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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nrf1

Z-value: 1.50

Motif logo

Transcription factors associated with Nrf1

Gene Symbol Gene ID Gene Info
ENSRNOG00000008752 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nrf1rn6_v1_chr4_+_57378069_573781660.177.8e-01Click!

Activity profile of Nrf1 motif

Sorted Z-values of Nrf1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_30893310 0.91 ENSRNOT00000037444
MIS18 kinetochore protein A
chr3_-_66417741 0.65 ENSRNOT00000007662
neuronal differentiation 1
chr7_-_13751271 0.51 ENSRNOT00000009931
solute carrier family 1 member 6
chr6_+_33885495 0.50 ENSRNOT00000086633
syndecan 1
chr20_+_4967194 0.49 ENSRNOT00000070846
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
chr1_-_37742932 0.43 ENSRNOT00000034410
FAST kinase domains 3
chr1_+_37743147 0.41 ENSRNOT00000061790
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr1_-_213534641 0.40 ENSRNOT00000033074
synaptonemal complex central element protein 1
chr5_+_153260930 0.39 ENSRNOT00000023289
ENSRNOT00000082184
arginine and serine rich protein 1
chr9_+_14551758 0.39 ENSRNOT00000017157
nuclear transcription factor Y subunit alpha
chr5_+_169475270 0.39 ENSRNOT00000014625
isoprenylcysteine carboxyl methyltransferase
chr1_+_101884019 0.38 ENSRNOT00000028650
transmembrane protein 143
chr14_+_87312203 0.35 ENSRNOT00000088032
adenylate cyclase 1
chr19_-_41433346 0.34 ENSRNOT00000022952
cap methyltransferase 2
chr8_+_59900651 0.33 ENSRNOT00000020410
transmembrane protein 266
chr7_-_91538673 0.33 ENSRNOT00000006209
RAD21 cohesin complex component
chr14_-_86395120 0.31 ENSRNOT00000006802
ENSRNOT00000078572
transmembrane p24 trafficking protein 4
chr1_+_101884276 0.31 ENSRNOT00000082917
transmembrane protein 143
chr4_+_5841998 0.31 ENSRNOT00000010025
X-ray repair cross complementing 2
chr14_-_86387606 0.30 ENSRNOT00000089384
ENSRNOT00000006642
DEAD-box helicase 56
chr16_+_85331866 0.29 ENSRNOT00000019615
DNA ligase 4
chr11_+_57486775 0.29 ENSRNOT00000086393
mycophenolic acid acyl-glucuronide esterase, mitochondrial
chr2_-_2891253 0.28 ENSRNOT00000029250
arylsulfatase family, member K
chr11_+_57486365 0.28 ENSRNOT00000048533
mycophenolic acid acyl-glucuronide esterase, mitochondrial
chr18_-_40518988 0.28 ENSRNOT00000004784
fem-1 homolog C
chr1_+_33910912 0.28 ENSRNOT00000044690
iroquois homeobox 1
chr19_+_57650163 0.28 ENSRNOT00000038257
ENSRNOT00000083572
SprT-like N-terminal domain
chr14_+_1959610 0.27 ENSRNOT00000085898
ring finger protein 212
chr1_+_266143818 0.26 ENSRNOT00000026987
SUFU negative regulator of hedgehog signaling
chr16_-_21089508 0.26 ENSRNOT00000072565
hyaluronan and proteoglycan link protein 4
chr7_-_113937941 0.25 ENSRNOT00000012408
potassium two pore domain channel subfamily K member 9
chr4_-_161743847 0.24 ENSRNOT00000064174
ENSRNOT00000084173
ENSRNOT00000064215
integrin alpha FG-GAP repeat containing 2
chr5_-_104980641 0.24 ENSRNOT00000071192
HAUS augmin-like complex, subunit 6
chr16_+_20740826 0.24 ENSRNOT00000038057
CREB regulated transcription coactivator 1
chr4_-_159482869 0.24 ENSRNOT00000088333
RAD51 associated protein 1
chr14_+_110676090 0.23 ENSRNOT00000029513
Fanconi anemia, complementation group L
chr19_-_19896421 0.23 ENSRNOT00000020793
HEAT repeat containing 3
chr13_-_45318822 0.23 ENSRNOT00000091514
ENSRNOT00000005143
C-X-C motif chemokine receptor 4
chr10_-_86690815 0.23 ENSRNOT00000012537
nuclear receptor subfamily 1, group D, member 1
chr4_+_71652354 0.23 ENSRNOT00000022672
ENSRNOT00000022543
caspase 2
chr1_-_198450688 0.22 ENSRNOT00000027392
Paxip1-associated glutamate-rich protein 1
chr11_+_89511191 0.22 ENSRNOT00000002510
minichromosome maintenance complex component 4
chr10_+_72909550 0.22 ENSRNOT00000004540
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr10_-_43760930 0.21 ENSRNOT00000003639
zinc finger protein 672
chr15_+_93634820 0.21 ENSRNOT00000093318
ceroid-lipofuscinosis, neuronal 5
chr11_+_60054408 0.21 ENSRNOT00000091756
abhydrolase domain containing 10
chr1_-_221321459 0.21 ENSRNOT00000028406
ENSRNOT00000084800
DNA polymerase alpha 2, accessory subunit
chrX_+_15098904 0.20 ENSRNOT00000007367
ENSRNOT00000087033
RNA binding motif (RNP1, RRM) protein 3
chr17_+_42064376 0.20 ENSRNOT00000023787
MRS2 magnesium transporter
chr15_-_24056073 0.20 ENSRNOT00000015100
WD repeat and HMG-box DNA binding protein 1
chr5_+_114940053 0.19 ENSRNOT00000012396
hook microtubule-tethering protein 1
chr2_+_127686925 0.19 ENSRNOT00000086653
ENSRNOT00000016946
polo-like kinase 4
chr19_-_914880 0.19 ENSRNOT00000017127
chemokine-like factor
chr15_+_41927241 0.19 ENSRNOT00000012035
tripartite motif-containing 13
chr4_-_66336901 0.19 ENSRNOT00000035326

chr8_-_76940094 0.18 ENSRNOT00000082709
ENSRNOT00000084313
ring finger protein 111
chr11_+_32450587 0.18 ENSRNOT00000061235
small integral membrane protein 11
chr1_+_280103695 0.18 ENSRNOT00000065289
enolase family member 4
chr5_+_160095427 0.18 ENSRNOT00000077609

chr17_-_78499881 0.18 ENSRNOT00000079260
family with sequence similarity 107, member B
chrX_+_144807392 0.18 ENSRNOT00000004529
leucine zipper down-regulated in cancer 1
chr9_+_70133969 0.18 ENSRNOT00000040525
ADAM metallopeptidase domain 23
chr18_+_87580424 0.18 ENSRNOT00000070984
thioredoxin-related transmembrane protein 3
chr11_-_71695000 0.18 ENSRNOT00000073550
UBX domain protein 7
chr9_-_19978013 0.17 ENSRNOT00000038222
phospholipase A2 group VII
chr1_-_226935689 0.17 ENSRNOT00000038807
transmembrane protein 109
chr13_+_51317460 0.17 ENSRNOT00000005845
similar to Mss4 protein
chr3_-_153250641 0.17 ENSRNOT00000008961
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
chr8_+_76400341 0.17 ENSRNOT00000087382
ENSRNOT00000081072
BCL2/adenovirus E1B interacting protein 2
chr12_-_2555164 0.17 ENSRNOT00000084460
ENSRNOT00000061821
mitogen activated protein kinase kinase 7
chr8_+_14239594 0.17 ENSRNOT00000015383
solute carrier family 36 member 4
chr14_-_3351553 0.17 ENSRNOT00000061556
BTB (POZ) domain containing 8
chr9_-_17163170 0.17 ENSRNOT00000025921
exportin 5
chr16_+_81587446 0.17 ENSRNOT00000092680
DCN1, defective in cullin neddylation 1, domain containing 2
chr7_+_125649688 0.17 ENSRNOT00000017906
PHD finger protein 21B
chr5_-_172623899 0.17 ENSRNOT00000080591
SKI proto-oncogene
chr10_-_73865364 0.17 ENSRNOT00000005226
ribosomal protein S6 kinase B1
chr2_-_261402880 0.17 ENSRNOT00000052396
ENSRNOT00000077839
ENSRNOT00000088561
fucose-1-phosphate guanylyltransferase
chr10_-_73690860 0.17 ENSRNOT00000004876
ENSRNOT00000075843
integrator complex subunit 2
chr5_-_166695134 0.16 ENSRNOT00000047763
transmembrane protein 201
chr5_-_14588422 0.16 ENSRNOT00000011312
lysophospholipase I
chr7_-_58219790 0.16 ENSRNOT00000067907
TBC1 domain family, member 15
chr9_-_38495126 0.16 ENSRNOT00000016933
ENSRNOT00000090385
RAB23, member RAS oncogene family
chr5_+_103024376 0.16 ENSRNOT00000058536

chr1_-_73733788 0.16 ENSRNOT00000025338
leukocyte receptor cluster member 8
chr2_-_22105710 0.16 ENSRNOT00000017705
zinc finger FYVE-type containing 16
chr10_-_53037816 0.16 ENSRNOT00000057509
shisa family member 6
chr1_+_88750462 0.16 ENSRNOT00000028247
CAP-Gly domain-containing linker protein 3
chr10_+_14547172 0.16 ENSRNOT00000092043
unkempt family like zinc finger
chr11_-_38457373 0.16 ENSRNOT00000041177
zinc finger protein 295
chr6_+_12415805 0.16 ENSRNOT00000022380
general transcription factor 2A subunit 1 like
chr16_+_83206004 0.16 ENSRNOT00000018870
ankyrin repeat domain 10
chr8_+_58120179 0.16 ENSRNOT00000049076
ENSRNOT00000090114
nuclear protein, co-activator of histone transcription
chr3_+_7635933 0.16 ENSRNOT00000061029
transcription termination factor 1
chr15_-_47800024 0.16 ENSRNOT00000072997
ENSRNOT00000016616
methionine sulfoxide reductase A
chr18_-_65768781 0.16 ENSRNOT00000016189
DNA polymerase iota
chr5_+_120568242 0.16 ENSRNOT00000050597
leptin receptor
chr10_+_47281786 0.15 ENSRNOT00000089123
potassium voltage-gated channel subfamily J member 12
chr9_-_65307995 0.15 ENSRNOT00000030934
CDC-like kinase 1
chr4_-_150506557 0.15 ENSRNOT00000076927
zinc finger protein 248
chr11_-_71108184 0.15 ENSRNOT00000051989
ENSRNOT00000073865
ENSRNOT00000063883
leucine rich repeats and calponin homology domain containing 3
chr3_-_130114770 0.15 ENSRNOT00000010638
jagged 1
chr1_+_196839321 0.15 ENSRNOT00000020388
lysine demethylase 8
chr9_+_17163354 0.15 ENSRNOT00000026049
DNA polymerase eta
chr10_-_56558487 0.15 ENSRNOT00000023256
solute carrier family 2 member 4
chr2_-_197935567 0.15 ENSRNOT00000085404
regulation of nuclear pre-mRNA domain containing 2
chr3_+_60024013 0.15 ENSRNOT00000025255
secernin 3
chr3_-_2727616 0.15 ENSRNOT00000061904
complement C8 gamma chain
chr17_-_77093308 0.15 ENSRNOT00000024110
coiled-coil domain containing 3
chr15_+_46008613 0.15 ENSRNOT00000066864
ENSRNOT00000080537
WD repeat and FYVE domain containing 2
chr7_-_53714879 0.15 ENSRNOT00000005078
zinc finger, DHHC-type containing 17
chr6_+_86651196 0.15 ENSRNOT00000034756
hypothetical LOC314168
chr6_-_64170122 0.14 ENSRNOT00000093248
ENSRNOT00000005363
DnaJ heat shock protein family (Hsp40) member B9
chr3_-_176791960 0.14 ENSRNOT00000018237
glucocorticoid modulatory element binding protein 2
chr1_+_197659187 0.14 ENSRNOT00000082228
serine/threonine-protein kinase SBK1
chr12_-_46845079 0.14 ENSRNOT00000047466
ENSRNOT00000064115
paxillin
chr1_-_192088520 0.14 ENSRNOT00000047420
partner and localizer of BRCA2
chr9_-_61134963 0.14 ENSRNOT00000017967
post-GPI attachment to proteins 1
chr3_+_151688454 0.14 ENSRNOT00000026856
reactive oxygen species modulator 1
chr3_-_112789282 0.14 ENSRNOT00000090680
ENSRNOT00000066181
tau tubulin kinase 2
chr11_+_83048636 0.14 ENSRNOT00000002408
RGD1562339
chr17_-_22863966 0.14 ENSRNOT00000046157
transmembrane protein 170B
chr10_-_96584896 0.14 ENSRNOT00000004699
ENSRNOT00000055073
protein kinase C, alpha
chr7_+_121350965 0.14 ENSRNOT00000092614
TGF-beta activated kinase 1/MAP3K7 binding protein 1
chr2_+_204512302 0.14 ENSRNOT00000021846
calsequestrin 2
chr1_+_228337767 0.14 ENSRNOT00000066247
PAT1 homolog 1, processing body mRNA decay factor
chr4_+_114776797 0.14 ENSRNOT00000089635
polycomb group RING finger protein 1
chr5_+_70441123 0.14 ENSRNOT00000087517
fibronectin type III and SPRY domain containing 1-like
chr6_+_137824213 0.14 ENSRNOT00000056880
phosphofurin acidic cluster sorting protein 2
chr14_-_82658891 0.14 ENSRNOT00000006841
UV-stimulated scaffold protein A
chrX_-_124464963 0.14 ENSRNOT00000036472
ENSRNOT00000077697
transmembrane protein 255A
chr16_+_2278701 0.14 ENSRNOT00000016233
DENN domain containing 6A
chr3_-_2123820 0.13 ENSRNOT00000086843
euchromatic histone lysine methyltransferase 1
chr3_+_124896618 0.13 ENSRNOT00000028888
CDP-diacylglycerol synthase 2
chr1_+_211543751 0.13 ENSRNOT00000049631
leucine rich repeat containing 27
chr1_-_261179790 0.13 ENSRNOT00000074420
ENSRNOT00000072073
exosome component 1
chr2_+_118746333 0.13 ENSRNOT00000079431

chr1_-_201942344 0.13 ENSRNOT00000027956
similar to RIKEN cDNA 2310057M21
chr15_+_52234563 0.13 ENSRNOT00000015169
receptor accessory protein 4
chr8_+_117737387 0.13 ENSRNOT00000090164
ENSRNOT00000091573
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr7_+_116943057 0.13 ENSRNOT00000056527
tigger transposable element derived 5
chr14_+_33108024 0.13 ENSRNOT00000090350
ENSRNOT00000067650
ENSRNOT00000077242
nitric oxide associated 1
chr5_-_150609352 0.13 ENSRNOT00000074374
phosphatase and actin regulator 4
chr4_+_97531083 0.13 ENSRNOT00000007285
MAD2 mitotic arrest deficient-like 1 (yeast)
chr16_-_79838212 0.13 ENSRNOT00000016756
ceroid-lipofuscinosis, neuronal 8
chr11_-_61294022 0.13 ENSRNOT00000064385
spindle and centriole associated protein 1
chr3_-_112676556 0.13 ENSRNOT00000014664
codanin 1
chrX_+_74200972 0.13 ENSRNOT00000076956
cysteine-rich hydrophobic domain 1
chr8_-_58119623 0.13 ENSRNOT00000050555
ATM serine/threonine kinase
chr1_+_199037544 0.13 ENSRNOT00000025499
ring finger protein 40
chr14_+_60657686 0.13 ENSRNOT00000070892
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
chr4_+_57823411 0.13 ENSRNOT00000030462
ENSRNOT00000088235
serine-rich single-pass membrane protein 1
chr4_+_84770375 0.13 ENSRNOT00000013528
pleckstrin homology domain containing A8
chr14_+_83510278 0.13 ENSRNOT00000081161
POZ (BTB) and AT hook containing zinc finger 1
chrX_+_128416722 0.13 ENSRNOT00000009336
ENSRNOT00000085110
X-linked inhibitor of apoptosis
chr10_-_19652898 0.13 ENSRNOT00000009648
spindle apparatus coiled-coil protein 1
chr8_+_130749838 0.13 ENSRNOT00000079273
SNF related kinase
chr13_+_56513286 0.12 ENSRNOT00000015596
zinc finger and BTB domain containing 41
chr14_+_38192446 0.12 ENSRNOT00000090242
nuclear transcription factor, X-box binding-like 1
chr17_-_42241066 0.12 ENSRNOT00000059570
tyrosyl-DNA phosphodiesterase 2
chr2_-_206997519 0.12 ENSRNOT00000027042
leucine-rich repeats and immunoglobulin-like domains 2
chr19_-_52206310 0.12 ENSRNOT00000087886
membrane-bound transcription factor peptidase, site 1
chr4_-_118472179 0.12 ENSRNOT00000023856
max dimerization protein 1
chr14_+_38192870 0.12 ENSRNOT00000077080
nuclear transcription factor, X-box binding-like 1
chr10_+_63829807 0.12 ENSRNOT00000006407
CRK proto-oncogene, adaptor protein
chr3_+_8958090 0.12 ENSRNOT00000086789
ENSRNOT00000064557
dolichyldiphosphatase 1
chr1_-_127599257 0.12 ENSRNOT00000018436
ankyrin repeat and SOCS box-containing 7
chr10_+_95242986 0.12 ENSRNOT00000065589
ENSRNOT00000080460
similar to hypothetical protein LOC284018 isoform b
chr8_+_62317265 0.12 ENSRNOT00000083418
ENSRNOT00000091204
family with sequence similarity 219, member B
chr12_-_38093050 0.12 ENSRNOT00000057814
coiled-coil domain containing 62
chr20_-_10912769 0.12 ENSRNOT00000051678
similar to pyridoxal (pyridoxine, vitamin B6) kinase
chr11_-_31213787 0.12 ENSRNOT00000002800
PAX3 and PAX7 binding protein 1
chr12_-_52658275 0.12 ENSRNOT00000041981
zinc finger protein 605
chr4_-_117589464 0.12 ENSRNOT00000021167
N-acetyltransferase 8 (GCN5-related) family member 1
chr8_-_21968415 0.12 ENSRNOT00000067325
ENSRNOT00000064932
DNA methyltransferase 1
chr1_+_211544157 0.12 ENSRNOT00000023610
leucine rich repeat containing 27
chr15_+_24056383 0.12 ENSRNOT00000015120
suppressor of cytokine signaling 4
chr6_+_86785771 0.12 ENSRNOT00000066702
pre-mRNA processing factor 39
chr11_-_31847490 0.12 ENSRNOT00000061304
downstream neighbor of SON
chr2_-_165600748 0.12 ENSRNOT00000013216
intraflagellar transport 80
chr14_+_82356916 0.12 ENSRNOT00000040229
stem-loop binding protein
chr4_-_148803988 0.12 ENSRNOT00000018101
Ras association domain family member 4
chr5_+_122847645 0.12 ENSRNOT00000009516
OMA1 zinc metallopeptidase
chr14_+_2613406 0.12 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr7_+_11908107 0.12 ENSRNOT00000041106
MAP kinase-interacting serine/threonine kinase 2
chr14_+_23611735 0.12 ENSRNOT00000031074
centromere protein C
chr10_+_45559578 0.12 ENSRNOT00000004011
similar to RIKEN cDNA 2310033P09
chr5_-_60559533 0.12 ENSRNOT00000092899
zinc finger and BTB domain containing 5
chr7_-_137856485 0.12 ENSRNOT00000007003
similar to splicing factor, arginine/serine-rich 2, interacting protein
chr18_+_6207280 0.12 ENSRNOT00000037955
TATA-box binding protein associated factor 4b
chr16_+_7435634 0.11 ENSRNOT00000026323
calpain 7
chr5_+_147246037 0.11 ENSRNOT00000089457
ring finger protein 19B
chr10_+_43744882 0.11 ENSRNOT00000078662
zinc finger protein 692
chr4_-_123713319 0.11 ENSRNOT00000012875
ENSRNOT00000086982
solute carrier family 6 member 6
chr13_+_69135128 0.11 ENSRNOT00000017858
ER degradation enhancing alpha-mannosidase like protein 3
chr1_+_80028928 0.11 ENSRNOT00000012082
F-box protein 46
chr7_-_124491004 0.11 ENSRNOT00000037710
tubulin tyrosine ligase like 12
chr8_+_28075551 0.11 ENSRNOT00000012078
non-SMC condensin II complex, subunit D3
chr16_-_82099991 0.11 ENSRNOT00000089447
ATPase phospholipid transporting 11A
chr4_+_159483131 0.11 ENSRNOT00000089513
similar to DNA segment, Chr 6, Wayne State University 163, expressed

Network of associatons between targets according to the STRING database.

First level regulatory network of Nrf1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.7 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.4 GO:0036451 cap mRNA methylation(GO:0036451)
0.1 0.5 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.1 0.4 GO:0072268 pattern specification involved in metanephros development(GO:0072268)
0.1 0.4 GO:0043418 homocysteine catabolic process(GO:0043418)
0.1 0.1 GO:0003275 apoptotic process involved in outflow tract morphogenesis(GO:0003275) regulation of apoptotic process involved in outflow tract morphogenesis(GO:1902256)
0.1 0.2 GO:1904882 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 0.2 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.1 0.3 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.1 0.2 GO:0019389 glucuronoside metabolic process(GO:0019389)
0.1 0.3 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.3 GO:0035822 meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.1 0.2 GO:0046601 positive regulation of centriole replication(GO:0046601)
0.1 0.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 0.1 GO:0090172 microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
0.1 0.2 GO:0015827 tryptophan transport(GO:0015827)
0.1 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470) response to ultrasound(GO:1990478)
0.1 0.2 GO:1900368 regulation of RNA interference(GO:1900368)
0.1 0.3 GO:0042148 strand invasion(GO:0042148)
0.1 0.2 GO:0061443 endocardial cushion cell differentiation(GO:0061443)
0.0 0.1 GO:0006431 methionyl-tRNA aminoacylation(GO:0006431)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.0 0.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 0.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.0 0.1 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.0 0.1 GO:0007571 age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571) amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.2 GO:0046061 dATP catabolic process(GO:0046061)
0.0 0.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.2 GO:0035627 ceramide transport(GO:0035627)
0.0 0.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.2 GO:1904059 negative regulation of eating behavior(GO:1903999) regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0043060 male meiosis chromosome segregation(GO:0007060) meiotic metaphase I plate congression(GO:0043060)
0.0 0.4 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.2 GO:0033184 positive regulation of histone ubiquitination(GO:0033184)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.1 GO:0045054 constitutive secretory pathway(GO:0045054)
0.0 0.1 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.0 0.3 GO:0071494 cellular response to UV-C(GO:0071494)
0.0 0.2 GO:1904426 positive regulation of GTP binding(GO:1904426)
0.0 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0 0.5 GO:0018410 C-terminal protein amino acid modification(GO:0018410)
0.0 0.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 0.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.2 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 0.1 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.2 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.1 GO:0019516 lactate oxidation(GO:0019516)
0.0 0.1 GO:1990839 response to endothelin(GO:1990839) cellular response to endothelin(GO:1990859)
0.0 0.1 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.3 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0 0.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.0 0.1 GO:0010847 regulation of chromatin assembly(GO:0010847)
0.0 0.1 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.0 0.1 GO:0045575 basophil activation(GO:0045575)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.1 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.0 0.2 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0061055 myotome development(GO:0061055)
0.0 0.4 GO:0007097 nuclear migration(GO:0007097)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:1904976 cellular response to bleomycin(GO:1904976)
0.0 0.2 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:1990785 response to water-immersion restraint stress(GO:1990785)
0.0 0.1 GO:0006543 glutamine catabolic process(GO:0006543)
0.0 0.3 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.0 0.1 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.2 GO:0035234 ectopic germ cell programmed cell death(GO:0035234)
0.0 0.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.0 GO:0021997 neural plate axis specification(GO:0021997)
0.0 0.1 GO:0051790 short-chain fatty acid biosynthetic process(GO:0051790)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.2 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.1 GO:0046544 development of secondary male sexual characteristics(GO:0046544)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.1 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0 0.1 GO:2000688 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
0.0 0.0 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0 0.1 GO:0071283 cellular response to iron(III) ion(GO:0071283)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:1901079 positive regulation of relaxation of muscle(GO:1901079)
0.0 0.2 GO:0001302 replicative cell aging(GO:0001302)
0.0 0.0 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.0 0.1 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.1 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.0 0.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.1 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:0042998 positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0 0.2 GO:0070673 response to interleukin-18(GO:0070673)
0.0 0.1 GO:0046356 acetyl-CoA catabolic process(GO:0046356)
0.0 0.1 GO:0009957 epidermal cell fate specification(GO:0009957) regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.1 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
0.0 0.1 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.1 GO:1901143 insulin catabolic process(GO:1901143)
0.0 0.1 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.0 GO:0046952 ketone body catabolic process(GO:0046952)
0.0 0.1 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.1 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.0 0.1 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0 0.1 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.1 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.2 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.2 GO:0002313 mature B cell differentiation involved in immune response(GO:0002313)
0.0 0.1 GO:0060722 spongiotrophoblast cell proliferation(GO:0060720) cell proliferation involved in embryonic placenta development(GO:0060722) spongiotrophoblast layer developmental growth(GO:0090214)
0.0 0.1 GO:0071440 regulation of histone H3-K14 acetylation(GO:0071440) positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0 0.2 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.1 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.0 0.0 GO:0060084 synaptic transmission involved in micturition(GO:0060084)
0.0 0.2 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.1 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0 0.0 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.2 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.1 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.1 GO:0015074 DNA integration(GO:0015074)
0.0 0.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.2 GO:0006968 cellular defense response(GO:0006968)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.0 0.0 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986) positive regulation of macrophage apoptotic process(GO:2000111)
0.0 0.0 GO:0036378 calcitriol biosynthetic process from calciol(GO:0036378)
0.0 0.2 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.1 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
0.0 0.0 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.0 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0 0.1 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
0.0 0.1 GO:0080009 mRNA methylation(GO:0080009)
0.0 0.1 GO:0035513 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.0 GO:1905063 regulation of vascular smooth muscle cell differentiation(GO:1905063)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 0.1 GO:0071000 response to magnetism(GO:0071000)
0.0 0.1 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.0 0.5 GO:2000036 regulation of stem cell population maintenance(GO:2000036)
0.0 0.1 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.1 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.2 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 0.0 GO:0035696 monocyte extravasation(GO:0035696)
0.0 0.2 GO:0060137 maternal process involved in parturition(GO:0060137)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.2 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.1 GO:0006102 isocitrate metabolic process(GO:0006102)
0.0 0.1 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.0 0.0 GO:0060383 regulation of DNA strand elongation(GO:0060382) positive regulation of DNA strand elongation(GO:0060383)
0.0 0.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.0 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.1 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.0 0.1 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0 0.1 GO:0097264 self proteolysis(GO:0097264)
0.0 0.0 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.0 0.0 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.0 0.0 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 0.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.4 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.0 GO:0006288 base-excision repair, DNA ligation(GO:0006288)
0.0 0.1 GO:0051596 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0 0.1 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)
0.0 0.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.0 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.0 0.0 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.0 GO:0080144 amino acid homeostasis(GO:0080144)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.3 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 0.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0005712 chiasma(GO:0005712)
0.0 0.3 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.2 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.0 0.2 GO:0070695 FHF complex(GO:0070695)
0.0 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.3 GO:0000796 condensin complex(GO:0000796)
0.0 0.4 GO:0000801 central element(GO:0000801)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.3 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 0.1 GO:0070522 ERCC4-ERCC1 complex(GO:0070522)
0.0 0.1 GO:0097196 Shu complex(GO:0097196)
0.0 0.2 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.2 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0032389 MutLalpha complex(GO:0032389)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.2 GO:0001652 granular component(GO:0001652)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.1 GO:0005962 mitochondrial isocitrate dehydrogenase complex (NAD+)(GO:0005962) isocitrate dehydrogenase complex (NAD+)(GO:0045242)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
0.0 0.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 0.1 GO:0035838 growing cell tip(GO:0035838)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.2 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 0.1 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.1 GO:0097361 CIA complex(GO:0097361)
0.0 0.1 GO:0010009 cytoplasmic side of endosome membrane(GO:0010009)
0.0 0.1 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0 0.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.2 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.1 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 0.1 GO:0030991 intraciliary transport particle A(GO:0030991)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0035061 interchromatin granule(GO:0035061)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.1 GO:0044194 cytolytic granule(GO:0044194)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0036396 MIS complex(GO:0036396)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.0 GO:0070939 Dsl1p complex(GO:0070939) RZZ complex(GO:1990423)
0.0 0.0 GO:0098835 presynaptic endocytic zone(GO:0098833) presynaptic endocytic zone membrane(GO:0098835)
0.0 0.0 GO:0070552 BRISC complex(GO:0070552)
0.0 0.0 GO:0034657 GID complex(GO:0034657)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 0.0 GO:0070421 DNA ligase III-XRCC1 complex(GO:0070421)
0.0 0.0 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0 0.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.1 GO:0005879 axonemal microtubule(GO:0005879)
0.0 0.0 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0035068 micro-ribonucleoprotein complex(GO:0035068) RISC-loading complex(GO:0070578)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0102390 mycophenolic acid acyl-glucuronide esterase activity(GO:0102390)
0.1 0.4 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.1 GO:0032138 single base insertion or deletion binding(GO:0032138)
0.1 0.5 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 0.3 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 0.4 GO:0097001 ceramide binding(GO:0097001)
0.1 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.1 GO:0004825 methionine-tRNA ligase activity(GO:0004825)
0.0 0.4 GO:0003958 NADPH-hemoprotein reductase activity(GO:0003958)
0.0 0.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698) histone kinase activity (H3-T6 specific)(GO:0035403)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 0.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.0 0.1 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity(GO:0004315)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.1 GO:0030977 taurine binding(GO:0030977)
0.0 0.1 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.0 0.1 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.3 GO:0001055 RNA polymerase II activity(GO:0001055)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.3 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.5 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.0 0.1 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0030626 U12 snRNA binding(GO:0030626)
0.0 0.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0 0.1 GO:0031559 lanosterol synthase activity(GO:0000250) oxidosqualene cyclase activity(GO:0031559)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173) L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.1 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.0 0.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.3 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.4 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.2 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.2 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0055105 ubiquitin-protein transferase inhibitor activity(GO:0055105)
0.0 0.1 GO:0019797 procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0 0.2 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.0 0.1 GO:0015154 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 0.1 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.0 0.1 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.0 0.1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.0 0.1 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.2 GO:0004331 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.0 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.1 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.0 0.1 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 0.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0033192 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.2 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.2 GO:0016805 dipeptidase activity(GO:0016805)
0.0 0.0 GO:0004793 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0 0.1 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.1 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.0 0.1 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.1 GO:0016936 galactoside binding(GO:0016936)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.1 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.0 0.0 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0048039 ubiquinone binding(GO:0048039)
0.0 0.0 GO:0001884 pyrimidine nucleoside binding(GO:0001884)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.0 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.0 0.0 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.0 0.0 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.0 0.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.0 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.0 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)
0.0 0.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 0.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.1 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)
0.0 0.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 0.5 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.0 GO:0070644 vitamin D response element binding(GO:0070644)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.3 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.5 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 0.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.2 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.3 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME ACTIVATION OF CHAPERONES BY ATF6 ALPHA Genes involved in Activation of Chaperones by ATF6-alpha
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.3 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.0 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.3 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.3 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.2 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.3 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.2 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.2 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.1 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.3 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 0.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.2 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex