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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Rfx2_Rfx7

Z-value: 1.59

Motif logo

Transcription factors associated with Rfx2_Rfx7

Gene Symbol Gene ID Gene Info
ENSRNOG00000045846 regulatory factor X2
ENSRNOG00000060367 regulatory factor X, 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rfx2rn6_v1_chr9_+_10216205_10216293-0.999.2e-04Click!
Rfx7rn6_v1_chr8_+_79159370_79159370-0.968.5e-03Click!

Activity profile of Rfx2_Rfx7 motif

Sorted Z-values of Rfx2_Rfx7 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_100473643 1.08 ENSRNOT00000026379
Josephin domain containing 2
chr20_+_14577166 0.99 ENSRNOT00000085583
rhabdoid tumor deletion region gene 1
chr5_-_147817852 0.92 ENSRNOT00000071940
doublecortin domain containing 2B
chr1_-_226526959 0.92 ENSRNOT00000028003
protein phosphatase 1, regulatory subunit 32
chrX_+_63520991 0.86 ENSRNOT00000071590
apolipoprotein O
chr10_-_84976170 0.84 ENSRNOT00000013542
leucine rich repeat containing 46
chr6_+_52702544 0.78 ENSRNOT00000014252
EF-hand calcium binding domain 10
chr19_-_53754602 0.72 ENSRNOT00000035651
family with sequence similarity 92, member B
chr1_+_100891866 0.71 ENSRNOT00000086890
ENSRNOT00000083336
fuzzy planar cell polarity protein
chr11_+_84094520 0.70 ENSRNOT00000046642
ribosomal protein S15A-like 2
chr17_-_88095729 0.66 ENSRNOT00000025140
enkurin, TRPC channel interacting protein
chr16_+_56248331 0.63 ENSRNOT00000085300
tumor suppressor candidate 3
chr17_+_85914410 0.62 ENSRNOT00000075188
armadillo repeat containing 3
chr1_-_145931583 0.60 ENSRNOT00000016433
cilia and flagella associated protein 161
chr7_+_54213319 0.59 ENSRNOT00000005286
nucleosome assembly protein 1-like 1
chr6_-_27323992 0.57 ENSRNOT00000013198
similar to RIKEN cDNA 1700001C02
chr8_+_79638696 0.55 ENSRNOT00000085959
dyslexia susceptibility 1 candidate 1
chr10_-_10767389 0.54 ENSRNOT00000066754
small integral membrane protein 22
chr10_-_44746549 0.52 ENSRNOT00000003841
family with sequence similarity 183, member B
chr5_-_136112344 0.51 ENSRNOT00000050195
RGD1563714
chr6_+_135856218 0.51 ENSRNOT00000066715
similar to novel protein
chr8_+_79054237 0.50 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr15_-_34352673 0.47 ENSRNOT00000064916
neural precursor cell expressed, developmentally down-regulated 8
chr20_-_14573519 0.44 ENSRNOT00000001772
RAB36, member RAS oncogene family
chr6_-_59950586 0.43 ENSRNOT00000005800
ADP-ribosylation factor like GTPase 4A
chr20_-_12938891 0.43 ENSRNOT00000017141
similar to Protein C21orf58
chr10_+_88459490 0.43 ENSRNOT00000080231
ENSRNOT00000067559
tetratricopeptide repeat domain 25
chr2_-_251970768 0.42 ENSRNOT00000020141
WD repeat domain 63
chr1_+_72732668 0.41 ENSRNOT00000024251
HSPA (heat shock 70) binding protein, cytoplasmic cochaperone 1
chr10_+_14828597 0.41 ENSRNOT00000025434
tektin 4
chr7_-_115981731 0.40 ENSRNOT00000036549
similar to secreted Ly6/uPAR related protein 2
chr19_+_44164935 0.38 ENSRNOT00000048998
GABA type A receptor associated protein like 2
chr5_+_136112417 0.37 ENSRNOT00000025990
transmembrane protein 53
chr16_-_14348046 0.37 ENSRNOT00000018630
cadherin-related family member 1
chr19_+_49016891 0.37 ENSRNOT00000016713
dynein light chain roadblock-type 2
chr12_+_46042413 0.36 ENSRNOT00000046882
coiled-coil domain containing 60
chr10_+_49472460 0.35 ENSRNOT00000038276
tektin 3
chr3_-_7051953 0.35 ENSRNOT00000013473
similar to hypothetical protein MGC29761
chr10_+_103266296 0.35 ENSRNOT00000038852
dynein, axonemal, intermediate chain 2
chr1_-_154111725 0.35 ENSRNOT00000055488
coiled-coil domain containing 81
chr16_+_20400577 0.34 ENSRNOT00000037756
microtubule associated serine/threonine kinase 3
chr14_+_91557601 0.34 ENSRNOT00000038733
hypothetical LOC289778
chr20_+_33945829 0.34 ENSRNOT00000064063
radial spoke head protein 4 homolog A
chr20_+_32450733 0.34 ENSRNOT00000036449
radial spoke head 4 homolog A
chr17_+_78817529 0.33 ENSRNOT00000021918
meiosis/spermiogenesis associated 1
chr1_-_199037267 0.32 ENSRNOT00000078779
coiled-coil domain containing 189
chr12_+_19714324 0.32 ENSRNOT00000072303
similar to cell surface receptor FDFACT
chr1_-_101803200 0.32 ENSRNOT00000028588
cytohesin 2
chr18_-_27374603 0.32 ENSRNOT00000027244
NME/NM23 family member 5
chr2_-_208633945 0.30 ENSRNOT00000049155
primary cilia formation
chr20_-_10680283 0.30 ENSRNOT00000001579
salt-inducible kinase 1
chr13_+_83681322 0.29 ENSRNOT00000004206
mitochondrial pyruvate carrier 2
chr1_+_84044551 0.29 ENSRNOT00000028290
coenzyme Q8B
chr8_-_23014499 0.29 ENSRNOT00000017820
coiled-coil domain containing 151
chr6_+_137386422 0.29 ENSRNOT00000018568
LOC362793
chr10_-_57671080 0.28 ENSRNOT00000082511
hypothetical protein LOC691995
chr6_+_99817431 0.28 ENSRNOT00000009621
churchill domain containing 1
chrX_+_76042239 0.28 ENSRNOT00000003667
polysaccharide biosynthesis domain containing 1
chr1_+_137014272 0.28 ENSRNOT00000014802
A-kinase anchoring protein 13
chr5_+_118574801 0.28 ENSRNOT00000035949
ubiquitin-conjugating enzyme E2U (putative)
chr7_+_121841855 0.28 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr19_+_10167797 0.28 ENSRNOT00000085440
cyclic nucleotide gated channel beta 1
chr7_-_123156558 0.27 ENSRNOT00000005943
RNA polymerase III subunit H
chr1_+_214182830 0.27 ENSRNOT00000022867
leucine rich repeat containing 56
chr2_+_252263386 0.27 ENSRNOT00000092913
ENSRNOT00000084034
ENSRNOT00000041186
ENSRNOT00000092931
SSX family member 2 interacting protein
chr7_+_126028350 0.26 ENSRNOT00000042412
RIB43A domain with coiled-coils 2
chr6_-_11063073 0.26 ENSRNOT00000086010
ENSRNOT00000061746
hypothetical protein LOC681766
chr8_-_112594261 0.26 ENSRNOT00000015240
ubiquitin-like modifier activating enzyme 5
chr10_+_106065712 0.25 ENSRNOT00000003690
SEC14-like lipid binding 1
chr10_-_95934345 0.25 ENSRNOT00000004349
calcium voltage-gated channel auxiliary subunit gamma 1
chr4_+_171250818 0.25 ENSRNOT00000040576
protein tyrosine phosphatase, receptor type, O
chr10_+_14062331 0.24 ENSRNOT00000029652
NADPH oxidase organizer 1
chr4_+_169147243 0.24 ENSRNOT00000011580
epithelial membrane protein 1
chr4_+_114854458 0.24 ENSRNOT00000013312
hypothetical gene supported by BC079424
chr10_+_55169282 0.24 ENSRNOT00000005423
coiled-coil domain containing 42
chr16_-_82439441 0.24 ENSRNOT00000040315

chr7_+_11724962 0.23 ENSRNOT00000026551
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
chr1_+_267689328 0.23 ENSRNOT00000077738
cilia and flagella associated protein 58
chr7_+_54859104 0.23 ENSRNOT00000087341
calcyphosine 2
chr2_+_164549455 0.23 ENSRNOT00000017151
myeloid leukemia factor 1
chr1_-_72464492 0.23 ENSRNOT00000068550
N-acetyltransferase 14
chrX_+_156963870 0.23 ENSRNOT00000077109
PDZ domain containing 4
chr5_+_57947716 0.23 ENSRNOT00000067657
dynein, axonemal, intermediate chain 1
chr5_+_161889342 0.22 ENSRNOT00000040481
ribosomal protein S20-like
chr3_+_171597241 0.22 ENSRNOT00000029558
similar to Protein C20orf85 homolog
chr8_-_79660439 0.22 ENSRNOT00000089949
cell cycle progression 1, opposite strand
chr1_-_164849749 0.22 ENSRNOT00000024772
signal peptidase complex subunit 2
chr6_+_129538982 0.22 ENSRNOT00000083626
ENSRNOT00000082522
adenylate kinase 7
chr7_-_74901997 0.22 ENSRNOT00000039378
regulator of G-protein signaling 22
chr5_-_78324278 0.22 ENSRNOT00000082642
ENSRNOT00000048904
WD repeat domain 31
chr10_-_109811323 0.22 ENSRNOT00000054970
MAF bZIP transcription factor G
chr16_-_7082193 0.21 ENSRNOT00000024447
signal peptidase complex subunit 1
chr14_+_106393959 0.21 ENSRNOT00000092168
WD repeat containing planar cell polarity effector
chr1_+_53220397 0.21 ENSRNOT00000089989

chr18_+_72005581 0.21 ENSRNOT00000072519
zinc finger and BTB domain containing 7C
chr9_-_43127887 0.21 ENSRNOT00000021685
ankyrin repeat domain 39
chr4_-_145555748 0.21 ENSRNOT00000013503
FANCD2 opposite strand
chr10_+_109107389 0.20 ENSRNOT00000068437
ENSRNOT00000005687
BAI1-associated protein 2
chr9_+_27068443 0.20 ENSRNOT00000017393
EF-hand domain containing 1
chr7_-_121058029 0.20 ENSRNOT00000068033
chromobox 6
chr4_-_159079003 0.20 ENSRNOT00000026691
potassium voltage-gated channel subfamily A member 5
chr2_+_174203693 0.20 ENSRNOT00000073540
uncharacterized LOC108350036
chr3_+_164424515 0.19 ENSRNOT00000083876
CCAAT/enhancer binding protein beta
chr13_-_89745835 0.19 ENSRNOT00000005352
kelch domain containing 9
chr9_+_66335492 0.19 ENSRNOT00000037555
similar to KIAA2012 protein
chr18_-_33414236 0.19 ENSRNOT00000020385
Yip1 domain family, member 5
chr1_-_37726151 0.19 ENSRNOT00000071842
LOC361192
chr2_-_243475639 0.18 ENSRNOT00000089222
similar to hypothetical protein DKFZp434G072
chr5_-_144345531 0.18 ENSRNOT00000014721
tektin 2
chr16_+_18648866 0.18 ENSRNOT00000014862
DPY30 domain containing 1
chr4_-_113988246 0.18 ENSRNOT00000013128
WD repeat-containing protein 54
chr1_-_146289465 0.18 ENSRNOT00000017362
abhydrolase domain containing 17C
chr1_-_212317244 0.18 ENSRNOT00000068604
sperm flagellar protein 1-like
chr20_-_3374344 0.17 ENSRNOT00000082999
protein phosphatase 1, regulatory subunit 18
chr2_-_178612470 0.17 ENSRNOT00000013499
transmembrane protein 144
chr2_+_181331464 0.17 ENSRNOT00000017448
microtubule-associated protein 9
chr6_-_135112775 0.17 ENSRNOT00000086310
heat shock protein HSP 90-alpha
chr13_+_97702097 0.17 ENSRNOT00000057787
saccharopine dehydrogenase-like oxidoreductase
chr17_+_44522140 0.17 ENSRNOT00000080490
histone H4 variant H4-v.1
chr14_+_86922223 0.17 ENSRNOT00000086468
receptor activity modifying protein 3
chr8_-_68525911 0.17 ENSRNOT00000080588
ENSRNOT00000011109
IQ motif containing H
chr15_+_34352914 0.17 ENSRNOT00000067150
guanosine monophosphate reductase 2
chr1_-_196884302 0.17 ENSRNOT00000089464
NSE1 homolog, SMC5-SMC6 complex component
chr13_-_77959089 0.16 ENSRNOT00000003586
calcyclin binding protein
chr5_-_172488822 0.16 ENSRNOT00000019620
retention in endoplasmic reticulum sorting receptor 1
chrX_+_32495809 0.16 ENSRNOT00000020999
similar to RIKEN cDNA 1700045I19
chr14_+_85113578 0.16 ENSRNOT00000011158
nipsnap homolog 1
chr3_-_148313810 0.16 ENSRNOT00000010762
Bcl2-like 1
chr8_-_115388266 0.16 ENSRNOT00000018122
testis expressed 264
chr19_+_39357791 0.16 ENSRNOT00000086435
ENSRNOT00000015006
cytochrome b5 type B
chr14_-_106393670 0.16 ENSRNOT00000011429
malate dehydrogenase 1
chrX_-_79909678 0.16 ENSRNOT00000050336
bromodomain and WD repeat domain containing 3
chr19_+_26142720 0.16 ENSRNOT00000005270
similar to RIKEN cDNA 2310036O22
chr9_-_94601852 0.15 ENSRNOT00000022485
neuronal guanine nucleotide exchange factor
chr7_+_54859326 0.15 ENSRNOT00000039141
calcyphosine 2
chr9_-_64096265 0.15 ENSRNOT00000013502
tRNA-yW synthesizing protein 5
chr1_-_267598639 0.15 ENSRNOT00000031925
cilia and flagella associated protein 43
chr5_+_164808323 0.15 ENSRNOT00000011005
natriuretic peptide A
chr3_-_58181971 0.15 ENSRNOT00000002076
distal-less homeobox 2
chr6_-_135259603 0.15 ENSRNOT00000010529
MOK protein kinase
chr18_+_63394900 0.15 ENSRNOT00000024126
proteasome assembly chaperone 2
chr1_+_170242846 0.15 ENSRNOT00000023751
cyclic nucleotide gated channel alpha 4
chr3_+_153491151 0.15 ENSRNOT00000047047
mannosidase beta like
chr10_-_19715832 0.15 ENSRNOT00000040278
similar to ribosomal protein S10
chr7_-_126028279 0.15 ENSRNOT00000044883
structural maintenance of chromosomes 1B
chr7_+_117420788 0.15 ENSRNOT00000049198
WD repeat domain 97
chr8_-_58542844 0.14 ENSRNOT00000012041
ELMO domain containing 1
chr19_+_37795658 0.14 ENSRNOT00000025686
translin-associated factor X interacting protein 1
chr3_+_7051695 0.14 ENSRNOT00000013548
mitochondrial ribosomal protein S2
chr4_-_10020022 0.14 ENSRNOT00000044020
armadillo repeat containing 10
chr3_-_10371240 0.14 ENSRNOT00000012075
argininosuccinate synthase 1
chr14_+_2325308 0.14 ENSRNOT00000000072
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr1_+_86949413 0.14 ENSRNOT00000064153
sirtuin 2
chr1_-_225631468 0.14 ENSRNOT00000072579

chr11_-_83483513 0.14 ENSRNOT00000084380

chr8_-_87315955 0.14 ENSRNOT00000081437
filamin A interacting protein 1
chr3_+_56802714 0.14 ENSRNOT00000077551
glutamate-rich 2
chr8_+_64364741 0.14 ENSRNOT00000082840
CUGBP, Elav-like family member 6
chr6_-_10899200 0.13 ENSRNOT00000089104
multiple coagulation factor deficiency 2
chr10_-_65424802 0.13 ENSRNOT00000018468
Tnf receptor associated factor 4
chr11_-_90234286 0.13 ENSRNOT00000071986
EF hand calcium binding domain 1
chr1_-_142720257 0.13 ENSRNOT00000032294
WD repeat domain 73
chr4_+_21317695 0.13 ENSRNOT00000007572
glutamate metabotropic receptor 3
chr20_-_32296840 0.13 ENSRNOT00000080727
storkhead box 1
chr1_+_265298868 0.13 ENSRNOT00000023278
deleted in primary ciliary dyskinesia
chr1_-_142020525 0.13 ENSRNOT00000042558
calcium and integrin binding 1
chr6_+_111223026 0.13 ENSRNOT00000074634
sterile alpha motif domain containing 15
chrX_+_20351486 0.13 ENSRNOT00000093675
ENSRNOT00000047444
WNK lysine deficient protein kinase 3
chr1_-_64021321 0.13 ENSRNOT00000090819
ribosomal protein S9
chr4_+_25435873 0.13 ENSRNOT00000000018
STEAP family member 1
chr2_+_211050360 0.13 ENSRNOT00000026928
proteasome subunit alpha 5
chr16_-_39970532 0.13 ENSRNOT00000071331
spermatogenesis associated 4
chrX_+_122808605 0.13 ENSRNOT00000017567
zinc finger CCHC-type containing 12
chr7_+_120140460 0.12 ENSRNOT00000040513
ENSRNOT00000073905
pyridoxal phosphatase
chr11_-_31892531 0.12 ENSRNOT00000033745
crystallin zeta like 1
chr9_+_81644355 0.12 ENSRNOT00000071700
ciliogenesis associated TTC17 interacting protein
chr12_+_47024442 0.12 ENSRNOT00000001545
cytochrome c oxidase subunit 6A1
chr3_+_148438939 0.12 ENSRNOT00000064196
tubulin tyrosine ligase like 9
chr20_-_32353677 0.12 ENSRNOT00000035355
storkhead box 1
chr8_-_63291966 0.12 ENSRNOT00000077762

chr16_-_7758189 0.12 ENSRNOT00000026588
2-hydroxyacyl-CoA lyase 1
chr10_-_110585376 0.12 ENSRNOT00000054917
Rab40b, member RAS oncogene family
chr16_+_51748970 0.12 ENSRNOT00000059182
a disintegrin and metallopeptidase domain 26A
chr3_-_56030744 0.12 ENSRNOT00000089637
coiled-coil domain containing 173
chrX_-_80354604 0.12 ENSRNOT00000049790
similar to MGC82337 protein
chr11_-_61470046 0.12 ENSRNOT00000073436
N-alpha-acetyltransferase 50-like
chr1_-_229601032 0.12 ENSRNOT00000016690
ciliary neurotrophic factor
chr12_+_23954574 0.11 ENSRNOT00000046343
serine/threonine/tyrosine interacting-like 1
chr1_+_78739930 0.11 ENSRNOT00000021976
striatin 4
chrX_-_115073890 0.11 ENSRNOT00000006638
calpain 6
chr2_-_250600517 0.11 ENSRNOT00000016872
heparan sulfate 2-O-sulfotransferase 1
chr12_-_20660304 0.11 ENSRNOT00000091323
similar to cell surface receptor FDFACT
chr4_-_66380734 0.11 ENSRNOT00000009194
killer cell lectin like receptor G2
chr6_-_94932806 0.11 ENSRNOT00000006346
coiled-coil domain containing 175
chr8_+_117221367 0.11 ENSRNOT00000073445
hypothetical protein LOC680045
chr10_-_11878792 0.11 ENSRNOT00000064964
clusterin associated protein 1
chr10_-_38782419 0.11 ENSRNOT00000073964
ubiquinol-cytochrome c reductase, complex III subunit VII
chr16_-_7406951 0.11 ENSRNOT00000066508
dynein, axonemal, heavy chain 1
chr10_-_34961349 0.11 ENSRNOT00000004885
heterogeneous nuclear ribonucleoprotein A/B
chr5_+_113592919 0.11 ENSRNOT00000011336
intraflagellar transport 74

Network of associatons between targets according to the STRING database.

First level regulatory network of Rfx2_Rfx7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 0.8 GO:0080154 regulation of fertilization(GO:0080154)
0.1 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.1 0.2 GO:1900195 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.1 0.2 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.1 0.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 0.2 GO:0002432 granuloma formation(GO:0002432) T-helper 1 cell activation(GO:0035711)
0.1 0.3 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.9 GO:0042407 cristae formation(GO:0042407)
0.1 0.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 0.2 GO:1905218 cellular response to astaxanthin(GO:1905218)
0.1 0.2 GO:1902304 positive regulation of potassium ion export(GO:1902304)
0.1 0.2 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
0.0 0.1 GO:0000053 argininosuccinate metabolic process(GO:0000053)
0.0 0.8 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0045903 positive regulation of translational fidelity(GO:0045903)
0.0 0.6 GO:1903830 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.0 0.4 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 0.3 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.1 GO:0021678 third ventricle development(GO:0021678)
0.0 0.1 GO:0038163 thrombopoietin-mediated signaling pathway(GO:0038163)
0.0 0.3 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.0 0.1 GO:2000682 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
0.0 0.3 GO:0071500 cellular response to nitrosative stress(GO:0071500)
0.0 0.1 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.0 0.2 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.0 0.6 GO:0014010 Schwann cell proliferation(GO:0014010)
0.0 0.1 GO:0033505 floor plate formation(GO:0021508) floor plate morphogenesis(GO:0033505)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0021539 subthalamus development(GO:0021539)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.5 GO:0003351 epithelial cilium movement(GO:0003351)
0.0 0.2 GO:0034486 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741)
0.0 0.2 GO:1905232 cellular response to L-glutamate(GO:1905232)
0.0 0.2 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.1 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 0.1 GO:1903002 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
0.0 0.1 GO:1902953 endoplasmic reticulum membrane organization(GO:0090158) positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0 0.1 GO:0048691 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.0 0.5 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.3 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.0 0.3 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 0.1 GO:0030043 actin filament fragmentation(GO:0030043)
0.0 0.1 GO:2001013 positive regulation of macrophage apoptotic process(GO:2000111) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0 0.1 GO:1903413 cellular response to bile acid(GO:1903413)
0.0 0.1 GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.0 0.2 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.1 GO:0009182 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0 0.1 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.1 GO:0035964 COPI-coated vesicle budding(GO:0035964)
0.0 0.1 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.1 GO:1904569 response to selenite ion(GO:0072714) regulation of selenocysteine incorporation(GO:1904569)
0.0 0.1 GO:0070900 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0 0.2 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.2 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.2 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.1 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0070946 neutrophil mediated killing of gram-positive bacterium(GO:0070946)
0.0 0.2 GO:0006108 malate metabolic process(GO:0006108)
0.0 0.1 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.0 0.3 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:1902774 terminal button organization(GO:0072553) late endosome to lysosome transport(GO:1902774)
0.0 0.1 GO:0071899 transcriptional activation by promoter-enhancer looping(GO:0071733) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0 0.1 GO:0097461 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.0 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.0 0.1 GO:1903751 regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0 0.2 GO:0086103 G-protein coupled receptor signaling pathway involved in heart process(GO:0086103)
0.0 0.1 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.0 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.0 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.0 0.1 GO:0002176 male germ cell proliferation(GO:0002176)
0.0 0.1 GO:2000664 positive regulation of interleukin-5 secretion(GO:2000664)
0.0 1.1 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 0.1 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.0 0.1 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.0 0.1 GO:0009134 nucleoside diphosphate catabolic process(GO:0009134)
0.0 0.2 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.1 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.0 GO:0044313 protein K6-linked deubiquitination(GO:0044313)
0.0 0.1 GO:0018243 protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.2 GO:0003341 cilium movement(GO:0003341)
0.0 0.1 GO:0098734 macromolecule depalmitoylation(GO:0098734)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0061617 MICOS complex(GO:0061617)
0.1 0.6 GO:0036157 outer dynein arm(GO:0036157)
0.1 0.3 GO:0033503 HULC complex(GO:0033503)
0.1 0.2 GO:0046691 intracellular canaliculus(GO:0046691)
0.1 0.3 GO:0042585 germinal vesicle(GO:0042585)
0.1 0.2 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.1 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.2 GO:0036156 inner dynein arm(GO:0036156)
0.0 0.2 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.0 1.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0033010 paranodal junction(GO:0033010)
0.0 0.3 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0071942 XPC complex(GO:0071942)
0.0 0.2 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.2 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.1 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.0 0.5 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.1 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.1 GO:0097255 R2TP complex(GO:0097255)
0.0 0.2 GO:0005641 nuclear envelope lumen(GO:0005641) beta-catenin destruction complex(GO:0030877)
0.0 0.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0 0.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 1.1 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.3 GO:0019013 viral nucleocapsid(GO:0019013) viral capsid(GO:0019028)
0.0 0.0 GO:0097451 glial limiting end-foot(GO:0097451)
0.0 0.1 GO:0044447 axoneme part(GO:0044447)
0.0 0.1 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.0 0.2 GO:0070971 endoplasmic reticulum exit site(GO:0070971)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.2 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.1 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1 0.4 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.2 GO:0004127 cytidylate kinase activity(GO:0004127)
0.1 0.2 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.0 0.2 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.6 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.0 0.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.2 GO:1990932 5.8S rRNA binding(GO:1990932)
0.0 0.3 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.0 0.1 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0 0.1 GO:0046911 metal chelating activity(GO:0046911)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.3 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.0 0.4 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0004945 angiotensin type II receptor activity(GO:0004945)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.3 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.1 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.1 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.0 0.2 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.3 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0042610 CD8 receptor binding(GO:0042610)
0.0 0.1 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.0 0.1 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.0 0.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0016672 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0 0.1 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 0.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 0.1 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.1 GO:0004971 AMPA glutamate receptor activity(GO:0004971)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.4 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.3 PID ARF 3PATHWAY Arf1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules