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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Pou5f1

Z-value: 0.46

Motif logo

Transcription factors associated with Pou5f1

Gene Symbol Gene ID Gene Info
ENSRNOG00000046487 POU class 5 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Pou5f1rn6_v1_chr20_-_3751994_37519940.306.3e-01Click!

Activity profile of Pou5f1 motif

Sorted Z-values of Pou5f1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr20_-_22459025 0.36 ENSRNOT00000000792
early growth response 2
chr10_+_77537340 0.31 ENSRNOT00000003297
transmembrane protein 100
chr1_+_81372650 0.21 ENSRNOT00000088829
zinc finger protein 428
chr17_+_49417067 0.21 ENSRNOT00000090024
POU domain, class 6, transcription factor 2
chr17_+_43632397 0.19 ENSRNOT00000013790
histone cluster 1, H2ah
chr2_-_198360678 0.18 ENSRNOT00000051917
histone cluster 2 H2A family member c
chr17_-_44527801 0.16 ENSRNOT00000089643
histone cluster 1 H2B family member k
chr1_-_88111293 0.15 ENSRNOT00000077195
sprouty-related, EVH1 domain containing 3
chr2_-_139528162 0.14 ENSRNOT00000014317
solute carrier family 7 member 11
chr18_-_12640716 0.14 ENSRNOT00000020697
kelch-like family member 14
chr1_-_218100272 0.13 ENSRNOT00000028411
ENSRNOT00000088588
cyclin D1
chr8_-_117932518 0.12 ENSRNOT00000028130
cathelicidin antimicrobial peptide
chr15_-_62200837 0.12 ENSRNOT00000017599
protocadherin 8
chr7_+_3133506 0.12 ENSRNOT00000049972
premelanosome protein
chr3_+_79918969 0.11 ENSRNOT00000016306
Spi-1 proto-oncogene
chr1_-_260254600 0.11 ENSRNOT00000019014
B-cell linker
chr1_+_64101018 0.11 ENSRNOT00000078640
membrane bound O-acyltransferase domain containing 7
chr10_+_55687050 0.10 ENSRNOT00000057136
period circadian clock 1
chrX_+_80213332 0.10 ENSRNOT00000042827
SH3 domain binding glutamate-rich protein like
chr7_+_28412198 0.10 ENSRNOT00000081822
ENSRNOT00000038780
ENSRNOT00000005995
insulin-like growth factor 1
chr16_-_20486707 0.09 ENSRNOT00000026470
JunD proto-oncogene, AP-1 transcription factor subunit
chr10_-_50402616 0.09 ENSRNOT00000004546
heparan sulfate-glucosamine 3-sulfotransferase 3B1
chr1_-_57327379 0.09 ENSRNOT00000080429
delta like canonical Notch ligand 1
chr1_+_72545596 0.08 ENSRNOT00000022698
shisa family member 7
chr5_+_145257714 0.08 ENSRNOT00000019214
DLG associated protein 3
chr13_-_60849094 0.08 ENSRNOT00000005156
regulator of G-protein signaling 2
chr2_+_182723854 0.08 ENSRNOT00000012658
secreted frizzled-related protein 2
chr5_-_79874671 0.08 ENSRNOT00000084563
tenascin C
chr4_+_102351036 0.08 ENSRNOT00000079277

chr7_+_12619774 0.08 ENSRNOT00000015257
mediator complex subunit 16
chr2_+_222214885 0.08 ENSRNOT00000055723
dihydropyrimidine dehydrogenase
chr10_+_98706960 0.08 ENSRNOT00000006217
mitogen-activated protein kinase kinase 6
chr20_-_5155293 0.08 ENSRNOT00000092322
proline-rich coiled-coil 2A
chr17_+_15749978 0.08 ENSRNOT00000067311
FYVE, RhoGEF and PH domain containing 3
chr15_+_12827707 0.08 ENSRNOT00000012452
Fez family zinc finger 2
chr10_+_45297937 0.07 ENSRNOT00000066367
tripartite motif-containing 17
chr8_+_64364741 0.07 ENSRNOT00000082840
CUGBP, Elav-like family member 6
chr15_-_14737704 0.07 ENSRNOT00000011307
synaptoporin
chr2_-_250232295 0.07 ENSRNOT00000082132
LIM domain only 4
chr18_-_37776453 0.07 ENSRNOT00000087876
dihydropyrimidinase-like 3
chr2_-_25235275 0.07 ENSRNOT00000061580
F2R like trypsin receptor 1
chr10_-_108196217 0.07 ENSRNOT00000075440
chromobox 4
chr1_-_88690534 0.06 ENSRNOT00000072570
ovo-like zinc finger 3
chr5_+_64294321 0.06 ENSRNOT00000083796
Myb/SANT DNA binding domain containing 3
chr10_-_45297385 0.06 ENSRNOT00000041187
histone cluster 3 H2B family member b
chr13_-_89874008 0.06 ENSRNOT00000051368
prothymosin alpha
chr10_-_86004096 0.06 ENSRNOT00000091978
ENSRNOT00000066855
SH3 and cysteine rich domain 2
chr18_-_37245809 0.06 ENSRNOT00000079585
protein phosphatase 2, regulatory subunit B, beta
chr7_+_97559841 0.06 ENSRNOT00000007326
zinc fingers and homeoboxes 2
chr18_-_36893797 0.06 ENSRNOT00000043544
G protein-coupled receptor 151
chr2_+_32820322 0.06 ENSRNOT00000013768
CD180 molecule
chr18_+_65155685 0.06 ENSRNOT00000081797
transcription factor 4
chr2_-_89310946 0.05 ENSRNOT00000015195
RALY RNA binding protein-like
chr3_+_2396143 0.05 ENSRNOT00000012388
Notch-regulated ankyrin repeat protein
chr1_+_87938042 0.05 ENSRNOT00000027837
mitogen activated protein kinase kinase kinase kinase 1
chr1_+_151439409 0.05 ENSRNOT00000022060
ENSRNOT00000050639
glutamate metabotropic receptor 5
chr5_+_16526058 0.05 ENSRNOT00000011130
LYN proto-oncogene, Src family tyrosine kinase
chr7_-_104541392 0.05 ENSRNOT00000078116
family with sequence similarity 49, member B
chr18_+_44737154 0.05 ENSRNOT00000021972
TNF alpha induced protein 8
chr1_+_91038886 0.05 ENSRNOT00000041301
ovo-like zinc finger 3
chrX_-_30831483 0.05 ENSRNOT00000004443
glycine receptor, alpha 2
chr4_-_55011415 0.05 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr5_+_59228199 0.05 ENSRNOT00000060282
histidine rich carboxyl terminus 1
chr4_+_142453013 0.05 ENSRNOT00000056573

chr20_+_5646097 0.05 ENSRNOT00000090925
inositol 1,4,5-trisphosphate receptor, type 3
chr9_+_16737642 0.05 ENSRNOT00000061430
serum response factor
chr3_+_98297554 0.05 ENSRNOT00000006524
potassium voltage-gated channel subfamily A member 4
chr14_+_104191517 0.04 ENSRNOT00000006573
sprouty-related, EVH1 domain containing 2
chr7_+_123381077 0.04 ENSRNOT00000082603
ENSRNOT00000056041
sterol regulatory element binding transcription factor 2
chr14_-_83741969 0.04 ENSRNOT00000026293
inositol polyphosphate-5-phosphatase J
chr16_+_46731403 0.04 ENSRNOT00000017624
teneurin transmembrane protein 3
chr10_-_94500591 0.04 ENSRNOT00000015976
CD79b molecule
chr9_-_54457753 0.04 ENSRNOT00000020032
signal transducer and activator of transcription 1
chr2_+_121165137 0.04 ENSRNOT00000016236
SRY box 2
chr3_-_3951025 0.04 ENSRNOT00000026212
notch 1
chr3_+_93495106 0.04 ENSRNOT00000029922
ENSRNOT00000085760
ankyrin repeat and BTB domain containing 2
chr3_+_150910398 0.04 ENSRNOT00000055310
tumor protein p53 inducible nuclear protein 2
chr9_-_23493081 0.04 ENSRNOT00000072144
Rh-associated glycoprotein
chr3_-_152179193 0.03 ENSRNOT00000026700
RNA binding motif protein 12
chr5_+_154489590 0.03 ENSRNOT00000035788
inhibitor of DNA binding 3, HLH protein
chr4_-_157266018 0.03 ENSRNOT00000019570
protein C10-like
chr8_+_93491761 0.03 ENSRNOT00000014326
trophoblast glycoprotein
chr4_+_120672152 0.03 ENSRNOT00000077231
monoglyceride lipase
chr16_-_49820235 0.03 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr2_-_179704629 0.03 ENSRNOT00000083361
ENSRNOT00000077941
glutamate ionotropic receptor AMPA type subunit 2
chr9_+_93545396 0.03 ENSRNOT00000025093
hypothetical protein LOC100359583
chr2_+_243502073 0.03 ENSRNOT00000015870
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr4_-_85915099 0.03 ENSRNOT00000016182
neuronal differentiation 6
chr4_-_119327822 0.03 ENSRNOT00000012645
Rho GTPase activating protein 25
chr20_+_7788084 0.03 ENSRNOT00000000597
DEF6 guanine nucleotide exchange factor
chr15_-_43542939 0.03 ENSRNOT00000012996
dihydropyrimidinase-like 2
chr3_-_2411544 0.03 ENSRNOT00000012406
torsin family 4, member A
chr11_+_3119885 0.03 ENSRNOT00000042316
vestigial-like family member 3
chr2_+_198418691 0.03 ENSRNOT00000089409
histone cluster 1, H2bk
chr2_-_231877307 0.03 ENSRNOT00000073860
La ribonucleoprotein domain family, member 7
chr8_+_93492122 0.03 ENSRNOT00000089491
trophoblast glycoprotein
chr15_+_58016238 0.03 ENSRNOT00000075786
potassium channel tetramerization domain containing 4
chr10_-_87335823 0.03 ENSRNOT00000079297
keratin 12
chr18_+_53915807 0.03 ENSRNOT00000026543
ADAM metallopeptidase with thrombospondin type 1 motif, 19
chr2_+_55835151 0.03 ENSRNOT00000018634
FYN binding protein
chr2_+_198360998 0.03 ENSRNOT00000046129
histone cluster 2, H2be
chr8_+_54993859 0.03 ENSRNOT00000013093
interleukin 18
chr2_+_174542667 0.03 ENSRNOT00000076793
follistatin-like 5
chr10_-_86690815 0.03 ENSRNOT00000012537
nuclear receptor subfamily 1, group D, member 1
chr5_+_140870140 0.03 ENSRNOT00000074347
hippocalcin-like 4
chr1_+_225140863 0.02 ENSRNOT00000027141
metastasis associated 1 family, member 2
chr1_+_144070754 0.02 ENSRNOT00000079989
SH3 domain-containing GRB2-like 3
chr4_-_183424449 0.02 ENSRNOT00000071930
family with sequence similarity 60, member A
chr17_+_44520537 0.02 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chrX_-_15467875 0.02 ENSRNOT00000011207
Pim-2 proto-oncogene, serine/threonine kinase
chr1_-_87937516 0.02 ENSRNOT00000087522
eukaryotic translation initiation factor 3, subunit K
chr4_-_125808281 0.02 ENSRNOT00000037848
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr20_+_25990656 0.02 ENSRNOT00000081254
leucine rich repeat transmembrane neuronal 3
chr1_-_255376833 0.02 ENSRNOT00000024941
protein phosphatase 1, regulatory subunit 3C
chr6_+_124217241 0.02 ENSRNOT00000064679
calmodulin 3
chr12_+_38160464 0.02 ENSRNOT00000032249
hydroxycarboxylic acid receptor 2
chrX_+_159505344 0.02 ENSRNOT00000001164
bombesin receptor subtype 3
chrX_-_107442878 0.02 ENSRNOT00000052302
glycine receptor, alpha 4
chr6_-_55524436 0.02 ENSRNOT00000006752
tetraspanin 13
chr3_-_17081510 0.02 ENSRNOT00000063862

chr10_-_37311625 0.02 ENSRNOT00000043343
jade family PHD finger 2
chr2_+_18354542 0.02 ENSRNOT00000042958
hyaluronan and proteoglycan link protein 1
chr17_+_52938980 0.02 ENSRNOT00000081052
GA binding protein transcription factor, beta subunit 1-like
chr7_-_60416925 0.02 ENSRNOT00000008193
cleavage and polyadenylation specific factor 6
chr2_+_116970344 0.02 ENSRNOT00000039603
EGF-like and EMI domain containing 1
chr1_+_80141630 0.02 ENSRNOT00000029552
optic atrophy 3
chr16_-_20939545 0.02 ENSRNOT00000027457
SURP and G patch domain containing 2
chr3_+_116899878 0.02 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr8_-_59239954 0.02 ENSRNOT00000016104
acyl-CoA synthetase bubblegum family member 1
chr14_-_45165207 0.02 ENSRNOT00000002960
Kruppel like factor 3
chr17_-_43689311 0.02 ENSRNOT00000028779
histone cluster 1, H2bc-like 1
chr18_+_61261418 0.02 ENSRNOT00000064250
zinc finger protein 532
chr8_-_111850393 0.02 ENSRNOT00000044956
CDV3 homolog
chr19_-_25062934 0.01 ENSRNOT00000060117
predicted gene 10644
chr20_+_25990304 0.01 ENSRNOT00000033980
leucine rich repeat transmembrane neuronal 3
chr7_-_11443357 0.01 ENSRNOT00000082126
zinc finger and BTB domain containing 7a
chr2_+_18392142 0.01 ENSRNOT00000043196
hyaluronan and proteoglycan link protein 1
chr1_+_268189277 0.01 ENSRNOT00000065001
sortilin-related VPS10 domain containing receptor 3
chr12_+_37544918 0.01 ENSRNOT00000001403
Rab interacting lysosomal protein-like 2
chr19_+_50848736 0.01 ENSRNOT00000077053
cadherin 13
chr13_-_61003744 0.01 ENSRNOT00000005163
regulator of G-protein signaling 13
chr1_-_251379593 0.01 ENSRNOT00000014684
ATPase family, AAA domain containing 1
chr4_-_148048726 0.01 ENSRNOT00000042418
ENSRNOT00000056393
transmembrane and coiled-coil domain family 1
chr8_-_78397123 0.01 ENSRNOT00000087270
ENSRNOT00000084925
transcription factor 12
chr12_-_38995570 0.01 ENSRNOT00000001806
ORAI calcium release-activated calcium modulator 1
chr9_+_73529612 0.01 ENSRNOT00000032430
unc-80 homolog, NALCN activator
chr5_+_2353468 0.01 ENSRNOT00000090346
staufen double-stranded RNA binding protein 2
chr6_-_37122023 0.01 ENSRNOT00000007609
visinin-like 1
chr8_-_112648880 0.01 ENSRNOT00000015265
atypical chemokine receptor 4
chr4_+_147333056 0.01 ENSRNOT00000012137
peroxisome proliferator-activated receptor gamma
chr17_-_67904674 0.01 ENSRNOT00000078532
Kruppel-like factor 6
chr2_-_173563273 0.01 ENSRNOT00000081423
zinc finger, B-box domain containing
chr2_-_250805445 0.01 ENSRNOT00000055362
chloride channel calcium activated 4-like
chr2_-_184309664 0.01 ENSRNOT00000052051
F-box and WD repeat domain containing 7
chr10_-_8498422 0.01 ENSRNOT00000082332
RNA binding protein, fox-1 homolog 1
chr10_+_86657285 0.01 ENSRNOT00000087346
thyroid hormone receptor alpha
chr6_-_61405195 0.01 ENSRNOT00000008655
leucine rich repeat neuronal 3
chr17_+_72160735 0.01 ENSRNOT00000038817
inter-alpha-trypsin inhibitor heavy chain 2
chr4_-_18396035 0.00 ENSRNOT00000034692
semaphorin 3A
chr1_+_252894663 0.00 ENSRNOT00000054757
interferon-induced protein with tetratricopeptide repeats 2
chr2_-_250778269 0.00 ENSRNOT00000085670
ENSRNOT00000083535
ENSRNOT00000017824
chloride channel accessory 5
chr2_-_149088787 0.00 ENSRNOT00000064833
clarin 1
chr8_-_71337746 0.00 ENSRNOT00000021554
zinc finger protein 609
chr10_-_74119009 0.00 ENSRNOT00000085712
ENSRNOT00000006926
DEAH-box helicase 40
chr13_+_57131395 0.00 ENSRNOT00000017884
potassium sodium-activated channel subfamily T member 2
chr10_+_89285855 0.00 ENSRNOT00000028033
glucose-6-phosphatase, catalytic subunit
chr1_+_277068761 0.00 ENSRNOT00000044183
ENSRNOT00000022382
hyaluronan binding protein 2
chr6_-_138632159 0.00 ENSRNOT00000082921
ENSRNOT00000040702
immunoglobulin heavy constant mu

Network of associatons between targets according to the STRING database.

First level regulatory network of Pou5f1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.1 0.4 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.1 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 0.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.1 GO:2000041 regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0 0.1 GO:0034136 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0006214 thymidine catabolic process(GO:0006214) pyrimidine deoxyribonucleoside catabolic process(GO:0046127)
0.0 0.1 GO:0001834 trophectodermal cell proliferation(GO:0001834)
0.0 0.1 GO:0043311 negative regulation of toll-like receptor 3 signaling pathway(GO:0034140) regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) positive regulation of renin secretion into blood stream(GO:1900135) positive regulation of eosinophil activation(GO:1902568)
0.0 0.0 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.1 GO:0071799 bud outgrowth involved in lung branching(GO:0060447) response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 0.1 GO:0099552 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.0 0.1 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0 0.0 GO:0046016 positive regulation of transcription by glucose(GO:0046016) negative regulation of beta-amyloid clearance(GO:1900222)
0.0 0.1 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.0 0.0 GO:0034240 negative regulation of macrophage fusion(GO:0034240)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.0 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.0 GO:0019815 B cell receptor complex(GO:0019815)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.1 GO:0004159 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
0.0 0.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.0 0.1 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0052743 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485) inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0051525 NFAT protein binding(GO:0051525)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0 0.1 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.0 GO:0004971 AMPA glutamate receptor activity(GO:0004971)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends