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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Rfx2_Rfx7
Z-value: 1.59
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Transcription factors associated with Rfx2_Rfx7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rfx2 | rn6_v1_chr9_+_10216205_10216293 | -0.99 | 9.2e-04 | Click! |
| Rfx7 | rn6_v1_chr8_+_79159370_79159370 | -0.96 | 8.5e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_100473643 Show fit | 1.08 |
ENSRNOT00000026379
|
Josephin domain containing 2 |
|
| chr20_+_14577166 Show fit | 0.99 |
ENSRNOT00000085583
|
rhabdoid tumor deletion region gene 1 |
|
| chr5_-_147817852 Show fit | 0.92 |
ENSRNOT00000071940
|
doublecortin domain containing 2B |
|
| chr1_-_226526959 Show fit | 0.92 |
ENSRNOT00000028003
|
protein phosphatase 1, regulatory subunit 32 |
|
| chrX_+_63520991 Show fit | 0.86 |
ENSRNOT00000071590
|
apolipoprotein O |
|
| chr10_-_84976170 Show fit | 0.84 |
ENSRNOT00000013542
|
leucine rich repeat containing 46 |
|
| chr6_+_52702544 Show fit | 0.78 |
ENSRNOT00000014252
|
EF-hand calcium binding domain 10 |
|
| chr19_-_53754602 Show fit | 0.72 |
ENSRNOT00000035651
|
family with sequence similarity 92, member B |
|
| chr1_+_100891866 Show fit | 0.71 |
ENSRNOT00000086890
ENSRNOT00000083336 |
fuzzy planar cell polarity protein |
|
| chr11_+_84094520 Show fit | 0.70 |
ENSRNOT00000046642
|
ribosomal protein S15A-like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rfx2_Rfx7
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:1903955 | positive regulation of protein targeting to mitochondrion(GO:1903955) |
| 0.1 | 0.9 | GO:0042407 | cristae formation(GO:0042407) |
| 0.2 | 0.8 | GO:0080154 | regulation of fertilization(GO:0080154) |
| 0.0 | 0.8 | GO:0036158 | outer dynein arm assembly(GO:0036158) |
| 0.2 | 0.7 | GO:2000313 | fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313) |
| 0.0 | 0.6 | GO:1903830 | magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830) |
| 0.0 | 0.6 | GO:0014010 | Schwann cell proliferation(GO:0014010) |
| 0.0 | 0.5 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.0 | 0.5 | GO:0070986 | left/right axis specification(GO:0070986) |
| 0.1 | 0.4 | GO:0061732 | mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.2 | GO:0097228 | sperm principal piece(GO:0097228) |
| 0.0 | 1.1 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.1 | 0.9 | GO:0061617 | MICOS complex(GO:0061617) |
| 0.1 | 0.6 | GO:0036157 | outer dynein arm(GO:0036157) |
| 0.0 | 0.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.5 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.4 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.0 | 0.4 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 0.3 | GO:0033503 | HULC complex(GO:0033503) |
| 0.1 | 0.3 | GO:0042585 | germinal vesicle(GO:0042585) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.1 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 0.6 | GO:0004576 | oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 0.4 | GO:0050833 | pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.4 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 0.1 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.3 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.3 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 0.4 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.3 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.0 | 0.3 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 0.0 | 0.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.0 | 0.2 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.0 | 0.1 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |