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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nr1h4

Z-value: 0.36

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Transcription factors associated with Nr1h4

Gene Symbol Gene ID Gene Info
ENSRNOG00000007197 nuclear receptor subfamily 1, group H, member 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h4rn6_v1_chr7_-_30105132_301051320.913.1e-02Click!

Activity profile of Nr1h4 motif

Sorted Z-values of Nr1h4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_55178289 0.20 ENSRNOT00000059127
crystallin, alpha B
chr15_-_25521393 0.19 ENSRNOT00000085910
orthodenticle homeobox 2
chr14_+_83724933 0.14 ENSRNOT00000029848
phospholipase A2, group III
chr1_-_89488223 0.13 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr2_+_187740531 0.12 ENSRNOT00000092653
progestin and adipoQ receptor family member 6
chr15_-_25505691 0.12 ENSRNOT00000074488
homeobox protein OTX2-like
chr7_+_130542202 0.12 ENSRNOT00000079501
ENSRNOT00000045647
acrosin
chr12_+_47024442 0.11 ENSRNOT00000001545
cytochrome c oxidase subunit 6A1
chr8_+_23113048 0.11 ENSRNOT00000029577
calponin 1
chr19_-_15733412 0.10 ENSRNOT00000014831
iroquois homeobox 6
chr4_+_100407658 0.10 ENSRNOT00000018562
capping actin protein, gelsolin like
chr2_-_187401786 0.10 ENSRNOT00000025624
hyaluronan and proteoglycan link protein 2
chr7_-_12609694 0.10 ENSRNOT00000093287
ENSRNOT00000079485
KISS1 receptor
chr8_-_23014499 0.09 ENSRNOT00000017820
coiled-coil domain containing 151
chr10_+_13836128 0.09 ENSRNOT00000012720
phosphoglycolate phosphatase
chr7_-_12609868 0.09 ENSRNOT00000016396
KISS1 receptor
chr18_+_57011575 0.08 ENSRNOT00000026679
interleukin 17B
chr3_+_118317761 0.08 ENSRNOT00000012700
fibroblast growth factor 7
chr9_+_69953440 0.07 ENSRNOT00000034740
eukaryotic translation elongation factor 1 beta 2
chr15_+_4475051 0.07 ENSRNOT00000008461
potassium two pore domain channel subfamily K member 16
chr4_+_61850348 0.07 ENSRNOT00000013423
aldo-keto reductase family 1, member B7
chr14_-_83776863 0.07 ENSRNOT00000026481
smoothelin
chr9_+_27068443 0.07 ENSRNOT00000017393
EF-hand domain containing 1
chr20_+_5049496 0.07 ENSRNOT00000088251
ENSRNOT00000001118
dimethylarginine dimethylaminohydrolase 2
chr10_+_14598014 0.07 ENSRNOT00000068336
TSR3, 20S rRNA accumulation
chr10_-_97756521 0.06 ENSRNOT00000045902
solute carrier family 16, member 6
chr13_+_71086745 0.06 ENSRNOT00000083366
regulator of G-protein signaling 8
chr1_+_221773254 0.06 ENSRNOT00000028646
RAS guanyl releasing protein 2
chr10_-_19715832 0.06 ENSRNOT00000040278
similar to ribosomal protein S10
chr14_+_2325308 0.06 ENSRNOT00000000072
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
chr17_-_9234766 0.06 ENSRNOT00000015893

chr9_+_74124016 0.06 ENSRNOT00000019023
carbamoyl-phosphate synthase 1
chr15_+_44441856 0.06 ENSRNOT00000018006
gonadotropin releasing hormone 1
chr12_-_30566032 0.06 ENSRNOT00000093378
glioblastoma amplified sequence
chr1_-_64099277 0.05 ENSRNOT00000084846
tRNA splicing endonuclease subunit 34
chr8_+_116857684 0.05 ENSRNOT00000026711
macrophage stimulating 1
chr6_-_136550371 0.05 ENSRNOT00000065971
retinal degeneration 3-like
chr1_+_225037737 0.05 ENSRNOT00000077959
BSCL2, seipin lipid droplet biogenesis associated
chr20_+_5441876 0.05 ENSRNOT00000092476
ribosomal protein S18
chr10_+_59539405 0.05 ENSRNOT00000077107
integrin subunit alpha E
chr1_-_170431073 0.05 ENSRNOT00000024710
hemopexin
chr10_-_56223245 0.05 ENSRNOT00000015248
sex hormone binding globulin
chr9_-_64096265 0.05 ENSRNOT00000013502
tRNA-yW synthesizing protein 5
chr9_+_64095978 0.05 ENSRNOT00000021533
matrix AAA peptidase interacting protein 1
chr14_+_88549947 0.04 ENSRNOT00000086177
heterogeneous nuclear ribonucleoprotein C
chr13_-_89619398 0.04 ENSRNOT00000058423
NADH dehydrogenase (ubiquinone) Fe-S protein 2
chr5_+_136683592 0.04 ENSRNOT00000085527
solute carrier family 6 member 9
chr16_+_6903212 0.04 ENSRNOT00000023314
transmembrane protein 110
chr12_+_2180150 0.04 ENSRNOT00000001322
syntaxin binding protein 2
chr3_-_47025128 0.04 ENSRNOT00000011682
RNA binding motif, single stranded interacting protein 1
chr19_+_24786628 0.04 ENSRNOT00000005374
GIPC PDZ domain containing family, member 1
chr3_-_55587946 0.04 ENSRNOT00000075107
ATP binding cassette subfamily B member 11
chr9_+_61655963 0.04 ENSRNOT00000040461
coenzyme Q10B
chr7_+_70580198 0.04 ENSRNOT00000083472
ENSRNOT00000008941
DNA-damage inducible transcript 3
chr7_-_12882753 0.04 ENSRNOT00000011275
ENSRNOT00000044275
basigin
chr6_+_107245820 0.04 ENSRNOT00000012757
papilin, proteoglycan-like sulfated glycoprotein
chr3_-_11810901 0.04 ENSRNOT00000071233
tetratricopeptide repeat domain 16
chr7_-_143837780 0.03 ENSRNOT00000016642
integrin subunit beta 7
chr18_-_62965538 0.03 ENSRNOT00000025164
metallophosphoesterase 1
chr14_+_24129592 0.03 ENSRNOT00000040647
similar to 60S ribosomal protein L23a
chr6_+_124123228 0.03 ENSRNOT00000005329
proteasome 26S subunit, ATPase 1
chr2_+_248649441 0.03 ENSRNOT00000067165
kynurenine aminotransferase 3
chr16_-_7007287 0.03 ENSRNOT00000041216
inter-alpha trypsin inhibitor, heavy chain 3
chr18_+_16616937 0.03 ENSRNOT00000093641
molybdenum cofactor sulfurase
chrX_+_80359555 0.03 ENSRNOT00000030692
hypothetical protein LOC681325
chr9_+_43830630 0.03 ENSRNOT00000084742
cyclic nucleotide gated channel alpha 3
chr6_-_10899200 0.03 ENSRNOT00000089104
multiple coagulation factor deficiency 2
chr8_-_25829569 0.03 ENSRNOT00000071884
dpy-19 like 2
chr12_+_22727335 0.03 ENSRNOT00000077293
zinc finger, HIT-type containing 1
chr7_-_127081704 0.03 ENSRNOT00000055893
uncharacterized LOC108351584
chr6_+_107550904 0.03 ENSRNOT00000013760
acyl-CoA thioesterase 5
chr4_+_100277391 0.03 ENSRNOT00000086820
ENSRNOT00000084281
ENSRNOT00000017927
gamma-glutamyl carboxylase
chr2_-_198439454 0.03 ENSRNOT00000028780
Fc fragment of IgG receptor Ia
chr20_+_5442390 0.03 ENSRNOT00000037499
ribosomal protein S18
chr9_+_82647071 0.02 ENSRNOT00000027135
acid sensing ion channel subunit family member 4
chr3_-_153468221 0.02 ENSRNOT00000010443
growth hormone releasing hormone
chr1_+_198409360 0.02 ENSRNOT00000013691
ENSRNOT00000091295
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr3_+_102925471 0.02 ENSRNOT00000040364
olfactory receptor 772
chr7_+_117326279 0.02 ENSRNOT00000050522
spermatogenesis and centriole associated 1
chr18_-_36579403 0.02 ENSRNOT00000025284
leucyl-tRNA synthetase
chr1_-_80617057 0.02 ENSRNOT00000080453
apolipoprotein E
chr10_+_56576428 0.02 ENSRNOT00000079237
ENSRNOT00000023291
claudin 7
chr8_+_117455262 0.02 ENSRNOT00000027520
solute carrier family 25 member 20
chr1_-_170628915 0.02 ENSRNOT00000042865
dachsous cadherin-related 1
chr16_+_35934970 0.02 ENSRNOT00000084707
ENSRNOT00000016474
polypeptide N-acetylgalactosaminyltransferase 7
chr17_-_42127678 0.02 ENSRNOT00000024196
glycosylphosphatidylinositol specific phospholipase D1
chr17_+_81280898 0.02 ENSRNOT00000057785
transmembrane protein 236
chr15_-_51839341 0.02 ENSRNOT00000011277
similar to 9930012K11Rik protein
chr3_-_151371501 0.02 ENSRNOT00000073178
family with sequence similarity 83, member C
chr15_-_52712995 0.02 ENSRNOT00000039731
ribosomal protein L31-like
chr1_+_72692105 0.02 ENSRNOT00000032439
transmembrane protein 150B
chr1_-_219259448 0.02 ENSRNOT00000024517
NADH:ubiquinone oxidoreductase core subunit V1
chr14_-_33580566 0.02 ENSRNOT00000063942
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
chr12_+_9034308 0.02 ENSRNOT00000001248
FMS-related tyrosine kinase 1
chr5_+_36024649 0.02 ENSRNOT00000013384
coenzyme Q3 methyltransferase
chr8_+_23014956 0.02 ENSRNOT00000018009
protein kinase C substrate 80K-H
chr13_-_74740458 0.02 ENSRNOT00000006548
testis expressed 35
chr6_+_126766967 0.02 ENSRNOT00000052296
cytochrome c oxidase subunit 8C
chr10_+_37582706 0.01 ENSRNOT00000007630
similar to growth and transformation-dependent protein
chr1_+_100470722 0.01 ENSRNOT00000086917
aspartate dehydrogenase domain containing
chr3_-_81911197 0.01 ENSRNOT00000066526
PR/SET domain 11
chrX_+_21696772 0.01 ENSRNOT00000043559
hydroxysteroid (17-beta) dehydrogenase 10
chr5_+_151776004 0.01 ENSRNOT00000009683
nuclear receptor subfamily 0, group B, member 2
chr10_-_46582854 0.01 ENSRNOT00000004753
sterol regulatory element binding transcription factor 1
chr1_+_100447998 0.01 ENSRNOT00000026259
leucine rich repeat containing 4B
chr3_+_4233111 0.01 ENSRNOT00000042910
lipocalin 1
chr9_+_82700468 0.01 ENSRNOT00000027227
inhibin alpha subunit
chr1_+_219833299 0.01 ENSRNOT00000087432
pyruvate carboxylase
chrX_-_15768522 0.01 ENSRNOT00000077391
forkhead box P3
chr5_-_154319629 0.01 ENSRNOT00000014415
lysophospholipase II
chr1_-_98486976 0.01 ENSRNOT00000024083
electron transfer flavoprotein beta subunit
chr10_-_109913879 0.01 ENSRNOT00000072947
similar to Lung carbonyl reductase [NADPH] (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27)
chr1_+_89215266 0.01 ENSRNOT00000093612
ENSRNOT00000084799
dermokine
chr14_+_36216002 0.01 ENSRNOT00000038506
sec1 family domain containing 2
chr6_-_59531574 0.01 ENSRNOT00000042029
similar to ribosomal protein S10
chr8_+_115151627 0.01 ENSRNOT00000064252
abhydrolase domain containing 14b
chr7_-_102298522 0.00 ENSRNOT00000006273
alpha-1-B glycoprotein
chr3_+_7051695 0.00 ENSRNOT00000013548
mitochondrial ribosomal protein S2
chr7_-_123655896 0.00 ENSRNOT00000012413
cytochrome P450, family 2, subfamily d, polypeptide 2
chr14_+_79261092 0.00 ENSRNOT00000029191
hypothetical protein LOC680039
chr16_-_7007051 0.00 ENSRNOT00000023984
inter-alpha trypsin inhibitor, heavy chain 3
chr4_-_157381105 0.00 ENSRNOT00000021670
G protein-coupled receptor 162
chr2_+_20857202 0.00 ENSRNOT00000078919
acyl-CoA thioesterase 12
chr12_-_12907771 0.00 ENSRNOT00000001412
cytohesin 3
chr4_-_117790350 0.00 ENSRNOT00000088557
N-acetyltransferase 8B
chr1_+_264741911 0.00 ENSRNOT00000019956
semaphorin 4G
chr12_+_37490584 0.00 ENSRNOT00000001401
ENSRNOT00000090831
Rab interacting lysosomal protein-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042706 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0 0.1 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.1 GO:0007341 penetration of zona pellucida(GO:0007341)
0.0 0.0 GO:0032978 protein insertion into membrane from inner side(GO:0032978)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.1 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0 0.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.0 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0 0.1 GO:0071400 cellular response to oleic acid(GO:0071400)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.1 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0043159 acrosomal matrix(GO:0043159)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.0 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.1 GO:1990005 granular vesicle(GO:1990005)
0.0 0.0 GO:1990622 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.0 0.1 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0004040 amidase activity(GO:0004040)
0.0 0.1 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0 0.1 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)