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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx2-9

Z-value: 0.46

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Transcription factors associated with Nkx2-9

Gene Symbol Gene ID Gene Info

Activity profile of Nkx2-9 motif

Sorted Z-values of Nkx2-9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_28654733 0.81 ENSRNOT00000006174
pro-melanin-concentrating hormone
chr1_+_33910912 0.24 ENSRNOT00000044690
iroquois homeobox 1
chr1_-_7801438 0.17 ENSRNOT00000022273

chr5_+_50381244 0.17 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr1_+_279798187 0.15 ENSRNOT00000024065
pancreatic lipase
chr5_-_127273656 0.14 ENSRNOT00000057341
DMRT-like family B with proline-rich C-terminal, 1
chr7_-_119441487 0.13 ENSRNOT00000067635
parvalbumin
chr8_-_61917125 0.11 ENSRNOT00000085049
similar to human chromosome 15 open reading frame 39
chr10_-_87407634 0.11 ENSRNOT00000016657
keratin 23
chr3_+_161018511 0.11 ENSRNOT00000019804
ENSRNOT00000039664
WAP four-disulfide core domain 2
chr4_-_30338679 0.10 ENSRNOT00000012050
paraoxonase 3
chr6_-_145777767 0.10 ENSRNOT00000046799
ribosomal protein L32
chr5_-_38923095 0.09 ENSRNOT00000009146

chr11_+_81358592 0.09 ENSRNOT00000002487
replication factor C subunit 4
chrM_+_7758 0.08 ENSRNOT00000046201
mitochondrially encoded ATP synthase 8
chr14_-_44375804 0.08 ENSRNOT00000042825
ribosomal protein P2-like
chr9_-_29337922 0.08 ENSRNOT00000018896
similar to RIKEN cDNA 4933415F23
chr20_-_27117663 0.07 ENSRNOT00000000434
phenazine biosynthesis-like protein domain containing 1
chrX_+_77065397 0.07 ENSRNOT00000090007
cytochrome c oxidase subunit 7B
chr9_+_69953440 0.07 ENSRNOT00000034740
eukaryotic translation elongation factor 1 beta 2
chr1_+_256786124 0.07 ENSRNOT00000034563
free fatty acid receptor 4
chr8_-_43480777 0.07 ENSRNOT00000060074
similar to 40S ribosomal protein S2
chr3_-_2798470 0.07 ENSRNOT00000022495
phosphohistidine phosphatase 1
chr12_+_22274828 0.07 ENSRNOT00000001914
erythropoietin
chr1_-_84812486 0.06 ENSRNOT00000078369

chr3_-_60813869 0.06 ENSRNOT00000058234
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr12_-_30566032 0.06 ENSRNOT00000093378
glioblastoma amplified sequence
chr11_+_60072727 0.06 ENSRNOT00000090230
transgelin 3
chr11_+_57505005 0.06 ENSRNOT00000002942
transgelin-3
chr7_+_98813040 0.06 ENSRNOT00000012616
NADH:ubiquinone oxidoreductase subunit B9
chr6_-_93562314 0.06 ENSRNOT00000010871
ENSRNOT00000088790
translocase of inner mitochondrial membrane 9
chr12_+_44046217 0.05 ENSRNOT00000080853
ENSRNOT00000079510
F-box and WD repeat domain containing 8
chr1_-_233140237 0.05 ENSRNOT00000083372
phosphoserine aminotransferase 1
chr13_+_42220251 0.05 ENSRNOT00000078185

chr14_+_46649971 0.04 ENSRNOT00000085875

chr4_-_176720012 0.04 ENSRNOT00000017965
lactate dehydrogenase B
chr8_+_89369417 0.04 ENSRNOT00000037530
meiotic double-stranded break formation protein 4
chr4_+_145413230 0.04 ENSRNOT00000056508
interleukin 17 receptor E
chr13_+_51972974 0.04 ENSRNOT00000008164
ADP-ribosylation factor like GTPase 8A
chr7_-_55604403 0.04 ENSRNOT00000088732
ataxin 7-like 3B
chr15_-_29369504 0.04 ENSRNOT00000060297

chr8_+_48406260 0.04 ENSRNOT00000009975
ubiquitin specific peptidase 2
chrX_-_15467875 0.04 ENSRNOT00000011207
Pim-2 proto-oncogene, serine/threonine kinase
chr8_+_62283336 0.04 ENSRNOT00000025410
ribonuclease P/MRP 25 subunit
chr8_-_115626380 0.04 ENSRNOT00000019107
mesencephalic astrocyte-derived neurotrophic factor
chr9_-_17254949 0.04 ENSRNOT00000026499
mitochondrial ribosomal protein S18A
chr2_+_251983339 0.03 ENSRNOT00000020230
mucolipin 3
chr4_-_145390447 0.03 ENSRNOT00000091965
ENSRNOT00000012136
cell death-inducing DFFA-like effector c
chr6_+_58467254 0.03 ENSRNOT00000065396
ets variant 1
chrX_+_128493614 0.03 ENSRNOT00000044240
stromal antigen 2
chrM_+_7919 0.03 ENSRNOT00000046108
mitochondrially encoded ATP synthase 6
chr4_-_131694755 0.03 ENSRNOT00000013271
forkhead box P1
chr9_+_66058047 0.03 ENSRNOT00000071819
cyclin-dependent kinase 15
chr10_-_31493419 0.03 ENSRNOT00000009211
IL2-inducible T-cell kinase
chr14_+_108826831 0.03 ENSRNOT00000083146
ENSRNOT00000009421
B-cell CLL/lymphoma 11A
chr2_+_205525204 0.03 ENSRNOT00000091210
cold shock domain containing E1
chr15_-_28696122 0.03 ENSRNOT00000060467
RAB2B, member RAS oncogene family
chr7_+_35773928 0.03 ENSRNOT00000034639
centrosomal protein 83
chr6_-_138662365 0.03 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr2_-_23260965 0.03 ENSRNOT00000046772
60S ribosomal protein L36 pseudogene
chrX_-_16526028 0.03 ENSRNOT00000093647
diacylglycerol kinase kappa
chr1_-_90091287 0.02 ENSRNOT00000032613
glucose-6-phosphate isomerase
chr2_-_241472694 0.02 ENSRNOT00000051498
B-cell scaffold protein with ankyrin repeats 1
chr3_-_113342675 0.02 ENSRNOT00000020130
stereocilin
chr20_+_41184287 0.02 ENSRNOT00000081117
collagen type X alpha 1 chain
chrX_-_152367861 0.02 ENSRNOT00000089414
melanoma-associated antigen 10-like
chr1_-_174047572 0.02 ENSRNOT00000019597
serine/threonine kinase 33
chr12_+_48101673 0.02 ENSRNOT00000065060
forkhead box N4
chr17_+_54280851 0.02 ENSRNOT00000024022
Rho GTPase activating protein 12
chr10_+_15241590 0.02 ENSRNOT00000037372
ENSRNOT00000037381
methyltransferase like 26
chr7_+_141355994 0.02 ENSRNOT00000081195
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chrX_-_64908682 0.02 ENSRNOT00000084107
zinc finger C4H2-type containing
chr19_-_14945302 0.02 ENSRNOT00000079391

chr5_-_107388182 0.01 ENSRNOT00000058358
interferon alpha-1-like
chr9_+_81644355 0.01 ENSRNOT00000071700
ciliogenesis associated TTC17 interacting protein
chr15_+_28696378 0.01 ENSRNOT00000017476
TOX high mobility group box family member 4
chr20_-_4132604 0.01 ENSRNOT00000077630
ENSRNOT00000048332
RT1 class II, locus Da
chr20_+_3364814 0.01 ENSRNOT00000001077
hypothetical protein MGC:15854
chrX_-_81817101 0.01 ENSRNOT00000003730

chr5_-_153184940 0.01 ENSRNOT00000079536
transmembrane protein 57
chr15_+_58170967 0.01 ENSRNOT00000001366
NUFIP1, FMR1 interacting protein 1
chr8_-_39266959 0.01 ENSRNOT00000046590
EI24, autophagy associated transmembrane protein
chr18_-_52017734 0.01 ENSRNOT00000081020
membrane associated ring-CH-type finger 3
chr1_-_90961717 0.01 ENSRNOT00000071180
alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
chr5_-_73494030 0.01 ENSRNOT00000022291
actin-like 7b
chr1_-_197778490 0.01 ENSRNOT00000024185
SPNS sphingolipid transporter 1
chr7_+_142106465 0.01 ENSRNOT00000042786
ENSRNOT00000088681
LETM1 domain containing 1
chr17_-_52569036 0.01 ENSRNOT00000019396
GLI family zinc finger 3
chr17_+_47721977 0.01 ENSRNOT00000080800
amphiphysin-like
chr18_+_30010918 0.01 ENSRNOT00000084132
protocadherin alpha 4
chr19_-_41010122 0.00 ENSRNOT00000088770
Vac14, PIKFYVE complex component
chr11_-_67037115 0.00 ENSRNOT00000003137
immunoglobulin-like domain containing receptor 1
chrX_-_23649466 0.00 ENSRNOT00000059431
shroom family member 2
chr8_+_50525091 0.00 ENSRNOT00000074357
apolipoprotein A1
chr9_+_81427730 0.00 ENSRNOT00000019109
ENSRNOT00000081711
C-X-C motif chemokine receptor 2
chrX_+_71155894 0.00 ENSRNOT00000076479
forkhead box O4
chr8_+_85951191 0.00 ENSRNOT00000037665
CD109 molecule
chr1_+_46779860 0.00 ENSRNOT00000075268
sorting nexin 9
chr12_-_11144754 0.00 ENSRNOT00000084637
zinc finger protein 655

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 0.2 GO:0072268 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.0 0.1 GO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0 0.1 GO:0009804 coumarin metabolic process(GO:0009804) negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0046884 thyroid hormone generation(GO:0006590) follicle-stimulating hormone secretion(GO:0046884)
0.0 0.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones