeobox 2
chr1_+_13595295 0.01 ENSRNOT00000079250
NHS-like 1
chr14_-_77810147 0.01 ENSRNOT00000035427
cytokine like 1
chr14_-_16903242 0.01 ENSRNOT00000003001
shroom family member 3
chr3_+_8547349 0.01 ENSRNOT00000079108
ENSRNOT00000091697
spectrin, alpha, non-erythrocytic 1
chr5_+_122100099 0.01 ENSRNOT00000007738
phosphodiesterase 4B
chr5_-_16799776 0.01 ENSRNOT00000011721
PLAG1 zinc finger
chr1_-_48825364 0.01 ENSRNOT00000024213
1-acylglycerol-3-phosphate O-acyltransferase 4
chr8_-_102149912 0.01 ENSRNOT00000011263
similar to Ab2-095
chr3_-_15278645 0.01 ENSRNOT00000032204
tubulin tyrosine ligase like11
chr6_-_44363915 0.01 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr7_+_2752680 0.01 ENSRNOT00000033726
citrate synthase
chr5_+_153269526 0.01 ENSRNOT00000091494
SYF2 pre-mRNA-splicing factor
chr1_-_67065797 0.01 ENSRNOT00000048152
vomeronasal 1 receptor 46
chr16_-_83084975 0.01 ENSRNOT00000017947
Rho guanine nucleotide exchange factor 7
chr11_-_86303453 0.01 ENSRNOT00000071453
similar to CG15908-PA
chr19_-_11263980 0.01 ENSRNOT00000025086
nucleoporin 93
chr6_-_26241337 0.01 ENSRNOT00000006525
solute carrier family 4 member 1 adaptor protein
chr2_+_240642847 0.01 ENSRNOT00000079694
ubiquitin-conjugating enzyme E2D 3
chr2_+_188583664 0.01 ENSRNOT00000045477
dolichyl-phosphate mannosyltransferase subunit 3
chrX_+_74205842 0.01 ENSRNOT00000077003
cysteine-rich hydrophobic domain 1
chr18_-_16543992 0.01 ENSRNOT00000036306
solute carrier family 39 member 6
chr10_-_94576512 0.01 ENSRNOT00000035474
intercellular adhesion molecule 2
chr12_+_24761210 0.01 ENSRNOT00000002003
claudin 4
chr18_+_4084228 0.01 ENSRNOT00000071392
calcium binding tyrosine phosphorylation regulated
chr2_+_86891092 0.01 ENSRNOT00000077162
ENSRNOT00000083066
zinc finger protein 457-like
chr16_+_39144972 0.01 ENSRNOT00000086728
ADAM metallopeptidase domain 21
chr7_-_28711761 0.01 ENSRNOT00000006249
PARP1 binding protein
chr5_-_127878792 0.01 ENSRNOT00000014436
zyg-11 family member B, cell cycle regulator
chr5_+_154294806 0.01 ENSRNOT00000012853
3-hydroxymethyl-3-methylglutaryl-CoA lyase
chr3_+_2591331 0.01 ENSRNOT00000017466
suppressor APC domain containing 2
chr2_+_80269661 0.01 ENSRNOT00000015975

chr10_-_97754445 0.01 ENSRNOT00000088215
solute carrier family 16, member 6
chr6_+_26241672 0.01 ENSRNOT00000006543
SPT7-like STAGA complex gamma subunit
chr11_+_46737892 0.01 ENSRNOT00000052182

chr2_-_178521038 0.01 ENSRNOT00000033107
relaxin/insulin-like family peptide receptor 1
chr9_+_88493593 0.01 ENSRNOT00000020712
mitochondrial fission factor-like
chr10_-_87286387 0.01 ENSRNOT00000044206
keratin 28
chr16_+_71889235 0.01 ENSRNOT00000038266
ADAM metallopeptidase domain 32
chr1_-_15374850 0.01 ENSRNOT00000016728
peroxisomal biogenesis factor 7
chr1_-_252461461 0.01 ENSRNOT00000026093
ankyrin repeat domain 22
chr13_-_50514151 0.01 ENSRNOT00000003951
renin
chr5_+_155934490 0.01 ENSRNOT00000077933
ubiquitin carboxyl-terminal hydrolase 48-like
chr9_+_79630604 0.01 ENSRNOT00000021539
ENSRNOT00000083979
transmembrane protein 169
chr1_-_241046249 0.01 ENSRNOT00000067796
ENSRNOT00000081866
structural maintenance of chromosomes 5
chr6_-_114476723 0.01 ENSRNOT00000005162
deiodinase, iodothyronine, type II
chr1_-_134871167 0.01 ENSRNOT00000076300
chromodomain helicase DNA binding protein 2
chr19_+_24329023 0.01 ENSRNOT00000065558
TBC1 domain family member 9
chr4_-_100252755 0.01 ENSRNOT00000017301
vesicle-associated membrane protein 8
chr2_+_51672722 0.01 ENSRNOT00000016485
fibroblast growth factor 10
chr19_-_50220455 0.01 ENSRNOT00000079760
short chain dehydrogenase/reductase family 42E, member 1
chr6_+_102215603 0.01 ENSRNOT00000014257
pleckstrin homology, MyTH4 and FERM domain containing H1
chr13_+_84474319 0.01 ENSRNOT00000031367
ENSRNOT00000072244
ENSRNOT00000072897
ENSRNOT00000064168
ENSRNOT00000074954
ENSRNOT00000073696
immunoglobulin-like domain containing receptor 2
chr17_+_9736786 0.01 ENSRNOT00000081920
coagulation factor XII
chr20_-_11721838 0.01 ENSRNOT00000001636
ubiquitin-conjugating enzyme E2G 2
chr20_-_9855443 0.01 ENSRNOT00000090275
ENSRNOT00000066266
trefoil factor 3
chr5_-_166695134 0.01 ENSRNOT00000047763
transmembrane protein 201
chr8_+_33239139 0.01 ENSRNOT00000011589
Rho GTPase activating protein 32
chr7_+_26256459 0.01 ENSRNOT00000010986
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
chr7_+_44009069 0.01 ENSRNOT00000005523
MGAT4 family, member C
chr1_+_101554642 0.01 ENSRNOT00000028474
branched chain amino acid transaminase 2
chr1_+_229416489 0.01 ENSRNOT00000028617
olfactory receptor 336
chr10_-_56409017 0.01 ENSRNOT00000020152
fibroblast growth factor 11
chr8_-_78096302 0.01 ENSRNOT00000086185
ENSRNOT00000077999
myocardial zonula adherens protein
chr15_-_55209342 0.01 ENSRNOT00000021752
RB transcriptional corepressor 1
chr11_-_14304603 0.01 ENSRNOT00000040202
ENSRNOT00000082143
SAM domain, SH3 domain and nuclear localization signals, 1
chr19_-_29968424 0.01 ENSRNOT00000024981
inositol polyphosphate-4-phosphatase type II B
chr5_-_154222702 0.01 ENSRNOT00000080069
proline-rich nuclear receptor coactivator 2
chr1_+_188420461 0.01 ENSRNOT00000037870
centriolar coiled-coil protein 110
chr14_+_39964588 0.00 ENSRNOT00000003240
gamma-aminobutyric acid type A receptor gamma 1 subunit
chr4_+_180291389 0.00 ENSRNOT00000002465
sarcospan
chr1_-_88657845 0.00 ENSRNOT00000074211
calpain small subunit 1-like
chr19_+_45938915 0.00 ENSRNOT00000065508
MON1 homolog B, secretory trafficking associated
chr16_-_48692476 0.00 ENSRNOT00000013118
interferon regulatory factor 2
chr3_-_91370167 0.00 ENSRNOT00000006291
proline rich 5 like
chr8_+_117062884 0.00 ENSRNOT00000082452
ENSRNOT00000071540
nicolin 1
chr18_-_26656879 0.00 ENSRNOT00000086729
erythrocyte membrane protein band 4.1 like 4A
chr12_-_37538403 0.00 ENSRNOT00000001402
small nuclear ribonucleoprotein U11/U12 subunit 35
chr1_-_214067657 0.00 ENSRNOT00000044390
chitinase domain-containing protein 1-like
chr18_+_79773608 0.00 ENSRNOT00000088484
zinc finger protein 516
chr2_-_60657712 0.00 ENSRNOT00000040348
retinoic acid induced 14
chr15_-_95514259 0.00 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chr7_-_91538673 0.00 ENSRNOT00000006209
RAD21 cohesin complex component
chr11_-_87403367 0.00 ENSRNOT00000057751
THAP domain containing 7
chr8_-_84506328 0.00 ENSRNOT00000064754
muscular LMNA-interacting protein
chr7_-_29171783 0.00 ENSRNOT00000079235
myosin binding protein C, slow type
chr12_-_5685448 0.00 ENSRNOT00000077167
FRY microtubule binding protein
chrX_-_32095867 0.00 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr9_-_11027506 0.00 ENSRNOT00000071107
chromatin assembly factor 1 subunit A
chr4_+_162937774 0.00 ENSRNOT00000083188
C-type lectin domain family 2, member G
chr13_+_31081804 0.00 ENSRNOT00000041413
cadherin 7
chr8_-_33121002 0.00 ENSRNOT00000047211
LRRGT00010-like
chr1_+_80141630 0.00 ENSRNOT00000029552
optic atrophy 3
chr8_+_117297670 0.00 ENSRNOT00000082628
glutaminyl-tRNA synthetase
chr9_+_60883981 0.00 ENSRNOT00000081002
coiled-coil domain containing 150
chr4_+_99823252 0.00 ENSRNOT00000013587
RNA polymerase I subunit A
chr13_+_67611708 0.00 ENSRNOT00000063833
translocated promoter region, nuclear basket protein
chr2_-_58534211 0.00 ENSRNOT00000089178
S-phase kinase associated protein 2
chr20_+_3155652 0.00 ENSRNOT00000042882
RT1 class Ib, locus S2
chr14_-_44078897 0.00 ENSRNOT00000031792
NEDD4 binding protein 2
chr3_+_17889972 0.00 ENSRNOT00000073021

chr6_-_23316962 0.00 ENSRNOT00000065421
CAP-GLY domain containing linker protein family, member 4
chr3_+_3389612 0.00 ENSRNOT00000041984
ribosomal protein L8
chr8_+_85059051 0.00 ENSRNOT00000033196
glutamate-cysteine ligase, catalytic subunit
chr3_+_173799833 0.00 ENSRNOT00000081235
phosphatase and actin regulator 3
chr5_-_119564846 0.00 ENSRNOT00000012977
cytochrome P450, family 2, subfamily j, polypeptide 4
chr16_+_39145230 0.00 ENSRNOT00000092942
ADAM metallopeptidase domain 21
chr14_+_44889287 0.00 ENSRNOT00000091312
ENSRNOT00000032273
transmembrane protein 156
chr17_+_2690062 0.00 ENSRNOT00000024937
olfactory receptor 1653
chr16_+_23447366 0.00 ENSRNOT00000068629
pleckstrin and Sec7 domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422) regulation of exo-alpha-sialidase activity(GO:1903015)
0.0 0.1 GO:0043324 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
0.0 0.1 GO:0006567 threonine catabolic process(GO:0006567)
0.0 0.1 GO:0098885 modification of postsynaptic actin cytoskeleton(GO:0098885)
0.0 0.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.0 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.0 0.0 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.1 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0 0.0 GO:0051684 maintenance of Golgi location(GO:0051684)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0098871 postsynaptic actin cytoskeleton(GO:0098871) postsynaptic cytoskeleton(GO:0099571)
0.0 0.0 GO:0097444 spine apparatus(GO:0097444)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.0 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.1 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.0 0.1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0 0.0 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases