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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Pitx3
Z-value: 0.51
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Transcription factors associated with Pitx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pitx3 | rn6_v1_chr1_-_265899958_265899958 | -0.66 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_124005280 Show fit | 0.51 |
ENSRNOT00000014353
|
nuclear receptor subfamily 2, group C, member 2 |
|
| chr4_+_86275717 Show fit | 0.46 |
ENSRNOT00000016414
|
protein phosphatase 1, regulatory subunit 17 |
|
| chr12_-_48365784 Show fit | 0.31 |
ENSRNOT00000077317
|
D-amino-acid oxidase |
|
| chr7_+_141666111 Show fit | 0.27 |
ENSRNOT00000083250
|
|
|
| chr20_+_5080070 Show fit | 0.24 |
ENSRNOT00000086950
ENSRNOT00000077082 |
abhydrolase domain containing 16A |
|
| chr3_-_176926722 Show fit | 0.18 |
ENSRNOT00000020168
|
zinc finger and BTB domain containing 46 |
|
| chr3_-_113438801 Show fit | 0.18 |
ENSRNOT00000091665
|
microfibrillar-associated protein 1A |
|
| chr1_-_66212418 Show fit | 0.17 |
ENSRNOT00000026074
|
hypothetical protein LOC691722 |
|
| chr8_-_61919874 Show fit | 0.17 |
ENSRNOT00000064830
|
similar to human chromosome 15 open reading frame 39 |
|
| chr10_-_62184874 Show fit | 0.15 |
ENSRNOT00000004229
|
replication protein A1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pitx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0045663 | positive regulation of myoblast differentiation(GO:0045663) |
| 0.1 | 0.3 | GO:0046416 | alanine catabolic process(GO:0006524) pyruvate family amino acid catabolic process(GO:0009080) D-amino acid metabolic process(GO:0046416) |
| 0.1 | 0.2 | GO:0046462 | monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651) |
| 0.0 | 0.2 | GO:1902990 | mitotic telomere maintenance via semi-conservative replication(GO:1902990) |
| 0.0 | 0.2 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 0.0 | 0.2 | GO:0010728 | regulation of hydrogen peroxide biosynthetic process(GO:0010728) |
| 0.0 | 0.2 | GO:0048550 | negative regulation of pinocytosis(GO:0048550) |
| 0.0 | 0.2 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
| 0.0 | 0.1 | GO:0045900 | negative regulation of translational elongation(GO:0045900) |
| 0.0 | 0.1 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:0005760 | gamma DNA polymerase complex(GO:0005760) |
| 0.0 | 0.2 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 0.1 | GO:0071006 | U2-type catalytic step 1 spliceosome(GO:0071006) |
| 0.0 | 0.1 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.1 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.0 | 0.1 | GO:0034098 | VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098) |
| 0.0 | 0.1 | GO:0071556 | integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553) |
| 0.0 | 0.0 | GO:0035101 | FACT complex(GO:0035101) |
| 0.0 | 0.0 | GO:0046691 | intracellular canaliculus(GO:0046691) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 0.2 | GO:0000827 | inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) |
| 0.1 | 0.2 | GO:0032810 | sterol response element binding(GO:0032810) |
| 0.0 | 0.2 | GO:0016890 | site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890) |
| 0.0 | 0.2 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 0.2 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.0 | 0.1 | GO:0097363 | protein O-GlcNAc transferase activity(GO:0097363) |
| 0.0 | 0.1 | GO:2001070 | starch binding(GO:2001070) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.0 | 0.2 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |
| 0.0 | 0.1 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |