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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Rfx3_Rfx1_Rfx4

Z-value: 2.01

Motif logo

Transcription factors associated with Rfx3_Rfx1_Rfx4

Gene Symbol Gene ID Gene Info
ENSRNOG00000014486 regulatory factor X3
ENSRNOG00000006049 regulatory factor X1
ENSRNOG00000051536 regulatory factor X4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx1rn6_v1_chr19_+_25181564_25181564-0.256.9e-01Click!
Rfx4rn6_v1_chr7_+_25808419_25808419-0.237.1e-01Click!
Rfx3rn6_v1_chr1_-_246010594_246010594-0.177.9e-01Click!

Activity profile of Rfx3_Rfx1_Rfx4 motif

Sorted Z-values of Rfx3_Rfx1_Rfx4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_14573519 0.94 ENSRNOT00000001772
RAB36, member RAS oncogene family
chr6_+_8886591 0.92 ENSRNOT00000091510
ENSRNOT00000089174
SIX homeobox 3
chr11_+_88424414 0.91 ENSRNOT00000022328
sperm associated antigen 6-like
chr17_-_88095729 0.90 ENSRNOT00000025140
enkurin, TRPC channel interacting protein
chr2_+_164549455 0.78 ENSRNOT00000017151
myeloid leukemia factor 1
chr2_-_195712461 0.78 ENSRNOT00000056449
regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1
chr12_+_22665112 0.78 ENSRNOT00000001918
adaptor-related protein complex 1, sigma 1 subunit
chr10_+_96663740 0.76 ENSRNOT00000037067
centrosomal protein 112
chr2_-_208623314 0.75 ENSRNOT00000022731
primary cilia formation
chr7_-_18577325 0.74 ENSRNOT00000084308
ENSRNOT00000090849
membrane associated ring-CH-type finger 2
chr1_-_199037267 0.73 ENSRNOT00000078779
coiled-coil domain containing 189
chr2_-_211322719 0.73 ENSRNOT00000027493
similar to KIAA1324 protein
chr1_-_226501920 0.66 ENSRNOT00000050716
leucine rich repeat containing 10B
chr1_+_188571953 0.61 ENSRNOT00000055096
IQ motif containing K
chr12_+_2534212 0.59 ENSRNOT00000001399
cortexin 1
chr16_-_21338771 0.59 ENSRNOT00000014265
PBX homeobox 4
chr4_-_157304653 0.59 ENSRNOT00000051613
leucine rich repeat containing 23
chr1_+_78893271 0.59 ENSRNOT00000029825
paraneoplastic Ma antigen family-like 1
chr12_+_47074200 0.57 ENSRNOT00000014910
dynein light chain LC8-type 1
chr9_-_94601852 0.55 ENSRNOT00000022485
neuronal guanine nucleotide exchange factor
chr3_-_7632345 0.54 ENSRNOT00000049889
cilia and flagella associated protein 77
chr10_+_57185347 0.54 ENSRNOT00000040488
ENSRNOT00000086374
misshapen-like kinase 1
chr9_+_20241062 0.52 ENSRNOT00000071593
leucine-rich repeat-containing protein 23-like
chr1_-_145931583 0.51 ENSRNOT00000016433
cilia and flagella associated protein 161
chr3_-_102151489 0.51 ENSRNOT00000006349
anoctamin 3
chr1_+_205842489 0.50 ENSRNOT00000081610
fibronectin type 3 and ankyrin repeat domains 1
chr7_-_120744602 0.49 ENSRNOT00000018564
potassium voltage-gated channel subfamily J member 4
chr15_+_27875911 0.49 ENSRNOT00000013582
purine nucleoside phosphorylase
chr2_-_144467912 0.49 ENSRNOT00000040002
cyclin A1
chr5_-_143062226 0.49 ENSRNOT00000029388
dynein, axonemal, light intermediate chain 1
chr3_-_123702732 0.49 ENSRNOT00000028859
similar to RIKEN cDNA 1700037H04
chr5_+_61474000 0.47 ENSRNOT00000013930
coiled-coil domain containing 180
chr8_-_6235967 0.47 ENSRNOT00000068290
hypothetical protein LOC654482
chr6_+_137953545 0.46 ENSRNOT00000006804
cysteine-rich protein 2
chr12_-_6703979 0.46 ENSRNOT00000061246
testis expressed 26
chr12_+_24803686 0.45 ENSRNOT00000033499
Williams-Beuren syndrome chromosome region 28
chr8_-_55491152 0.45 ENSRNOT00000014965
rCG58364-like
chr7_+_139762614 0.45 ENSRNOT00000031157
coiled-coil domain containing 184
chr11_-_90234286 0.43 ENSRNOT00000071986
EF hand calcium binding domain 1
chr10_-_57671080 0.42 ENSRNOT00000082511
hypothetical protein LOC691995
chr20_-_10680283 0.42 ENSRNOT00000001579
salt-inducible kinase 1
chr1_+_265298868 0.41 ENSRNOT00000023278
deleted in primary ciliary dyskinesia
chr8_-_13290773 0.41 ENSRNOT00000012217
similar to RIKEN cDNA 1700012B09
chr10_-_54512169 0.41 ENSRNOT00000005066
cilia and flagella associated protein 52
chr5_-_135994848 0.41 ENSRNOT00000067675
BTB domain containing 19
chr7_+_12652415 0.40 ENSRNOT00000031315
phospholipid phosphatase related 3
chr14_-_43584343 0.40 ENSRNOT00000039835
NOP2/Sun RNA methyltransferase family member 7
chr7_-_144837583 0.39 ENSRNOT00000055289
chromobox 5
chr19_-_10380809 0.39 ENSRNOT00000031064
dynein regulatory complex subunit 7
chr1_+_78739930 0.39 ENSRNOT00000021976
striatin 4
chr1_+_72874404 0.38 ENSRNOT00000058900
dynein, axonemal, assembly factor 3
chr3_+_160047296 0.38 ENSRNOT00000051590
cAMP-dependent protein kinase inhibitor gamma
chr1_-_266074181 0.38 ENSRNOT00000026378
pleckstrin and Sec7 domain containing
chr19_-_10653800 0.35 ENSRNOT00000022128
C-X3-C motif chemokine ligand 1
chr10_-_61744976 0.35 ENSRNOT00000079926
ENSRNOT00000092314
ENSRNOT00000034298
small G protein signaling modulator 2
chr12_-_6341902 0.34 ENSRNOT00000001201
heat shock protein family H (Hsp110) member 1
chr19_+_52225582 0.34 ENSRNOT00000020917
dynein, axonemal, assembly factor 1
chr4_+_2053712 0.34 ENSRNOT00000045086
ring finger protein 32
chr10_+_14062331 0.34 ENSRNOT00000029652
NADPH oxidase organizer 1
chr1_+_220335254 0.34 ENSRNOT00000072261
Ras and Rab interactor 1
chr5_+_140712583 0.34 ENSRNOT00000019587
tRNA isopentenyltransferase 1
chr9_-_17114177 0.34 ENSRNOT00000061185
leucine rich repeat containing 73
chrX_+_135470915 0.33 ENSRNOT00000009637
solute carrier family 25 member 14
chr16_-_49820235 0.33 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr7_+_27240876 0.32 ENSRNOT00000091725
first gene upstream of Nt5dc3
chr9_+_81644355 0.32 ENSRNOT00000071700
ciliogenesis associated TTC17 interacting protein
chr15_-_8914501 0.32 ENSRNOT00000008752
thyroid hormone receptor beta
chr8_+_64364741 0.32 ENSRNOT00000082840
CUGBP, Elav-like family member 6
chr13_-_105684374 0.31 ENSRNOT00000073142
spermatogenesis associated 17
chr4_+_114854458 0.31 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr1_+_84070983 0.31 ENSRNOT00000090478
NUMB-like, endocytic adaptor protein
chr8_-_130475320 0.30 ENSRNOT00000075439
coiled-coil domain containing 13
chrX_+_32495809 0.30 ENSRNOT00000020999
similar to RIKEN cDNA 1700045I19
chr19_-_38321528 0.30 ENSRNOT00000031977
sphingomyelin phosphodiesterase 3
chr20_-_4392343 0.30 ENSRNOT00000080476
palmitoyl-protein thioesterase 2
chr1_-_129780356 0.29 ENSRNOT00000077479
arrestin domain containing 4
chr10_-_89338739 0.29 ENSRNOT00000073923
prostaglandin E synthase 3 like
chr8_-_106858543 0.29 ENSRNOT00000051939
coxsackievirus and adenovirus receptor-like
chr8_+_79638696 0.29 ENSRNOT00000085959
dyslexia susceptibility 1 candidate 1
chr10_+_55653946 0.29 ENSRNOT00000008787
transmembrane protein 107
chr14_-_81100803 0.29 ENSRNOT00000014692
Myb/SANT DNA binding domain containing 1
chr2_-_33841499 0.29 ENSRNOT00000040533
splicing regulatory glutamic acid and lysine rich protein 1
chr7_-_144837395 0.29 ENSRNOT00000089024
chromobox 5
chr3_+_148438939 0.28 ENSRNOT00000064196
tubulin tyrosine ligase like 9
chr1_+_214182830 0.28 ENSRNOT00000022867
leucine rich repeat containing 56
chr3_+_80833272 0.28 ENSRNOT00000023583
cholinergic receptor, muscarinic 4
chr10_+_58776792 0.28 ENSRNOT00000019574
thioredoxin domain containing 17
chr2_-_30340103 0.28 ENSRNOT00000024023
ENSRNOT00000067722
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr1_-_82120902 0.27 ENSRNOT00000027684
Ets2 repressor factor
chr8_+_90343154 0.27 ENSRNOT00000068482
interleukin-1 receptor-associated kinase 1 binding protein 1
chr18_-_73360373 0.27 ENSRNOT00000048702
katanin catalytic subunit A1 like 2
chr5_+_140870140 0.27 ENSRNOT00000074347
hippocalcin-like 4
chr2_+_206064179 0.27 ENSRNOT00000025953
synaptotagmin 6
chr8_-_79660439 0.27 ENSRNOT00000089949
cell cycle progression 1, opposite strand
chr9_+_88964525 0.26 ENSRNOT00000068236
dynein assembly factor with WD repeats 1
chr20_+_4959294 0.26 ENSRNOT00000074223
heat shock protein family A (Hsp70) member 1 like
chr2_-_187820952 0.26 ENSRNOT00000092762
semaphorin 4A
chr1_-_188373571 0.26 ENSRNOT00000075020
lysine-rich nucleolar protein 1
chr6_-_27024129 0.26 ENSRNOT00000012273
dihydropyrimidinase-like 5
chr5_+_169519212 0.26 ENSRNOT00000024732
chromodomain helicase DNA binding protein 5
chr4_+_172709724 0.26 ENSRNOT00000010707
immunoglobulin (CD79A) binding protein 1b
chr7_-_74901997 0.26 ENSRNOT00000039378
regulator of G-protein signaling 22
chr19_+_56010085 0.25 ENSRNOT00000058216
spermatogenesis associated 33
chr1_-_281101438 0.25 ENSRNOT00000012734
RAB11 family interacting protein 2
chr8_+_107699480 0.25 ENSRNOT00000048864
NME/NM23 family member 9
chr13_-_70174565 0.24 ENSRNOT00000067135
ral guanine nucleotide dissociation stimulator,-like 1
chr5_+_153845094 0.24 ENSRNOT00000041600
sperm-tail PG-rich repeat containing 1
chr3_-_110021149 0.24 ENSRNOT00000007808
fibrous sheath interacting protein 1
chr6_+_109617596 0.24 ENSRNOT00000085031
ENSRNOT00000089972
ENSRNOT00000082402
feline leukemia virus subgroup C cellular receptor family, member 2
chr5_+_159735008 0.24 ENSRNOT00000064310
REM2 and RAB-like small GTPase 1
chrX_+_122808605 0.24 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr4_-_126071261 0.24 ENSRNOT00000080234
dynein light chain 1-like
chr13_+_83681322 0.24 ENSRNOT00000004206
mitochondrial pyruvate carrier 2
chr4_-_100380578 0.24 ENSRNOT00000018251
SH2 domain containing 6
chr2_+_181331464 0.23 ENSRNOT00000017448
microtubule-associated protein 9
chr17_-_78910671 0.23 ENSRNOT00000064609
acyl-CoA binding domain containing 7
chr10_+_38919167 0.23 ENSRNOT00000077569
kinesin family member 3a
chr1_-_222495382 0.23 ENSRNOT00000028759
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr10_-_56154548 0.23 ENSRNOT00000090809
dynein, axonemal, heavy chain 2
chr8_+_67753279 0.23 ENSRNOT00000009716
calmodulin-like 4
chr1_+_213583606 0.23 ENSRNOT00000088899

chr19_+_37795658 0.23 ENSRNOT00000025686
translin-associated factor X interacting protein 1
chr4_+_147756553 0.23 ENSRNOT00000086549
ENSRNOT00000014733
intraflagellar transport 122
chr5_-_136706936 0.23 ENSRNOT00000081925
ENSRNOT00000068130
coiled-coil domain containing 24
chr5_+_159734838 0.22 ENSRNOT00000079905
REM2 and RAB-like small GTPase 1
chr18_+_47740328 0.22 ENSRNOT00000025119
synuclein, alpha interacting protein
chr7_-_54855557 0.22 ENSRNOT00000039475
GLI pathogenesis-related 1 like 1
chr16_-_39970532 0.22 ENSRNOT00000071331
spermatogenesis associated 4
chr9_-_13311924 0.22 ENSRNOT00000015584
kinesin family member 6
chr3_-_15379381 0.21 ENSRNOT00000084069
NADH:ubiquinone oxidoreductase subunit A8
chr1_+_91042635 0.21 ENSRNOT00000028211
tubulin-folding cofactor B
chr12_-_2007516 0.21 ENSRNOT00000037564
peroxisomal biogenesis factor 11 gamma
chr3_-_123718432 0.21 ENSRNOT00000028861
sperm flagellar 1
chr1_-_88162583 0.21 ENSRNOT00000087411
cation channel sperm associated auxiliary subunit gamma
chr2_-_89310946 0.21 ENSRNOT00000015195
RALY RNA binding protein-like
chr9_+_82718709 0.21 ENSRNOT00000027256
ENSRNOT00000080524
serine/threonine kinase 11 interacting protein
chr12_-_37425596 0.21 ENSRNOT00000084553
tectonic family member 2
chr20_-_3299580 0.21 ENSRNOT00000050373
G protein nucleolar 1
chr13_-_30800451 0.20 ENSRNOT00000046791
ribosomal protein L21
chr16_+_26859397 0.20 ENSRNOT00000044171
methylsterol monooxygenase 1
chr1_+_72874583 0.20 ENSRNOT00000077719
dynein, axonemal, assembly factor 3
chr3_+_113251778 0.20 ENSRNOT00000083005
microtubule-associated protein 1A
chr8_-_107272122 0.20 ENSRNOT00000041894
coxsackie virus and adenovirus receptor-like 1
chr5_-_122642202 0.20 ENSRNOT00000046691
WD repeat domain 78
chr7_-_120380200 0.19 ENSRNOT00000014878
similar to RIKEN cDNA 1700088E04
chr5_+_136406308 0.19 ENSRNOT00000072492
ERI1 exoribonuclease family member 3
chr19_+_10519493 0.19 ENSRNOT00000030229
coiled-coil domain containing 102A
chr13_-_90832469 0.19 ENSRNOT00000086508
immunoglobulin superfamily, member 9
chr5_+_157165341 0.19 ENSRNOT00000087072
phospholipase A2, group IIC
chr6_+_1534594 0.19 ENSRNOT00000007000
NADH:ubiquinone oxidoreductase complex assembly factor 7
chr13_+_82574966 0.19 ENSRNOT00000003844
coiled-coil domain containing 181
chr1_+_220325352 0.19 ENSRNOT00000027258
breast cancer metastasis-suppressor 1 homolog
chr6_+_145770662 0.19 ENSRNOT00000088969
cell division cycle associated 7 like
chr9_+_10446699 0.19 ENSRNOT00000075344
hypothetical LOC301124
chr3_-_147849875 0.19 ENSRNOT00000081153
neurensin 2
chr5_+_157165888 0.19 ENSRNOT00000043029
phospholipase A2, group IIC
chr1_-_72674271 0.19 ENSRNOT00000023744
lysine methyltransferase 5C
chr15_+_34584320 0.18 ENSRNOT00000048255

chr10_+_49472460 0.18 ENSRNOT00000038276
tektin 3
chr3_+_110442637 0.18 ENSRNOT00000010471
p21 (RAC1) activated kinase 6
chr20_+_33945829 0.18 ENSRNOT00000064063
radial spoke head protein 4 homolog A
chr2_+_189430041 0.18 ENSRNOT00000023567
ENSRNOT00000023605
tropomyosin 3
chr11_-_64421248 0.18 ENSRNOT00000066997
immunoglobulin superfamily, member 11
chr10_+_38918748 0.18 ENSRNOT00000009999
kinesin family member 3a
chr1_+_100471066 0.18 ENSRNOT00000067562
aspartate dehydrogenase domain containing
chr1_+_203971152 0.18 ENSRNOT00000075540
G protein-coupled receptor 26
chr9_-_65917132 0.18 ENSRNOT00000031866
transmembrane protein 237
chr20_-_46871946 0.18 ENSRNOT00000031047
armadillo repeat containing 2
chr16_+_49485256 0.18 ENSRNOT00000059317
similar to LOC495042 protein
chr1_-_220786615 0.18 ENSRNOT00000038198
testis specific 10 interacting protein
chr20_+_32450733 0.17 ENSRNOT00000036449
radial spoke head 4 homolog A
chr13_-_89661150 0.17 ENSRNOT00000058390
ubiquitin specific peptidase 21
chr11_-_53731779 0.17 ENSRNOT00000002684
intraflagellar transport 57
chr1_-_188572141 0.17 ENSRNOT00000073003
lysine-rich nucleolar protein 1
chr6_-_51356383 0.17 ENSRNOT00000012415
protein kinase cAMP-dependent type 2 regulatory subunit beta
chr4_+_183656013 0.17 ENSRNOT00000055442
electron transfer flavoprotein beta subunit lysine methyltransferase
chr3_-_58181971 0.17 ENSRNOT00000002076
distal-less homeobox 2
chr1_-_141604273 0.17 ENSRNOT00000092125
alanyl aminopeptidase, membrane
chr11_+_70967223 0.17 ENSRNOT00000087633
IQ motif containing G
chr5_+_136406130 0.17 ENSRNOT00000093099
ERI1 exoribonuclease family member 3
chr1_+_82473737 0.17 ENSRNOT00000028029
B9 protein domain 2
chr15_-_104168564 0.17 ENSRNOT00000093385
ENSRNOT00000038596
DAZ interacting zinc finger protein 1
chr8_-_66893083 0.17 ENSRNOT00000037028
ENSRNOT00000091755
kinesin family member 23
chr10_-_13352371 0.16 ENSRNOT00000034340
protease, serine, 30
chr10_+_90085559 0.16 ENSRNOT00000028332
N-acetylglutamate synthase
chr12_+_31335372 0.16 ENSRNOT00000001242
ENSRNOT00000037296
syntaxin 2
chr1_+_144601410 0.16 ENSRNOT00000047408
elongation factor like GTPase 1
chr15_-_32888095 0.16 ENSRNOT00000012233
defender against cell death 1
chrX_-_23469041 0.16 ENSRNOT00000065789
hypothetical protein LOC685699
chr1_+_266952561 0.16 ENSRNOT00000076452
neuralized E3 ubiquitin protein ligase 1
chr11_+_61661724 0.16 ENSRNOT00000079423
zinc finger, DHHC-type containing 23
chr17_-_9791781 0.16 ENSRNOT00000090536
regulator of G-protein signaling 14
chr17_-_9792007 0.16 ENSRNOT00000021596
regulator of G-protein signaling 14
chr5_+_166870011 0.16 ENSRNOT00000088299
ribosomal protein S2
chr14_-_84393421 0.16 ENSRNOT00000006911
coiled-coil domain containing 157
chr4_-_123118186 0.16 ENSRNOT00000038096
coiled-coil-helix-coiled-coil-helix domain containing 4
chr6_-_36940868 0.16 ENSRNOT00000006470
GEN1 Holliday junction 5' flap endonuclease
chr9_-_82382272 0.16 ENSRNOT00000025627
ATP-binding cassette, subfamily B (MDR/TAP), member 6
chr4_+_66165845 0.15 ENSRNOT00000064175
ubinuclein 2
chr12_+_23544287 0.15 ENSRNOT00000001938
ORAI calcium release-activated calcium modulator 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0014016 neuroblast differentiation(GO:0014016)
0.2 0.5 GO:0070638 nicotinamide riboside catabolic process(GO:0006738) urate biosynthetic process(GO:0034418) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
0.1 0.4 GO:0021678 third ventricle development(GO:0021678)
0.1 0.4 GO:2000769 epidermal stem cell homeostasis(GO:0036334) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771)
0.1 0.4 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.1 0.3 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
0.1 0.3 GO:0010070 zygote asymmetric cell division(GO:0010070)
0.1 0.9 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.1 0.3 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.1 0.5 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.1 1.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.4 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.1 0.4 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.2 GO:0044375 regulation of peroxisome size(GO:0044375)
0.1 0.4 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.1 0.5 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 0.4 GO:0015851 purine nucleobase transport(GO:0006863) nucleobase transport(GO:0015851)
0.1 0.7 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.1 0.3 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
0.1 0.2 GO:0021898 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.1 0.3 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.1 0.2 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.1 0.5 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 0.2 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.1 0.4 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.1 0.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.2 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
0.0 0.3 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.2 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.0 0.4 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0006532 aspartate biosynthetic process(GO:0006532)
0.0 0.2 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.2 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.3 GO:0015886 heme transport(GO:0015886)
0.0 0.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.8 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 0.2 GO:0080154 regulation of fertilization(GO:0080154)
0.0 0.8 GO:0071218 cellular response to misfolded protein(GO:0071218)
0.0 0.2 GO:0097332 response to antipsychotic drug(GO:0097332)
0.0 0.2 GO:1904732 regulation of electron carrier activity(GO:1904732)
0.0 0.5 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.1 GO:1905076 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
0.0 0.1 GO:1902953 endoplasmic reticulum membrane organization(GO:0090158) positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0 0.1 GO:0051594 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0034773 histone H4-K20 trimethylation(GO:0034773)
0.0 0.1 GO:0001834 trophectodermal cell proliferation(GO:0001834)
0.0 0.4 GO:0044458 motile cilium assembly(GO:0044458)
0.0 0.1 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0 0.1 GO:0071733 regulation of primitive erythrocyte differentiation(GO:0010725) transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.3 GO:0051013 microtubule severing(GO:0051013)
0.0 0.1 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.2 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.1 GO:0048669 somite specification(GO:0001757) collateral sprouting in absence of injury(GO:0048669)
0.0 0.1 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.0 0.2 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.1 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:1990401 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling(GO:0060683) embryonic lung development(GO:1990401)
0.0 0.2 GO:0090232 positive regulation of spindle checkpoint(GO:0090232) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 0.0 GO:1990790 response to glial cell derived neurotrophic factor(GO:1990790) cellular response to glial cell derived neurotrophic factor(GO:1990792)
0.0 0.1 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0 0.2 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 0.1 GO:0071579 regulation of zinc ion transport(GO:0071579)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.1 GO:0032264 IMP salvage(GO:0032264)
0.0 0.1 GO:0097106 postsynaptic density organization(GO:0097106)
0.0 0.4 GO:0042026 protein refolding(GO:0042026)
0.0 0.1 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.1 GO:0021769 orbitofrontal cortex development(GO:0021769)
0.0 0.0 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:1902569 regulation of activation of JAK2 kinase activity(GO:0010534) activation of JAK2 kinase activity(GO:0042977) negative regulation of activation of JAK2 kinase activity(GO:1902569)
0.0 0.0 GO:1904457 positive regulation of neuronal action potential(GO:1904457)
0.0 0.3 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:0098759 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
0.0 0.1 GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:1903912)
0.0 0.2 GO:0035814 negative regulation of renal sodium excretion(GO:0035814)
0.0 0.2 GO:0042407 cristae formation(GO:0042407)
0.0 0.1 GO:0072553 terminal button organization(GO:0072553)
0.0 0.1 GO:2000035 regulation of stem cell division(GO:2000035)
0.0 0.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.0 GO:0052572 response to immune response of other organism involved in symbiotic interaction(GO:0052564) response to host immune response(GO:0052572)
0.0 0.3 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.0 0.1 GO:0039526 suppression by virus of host apoptotic process(GO:0019050) modulation by virus of host apoptotic process(GO:0039526)
0.0 0.0 GO:0021873 forebrain neuroblast division(GO:0021873)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.0 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.0 0.1 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:1901386 negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0 0.4 GO:0050482 arachidonic acid secretion(GO:0050482) arachidonate transport(GO:1903963)
0.0 0.0 GO:1903413 cellular response to bile acid(GO:1903413)
0.0 0.1 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.0 0.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0 0.4 GO:0010107 potassium ion import(GO:0010107)
0.0 0.3 GO:0071625 vocalization behavior(GO:0071625)
0.0 0.4 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 0.2 GO:0031167 rRNA methylation(GO:0031167)
0.0 0.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.0 GO:0010751 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.0 0.2 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:1990716 axonemal central apparatus(GO:1990716)
0.1 0.4 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.2 GO:0097149 centralspindlin complex(GO:0097149)
0.0 2.0 GO:0030286 dynein complex(GO:0030286)
0.0 0.9 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.6 GO:0001741 XY body(GO:0001741)
0.0 0.3 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.7 GO:0010369 chromocenter(GO:0010369)
0.0 0.2 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 1.1 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.0 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.4 GO:0044292 dendrite terminus(GO:0044292)
0.0 0.2 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.7 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.4 GO:0097546 ciliary base(GO:0097546)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 0.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.0 GO:0099522 region of cytosol(GO:0099522) postsynaptic cytosol(GO:0099524)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.0 GO:1990423 RZZ complex(GO:1990423)
0.0 0.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.0 GO:0032021 NELF complex(GO:0032021)
0.0 0.3 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.0 GO:0031417 NatC complex(GO:0031417)
0.0 0.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0004731 purine nucleobase binding(GO:0002060) purine-nucleoside phosphorylase activity(GO:0004731)
0.1 0.6 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.3 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 0.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995) TFIIIC-class transcription factor binding(GO:0001156)
0.1 0.7 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.1 0.2 GO:0042799 histone methyltransferase activity (H4-K20 specific)(GO:0042799)
0.1 0.2 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.4 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.1 0.2 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.2 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.2 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0 0.9 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.1 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.2 GO:0034618 arginine binding(GO:0034618)
0.0 0.4 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.3 GO:0015232 heme transporter activity(GO:0015232)
0.0 0.2 GO:0070568 guanylyltransferase activity(GO:0070568)
0.0 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.3 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.4 GO:0015216 purine nucleotide transmembrane transporter activity(GO:0015216)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.4 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.1 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.0 0.2 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 0.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.4 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.4 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.2 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.3 GO:0070840 dynein complex binding(GO:0070840)
0.0 0.0 GO:0004918 interleukin-8 receptor activity(GO:0004918)
0.0 0.2 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.1 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0 0.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 0.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0032183 SUMO binding(GO:0032183)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.0 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling
0.0 0.5 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.4 PID IGF1 PATHWAY IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 0.5 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.0 0.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK