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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Pou2f2_Pou3f1
Z-value: 1.19
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Transcription factors associated with Pou2f2_Pou3f1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou2f2 | rn6_v1_chr1_-_82004538_82004538 | -0.37 | 5.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_81372650 Show fit | 1.64 |
ENSRNOT00000088829
|
zinc finger protein 428 |
|
| chr1_-_25839198 Show fit | 1.19 |
ENSRNOT00000090388
ENSRNOT00000092757 ENSRNOT00000042072 |
triadin |
|
| chr2_-_198360678 Show fit | 1.09 |
ENSRNOT00000051917
|
histone cluster 2 H2A family member c |
|
| chr2_-_198382190 Show fit | 1.03 |
ENSRNOT00000044268
|
histone cluster 2, H2aa2 |
|
| chr2_+_198388809 Show fit | 1.01 |
ENSRNOT00000083087
|
histone cluster 2, H2aa3 |
|
| chr17_-_44527801 Show fit | 1.00 |
ENSRNOT00000089643
|
histone cluster 1 H2B family member k |
|
| chr16_-_20486707 Show fit | 0.86 |
ENSRNOT00000026470
|
JunD proto-oncogene, AP-1 transcription factor subunit |
|
| chr3_-_9037942 Show fit | 0.83 |
ENSRNOT00000036770
|
immediate early response 5-like |
|
| chr10_-_45297385 Show fit | 0.74 |
ENSRNOT00000041187
|
histone cluster 3 H2B family member b |
|
| chr2_+_198418691 Show fit | 0.64 |
ENSRNOT00000089409
|
histone cluster 1, H2bk |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pou2f2_Pou3f1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.1 | 1.7 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.0 | 1.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.4 | 1.2 | GO:0090158 | endoplasmic reticulum membrane organization(GO:0090158) |
| 0.0 | 0.9 | GO:0002076 | osteoblast development(GO:0002076) |
| 0.0 | 0.8 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.5 | GO:0060842 | arterial endothelial cell differentiation(GO:0060842) |
| 0.1 | 0.5 | GO:0042905 | optic cup morphogenesis involved in camera-type eye development(GO:0002072) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.4 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
| 0.1 | 0.3 | GO:0034136 | negative regulation of toll-like receptor 2 signaling pathway(GO:0034136) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0000786 | nucleosome(GO:0000786) |
| 0.4 | 1.2 | GO:0014701 | junctional sarcoplasmic reticulum membrane(GO:0014701) |
| 0.2 | 0.9 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 0.5 | GO:0017146 | NMDA selective glutamate receptor complex(GO:0017146) |
| 0.1 | 0.4 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.1 | 0.3 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.0 | 0.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.0 | 0.2 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.2 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 0.1 | GO:0032937 | SREBP-SCAP-Insig complex(GO:0032937) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.0 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.9 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.2 | 0.5 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.0 | 0.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.3 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.0 | 0.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.3 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.3 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.0 | 0.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.0 | 0.2 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 0.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.3 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.9 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.1 | 0.5 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.0 | 0.3 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 0.2 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |