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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nrf1
Z-value: 1.50
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Transcription factors associated with Nrf1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nrf1 | rn6_v1_chr4_+_57378069_57378166 | 0.17 | 7.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr11_-_30893310 Show fit | 0.91 |
ENSRNOT00000037444
|
MIS18 kinetochore protein A |
|
| chr3_-_66417741 Show fit | 0.65 |
ENSRNOT00000007662
|
neuronal differentiation 1 |
|
| chr7_-_13751271 Show fit | 0.51 |
ENSRNOT00000009931
|
solute carrier family 1 member 6 |
|
| chr6_+_33885495 Show fit | 0.50 |
ENSRNOT00000086633
|
syndecan 1 |
|
| chr20_+_4967194 Show fit | 0.49 |
ENSRNOT00000070846
|
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated |
|
| chr1_-_37742932 Show fit | 0.43 |
ENSRNOT00000034410
|
FAST kinase domains 3 |
|
| chr1_+_37743147 Show fit | 0.41 |
ENSRNOT00000061790
|
5-methyltetrahydrofolate-homocysteine methyltransferase reductase |
|
| chr1_-_213534641 Show fit | 0.40 |
ENSRNOT00000033074
|
synaptonemal complex central element protein 1 |
|
| chr5_+_153260930 Show fit | 0.39 |
ENSRNOT00000023289
ENSRNOT00000082184 |
arginine and serine rich protein 1 |
|
| chr9_+_14551758 Show fit | 0.39 |
ENSRNOT00000017157
|
nuclear transcription factor Y subunit alpha |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nrf1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0034080 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 0.1 | 0.7 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.1 | 0.5 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.0 | 0.5 | GO:0018410 | C-terminal protein amino acid modification(GO:0018410) |
| 0.0 | 0.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.0 | 0.5 | GO:2000036 | regulation of stem cell population maintenance(GO:2000036) |
| 0.1 | 0.4 | GO:0036451 | cap mRNA methylation(GO:0036451) |
| 0.1 | 0.4 | GO:0072268 | pattern specification involved in metanephros development(GO:0072268) |
| 0.1 | 0.4 | GO:0043418 | homocysteine catabolic process(GO:0043418) |
| 0.0 | 0.4 | GO:0045876 | positive regulation of sister chromatid cohesion(GO:0045876) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 0.4 | GO:0000801 | central element(GO:0000801) |
| 0.0 | 0.4 | GO:0030014 | CCR4-NOT complex(GO:0030014) |
| 0.1 | 0.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 0.3 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.3 | GO:0000798 | nuclear cohesin complex(GO:0000798) |
| 0.0 | 0.3 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.3 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 0.8 | GO:0102390 | mycophenolic acid acyl-glucuronide esterase activity(GO:0102390) |
| 0.0 | 0.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.7 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 0.5 | GO:0010340 | carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998) |
| 0.0 | 0.5 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.0 | 0.5 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 0.1 | 0.4 | GO:0004483 | mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483) |
| 0.1 | 0.4 | GO:0097001 | ceramide binding(GO:0097001) |
| 0.0 | 0.4 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 0.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.5 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 0.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 0.3 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.0 | 0.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 0.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.7 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.6 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.0 | 0.5 | REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA | Genes involved in Activation of Chaperones by ATF6-alpha |
| 0.0 | 0.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.4 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.4 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.0 | 0.3 | REACTOME INTEGRATION OF PROVIRUS | Genes involved in Integration of provirus |
| 0.0 | 0.3 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |
| 0.0 | 0.3 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |