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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx2-1

Z-value: 0.47

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Transcription factors associated with Nkx2-1

Gene Symbol Gene ID Gene Info
ENSRNOG00000008644 NK2 homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx2-1rn6_v1_chr6_-_77421286_774212860.866.3e-02Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr7_+_28654733 0.62 ENSRNOT00000006174
pro-melanin-concentrating hormone
chr10_-_90307658 0.25 ENSRNOT00000092102
solute carrier family 4 member 1
chrX_+_136460215 0.19 ENSRNOT00000093538
Rho GTPase activating protein 36
chr1_+_279798187 0.15 ENSRNOT00000024065
pancreatic lipase
chr10_+_40247436 0.14 ENSRNOT00000079830
glutathione peroxidase 3
chr1_+_243589607 0.13 ENSRNOT00000021792
doublesex and mab-3 related transcription factor 3
chr17_-_43640387 0.12 ENSRNOT00000087731
histone cluster 1 H1 family member c
chr15_+_10120206 0.11 ENSRNOT00000033048
retinoic acid receptor, beta
chr9_+_82647071 0.11 ENSRNOT00000027135
acid sensing ion channel subunit family member 4
chr5_-_127273656 0.10 ENSRNOT00000057341
DMRT-like family B with proline-rich C-terminal, 1
chr15_-_34198921 0.09 ENSRNOT00000024991
neural retina leucine zipper
chr1_+_33910912 0.09 ENSRNOT00000044690
iroquois homeobox 1
chr2_+_202200797 0.08 ENSRNOT00000042263
ENSRNOT00000071938
sperm associated antigen 17
chr5_-_145423172 0.08 ENSRNOT00000081919
gap junction protein, beta 5
chr1_+_86949413 0.08 ENSRNOT00000064153
sirtuin 2
chr1_+_216237697 0.05 ENSRNOT00000027760
Cd81 molecule
chr3_-_168018410 0.04 ENSRNOT00000087579
breast carcinoma amplified sequence 1
chr10_-_12990405 0.04 ENSRNOT00000078647
THO complex 6
chr1_-_233140237 0.04 ENSRNOT00000083372
phosphoserine aminotransferase 1
chr6_-_145777767 0.04 ENSRNOT00000046799
ribosomal protein L32
chr12_+_11814071 0.04 ENSRNOT00000039149
transmembrane protein 130
chr6_-_49851677 0.04 ENSRNOT00000007287
ENSRNOT00000077442
acid phosphatase 1, soluble
chr6_-_136145837 0.04 ENSRNOT00000015122
creatine kinase B
chr10_-_84789832 0.03 ENSRNOT00000071719
CDK5 regulatory subunit associated protein 3
chr13_-_82005741 0.03 ENSRNOT00000076404
methyltransferase like 11B
chr12_+_25305823 0.03 ENSRNOT00000002010
GTF2I repeat domain containing 1
chr7_+_141355994 0.02 ENSRNOT00000081195
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr10_-_65820538 0.02 ENSRNOT00000011808
transmembrane protein 97
chr6_+_128973956 0.02 ENSRNOT00000075399
family with sequence similarity 181, member A
chr11_-_78456501 0.02 ENSRNOT00000036193
tumor protein p63
chr12_-_13462038 0.02 ENSRNOT00000043110
ribosomal protein L36-like
chr7_-_55604403 0.02 ENSRNOT00000088732
ataxin 7-like 3B
chr1_+_170383682 0.02 ENSRNOT00000024224
sphingomyelin phosphodiesterase 1
chr1_-_141470380 0.02 ENSRNOT00000065759
perilipin 1
chr1_-_227441442 0.02 ENSRNOT00000028433
membrane spanning 4-domains A1
chr7_+_116745061 0.02 ENSRNOT00000076174
rhophilin, Rho GTPase binding protein 1
chr5_-_22769907 0.02 ENSRNOT00000047805
ENSRNOT00000076167
ENSRNOT00000076507
ENSRNOT00000076113
ENSRNOT00000083779
aspartate-beta-hydroxylase
chr11_-_78456200 0.02 ENSRNOT00000067251
ENSRNOT00000036179
tumor protein p63
chr7_-_11406771 0.02 ENSRNOT00000047450
eukaryotic translation elongation factor 2
chr13_+_52887649 0.01 ENSRNOT00000048033
achaete-scute family bHLH transcription factor 5
chr15_-_51386190 0.01 ENSRNOT00000022706
R3H domain and coiled-coil containing 1
chr7_+_107467260 0.01 ENSRNOT00000009240
ENSRNOT00000077382
thyroglobulin
chr2_-_250232295 0.01 ENSRNOT00000082132
LIM domain only 4
chr12_+_41486076 0.01 ENSRNOT00000057242
RBPJ interacting and tubulin associated 1
chr6_+_101923785 0.01 ENSRNOT00000012005
membrane palmitoylated protein 5
chr10_-_90096096 0.01 ENSRNOT00000081539
transmembrane protein 101
chr9_+_10061978 0.01 ENSRNOT00000075180
alkaline ceramidase 1
chr9_+_81427730 0.01 ENSRNOT00000019109
ENSRNOT00000081711
C-X-C motif chemokine receptor 2
chr6_+_101924000 0.01 ENSRNOT00000092157
membrane palmitoylated protein 5
chr10_+_89069256 0.01 ENSRNOT00000008576
tubulin, gamma 2
chr2_+_188844073 0.01 ENSRNOT00000028117
potassium calcium-activated channel subfamily N member 3
chr16_-_2227258 0.01 ENSRNOT00000089377
ENSRNOT00000067464
sarcolemma associated protein
chrX_-_123600890 0.00 ENSRNOT00000067942
septin 6
chr4_-_70934295 0.00 ENSRNOT00000020616
transient receptor potential cation channel, subfamily V, member 6
chr4_+_100166863 0.00 ENSRNOT00000014505
surfactant protein B
chr1_-_197590277 0.00 ENSRNOT00000022502
ENSRNOT00000043433
exportin 6
chr10_+_11240138 0.00 ENSRNOT00000048687
sarcalumenin

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1 0.3 GO:0010037 response to carbon dioxide(GO:0010037)
0.0 0.1 GO:0007468 regulation of rhodopsin gene expression(GO:0007468)
0.0 0.1 GO:2000777 positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0 0.1 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.1 GO:0002238 response to molecule of fungal origin(GO:0002238)
0.0 0.1 GO:1904350 regulation of protein catabolic process in the vacuole(GO:1904350)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.1 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0003406 retinal pigment epithelium development(GO:0003406)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990716 axonemal central apparatus(GO:1990716)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.1 GO:0008430 selenium binding(GO:0008430)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 0.3 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation