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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nr1h2

Z-value: 0.36

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Transcription factors associated with Nr1h2

Gene Symbol Gene ID Gene Info
ENSRNOG00000019812 nuclear receptor subfamily 1, group H, member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nr1h2rn6_v1_chr1_-_100559942_1005599420.761.3e-01Click!

Activity profile of Nr1h2 motif

Sorted Z-values of Nr1h2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr9_-_10047507 0.19 ENSRNOT00000072118
alkB homolog 7
chr12_-_38995570 0.18 ENSRNOT00000001806
ORAI calcium release-activated calcium modulator 1
chr1_+_88182585 0.15 ENSRNOT00000044145
Yip1 interacting factor homolog B, membrane trafficking protein
chr1_+_87180624 0.12 ENSRNOT00000056933
ENSRNOT00000027987
protein YIF1B
chr1_+_88182155 0.12 ENSRNOT00000083176
Yip1 interacting factor homolog B, membrane trafficking protein
chr1_-_80744831 0.12 ENSRNOT00000025913
B-cell CLL/lymphoma 3
chr1_+_81373340 0.12 ENSRNOT00000026814
zinc finger protein 428
chr10_-_46582854 0.11 ENSRNOT00000004753
sterol regulatory element binding transcription factor 1
chr12_+_18516946 0.10 ENSRNOT00000029485
dehydrogenase/reductase X-linked
chrX_-_13116743 0.09 ENSRNOT00000004305
MID1 interacting protein 1
chr16_+_19792838 0.09 ENSRNOT00000022938
BRISC and BRCA1 A complex member 1
chr20_+_7136007 0.08 ENSRNOT00000000580
high mobility group AT-hook 1
chr4_+_83391283 0.08 ENSRNOT00000031365
cAMP responsive element binding protein 5
chr5_-_153790157 0.07 ENSRNOT00000025051
RCAN family member 3
chr6_-_7058314 0.07 ENSRNOT00000045996
3-hydroxyanthranilate 3,4-dioxygenase
chr10_-_89084885 0.07 ENSRNOT00000027452
pleckstrin homology, MyTH4 and FERM domain containing H3
chr4_-_165629996 0.07 ENSRNOT00000068185
ENSRNOT00000007427
Y box binding protein 3
chr13_+_52553775 0.06 ENSRNOT00000011991
cysteine and glycine-rich protein 1
chr10_+_86860685 0.06 ENSRNOT00000084644
retinoic acid receptor, alpha
chrX_+_13117239 0.06 ENSRNOT00000088998

chr7_-_11963268 0.06 ENSRNOT00000080342
ENSRNOT00000025266
casein kinase 1, gamma 2
chr9_+_45672157 0.06 ENSRNOT00000017882
phosducin-like 3
chr12_-_46889082 0.06 ENSRNOT00000001525
phospholipase A2 group IB
chr3_+_172195844 0.05 ENSRNOT00000034915
aminopeptidase-like 1
chr5_-_151768123 0.05 ENSRNOT00000079380
nuclear distribution C, dynein complex regulator
chr20_+_44680449 0.05 ENSRNOT00000000728
Traf3 interacting protein 2
chr1_-_221507181 0.05 ENSRNOT00000093048
ADP-ribosylation factor like GTPase 2
chr12_+_52356832 0.05 ENSRNOT00000050252
fibrosin-like 1
chr2_-_140464607 0.05 ENSRNOT00000058190
NADH:ubiquinone oxidoreductase subunit C1
chr10_-_56558487 0.05 ENSRNOT00000023256
solute carrier family 2 member 4
chr2_+_30685840 0.05 ENSRNOT00000031385
coiled-coil domain containing 125
chr20_-_22459025 0.05 ENSRNOT00000000792
early growth response 2
chr10_-_62273119 0.04 ENSRNOT00000004322
serpin family F member 2
chr1_-_80689171 0.04 ENSRNOT00000045574
basal cell adhesion molecule (Lutheran blood group)
chr4_+_84597323 0.04 ENSRNOT00000074054
ENSRNOT00000012755
WAS/WASL interacting protein family, member 3
chr5_+_157423213 0.04 ENSRNOT00000023431
transmembrane and coiled-coil domains 4
chr10_+_40438356 0.04 ENSRNOT00000078910
GM2 ganglioside activator
chr7_+_141034982 0.04 ENSRNOT00000091050
transmembrane BAX inhibitor motif containing 6
chr17_-_43675934 0.04 ENSRNOT00000081345
histone cluster 1 H1 family member t
chr18_+_3565166 0.04 ENSRNOT00000039377
RIO kinase 3
chr12_-_22006533 0.03 ENSRNOT00000059593
Uncharacterized protein C7orf61 homolog
chr9_-_71313940 0.03 ENSRNOT00000019670
methyltransferase like 21A
chr13_-_92089980 0.03 ENSRNOT00000036040
myeloid cell nuclear differentiation antigen
chr3_+_150910398 0.03 ENSRNOT00000055310
tumor protein p53 inducible nuclear protein 2
chr7_-_144269486 0.03 ENSRNOT00000090051
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr3_-_94808861 0.03 ENSRNOT00000038464
proline rich and Gla domain 4
chr2_-_196415530 0.03 ENSRNOT00000064238
similar to hypothetical protein FLJ20519
chr20_-_7208292 0.03 ENSRNOT00000083169
nudix hydrolase 3
chr5_-_138470096 0.03 ENSRNOT00000011392
phosphopantothenoylcysteine synthetase
chr1_-_188407132 0.03 ENSRNOT00000073233
glycerophosphodiester phosphodiesterase 1
chr15_-_56970365 0.03 ENSRNOT00000047192
leucine rich repeats and calponin homology domain containing 1
chr7_-_58286770 0.03 ENSRNOT00000005258
RAB21, member RAS oncogene family
chrX_+_22788660 0.03 ENSRNOT00000071886

chr14_+_80195715 0.03 ENSRNOT00000010784
SH3 domain and tetratricopeptide repeats 1
chr1_-_24191908 0.02 ENSRNOT00000061157
serum/glucocorticoid regulated kinase 1
chr19_+_25969255 0.02 ENSRNOT00000004370
phenylalanyl-tRNA synthetase, alpha subunit
chr1_-_199177365 0.02 ENSRNOT00000041840
cardiotrophin 2
chr3_-_123206828 0.02 ENSRNOT00000030192
DDRGK domain containing 1
chr1_+_140477868 0.02 ENSRNOT00000025008
mitochondrial ribosomal protein S11
chr1_-_153096269 0.02 ENSRNOT00000022578
transmembrane protein 135
chr5_-_157758084 0.02 ENSRNOT00000083341
PQ loop repeat containing 2
chr3_-_5452156 0.02 ENSRNOT00000006699
surfeit 6
chr4_-_170167633 0.02 ENSRNOT00000007402
WW domain-binding protein 11-like 1
chr12_+_41543696 0.02 ENSRNOT00000079639
two pore segment channel 1
chr11_-_87236445 0.02 ENSRNOT00000057806
testis-specific serine kinase 2
chr1_-_140477796 0.02 ENSRNOT00000067172
mitochondrial ribosomal protein L46
chr6_+_145770662 0.02 ENSRNOT00000088969
cell division cycle associated 7 like
chr11_-_55240241 0.02 ENSRNOT00000064614
developmental pluripotency associated 4
chr2_+_187740531 0.02 ENSRNOT00000092653
progestin and adipoQ receptor family member 6
chr9_+_81631409 0.02 ENSRNOT00000089580
paroxysmal nonkinesigenic dyskinesia
chr13_+_34483876 0.02 ENSRNOT00000092998
cytoplasmic linker associated protein 1
chr4_-_145390447 0.02 ENSRNOT00000091965
ENSRNOT00000012136
cell death-inducing DFFA-like effector c
chr20_+_28920616 0.02 ENSRNOT00000070897
prolyl 4-hydroxylase subunit alpha 1
chr1_+_227670159 0.02 ENSRNOT00000072077
membrane-spanning 4-domains, subfamily A, member 6C
chr16_+_20824864 0.02 ENSRNOT00000092293
ENSRNOT00000092446
UPF1, RNA helicase and ATPase
chr1_+_247688789 0.02 ENSRNOT00000021783
RIC1 homolog, RAB6A GEF complex partner 1
chr1_-_216920625 0.02 ENSRNOT00000028119
oxysterol binding protein-like 5
chr3_+_38742072 0.02 ENSRNOT00000006774
ADP ribosylation factor like GTPase 6 interacting protein 6
chr1_-_216744066 0.02 ENSRNOT00000087961
nucleosome assembly protein 1-like 4
chr7_-_144837395 0.01 ENSRNOT00000089024
chromobox 5
chr1_-_84254645 0.01 ENSRNOT00000077651
spectrin, beta, non-erythrocytic 4
chr11_-_61530830 0.01 ENSRNOT00000059666
ENSRNOT00000068345
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr13_-_90977734 0.01 ENSRNOT00000011869
SLAM family member 8
chr1_-_72335855 0.01 ENSRNOT00000021613
coiled-coil domain containing 106
chr20_+_21316826 0.01 ENSRNOT00000000785
similar to RIKEN cDNA 1700040L02
chr9_-_16647458 0.01 ENSRNOT00000024380
mitochondrial ribosomal protein L2
chr17_+_507377 0.01 ENSRNOT00000023638
aminopeptidase O
chr9_+_53626592 0.01 ENSRNOT00000031267
major facilitator superfamily domain containing 6
chr19_-_10653800 0.01 ENSRNOT00000022128
C-X3-C motif chemokine ligand 1
chr3_-_161322289 0.01 ENSRNOT00000022594
phospholipid transfer protein
chr3_+_128756799 0.01 ENSRNOT00000049855
ENSRNOT00000042853
phospholipase C, beta 4
chr8_+_61901128 0.01 ENSRNOT00000033209
similar to taste receptor protein 1
chr14_+_11095163 0.01 ENSRNOT00000003076
transmembrane protein 150C
chr7_-_11330278 0.01 ENSRNOT00000027730
megakaryocyte-associated tyrosine kinase
chr1_+_244630377 0.01 ENSRNOT00000016740
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr12_-_6703979 0.01 ENSRNOT00000061246
testis expressed 26
chr9_+_16647598 0.01 ENSRNOT00000087413
kinesin light chain 4
chr4_+_162392869 0.01 ENSRNOT00000047790
C-type lectin domain family 2, member D
chr10_-_15346236 0.01 ENSRNOT00000088104
ENSRNOT00000027430
calpain 15
chrX_+_26294066 0.01 ENSRNOT00000037862
holocytochrome c synthase
chr3_-_9936352 0.01 ENSRNOT00000011224
ENSRNOT00000042798
formin binding protein 1
chr5_+_136406130 0.01 ENSRNOT00000093099
ERI1 exoribonuclease family member 3
chr12_+_10254951 0.01 ENSRNOT00000061129
G protein-coupled receptor 12
chr6_-_129509720 0.01 ENSRNOT00000006131
autophagy related 2B
chr10_+_65507364 0.01 ENSRNOT00000016297
stromal cell derived factor 2
chr4_-_117607428 0.01 ENSRNOT00000021243
probable N-acetyltransferase CML6
chr10_-_4910305 0.01 ENSRNOT00000033122
RecQ mediated genome instability 2
chr7_+_106535434 0.01 ENSRNOT00000045357
EFR3 homolog A
chr4_-_90882285 0.01 ENSRNOT00000039247
synuclein alpha
chrX_+_106823491 0.01 ENSRNOT00000045997
brain expressed X-linked 3
chr2_-_188561267 0.01 ENSRNOT00000089781
ENSRNOT00000092093
tripartite motif-containing 46
chr11_-_43992598 0.00 ENSRNOT00000002260
claudin domain containing 1
chr18_-_57866741 0.00 ENSRNOT00000025790
F-box protein 38
chr16_-_81797815 0.00 ENSRNOT00000026666
protein Z, vitamin K-dependent plasma glycoprotein
chr1_+_252375933 0.00 ENSRNOT00000078405
lipase, family member N
chr10_-_82785142 0.00 ENSRNOT00000005381
sarcoglycan, alpha
chr16_+_47368768 0.00 ENSRNOT00000017966
WW and C2 domain containing 2
chr1_-_156296161 0.00 ENSRNOT00000025653
CREB/ATF bZIP transcription factor
chr13_-_111765944 0.00 ENSRNOT00000073041
synaptotagmin 14
chr4_-_117790350 0.00 ENSRNOT00000088557
N-acetyltransferase 8B
chr11_+_38035611 0.00 ENSRNOT00000087603
ENSRNOT00000002695
MX dynamin like GTPase 2
chr13_-_82758004 0.00 ENSRNOT00000003932
ATPase Na+/K+ transporting subunit beta 1
chr4_+_117371659 0.00 ENSRNOT00000045735
ALMS1, centrosome and basal body associated protein
chr10_+_66509107 0.00 ENSRNOT00000017230
similar to ubiquitin-like/S30 ribosomal fusion protein
chr20_+_13827660 0.00 ENSRNOT00000093131
D-dopachrome tautomerase
chr11_-_78341349 0.00 ENSRNOT00000068116
tumor protein p63
chr6_+_99444013 0.00 ENSRNOT00000058642
protein phosphatase 1, regulatory subunit 36
chr5_-_78376032 0.00 ENSRNOT00000075916
aminolevulinate dehydratase
chr20_-_8019020 0.00 ENSRNOT00000033119
FK506 binding protein 5
chr4_-_164015365 0.00 ENSRNOT00000078121
immunoreceptor Ly49si2
chr10_-_86355006 0.00 ENSRNOT00000075076
post-GPI attachment to proteins 3
chr1_-_94669461 0.00 ENSRNOT00000020474
POP4 homolog, ribonuclease P/MRP subunit
chr14_+_1462358 0.00 ENSRNOT00000077243
colony stimulating factor 2 receptor alpha subunit

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr1h2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0 0.1 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.1 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.0 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.0 0.1 GO:0003062 regulation of heart rate by chemical signal(GO:0003062)
0.0 0.0 GO:0021593 rhombomere morphogenesis(GO:0021593)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0032810 sterol response element binding(GO:0032810)
0.0 0.1 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels