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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Pbx1_Pbx3
Z-value: 0.48
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Transcription factors associated with Pbx1_Pbx3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pbx1 | rn6_v1_chr13_-_86451002_86451002 | -0.59 | 3.0e-01 | Click! |
| Pbx3 | rn6_v1_chr3_-_13525983_13525983 | -0.13 | 8.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_55669626 Show fit | 1.36 |
ENSRNOT00000033352
|
cadherin 15 |
|
| chr10_+_91830654 Show fit | 0.41 |
ENSRNOT00000005176
|
wingless-type MMTV integration site family, member 3 |
|
| chr1_+_214454090 Show fit | 0.33 |
ENSRNOT00000049448
|
tetraspanin 4 |
|
| chr1_+_99762253 Show fit | 0.28 |
ENSRNOT00000065876
|
kallikrein related-peptidase 6 |
|
| chrX_+_107496072 Show fit | 0.27 |
ENSRNOT00000003283
|
proteolipid protein 1 |
|
| chr1_+_33910912 Show fit | 0.25 |
ENSRNOT00000044690
|
iroquois homeobox 1 |
|
| chr3_+_111135021 Show fit | 0.19 |
ENSRNOT00000018970
|
delta like canonical Notch ligand 4 |
|
| chr6_+_55812747 Show fit | 0.19 |
ENSRNOT00000008106
|
sclerostin domain containing 1 |
|
| chr8_-_23000455 Show fit | 0.18 |
ENSRNOT00000091027
ENSRNOT00000017493 |
ral guanine nucleotide dissociation stimulator-like 3 |
|
| chr6_+_8886591 Show fit | 0.17 |
ENSRNOT00000091510
ENSRNOT00000089174 |
SIX homeobox 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Pbx1_Pbx3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0060061 | Spemann organizer formation(GO:0060061) |
| 0.1 | 0.4 | GO:0072268 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.0 | 0.3 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.0 | 0.3 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.1 | 0.2 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 0.1 | 0.2 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
| 0.1 | 0.2 | GO:0021797 | neuroblast differentiation(GO:0014016) forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.0 | 0.1 | GO:1904207 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685) |
| 0.0 | 0.1 | GO:2001201 | calcium-independent cell-matrix adhesion(GO:0007161) interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) regulation of transforming growth factor-beta secretion(GO:2001201) |
| 0.0 | 0.1 | GO:0033058 | directional locomotion(GO:0033058) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.1 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 0.1 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.0 | 0.1 | GO:0030896 | checkpoint clamp complex(GO:0030896) |
| 0.0 | 0.1 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.1 | GO:0034992 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.0 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.0 | GO:0034774 | secretory granule lumen(GO:0034774) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.4 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.0 | 0.2 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 0.1 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.0 | 0.1 | GO:0035939 | microsatellite binding(GO:0035939) |
| 0.0 | 0.1 | GO:0033149 | FFAT motif binding(GO:0033149) |
| 0.0 | 0.1 | GO:0000703 | oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703) |
| 0.0 | 0.1 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 0.1 | GO:0004813 | alanine-tRNA ligase activity(GO:0004813) |
| 0.0 | 0.1 | GO:0045340 | mercury ion binding(GO:0045340) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 0.1 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.0 | 0.2 | REACTOME SIGNALING BY NOTCH4 | Genes involved in Signaling by NOTCH4 |
| 0.0 | 0.0 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |