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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx2-2

Z-value: 0.42

Motif logo

Transcription factors associated with Nkx2-2

Gene Symbol Gene ID Gene Info
ENSRNOG00000012728 NK2 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-2rn6_v1_chr3_-_141411170_141411170-0.622.7e-01Click!

Activity profile of Nkx2-2 motif

Sorted Z-values of Nkx2-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_28654733 0.89 ENSRNOT00000006174
pro-melanin-concentrating hormone
chr14_-_37770059 0.15 ENSRNOT00000029721
solute carrier family 10, member 4
chr2_+_71753816 0.14 ENSRNOT00000025809

chr20_-_22459025 0.12 ENSRNOT00000000792
early growth response 2
chr14_+_88549947 0.11 ENSRNOT00000086177
heterogeneous nuclear ribonucleoprotein C
chr4_-_120414118 0.11 ENSRNOT00000072795
40S ribosomal protein S25-like
chr10_-_13780283 0.10 ENSRNOT00000084200

chr1_-_227047290 0.10 ENSRNOT00000037226
membrane spanning 4-domains A15
chr4_-_129430251 0.10 ENSRNOT00000067881
family with sequence similarity 19 member A4, C-C motif chemokine like
chr4_+_6903198 0.10 ENSRNOT00000012285
crystallin, gamma N
chr8_+_82288705 0.10 ENSRNOT00000012409
BCL2 like 10
chr6_+_133552821 0.09 ENSRNOT00000006339
delta like non-canonical Notch ligand 1
chr20_-_4366957 0.08 ENSRNOT00000088244
ring finger protein 5
chr20_-_48310175 0.08 ENSRNOT00000000351
translocase of inner mitochondrial membrane 10B
chr6_+_3375476 0.08 ENSRNOT00000045349
eukaryotic translation initiation factor 1-like
chr17_+_27452638 0.08 ENSRNOT00000038349
cancer antigen 1
chr10_+_14258380 0.08 ENSRNOT00000021650
NME/NM23 nucleoside diphosphate kinase 3
chr5_-_155709215 0.08 ENSRNOT00000018118
cell division cycle 42
chr12_+_37668369 0.07 ENSRNOT00000001419
cyclin-dependent kinase 2 associated protein 1
chr9_+_94928489 0.07 ENSRNOT00000087366
ENSRNOT00000085770
ENSRNOT00000024733
S-antigen visual arrestin
chr9_-_121972055 0.07 ENSRNOT00000089735
clusterin-like protein 1
chr2_+_207350651 0.07 ENSRNOT00000019129
suppression of tumorigenicity 7-like
chr5_-_61077627 0.07 ENSRNOT00000015338
SH2 domain containing adaptor protein B
chr14_-_44375804 0.07 ENSRNOT00000042825
ribosomal protein P2-like
chr5_+_10125070 0.07 ENSRNOT00000085321

chr14_-_43992587 0.07 ENSRNOT00000003425
ras homolog family member H
chr4_-_28437676 0.07 ENSRNOT00000012995
HEPACAM family member 2
chr18_-_86279680 0.07 ENSRNOT00000006169
hypothetical protein LOC689166
chr17_+_44763598 0.07 ENSRNOT00000079880
histone cluster 1, H3b
chr1_+_227670159 0.07 ENSRNOT00000072077
membrane-spanning 4-domains, subfamily A, member 6C
chr14_-_18531179 0.06 ENSRNOT00000003703
amphiregulin
chr5_+_144031402 0.06 ENSRNOT00000011694
colony stimulating factor 3 receptor
chr6_+_8669722 0.06 ENSRNOT00000048550
calmodulin-lysine N-methyltransferase
chr17_+_85500113 0.06 ENSRNOT00000091937

chr18_-_74151950 0.06 ENSRNOT00000023101
HAUS augmin-like complex, subunit 1
chr1_+_169145445 0.06 ENSRNOT00000034019
hypothetical protein LOC499219
chr2_-_98610368 0.06 ENSRNOT00000011641
zinc finger homeobox 4
chr10_+_40247436 0.06 ENSRNOT00000079830
glutathione peroxidase 3
chr13_-_52136127 0.06 ENSRNOT00000009398
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr4_-_120041238 0.06 ENSRNOT00000073799
40S ribosomal protein S25-like
chr1_+_98398660 0.06 ENSRNOT00000047473
CD33 molecule
chr8_+_79054237 0.06 ENSRNOT00000077613
meiosis-specific nuclear structural 1
chr3_+_149466770 0.06 ENSRNOT00000065104
BPI fold containing family A, member 6
chr19_+_56220755 0.06 ENSRNOT00000023452
tubulin, beta 3 class III
chr20_+_13827132 0.06 ENSRNOT00000001664
D-dopachrome tautomerase
chr14_+_88543630 0.06 ENSRNOT00000060515
heterogeneous nuclear ribonucleoprotein C
chr20_-_4542947 0.06 ENSRNOT00000086140
complement factor B
chr2_+_207351051 0.06 ENSRNOT00000084302
suppression of tumorigenicity 7-like
chr7_-_29949603 0.06 ENSRNOT00000009419
60S ribosomal protein L9 pseudogene
chr1_+_175445088 0.06 ENSRNOT00000036718
adrenomedullin
chr1_+_101410019 0.05 ENSRNOT00000042039
luteinizing hormone beta polypeptide
chr1_-_104202591 0.05 ENSRNOT00000035512
E2F transcription factor 8
chr7_-_68512397 0.05 ENSRNOT00000058036
solute carrier family 16 member 7
chr10_+_14062331 0.05 ENSRNOT00000029652
NADPH oxidase organizer 1
chr1_-_211956858 0.05 ENSRNOT00000054886
cilia and flagella associated protein 46
chr13_-_89433815 0.05 ENSRNOT00000091541
Fc fragment of IgG receptor IIb
chr10_-_39405311 0.05 ENSRNOT00000074616
PDZ and LIM domain 4
chr1_-_80716143 0.05 ENSRNOT00000092048
ENSRNOT00000025829
Cbl proto-oncogene C
chr1_-_44474674 0.05 ENSRNOT00000078768
transcription factor B1, mitochondrial
chr15_+_4850122 0.05 ENSRNOT00000071133
G protein subunit gamma 2
chrX_+_78259409 0.05 ENSRNOT00000049779
similar to RIKEN cDNA A630033H20 gene
chr20_-_4391402 0.05 ENSRNOT00000090518
ENSRNOT00000083489
palmitoyl-protein thioesterase 2
chr6_-_22138286 0.05 ENSRNOT00000007607
Yip1 domain family, member 4
chr1_-_233140237 0.05 ENSRNOT00000083372
phosphoserine aminotransferase 1
chr1_-_196883051 0.05 ENSRNOT00000055034
NSE1 homolog, SMC5-SMC6 complex component
chr2_-_154763094 0.05 ENSRNOT00000031015
vomeronasal 2 receptor, 46
chr19_-_9843673 0.05 ENSRNOT00000015795
GINS complex subunit 3
chr1_+_7252349 0.05 ENSRNOT00000030329
PLAG1 like zinc finger 1
chr11_+_32450587 0.05 ENSRNOT00000061235
small integral membrane protein 11
chr2_-_91497091 0.05 ENSRNOT00000015185
proprotein convertase subtilisin/kexin type 1
chr2_-_147392062 0.05 ENSRNOT00000021535
transmembrane 4 L six family member 1
chr20_+_47911018 0.05 ENSRNOT00000038842
hypothetical protein LOC688390
chr2_-_26870421 0.05 ENSRNOT00000088791

chr18_+_81694808 0.05 ENSRNOT00000020446
cytochrome b5 type A
chrX_-_139229702 0.05 ENSRNOT00000042507

chr10_+_85257876 0.04 ENSRNOT00000014752
mitochondrial ribosomal protein L45
chr1_-_98570949 0.04 ENSRNOT00000033648
sialic acid binding Ig-like lectin 5
chrX_+_110404022 0.04 ENSRNOT00000041044
MUM1 like 1
chr17_-_13393243 0.04 ENSRNOT00000018252
growth arrest and DNA-damage-inducible, gamma
chr17_-_43537293 0.04 ENSRNOT00000091749
solute carrier family 17 member 3
chrX_-_138435391 0.04 ENSRNOT00000043258
muscleblind-like splicing regulator 3
chr16_-_38063821 0.04 ENSRNOT00000077452
ENSRNOT00000089533
glycine receptor, alpha 3
chr16_-_37908173 0.04 ENSRNOT00000075026
glycine receptor, alpha 3
chrX_+_14019961 0.04 ENSRNOT00000004785
synaptotagmin-like 5
chr18_+_30023828 0.04 ENSRNOT00000079008
protocadherin alpha 4
chr5_-_164747083 0.04 ENSRNOT00000010433
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chrX_+_78372257 0.04 ENSRNOT00000046164
G protein-coupled receptor 174
chr5_-_151895016 0.04 ENSRNOT00000081841
phosphatidylinositol glycan anchor biosynthesis, class V
chr2_+_92559929 0.04 ENSRNOT00000033404
GTPase activating protein testicular GAP1
chr7_+_107413691 0.04 ENSRNOT00000007587
PHD finger protein 20-like protein 1
chr7_-_54778848 0.04 ENSRNOT00000005399
GLI pathogenesis-related 1
chr3_+_15379109 0.04 ENSRNOT00000036495
MORN repeat containing 5
chr14_+_7630482 0.04 ENSRNOT00000091581
similar to hypothetical protein MGC26744
chr3_+_112950890 0.04 ENSRNOT00000015472
cyclin D1 binding protein 1
chr13_-_90814119 0.04 ENSRNOT00000011208
transgelin 2
chr1_-_163148948 0.04 ENSRNOT00000046850
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6
chr1_+_93242050 0.04 ENSRNOT00000013741
similar to 60S ribosomal protein L27a
chr18_+_35574002 0.04 ENSRNOT00000093442
ENSRNOT00000070817
ENSRNOT00000093356
myotilin
chr9_+_95221474 0.04 ENSRNOT00000066839
UDP glucuronosyltransferase family 1 member A5
chr18_+_57654290 0.04 ENSRNOT00000025892
5-hydroxytryptamine receptor 4
chr20_-_5112258 0.04 ENSRNOT00000092222
casein kinase 2 beta
chr7_+_129973480 0.04 ENSRNOT00000050620
ENSRNOT00000042686
Mov10 RISC complex RNA helicase like 1
chr4_-_182600258 0.04 ENSRNOT00000067970
ERGIC and golgi 2
chr8_-_132919110 0.04 ENSRNOT00000008747
X-C motif chemokine receptor 1
chr8_-_39266959 0.04 ENSRNOT00000046590
EI24, autophagy associated transmembrane protein
chr7_+_140781799 0.04 ENSRNOT00000087932
DnaJ heat shock protein family (Hsp40) member C22
chr12_-_22710674 0.04 ENSRNOT00000050456
monoacylglycerol O-acyltransferase 3
chr13_+_42220251 0.04 ENSRNOT00000078185

chr6_+_129609375 0.04 ENSRNOT00000083732
poly (A) polymerase alpha
chr2_-_93641497 0.04 ENSRNOT00000013720
charged multivesicular body protein 4C
chr3_-_133232322 0.04 ENSRNOT00000034487
ESF1 nucleolar pre-rRNA processing protein homolog
chr10_-_56429748 0.04 ENSRNOT00000020675
ENSRNOT00000092704
spermatid maturation 1
chr3_-_120011364 0.04 ENSRNOT00000018922
fumarylacetoacetate hydrolase domain containing 2A
chr8_-_115149419 0.04 ENSRNOT00000016056
ENSRNOT00000077514
abhydrolase domain containing 14A
chr19_+_26022849 0.03 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chr14_-_11198194 0.03 ENSRNOT00000003083
enolase-phosphatase 1
chr11_+_74984613 0.03 ENSRNOT00000035049
ATPase 13A5
chr4_-_140220487 0.03 ENSRNOT00000009008
sulfatase modifying factor 1
chr5_+_15043955 0.03 ENSRNOT00000047093
retinitis pigmentosa 1
chr9_+_37727942 0.03 ENSRNOT00000016511
ENSRNOT00000074276
myotilin-like
chr13_+_90116843 0.03 ENSRNOT00000006306
Cd48 molecule
chr1_+_102924059 0.03 ENSRNOT00000078137

chr9_+_91001828 0.03 ENSRNOT00000080956

chr10_+_58613674 0.03 ENSRNOT00000010975
family with sequence similarity 64, member A
chr10_-_66848388 0.03 ENSRNOT00000018891
oligodendrocyte-myelin glycoprotein
chr11_-_78327282 0.03 ENSRNOT00000002636
tumor protein p63
chr2_+_205568935 0.03 ENSRNOT00000025248
adenosine monophosphate deaminase 1
chr4_-_98593664 0.03 ENSRNOT00000007927
ribose 5-phosphate isomerase A
chr9_-_71852113 0.03 ENSRNOT00000083263
ENSRNOT00000072983

chr1_+_125229469 0.03 ENSRNOT00000021884
methylmalonyl CoA epimerase
chr14_+_100135271 0.03 ENSRNOT00000032965
F-box protein 48
chr8_+_99636749 0.03 ENSRNOT00000086524
phospholipid scramblase 1
chr1_+_101623308 0.03 ENSRNOT00000029167
MEF2 activating motif and SAP domain containing transcriptional regulator
chr13_+_51218468 0.03 ENSRNOT00000033636
similar to UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylgluco
chrX_-_113228265 0.03 ENSRNOT00000060001
similar to 40S ribosomal protein S9
chr2_-_250923744 0.03 ENSRNOT00000084996
chloride channel accessory 1
chr1_-_190965115 0.03 ENSRNOT00000023483

chr1_+_169562247 0.03 ENSRNOT00000023124
olfactory receptor 153
chr1_+_101249522 0.03 ENSRNOT00000033882
solute carrier family 6, member 16
chr9_+_92681078 0.03 ENSRNOT00000034152
SP100 nuclear antigen
chr7_-_104556419 0.03 ENSRNOT00000090784
family with sequence similarity 49, member B
chr13_-_89874008 0.03 ENSRNOT00000051368
prothymosin alpha
chr10_-_87437455 0.03 ENSRNOT00000051080
keratin 39
chr12_-_2826378 0.03 ENSRNOT00000061749
C-type lectin domain family 4 member M
chr5_-_6083083 0.03 ENSRNOT00000072411
sulfatase 1
chr8_-_108777717 0.03 ENSRNOT00000034188
interleukin 20 receptor subunit beta
chr13_+_52887649 0.03 ENSRNOT00000048033
achaete-scute family bHLH transcription factor 5
chr12_-_19439977 0.03 ENSRNOT00000060035
neurexophilin and PC-esterase domain family, member 5
chr8_+_113603533 0.03 ENSRNOT00000017280
mitochondrial ribosomal protein L3
chr13_+_76962504 0.03 ENSRNOT00000076581
ring finger and WD repeat domain 2
chr16_-_32439421 0.03 ENSRNOT00000043100
NIMA-related kinase 1
chr7_+_133856101 0.03 ENSRNOT00000038686
PDZ domain containing RING finger 4
chr4_+_97657671 0.03 ENSRNOT00000075400
G protein subunit gamma 12
chr3_+_133232432 0.03 ENSRNOT00000006412
NADH:ubiquinone oxidoreductase complex assembly factor 5
chr14_-_44225713 0.03 ENSRNOT00000049161
similar to ribosomal protein L14
chr16_-_20873344 0.03 ENSRNOT00000027381
coatomer protein complex, subunit epsilon
chr8_+_55603968 0.03 ENSRNOT00000066848
POU class 2 associating factor 1
chr3_+_160467552 0.03 ENSRNOT00000066657
serine/threonine kinase 4
chr14_+_33247274 0.03 ENSRNOT00000075226
serine peptidase inhibitor, Kazal type 2
chr1_+_173252058 0.03 ENSRNOT00000073421
similar to very large inducible GTPase 1 isoform A
chr1_+_16478127 0.03 ENSRNOT00000019076
Abelson helper integration site 1
chr7_+_15621989 0.02 ENSRNOT00000051928
olfactory receptor 1095
chr3_+_11476883 0.02 ENSRNOT00000072241
nuclear apoptosis inducing factor 1
chr11_-_46693565 0.02 ENSRNOT00000044900
interphotoreceptor matrix proteoglycan 2
chr7_+_126736732 0.02 ENSRNOT00000022012
G-2 and S-phase expressed 1
chrX_+_74497262 0.02 ENSRNOT00000003899
zinc finger CCHC-type containing 13
chr4_+_110699557 0.02 ENSRNOT00000030588
ENSRNOT00000092261
leucine rich repeat transmembrane neuronal 4
chr3_+_117421604 0.02 ENSRNOT00000008860
ENSRNOT00000008857
solute carrier family 12 member 1
chr7_-_116920507 0.02 ENSRNOT00000048363
maestro heat-like repeat family member 6
chr2_+_205592182 0.02 ENSRNOT00000081050
DENN domain containing 2C
chr20_-_6195463 0.02 ENSRNOT00000092474
peroxisomal, testis specific 1
chr15_+_57290849 0.02 ENSRNOT00000014909
carboxypeptidase B2
chr3_+_38280489 0.02 ENSRNOT00000011239

chr16_+_80729400 0.02 ENSRNOT00000036383
testis development related protein
chr15_+_28319136 0.02 ENSRNOT00000048723
tubulin polymerization-promoting protein family member 2
chr6_+_109939345 0.02 ENSRNOT00000013560
intraflagellar transport 43
chr15_-_49467174 0.02 ENSRNOT00000019209
ADAM metallopeptidase domain 7
chr8_-_114766803 0.02 ENSRNOT00000047563
collagen, type VI, alpha 4
chr10_-_63219309 0.02 ENSRNOT00000076357
bleomycin hydrolase
chr13_-_35511020 0.02 ENSRNOT00000003413
RAS like proto-oncogene B
chr4_+_31333970 0.02 ENSRNOT00000064866
coiled-coil domain-containing protein 132-like
chr6_-_99204590 0.02 ENSRNOT00000041872
ENSRNOT00000007109
estrogen receptor 2
chr20_-_4390436 0.02 ENSRNOT00000000497
ENSRNOT00000077655
palmitoyl-protein thioesterase 2
chr4_-_23718047 0.02 ENSRNOT00000011359
similar to RIKEN cDNA 4921511H03
chr2_+_243422811 0.02 ENSRNOT00000014694
tRNA methyltransferase 10A
chr1_+_198089446 0.02 ENSRNOT00000026146
SAGA complex associated factor 29
chr8_+_117126692 0.02 ENSRNOT00000083046
ENSRNOT00000085609
ubiquitin specific peptidase 4
chr1_+_61095171 0.02 ENSRNOT00000042702
vomeronasal 1 receptor 19
chr1_-_216750844 0.02 ENSRNOT00000054862
nucleosome assembly protein 1-like 4
chr10_+_53595854 0.02 ENSRNOT00000044116
SCO1 cytochrome c oxidase assembly protein
chr12_-_21450204 0.02 ENSRNOT00000065866
zinc finger CW-type PWWP domain protein 1-like
chr4_+_119842013 0.02 ENSRNOT00000057286
5-hydroxymethylcytosine (hmC) binding, ES cell-specific
chr16_+_19973636 0.02 ENSRNOT00000024413
multivesicular body subunit 12A
chr7_-_12922112 0.02 ENSRNOT00000010938
mucosal vascular addressin cell adhesion molecule 1
chr10_-_110701137 0.02 ENSRNOT00000074193
zinc finger protein 750
chr1_-_82004538 0.02 ENSRNOT00000087572
POU class 2 homeobox 2
chr6_-_99273033 0.02 ENSRNOT00000088808
testis expressed 21
chr20_-_32258286 0.02 ENSRNOT00000082114
DExD-box helicase 50
chr5_+_173340060 0.02 ENSRNOT00000067841
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr4_-_119591817 0.02 ENSRNOT00000048768

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.0 0.1 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.0 0.2 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.0 0.1 GO:0060661 submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338)
0.0 0.1 GO:0002884 negative regulation of hypersensitivity(GO:0002884)
0.0 0.0 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.0 0.0 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0 0.0 GO:0001928 regulation of exocyst assembly(GO:0001928)
0.0 0.1 GO:0032466 negative regulation of cytokinesis(GO:0032466)
0.0 0.1 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0 0.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.0 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.0 0.0 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982)
0.0 0.1 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0022852 glycine-gated chloride ion channel activity(GO:0022852)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 0.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.2 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.1 GO:0089720 caspase binding(GO:0089720)
0.0 0.1 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.0 0.1 GO:0002046 opsin binding(GO:0002046)
0.0 0.1 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.0 0.0 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0 0.0 GO:0034584 piRNA binding(GO:0034584)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.0 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)