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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Rad21_Smc3
Z-value: 0.76
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Transcription factors associated with Rad21_Smc3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Smc3 | rn6_v1_chr1_+_274309758_274309758 | -0.65 | 2.3e-01 | Click! |
| Rad21 | rn6_v1_chr7_-_91538673_91538673 | -0.53 | 3.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_9695292 Show fit | 0.82 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr3_+_164424515 Show fit | 0.81 |
ENSRNOT00000083876
|
CCAAT/enhancer binding protein beta |
|
| chr12_+_24651314 Show fit | 0.36 |
ENSRNOT00000077016
ENSRNOT00000071569 |
VPS37D, ESCRT-I subunit |
|
| chr16_+_19767264 Show fit | 0.35 |
ENSRNOT00000051802
ENSRNOT00000092073 |
occludin/ELL domain containing 1 |
|
| chr3_+_154395187 Show fit | 0.34 |
ENSRNOT00000050810
|
V-set and transmembrane domain containing 2 like |
|
| chr19_+_41482728 Show fit | 0.34 |
ENSRNOT00000022943
|
calbindin 2 |
|
| chr13_+_75059927 Show fit | 0.33 |
ENSRNOT00000080801
|
hypothetical protein LOC680254 |
|
| chr8_+_71822129 Show fit | 0.32 |
ENSRNOT00000089147
|
death-associated protein kinase 2 |
|
| chrX_+_72684329 Show fit | 0.30 |
ENSRNOT00000057644
|
DMRT-like family C1c1 |
|
| chr16_+_20672374 Show fit | 0.29 |
ENSRNOT00000063780
|
similar to RIKEN cDNA 2810428I15 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Rad21_Smc3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0035711 | granuloma formation(GO:0002432) T-helper 1 cell activation(GO:0035711) |
| 0.1 | 0.3 | GO:2000422 | regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424) |
| 0.1 | 0.3 | GO:1903544 | positive regulation of bicellular tight junction assembly(GO:1903348) response to butyrate(GO:1903544) |
| 0.1 | 0.3 | GO:0035511 | oxidative DNA demethylation(GO:0035511) |
| 0.0 | 0.3 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.1 | 0.2 | GO:1900126 | negative regulation of hyaluronan biosynthetic process(GO:1900126) |
| 0.1 | 0.2 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) |
| 0.1 | 0.2 | GO:0018283 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 0.1 | 0.2 | GO:0018199 | peptidyl-glutamine modification(GO:0018199) |
| 0.1 | 0.2 | GO:0042374 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0036488 | CHOP-C/EBP complex(GO:0036488) |
| 0.0 | 0.4 | GO:0000813 | ESCRT I complex(GO:0000813) |
| 0.0 | 0.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.3 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.2 | GO:1990246 | uniplex complex(GO:1990246) |
| 0.0 | 0.2 | GO:0065010 | extracellular membrane-bounded organelle(GO:0065010) |
| 0.0 | 0.2 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 0.2 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
| 0.0 | 0.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.1 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 0.3 | GO:0035514 | DNA demethylase activity(GO:0035514) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.2 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.0 | 0.2 | GO:0034714 | type III transforming growth factor beta receptor binding(GO:0034714) |
| 0.0 | 0.2 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.0 | 0.2 | GO:0008823 | cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851) |
| 0.0 | 0.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.2 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 0.5 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS | Genes involved in Membrane binding and targetting of GAG proteins |
| 0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.3 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 0.3 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |