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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Ppara
Z-value: 0.59
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Transcription factors associated with Ppara
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Ppara | rn6_v1_chr7_+_126619196_126619196 | 0.59 | 3.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_-_34550850 Show fit | 0.48 |
ENSRNOT00000027794
ENSRNOT00000090228 |
cerebellin 3 precursor |
|
| chr20_+_3827367 Show fit | 0.37 |
ENSRNOT00000079967
|
retinoid X receptor beta |
|
| chr7_+_121311024 Show fit | 0.37 |
ENSRNOT00000092260
ENSRNOT00000023066 ENSRNOT00000081377 |
synaptogyrin 1 |
|
| chr2_+_196334626 Show fit | 0.30 |
ENSRNOT00000050914
ENSRNOT00000028645 ENSRNOT00000090729 |
semaphorin 6C |
|
| chr8_-_45215974 Show fit | 0.30 |
ENSRNOT00000010792
|
cytotoxic and regulatory T cell molecule |
|
| chr6_+_28515025 Show fit | 0.28 |
ENSRNOT00000088033
ENSRNOT00000005317 ENSRNOT00000081141 |
DnaJ heat shock protein family (Hsp40) member C27 |
|
| chr4_+_51614676 Show fit | 0.28 |
ENSRNOT00000060494
|
ankyrin repeat and SOCS box containing 15 |
|
| chr1_+_274245184 Show fit | 0.28 |
ENSRNOT00000018889
|
dual specificity phosphatase 5 |
|
| chr10_-_71849293 Show fit | 0.27 |
ENSRNOT00000003799
|
LIM homeobox 1 |
|
| chr4_+_8256611 Show fit | 0.23 |
ENSRNOT00000061894
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Ppara
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.4 | GO:0055012 | ventricular cardiac muscle cell differentiation(GO:0055012) |
| 0.1 | 0.3 | GO:0060066 | metanephric part of ureteric bud development(GO:0035502) oviduct development(GO:0060066) |
| 0.1 | 0.3 | GO:1903244 | positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244) |
| 0.0 | 0.3 | GO:1901098 | positive regulation of autophagosome maturation(GO:1901098) |
| 0.0 | 0.3 | GO:0002860 | positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.3 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.2 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.1 | 0.2 | GO:1990167 | protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168) |
| 0.0 | 0.2 | GO:1901204 | positive regulation of adrenergic receptor signaling pathway(GO:0071879) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.1 | 0.2 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.0 | 0.2 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.2 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.2 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.2 | GO:0071565 | nBAF complex(GO:0071565) |
| 0.0 | 0.1 | GO:0032173 | septin collar(GO:0032173) |
| 0.0 | 0.1 | GO:0016514 | SWI/SNF complex(GO:0016514) |
| 0.0 | 0.1 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 0.1 | GO:1990005 | granular vesicle(GO:1990005) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 0.3 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 0.0 | 0.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 0.2 | GO:0034485 | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) inositol tetrakisphosphate phosphatase activity(GO:0052743) |
| 0.0 | 0.2 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.0 | 0.2 | GO:0004468 | lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468) |
| 0.0 | 0.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.2 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.0 | 0.1 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID ALK2 PATHWAY | ALK2 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.0 | 0.3 | REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.0 | 0.2 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.0 | 0.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.0 | 0.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |