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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Pparg_Rxrg
Z-value: 1.16
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Transcription factors associated with Pparg_Rxrg
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rxrg | rn6_v1_chr13_+_85818427_85818473 | -0.61 | 2.8e-01 | Click! |
| Pparg | rn6_v1_chr4_+_147333056_147333056 | 0.39 | 5.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_2174131 Show fit | 3.22 |
ENSRNOT00000001313
|
Purkinje cell protein 2 |
|
| chr3_-_66417741 Show fit | 1.76 |
ENSRNOT00000007662
|
neuronal differentiation 1 |
|
| chr10_+_84167331 Show fit | 0.90 |
ENSRNOT00000010965
|
homeo box B4 |
|
| chr1_-_226049929 Show fit | 0.88 |
ENSRNOT00000007320
|
bestrophin 1 |
|
| chr10_-_15603649 Show fit | 0.75 |
ENSRNOT00000051483
|
hemoglobin alpha, adult chain 2 |
|
| chr10_+_59533480 Show fit | 0.69 |
ENSRNOT00000087723
|
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 |
|
| chr7_-_119441487 Show fit | 0.62 |
ENSRNOT00000067635
|
parvalbumin |
|
| chr5_-_172809353 Show fit | 0.61 |
ENSRNOT00000022246
|
gamma-aminobutyric acid type A receptor delta subunit |
|
| chr19_+_41482728 Show fit | 0.58 |
ENSRNOT00000022943
|
calbindin 2 |
|
| chr3_+_123106694 Show fit | 0.56 |
ENSRNOT00000028829
|
oxytocin/neurophysin 1 prepropeptide |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pparg_Rxrg
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 3.2 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.4 | 1.8 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.3 | 1.0 | GO:0042412 | taurine biosynthetic process(GO:0042412) |
| 0.1 | 0.9 | GO:0048539 | bone marrow development(GO:0048539) |
| 0.1 | 0.9 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.2 | 0.7 | GO:0009972 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.1 | 0.7 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.2 | 0.6 | GO:0050828 | regulation of liquid surface tension(GO:0050828) |
| 0.2 | 0.6 | GO:0030186 | melatonin metabolic process(GO:0030186) |
| 0.2 | 0.5 | GO:0043133 | hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.5 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 0.8 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.6 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 0.6 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 0.4 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.4 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 0.3 | GO:0032173 | septin collar(GO:0032173) |
| 0.1 | 0.3 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.8 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 1.1 | GO:0038024 | cargo receptor activity(GO:0038024) |
| 0.0 | 1.0 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.9 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.3 | 0.8 | GO:0031720 | haptoglobin binding(GO:0031720) |
| 0.1 | 0.7 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.1 | 0.6 | GO:0048030 | disaccharide binding(GO:0048030) |
| 0.0 | 0.6 | GO:0008171 | O-methyltransferase activity(GO:0008171) |
| 0.0 | 0.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 0.2 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.1 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.1 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.0 | 0.8 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.7 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.0 | 0.7 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.0 | 0.5 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.0 | 0.3 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.0 | 0.3 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.3 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.0 | 0.2 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |