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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Relb

Z-value: 0.24

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Transcription factors associated with Relb

Gene Symbol Gene ID Gene Info
ENSRNOG00000033235 RELB proto-oncogene, NF-kB subunit

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Relbrn6_v1_chr1_-_80544825_80544825-0.118.6e-01Click!

Activity profile of Relb motif

Sorted Z-values of Relb motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_76270457 0.17 ENSRNOT00000009894
NFKB inhibitor alpha
chr13_-_89565813 0.08 ENSRNOT00000004347
Purkinje cell protein 4-like 1
chr10_+_77537340 0.07 ENSRNOT00000003297
transmembrane protein 100
chr5_-_169017295 0.05 ENSRNOT00000067481
calmodulin binding transcription activator 1
chr4_-_157266018 0.04 ENSRNOT00000019570
protein C10-like
chr11_+_47243342 0.04 ENSRNOT00000041116
NFKB inhibitor zeta
chr20_+_5184515 0.04 ENSRNOT00000089411
lymphotoxin-beta
chr20_-_4863011 0.04 ENSRNOT00000079503
lymphotoxin beta
chr20_-_4366957 0.04 ENSRNOT00000088244
ring finger protein 5
chr3_+_2643610 0.04 ENSRNOT00000037169
fucosyltransferase 7
chr9_+_9842585 0.04 ENSRNOT00000070806
Cd70 molecule
chr14_-_18733391 0.04 ENSRNOT00000003745
C-X-C motif chemokine ligand 2
chrX_-_32355296 0.03 ENSRNOT00000081652
ENSRNOT00000065075
adaptor-related protein complex 1, sigma 2 subunit
chr5_-_59025631 0.03 ENSRNOT00000049000
ENSRNOT00000022801
tropomyosin 2, beta
chr9_+_20279938 0.03 ENSRNOT00000075612
gene rich cluster, C10 gene
chr5_-_136002900 0.03 ENSRNOT00000025197
polo-like kinase 3
chr4_-_80313411 0.03 ENSRNOT00000041621
similar to ribosomal protein L27a
chr20_-_4863198 0.03 ENSRNOT00000001108
lymphotoxin beta
chr1_+_86948918 0.02 ENSRNOT00000084839
sirtuin 2
chr5_+_168019058 0.02 ENSRNOT00000077202
TNF receptor superfamily member 9
chr10_+_65448950 0.02 ENSRNOT00000082348
ENSRNOT00000037016
RAB34, member RAS oncogene family
chr1_-_86948845 0.02 ENSRNOT00000027212
NFKB inhibitor beta
chr1_-_3849080 0.02 ENSRNOT00000045301
similar to ribosomal protein L27a
chr12_+_27155587 0.02 ENSRNOT00000044800

chrX_-_40086870 0.02 ENSRNOT00000010027
small muscle protein, X-linked
chr17_+_56109549 0.02 ENSRNOT00000022190
mitogen-activated protein kinase kinase kinase 8
chr1_+_93242050 0.02 ENSRNOT00000013741
similar to 60S ribosomal protein L27a
chr11_-_82366505 0.02 ENSRNOT00000041326
similar to ribosomal protein L27a
chr9_+_82053581 0.01 ENSRNOT00000086375
wingless-type MMTV integration site family, member 10A
chr6_-_75763185 0.01 ENSRNOT00000072589
cofilin 2
chr3_-_105214989 0.01 ENSRNOT00000037895
gremlin 1, DAN family BMP antagonist
chr10_-_72188164 0.01 ENSRNOT00000085728
ENSRNOT00000042506
gametogenetin binding protein 2
chr5_-_1347921 0.01 ENSRNOT00000007994
ganglioside-induced differentiation-associated-protein 1
chr20_+_4852671 0.00 ENSRNOT00000001111
lymphotoxin alpha
chr18_-_36322320 0.00 ENSRNOT00000060260
glutaredoxin and cysteine rich domain containing 2
chr6_+_109562587 0.00 ENSRNOT00000011563
basic leucine zipper ATF-like transcription factor
chr1_-_80544825 0.00 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
RELB proto-oncogene, NF-kB subunit
chr20_+_4852496 0.00 ENSRNOT00000088936
lymphotoxin alpha
chr6_-_41039437 0.00 ENSRNOT00000005774
tribbles pseudokinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of Relb

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.1 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0 0.1 GO:0060842 arterial endothelial cell differentiation(GO:0060842)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043120 tumor necrosis factor binding(GO:0043120)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival