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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nkx2-2
Z-value: 0.42
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Transcription factors associated with Nkx2-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nkx2-2 | rn6_v1_chr3_-_141411170_141411170 | -0.62 | 2.7e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_28654733 Show fit | 0.89 |
ENSRNOT00000006174
|
pro-melanin-concentrating hormone |
|
| chr14_-_37770059 Show fit | 0.15 |
ENSRNOT00000029721
|
solute carrier family 10, member 4 |
|
| chr2_+_71753816 Show fit | 0.14 |
ENSRNOT00000025809
|
|
|
| chr20_-_22459025 Show fit | 0.12 |
ENSRNOT00000000792
|
early growth response 2 |
|
| chr14_+_88549947 Show fit | 0.11 |
ENSRNOT00000086177
|
heterogeneous nuclear ribonucleoprotein C |
|
| chr4_-_120414118 Show fit | 0.11 |
ENSRNOT00000072795
|
40S ribosomal protein S25-like |
|
| chr10_-_13780283 Show fit | 0.10 |
ENSRNOT00000084200
|
|
|
| chr1_-_227047290 Show fit | 0.10 |
ENSRNOT00000037226
|
membrane spanning 4-domains A15 |
|
| chr4_-_129430251 Show fit | 0.10 |
ENSRNOT00000067881
|
family with sequence similarity 19 member A4, C-C motif chemokine like |
|
| chr4_+_6903198 Show fit | 0.10 |
ENSRNOT00000012285
|
crystallin, gamma N |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nkx2-2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.9 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.0 | 0.2 | GO:0090367 | negative regulation of mRNA modification(GO:0090367) |
| 0.0 | 0.1 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.0 | 0.1 | GO:0060661 | submandibular salivary gland formation(GO:0060661) positive regulation of hair follicle cell proliferation(GO:0071338) |
| 0.0 | 0.1 | GO:0002884 | negative regulation of hypersensitivity(GO:0002884) |
| 0.0 | 0.1 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.0 | 0.1 | GO:0032466 | negative regulation of cytokinesis(GO:0032466) |
| 0.0 | 0.1 | GO:0060744 | thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744) |
| 0.0 | 0.1 | GO:1901475 | pyruvate transmembrane transport(GO:1901475) |
| 0.0 | 0.1 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.2 | GO:1990826 | nucleoplasmic periphery of the nuclear pore complex(GO:1990826) |
| 0.0 | 0.1 | GO:0016935 | glycine-gated chloride channel complex(GO:0016935) GABA-ergic synapse(GO:0098982) |
| 0.0 | 0.1 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.1 | GO:0000322 | storage vacuole(GO:0000322) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 0.2 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 0.2 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.0 | 0.1 | GO:0022852 | glycine-gated chloride ion channel activity(GO:0022852) |
| 0.0 | 0.1 | GO:0032427 | GBD domain binding(GO:0032427) |
| 0.0 | 0.1 | GO:0051916 | granulocyte colony-stimulating factor binding(GO:0051916) |
| 0.0 | 0.1 | GO:0089720 | caspase binding(GO:0089720) |
| 0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.1 | GO:0002046 | opsin binding(GO:0002046) |
| 0.0 | 0.1 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |