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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx3-1

Z-value: 0.35

Motif logo

Transcription factors associated with Nkx3-1

Gene Symbol Gene ID Gene Info
ENSRNOG00000015477 NK3 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx3-1rn6_v1_chr15_+_51065316_510653160.632.5e-01Click!

Activity profile of Nkx3-1 motif

Sorted Z-values of Nkx3-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_80860195 0.12 ENSRNOT00000038651
tRNA aspartic acid methyltransferase 1
chr3_+_176821652 0.10 ENSRNOT00000055030
regulator of telomere elongation helicase 1
chr13_+_90723092 0.09 ENSRNOT00000010146
ATP-sensitive inward rectifier potassium channel 10
chr2_+_43271092 0.08 ENSRNOT00000017571
mesoderm induction early response 1, family member 3
chr10_-_89958805 0.08 ENSRNOT00000084266
membrane palmitoylated protein 3
chr12_+_29266602 0.08 ENSRNOT00000076194
Williams-Beuren syndrome chromosome region 17
chr15_-_55209342 0.08 ENSRNOT00000021752
RB transcriptional corepressor 1
chr18_-_36513317 0.07 ENSRNOT00000025453
PLAC8-like 1
chr6_+_27887797 0.07 ENSRNOT00000015827
additional sex combs like 2, transcriptional regulator
chr1_+_80954858 0.06 ENSRNOT00000030440
zinc finger protein 112
chr2_-_49170025 0.06 ENSRNOT00000060595
poly (ADP-ribose) polymerase family, member 8
chr17_-_32015071 0.06 ENSRNOT00000070876
leukocyte elastase inhibitor A-like
chr2_+_55747318 0.06 ENSRNOT00000050655
DAB2, clathrin adaptor protein
chr8_+_19886382 0.06 ENSRNOT00000034254
zinc finger protein 317
chr8_-_118696187 0.05 ENSRNOT00000056141
kelch-like family member 18
chr8_-_13906355 0.05 ENSRNOT00000029634
centrosomal protein 295
chr1_-_277939039 0.05 ENSRNOT00000079579
ENSRNOT00000086726
actin-binding LIM protein 1
chr2_+_189714754 0.05 ENSRNOT00000086285
GATA zinc finger domain containing 2B
chr8_+_99894762 0.05 ENSRNOT00000081768
phospholipid scramblase 4
chr1_+_13595295 0.05 ENSRNOT00000079250
NHS-like 1
chr9_-_65957101 0.05 ENSRNOT00000014094
membrane palmitoylated protein 4
chr12_+_37878653 0.05 ENSRNOT00000091084
phosphatidylinositol transfer protein, membrane-associated 2
chr17_-_89923423 0.05 ENSRNOT00000076964
acyl-CoA binding domain containing 5
chr1_+_263448633 0.05 ENSRNOT00000064510
ectonucleoside triphosphate diphosphohydrolase 7
chr16_-_21473808 0.05 ENSRNOT00000066776
zinc finger protein 964
chrX_+_15114892 0.05 ENSRNOT00000078168
WD repeat domain 13
chr19_+_9668186 0.05 ENSRNOT00000016563
CCR4-NOT transcription complex, subunit 1
chr5_-_166695134 0.05 ENSRNOT00000047763
transmembrane protein 201
chr17_-_69862110 0.05 ENSRNOT00000058312
aldo-keto reductase family 1, member C-like
chrX_+_159081445 0.04 ENSRNOT00000056688

chr8_-_36388224 0.04 ENSRNOT00000038312
TIR domain containing adaptor protein
chr15_-_88670349 0.04 ENSRNOT00000012881
ring finger protein 219
chr14_+_108415068 0.04 ENSRNOT00000083763
pseudouridylate synthase 10
chr3_+_112371677 0.04 ENSRNOT00000013316
HAUS augmin-like complex subunit 2-like
chr8_-_93390305 0.04 ENSRNOT00000056930
inhibitor of Bruton tyrosine kinase
chr16_+_20039969 0.04 ENSRNOT00000024866
collagen beta(1-O)galactosyltransferase 1
chr6_+_126874193 0.04 ENSRNOT00000011775
unc-79 homolog (C. elegans)
chr7_-_134482607 0.04 ENSRNOT00000081104
glucoside xylosyltransferase 1
chr6_+_26390689 0.04 ENSRNOT00000079762
ENSRNOT00000091528
intraflagellar transport 172
chr18_+_30904498 0.04 ENSRNOT00000026969
protocadherin gamma subfamily A, 11
chr18_-_35817117 0.04 ENSRNOT00000015172
ENSRNOT00000085714
mutated in colorectal cancers
chr15_+_47455690 0.04 ENSRNOT00000075276
serine protease 55-like
chr6_+_2216623 0.04 ENSRNOT00000008045
regulator of microtubule dynamics 2
chr16_+_53998560 0.04 ENSRNOT00000077188
ENSRNOT00000013463
N-acylsphingosine amidohydrolase 1
chr3_+_112385601 0.04 ENSRNOT00000056210
similar to Centrosomal protein of 27 kDa (Cep27 protein)
chr13_+_98311827 0.04 ENSRNOT00000082844
CDC42 binding protein kinase alpha
chr3_+_172155496 0.04 ENSRNOT00000066279
syntaxin 16
chr5_+_135413275 0.04 ENSRNOT00000012263
GC-rich promoter binding protein 1-like 1
chrX_-_40086870 0.04 ENSRNOT00000010027
small muscle protein, X-linked
chr5_+_139783951 0.04 ENSRNOT00000081333
regulating synaptic membrane exocytosis 3
chr13_+_71110064 0.04 ENSRNOT00000088329
regulator of G-protein signaling 8
chr13_-_26769374 0.04 ENSRNOT00000003768
BCL2, apoptosis regulator
chr3_-_112371664 0.04 ENSRNOT00000079606
ENSRNOT00000012636
leucine-rich repeat-containing protein 57-like
chr3_+_151688454 0.04 ENSRNOT00000026856
reactive oxygen species modulator 1
chr3_+_80468154 0.03 ENSRNOT00000021837
cytoskeleton associated protein 5
chr2_+_197720259 0.03 ENSRNOT00000070919
golgi phosphoprotein 3-like
chr6_+_86872903 0.03 ENSRNOT00000086894
Fanconi anemia, complementation group M
chr6_+_99625306 0.03 ENSRNOT00000008573
pleckstrin homology and RhoGEF domain containing G3
chr1_+_156552328 0.03 ENSRNOT00000055401
discs large MAGUK scaffold protein 2
chr7_+_2645196 0.03 ENSRNOT00000083899
timeless circadian clock
chr16_+_54332660 0.03 ENSRNOT00000037685
microtubule associated tumor suppressor 1
chr17_-_42226377 0.03 ENSRNOT00000024536
similar to mKIAA0319 protein
chr9_+_71230108 0.03 ENSRNOT00000018326
cAMP responsive element binding protein 1
chr15_+_27933211 0.03 ENSRNOT00000013619
ribonuclease A family member 10
chr3_-_112385528 0.03 ENSRNOT00000049756
leucine rich repeat containing 57
chr2_+_86914989 0.03 ENSRNOT00000085164
ENSRNOT00000081966
zinc finger protein 457-like
chr2_-_54963448 0.03 ENSRNOT00000017886
prostaglandin E receptor 4
chr9_-_81772851 0.03 ENSRNOT00000032719
ubiquitin specific peptidase 37
chr7_-_139542461 0.03 ENSRNOT00000089425
SUMO1/sentrin specific peptidase 1
chr14_+_106153575 0.03 ENSRNOT00000010264
VPS54 GARP complex subunit
chr4_+_160020472 0.03 ENSRNOT00000078802
poly (ADP-ribose) polymerase family, member 11
chr1_-_67134827 0.03 ENSRNOT00000045214
vomeronasal 1 receptor 45
chr10_-_36419926 0.03 ENSRNOT00000004902
zinc finger protein 354B
chr16_-_9658484 0.03 ENSRNOT00000065216
mitogen-activated protein kinase 8
chr7_+_54031316 0.03 ENSRNOT00000039096
Bardet-Biedl syndrome 10
chr3_-_1868015 0.03 ENSRNOT00000048945
calcium voltage-gated channel subunit alpha1 B
chr14_+_77322012 0.03 ENSRNOT00000088600
ENSRNOT00000041639
zinc finger and BTB domain containing 49
chr5_-_159293673 0.03 ENSRNOT00000009081
peptidyl arginine deiminase 4
chr5_+_6373583 0.03 ENSRNOT00000084749

chr4_-_176596591 0.03 ENSRNOT00000086365
RecQ like helicase
chr13_+_105684420 0.03 ENSRNOT00000040543
G patch domain containing 2
chr19_+_46455761 0.03 ENSRNOT00000034012
ENSRNOT00000093392
nudix hydrolase 7
chr13_+_89524329 0.02 ENSRNOT00000004279
myelin protein zero
chr2_+_143895982 0.02 ENSRNOT00000080026
SPT20 homolog, SAGA complex component
chr3_-_64554953 0.02 ENSRNOT00000067452
serine/arginine repetitive matrix protein 1-like
chr11_+_87224421 0.02 ENSRNOT00000000308
DiGeorge syndrome critical region gene 14
chr2_-_231648122 0.02 ENSRNOT00000014962
ankyrin 2
chr10_+_13145099 0.02 ENSRNOT00000091287
serine/arginine repetitive matrix 2
chr7_+_40217991 0.02 ENSRNOT00000085684
centrosomal protein 290
chr3_-_71798531 0.02 ENSRNOT00000088170
calcitonin receptor like receptor
chr13_-_82295123 0.02 ENSRNOT00000090120
similar to hypothetical protein FLJ10706
chrX_+_9436707 0.02 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr2_-_39007976 0.02 ENSRNOT00000064292
zinc finger, SWIM-type containing 6
chr14_+_81858737 0.02 ENSRNOT00000029784
ENSRNOT00000058068
ENSRNOT00000058067
DNA polymerase nu
chr8_-_78397123 0.02 ENSRNOT00000087270
ENSRNOT00000084925
transcription factor 12
chr5_+_104394119 0.02 ENSRNOT00000093557
ENSRNOT00000093462
ADAMTS-like 1
chr6_-_42302254 0.02 ENSRNOT00000007071
PQ loop repeat containing 3
chr17_-_58301260 0.02 ENSRNOT00000083331
adenosine deaminase, RNA-specific, B2
chr10_-_70181708 0.02 ENSRNOT00000076598
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr14_+_48726045 0.02 ENSRNOT00000086646
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr1_-_73399579 0.02 ENSRNOT00000077186
leukocyte immunoglobulin like receptor B4
chr8_+_116826680 0.02 ENSRNOT00000026854
GDP-mannose pyrophosphorylase B
chr3_-_111266542 0.02 ENSRNOT00000031672
INO80 complex subunit
chr1_+_253221812 0.02 ENSRNOT00000085880
ENSRNOT00000054753
kinesin family member 20B
chr11_+_42936028 0.02 ENSRNOT00000074653

chr7_+_74350479 0.02 ENSRNOT00000089034

chr10_-_70681672 0.02 ENSRNOT00000013836
matrix metallopeptidase 28
chr14_+_66631690 0.02 ENSRNOT00000079658
potassium voltage-gated channel interacting protein 4
chr18_+_30820321 0.02 ENSRNOT00000060472
protocadherin gamma subfamily A, 3
chr8_+_111210811 0.02 ENSRNOT00000011347
angiomotin like 2
chr6_+_110410141 0.02 ENSRNOT00000013867
estrogen-related receptor beta
chr8_-_63750531 0.02 ENSRNOT00000009496
neogenin 1
chr10_-_65502936 0.02 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chr4_-_16669368 0.02 ENSRNOT00000007608
piccolo (presynaptic cytomatrix protein)
chr4_+_142780987 0.02 ENSRNOT00000056570
glutamate metabotropic receptor 7
chr2_-_184951950 0.02 ENSRNOT00000093486
family with sequence similarity 160, member A1
chr5_-_134776247 0.02 ENSRNOT00000057055
diencephalon/mesencephalon homeobox 1
chr2_-_203413124 0.02 ENSRNOT00000077898
ENSRNOT00000056140
CD101 molecule
chr6_-_2316717 0.02 ENSRNOT00000082017
ENSRNOT00000066363
cytochrome P450, family 1, subfamily b, polypeptide 1
chr1_+_84758233 0.02 ENSRNOT00000072734

chr1_+_30863217 0.02 ENSRNOT00000015421
ring finger protein 146
chr6_+_102477036 0.02 ENSRNOT00000087132
RAD51 paralog B
chrX_+_113510621 0.02 ENSRNOT00000025912
nuclear transport factor 2-like export factor 2
chrX_-_158261717 0.02 ENSRNOT00000086804
similar to RIKEN cDNA 1700001F22
chr14_+_3204390 0.02 ENSRNOT00000088078
glomulin, FKBP associated protein
chr13_-_95348913 0.02 ENSRNOT00000057879
AKT serine/threonine kinase 3
chr2_-_165591110 0.02 ENSRNOT00000091140
intraflagellar transport 80
chr8_-_39201588 0.02 ENSRNOT00000011226
STT3A, catalytic subunit of the oligosaccharyltransferase complex
chr8_+_117600749 0.02 ENSRNOT00000047482
NCK interacting protein with SH3 domain
chr1_+_255564409 0.02 ENSRNOT00000081786
B-TFIID TATA-box binding protein associated factor 1
chr4_+_22898527 0.02 ENSRNOT00000072455
ENSRNOT00000076123
DBF4 zinc finger
chr19_+_38162515 0.02 ENSRNOT00000027117
solute carrier family 7 member 6
chr3_-_21609853 0.02 ENSRNOT00000012160
phosducin-like
chr13_-_15395617 0.02 ENSRNOT00000046060
similar to contactin associated protein-like 5 isoform 1
chr9_-_23352668 0.02 ENSRNOT00000075279
methylmalonyl CoA mutase
chrM_+_9870 0.02 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr4_+_117743710 0.02 ENSRNOT00000021491
adducin 2
chrX_+_157759624 0.02 ENSRNOT00000003192
similar to motile sperm domain containing 1
chr12_+_12859661 0.02 ENSRNOT00000001404
ubiquitin specific peptidase 42
chr8_+_111209908 0.01 ENSRNOT00000090221
angiomotin like 2
chr18_+_3163214 0.01 ENSRNOT00000017291
RB binding protein 8, endonuclease
chr12_+_2140203 0.01 ENSRNOT00000084906
calmodulin regulated spectrin-associated protein family, member 3
chr15_-_33285779 0.01 ENSRNOT00000036150
cadherin 24
chr8_-_49269411 0.01 ENSRNOT00000021321
ubiquitination factor E4A
chr7_-_68523364 0.01 ENSRNOT00000077670
solute carrier family 16 member 7
chr1_-_126211439 0.01 ENSRNOT00000014988
tight junction protein 1
chr4_+_70572942 0.01 ENSRNOT00000051964

chr1_-_67065797 0.01 ENSRNOT00000048152
vomeronasal 1 receptor 46
chr2_-_220535751 0.01 ENSRNOT00000089082
palmdelphin
chr6_-_27460038 0.01 ENSRNOT00000036815
dynein regulatory complex subunit 1
chr2_+_53109684 0.01 ENSRNOT00000086590
selenoprotein P
chrX_+_68627313 0.01 ENSRNOT00000076699
ENSRNOT00000076795
ENSRNOT00000008705
Yip1 domain family, member 6
chr1_+_85162452 0.01 ENSRNOT00000093347
p21 (RAC1) activated kinase 4
chr10_-_31419235 0.01 ENSRNOT00000059496
cytoplasmic FMR1 interacting protein 2
chr17_+_22620721 0.01 ENSRNOT00000019478
androgen-dependent TFPI-regulating protein
chr1_+_41590494 0.01 ENSRNOT00000089984
estrogen receptor 1
chr2_+_127625683 0.01 ENSRNOT00000015474
heat shock protein 4-like
chr16_-_54137660 0.01 ENSRNOT00000085435
pericentriolar material 1
chr10_+_70520206 0.01 ENSRNOT00000088198
ENSRNOT00000090446
ENSRNOT00000085799
adaptor-related protein complex 2, beta 1 subunit
chr8_-_27852996 0.01 ENSRNOT00000037790
galactosidase, beta 1-like 2
chr19_+_37990374 0.01 ENSRNOT00000026827
dihydrouridine synthase 2
chr1_-_255976425 0.01 ENSRNOT00000085303
insulin degrading enzyme
chr2_-_211715311 0.01 ENSRNOT00000027738
pre-mRNA processing factor 38B
chr12_+_10577068 0.01 ENSRNOT00000001282
ring finger protein 6
chr10_+_90985653 0.01 ENSRNOT00000093364
coiled-coil domain containing 103
chr3_-_105470475 0.01 ENSRNOT00000011078
gap junction protein, delta 2
chr11_+_20474483 0.01 ENSRNOT00000082417
ENSRNOT00000002895
neural cell adhesion molecule 2
chrX_+_29504349 0.01 ENSRNOT00000005981
transcription elongation factor A N-terminal and central domain containing
chrX_-_64726210 0.01 ENSRNOT00000076012
ENSRNOT00000086265
ankyrin repeat and SOCS box-containing 12
chr8_+_103342929 0.01 ENSRNOT00000045455
Ab2-060
chr13_-_47623849 0.01 ENSRNOT00000006106
interleukin 24
chr4_-_140220487 0.01 ENSRNOT00000009008
sulfatase modifying factor 1
chr14_-_45859908 0.01 ENSRNOT00000086994
phosphoglucomutase 2
chr18_+_15738809 0.01 ENSRNOT00000075444
microtubule-associated protein, RP/EB family, member 2
chr10_+_67810810 0.01 ENSRNOT00000079156
proteasome 26S subunit, non-ATPase 11
chr20_-_27117663 0.01 ENSRNOT00000000434
phenazine biosynthesis-like protein domain containing 1
chr5_-_150949931 0.01 ENSRNOT00000067905
sphingomyelin phosphodiesterase, acid-like 3B
chr11_-_27094364 0.01 ENSRNOT00000050902
RWD domain containing 2B
chr20_+_3246739 0.01 ENSRNOT00000061299
RT1 class I, locus T24, gene 2
chr16_-_54137485 0.01 ENSRNOT00000014202
pericentriolar material 1
chr5_-_115184219 0.01 ENSRNOT00000045686
cytochrome P450 2J3-like
chr1_-_198354466 0.01 ENSRNOT00000027094
transmembrane protein 219
chr13_+_73708815 0.01 ENSRNOT00000071482
ENSRNOT00000077874
ENSRNOT00000050734
torsin 1A interacting protein 2
torsin 1A interacting protein 2
chr18_-_81682206 0.01 ENSRNOT00000058219
hypothetical protein LOC100359752
chr1_-_277867630 0.01 ENSRNOT00000054679
ENSRNOT00000091038
ENSRNOT00000079869
actin-binding LIM protein 1
chr19_+_43392085 0.01 ENSRNOT00000023854
splicing factor 3b, subunit 3
chr8_-_132911193 0.01 ENSRNOT00000087799
FYVE and coiled-coil domain containing 1
chr1_-_66639205 0.01 ENSRNOT00000082190
eukaryotic translation initiation factor 3 subunit E-like
chr9_-_15700235 0.01 ENSRNOT00000088713
ENSRNOT00000035907
transcriptional regulating factor 1
chr1_+_7252349 0.01 ENSRNOT00000030329
PLAG1 like zinc finger 1
chr9_-_27761365 0.01 ENSRNOT00000018552
potassium voltage-gated channel subfamily Q member 5
chr10_+_51478378 0.01 ENSRNOT00000004722
elaC ribonuclease Z 2
chr18_+_56887722 0.01 ENSRNOT00000078783
casein kinase 1, alpha 1
chr10_+_104377748 0.01 ENSRNOT00000080714
LLGL2, scribble cell polarity complex component
chr10_+_17579284 0.01 ENSRNOT00000079698
F-box and WD repeat domain containing 11
chr6_-_92398525 0.01 ENSRNOT00000007314
salvador family WW domain containing protein 1
chr2_-_60461458 0.01 ENSRNOT00000024285
BRX1, biogenesis of ribosomes
chr4_+_342302 0.01 ENSRNOT00000009233
insulin induced gene 1
chr10_+_72147816 0.01 ENSRNOT00000090085
SUMO-conjugating enzyme UBC9-like
chr8_+_13305152 0.01 ENSRNOT00000012940
MRE11 homolog A, double strand break repair nuclease

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx3-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.1 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.0 0.1 GO:1903943 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.0 0.0 GO:0034146 toll-like receptor 5 signaling pathway(GO:0034146) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0 0.1 GO:1900157 regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0 0.0 GO:0030242 pexophagy(GO:0030242)
0.0 0.0 GO:0046671 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.0 GO:1904976 cellular response to bleomycin(GO:1904976)
0.0 0.0 GO:0032916 positive regulation of transforming growth factor beta3 production(GO:0032916)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.0 0.0 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.0 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.0 0.0 GO:1990763 arrestin family protein binding(GO:1990763)