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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Rbpj

Z-value: 0.33

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Transcription factors associated with Rbpj

Gene Symbol Gene ID Gene Info
ENSRNOG00000007797 recombination signal binding protein for immunoglobulin kappa J region
ENSRNOG00000046327 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Rbpjrn6_v1_chr14_-_59735450_597354500.991.9e-03Click!

Activity profile of Rbpj motif

Sorted Z-values of Rbpj motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_31890778 0.22 ENSRNOT00000039166
tubulin polymerization promoting protein
chr19_+_755460 0.20 ENSRNOT00000076560
dynein, cytoplasmic 1 light intermediate chain 2
chr17_-_55709740 0.17 ENSRNOT00000033359
similar to OTTHUMP00000046255
chr18_+_27424328 0.15 ENSRNOT00000033784
kinesin family member 20A
chr5_+_172364421 0.13 ENSRNOT00000018769
hes family bHLH transcription factor 5
chr1_-_219412816 0.13 ENSRNOT00000083204
ENSRNOT00000029580
ribosomal protein S6 kinase B2
chr7_+_11033317 0.12 ENSRNOT00000007498
guanine nucleotide binding protein, alpha 11
chrX_-_73778595 0.10 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
ring finger protein, LIM domain interacting
chr1_+_84685931 0.10 ENSRNOT00000063839
zinc finger protein 780B
chr3_-_141411170 0.10 ENSRNOT00000017364
NK2 homeobox 2
chr9_+_94425252 0.09 ENSRNOT00000064965
ENSRNOT00000076099
GRB10 interacting GYF protein 2
chr18_+_56379890 0.09 ENSRNOT00000078764
platelet derived growth factor receptor beta
chr5_+_146383942 0.09 ENSRNOT00000078588
CUB and Sushi multiple domains 2
chr20_+_5080070 0.09 ENSRNOT00000086950
ENSRNOT00000077082
abhydrolase domain containing 16A
chr1_+_198214797 0.08 ENSRNOT00000068543
T-box 6
chr14_+_34727915 0.08 ENSRNOT00000085089
kinase insert domain receptor
chr3_-_112174269 0.08 ENSRNOT00000067836
transmembrane protein 87A
chr17_+_76532611 0.08 ENSRNOT00000024099
calcium/calmodulin-dependent protein kinase ID
chr1_+_87697005 0.08 ENSRNOT00000028158
zinc finger protein 84
chr3_-_9936352 0.08 ENSRNOT00000011224
ENSRNOT00000042798
formin binding protein 1
chr3_-_117990289 0.08 ENSRNOT00000011084
SHC adaptor protein 4
chr7_-_72328128 0.07 ENSRNOT00000008227
TSPY-like 5
chr11_+_81972219 0.07 ENSRNOT00000002452
diacylglycerol kinase, gamma
chr10_-_85636902 0.07 ENSRNOT00000017241
polycomb group ring finger 2
chr10_-_17075139 0.06 ENSRNOT00000039398
neuralized E3 ubiquitin protein ligase 1B
chr8_+_114876146 0.06 ENSRNOT00000075966
WD repeat domain 82
chr6_+_111049559 0.06 ENSRNOT00000015571
transmembrane protein 63c
chr1_+_87790104 0.06 ENSRNOT00000074580
zinc finger protein 383-like
chr18_-_27424090 0.06 ENSRNOT00000087968
bromodomain containing 8
chr16_+_78539489 0.06 ENSRNOT00000057897
CUB and Sushi multiple domains 1
chr17_-_22678253 0.06 ENSRNOT00000083122
LRRGT00112-like
chr8_+_69971778 0.06 ENSRNOT00000058007
ENSRNOT00000037941
ENSRNOT00000050649
multiple EGF-like-domains 11
chr5_+_139468546 0.06 ENSRNOT00000013193
schlafen-like 1
chr13_-_73056765 0.06 ENSRNOT00000000049
xenotropic and polytropic retrovirus receptor 1
chr8_-_61079526 0.05 ENSRNOT00000068658
pseudopodium-enriched atypical kinase 1
chr11_-_87628502 0.05 ENSRNOT00000002568
mediator complex subunit 15
chr8_+_119160731 0.05 ENSRNOT00000046745
ALS2 C-terminal like
chr2_+_184600721 0.05 ENSRNOT00000075823
glutamyl-tRNA amidotransferase subunit B
chr11_-_70961358 0.05 ENSRNOT00000002427
leishmanolysin like peptidase
chr5_-_144221263 0.05 ENSRNOT00000013570
thyroid hormone receptor associated protein 3
chr10_-_15346236 0.05 ENSRNOT00000088104
ENSRNOT00000027430
calpain 15
chr2_-_178334900 0.05 ENSRNOT00000090152
folliculin interacting protein 2
chr18_-_31071371 0.05 ENSRNOT00000060432
diaphanous-related formin 1
chr13_+_110257571 0.05 ENSRNOT00000005715
integrator complex subunit 7
chr1_-_100671074 0.05 ENSRNOT00000027132
myosin heavy chain 14
chr10_+_55707164 0.04 ENSRNOT00000009757
hes family bHLH transcription factor 7
chr4_+_147037179 0.04 ENSRNOT00000011292
synapsin II
chr1_-_88558696 0.04 ENSRNOT00000038642

chr6_+_107169528 0.04 ENSRNOT00000012495
presenilin 1
chr12_+_25450286 0.04 ENSRNOT00000092956
general transcription factor II I
chr8_+_61659445 0.04 ENSRNOT00000023831
protein tyrosine phosphatase, non-receptor type 9
chr1_+_252894663 0.04 ENSRNOT00000054757
interferon-induced protein with tetratricopeptide repeats 2
chr12_-_38782010 0.04 ENSRNOT00000001813
WD repeat domain 66
chr4_-_64831233 0.04 ENSRNOT00000079285
diacylglycerol kinase, iota
chr5_+_135860675 0.04 ENSRNOT00000024737
HECT domain E3 ubiquitin protein ligase 3
chr9_+_119517101 0.04 ENSRNOT00000020476
lipin 2
chr12_+_19328957 0.04 ENSRNOT00000033288
canopy FGF signaling regulator 4
chr1_-_88920291 0.03 ENSRNOT00000028306
kin of IRRE like 2 (Drosophila)
chr7_-_123088819 0.03 ENSRNOT00000056077

chr1_-_46978261 0.03 ENSRNOT00000060527
serine active site containing 1
chr3_+_8453609 0.03 ENSRNOT00000041921
outer dense fiber of sperm tails 2
chr2_+_114386019 0.03 ENSRNOT00000082148

chr1_+_91663736 0.03 ENSRNOT00000089587
ENSRNOT00000031236
centrosomal protein 89
chr14_+_4125380 0.03 ENSRNOT00000002882
zinc finger protein 644
chr12_+_19314251 0.03 ENSRNOT00000001827
adaptor-related protein complex 4, mu 1 subunit
chr1_+_185427736 0.03 ENSRNOT00000064706
pleckstrin homology domain containing A7
chr17_-_45154355 0.03 ENSRNOT00000084976
zinc finger with KRAB and SCAN domains 4
chr3_+_150052483 0.03 ENSRNOT00000022265
similar to chromosome 20 open reading frame 144
chr14_+_34727623 0.03 ENSRNOT00000071405
ENSRNOT00000090183
kinase insert domain receptor
chr5_+_82587420 0.03 ENSRNOT00000014020
toll-like receptor 4
chr1_+_192115966 0.03 ENSRNOT00000025629
polo-like kinase 1
chr7_-_123088279 0.03 ENSRNOT00000071998
transducer of ERBB2, 2
chr1_-_226152524 0.03 ENSRNOT00000027756
fatty acid desaturase 2
chr9_+_81880177 0.03 ENSRNOT00000022839
serine/threonine kinase 36
chr18_+_30808404 0.03 ENSRNOT00000060475
protocadherin gamma subfamily A, 1
chr12_-_29919320 0.03 ENSRNOT00000038092
tRNA-yW synthesizing protein 1 homolog
chr4_+_49017311 0.03 ENSRNOT00000007476
inhibitor of growth family, member 3
chr4_+_123118468 0.03 ENSRNOT00000010895
transmembrane protein 43
chr6_+_110968061 0.02 ENSRNOT00000014980
CLOCK-interacting pacemaker
chrX_+_68891227 0.02 ENSRNOT00000009635
ephrin B1
chrX_+_14994016 0.02 ENSRNOT00000006365
FtsJ RNA methyltransferase homolog 1 (E. coli)
chr1_+_84584596 0.02 ENSRNOT00000032933
zinc finger protein 60-like
chr13_+_67611708 0.02 ENSRNOT00000063833
translocated promoter region, nuclear basket protein
chr15_-_60766579 0.02 ENSRNOT00000079978
A-kinase anchoring protein 11
chr9_-_79545024 0.02 ENSRNOT00000021152
melanoregulin
chr1_-_88428685 0.02 ENSRNOT00000074582
zinc finger protein 566
chr5_-_129352886 0.02 ENSRNOT00000012088
cyclin-dependent kinase inhibitor 2C
chr2_-_236480502 0.02 ENSRNOT00000015020
sphingomyelin synthase 2
chr7_+_116745061 0.02 ENSRNOT00000076174
rhophilin, Rho GTPase binding protein 1
chr1_-_88558387 0.02 ENSRNOT00000074174

chr1_-_261179790 0.02 ENSRNOT00000074420
ENSRNOT00000072073
exosome component 1
chr19_+_61334168 0.02 ENSRNOT00000080465
neuropilin 1
chr17_-_10061750 0.02 ENSRNOT00000082042
ENSRNOT00000022646
zinc finger protein 346
chr2_-_233743866 0.02 ENSRNOT00000087062
glutamyl aminopeptidase
chr7_-_135630654 0.02 ENSRNOT00000047388
ENSRNOT00000088223
ENSRNOT00000074793
ADAM metallopeptidase with thrombospondin type 1 motif, 20
chr1_+_261180007 0.02 ENSRNOT00000072181
zinc finger, DHHC-type containing 16
chr6_+_34094306 0.02 ENSRNOT00000051970
WD repeat domain 35
chr10_+_103874383 0.02 ENSRNOT00000038935
otopetrin 2
chr2_+_166403265 0.02 ENSRNOT00000012417
NMD3 ribosome export adaptor
chr1_+_162342051 0.01 ENSRNOT00000016478
ALG8, alpha-1,3-glucosyltransferase
chr1_+_29191192 0.01 ENSRNOT00000018718
hes-related family bHLH transcription factor with YRPW motif 2
chr12_-_19328637 0.01 ENSRNOT00000001829
TATA-box binding protein associated factor 6
chr1_-_87777359 0.01 ENSRNOT00000074090

chrX_+_110894845 0.01 ENSRNOT00000080072
TBC1 domain family member 8B
chr12_-_48218955 0.01 ENSRNOT00000067975
ENSRNOT00000080557
ENSRNOT00000000821
acetyl-CoA carboxylase beta
chr6_-_30187337 0.01 ENSRNOT00000074150
intersectin 2
chr20_+_3556560 0.01 ENSRNOT00000085635
discoidin domain receptor tyrosine kinase 1
chr7_+_2635743 0.01 ENSRNOT00000004223
major intrinsic protein of lens fiber
chr3_+_7279340 0.01 ENSRNOT00000017029
adenylate kinase 8
chr7_-_137856485 0.01 ENSRNOT00000007003
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr10_+_39666991 0.01 ENSRNOT00000030760
acyl-CoA synthetase long-chain family member 6
chr3_+_37599728 0.01 ENSRNOT00000090575
replication timing regulatory factor 1
chr19_+_57820260 0.01 ENSRNOT00000057945
disrupted in schizophrenia 1
chr1_+_23977688 0.01 ENSRNOT00000014805
TATA-box binding protein like 1
chr1_+_199412834 0.01 ENSRNOT00000031891
fused in sarcoma RNA binding protein
chr3_-_3594475 0.01 ENSRNOT00000064861
RGD1564379
chr3_-_104502471 0.01 ENSRNOT00000040306
ryanodine receptor 3
chr1_+_79931156 0.01 ENSRNOT00000019814
ENSRNOT00000084985
symplekin
chrX_-_112473822 0.01 ENSRNOT00000079180
collagen type IV alpha 6 chain
chr1_+_157573324 0.01 ENSRNOT00000092066
RAB30, member RAS oncogene family
chr3_+_161212156 0.01 ENSRNOT00000020280
ENSRNOT00000083553
deoxynucleotidyltransferase, terminal, interacting protein 1
chr12_-_23727535 0.01 ENSRNOT00000085911
ENSRNOT00000001950
deltex E3 ubiquitin ligase 2
chr1_-_101008266 0.01 ENSRNOT00000081430
SR-related CTD-associated factor 1
chrX_-_15651332 0.01 ENSRNOT00000039000
G patch domain and KOW motifs
chr18_-_37245809 0.01 ENSRNOT00000079585
protein phosphatase 2, regulatory subunit B, beta
chr1_-_189181901 0.01 ENSRNOT00000092022
glycoprotein 2
chr16_-_74864816 0.01 ENSRNOT00000017164
ALG11, alpha-1,2-mannosyltransferase
chr4_+_67059939 0.01 ENSRNOT00000052393
chromatin modifying protein 4B-like 1
chr3_+_3834268 0.01 ENSRNOT00000031622
peptidase, mitochondrial processing alpha subunit
chr6_+_64252020 0.00 ENSRNOT00000047296
ENSRNOT00000082105
patatin-like phospholipase domain containing 8
chr7_-_33584564 0.00 ENSRNOT00000005463
neural precursor cell expressed, developmentally down-regulated 1
chr12_+_22142520 0.00 ENSRNOT00000038397
F-box protein 24
chr7_+_123043503 0.00 ENSRNOT00000026258
ENSRNOT00000086355
TEF, PAR bZIP transcription factor
chr3_+_45683993 0.00 ENSRNOT00000038983
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr8_+_116657371 0.00 ENSRNOT00000024966
MON1 homolog A, secretory trafficking associated
chr8_-_57830504 0.00 ENSRNOT00000017683
DEAD-box helicase 10
chr2_-_196456481 0.00 ENSRNOT00000028677
prune exopolyphosphatase

Network of associatons between targets according to the STRING database.

First level regulatory network of Rbpj

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.1 GO:0060816 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 0.1 GO:0072277 cell migration involved in vasculogenesis(GO:0035441) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 0.1 GO:0048597 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0 0.1 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.1 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.0 0.1 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.0 0.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0 0.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.0 0.2 GO:0008090 retrograde axonal transport(GO:0008090)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.0 GO:0097513 myosin II filament(GO:0097513)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.1 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.0 0.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 0.1 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.1 GO:0000822 inositol hexakisphosphate binding(GO:0000822)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions