ISMARA results: Nkx2-1

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx2-1

Z-value: 0.47

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Transcription factors associated with Nkx2-1

Gene Symbol	Gene ID	Gene Info
Nkx2-1 NCBI RGD Ensembl	ENSRNOG00000008644	NK2 homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Nkx2-1	rn6_v1_chr6_-_77421286_77421286	0.86	6.3e-02	Click!

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr7_+_28654733 Show fit	0.62	ENSRNOT00000006174	Pmch NCBI RGD Ensembl Show fit	pro-melanin-concentrating hormone
chr10_-_90307658 Show fit	0.25	ENSRNOT00000092102	Slc4a1 NCBI RGD Ensembl Show fit	solute carrier family 4 member 1
chrX_+_136460215 Show fit	0.19	ENSRNOT00000093538	Arhgap36 NCBI RGD Ensembl Show fit	Rho GTPase activating protein 36
chr1_+_279798187 Show fit	0.15	ENSRNOT00000024065	Pnlip NCBI RGD Ensembl Show fit	pancreatic lipase
chr10_+_40247436 Show fit	0.14	ENSRNOT00000079830	Gpx3 NCBI RGD Ensembl Show fit	glutathione peroxidase 3
chr1_+_243589607 Show fit	0.13	ENSRNOT00000021792	Dmrt3 NCBI RGD Ensembl Show fit	doublesex and mab-3 related transcription factor 3
chr17_-_43640387 Show fit	0.12	ENSRNOT00000087731	Hist1h1c NCBI RGD Ensembl Show fit	histone cluster 1 H1 family member c
chr15_+_10120206 Show fit	0.11	ENSRNOT00000033048	Rarb NCBI RGD Ensembl Show fit	retinoic acid receptor, beta
chr9_+_82647071 Show fit	0.11	ENSRNOT00000027135	Asic4 NCBI RGD Ensembl Show fit	acid sensing ion channel subunit family member 4
chr5_-_127273656 Show fit	0.10	ENSRNOT00000057341	Dmrtb1 NCBI RGD Ensembl Show fit	DMRT-like family B with proline-rich C-terminal, 1

Showing 1 to 10 of 57 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227)
0.1	0.3	GO:0010037	response to carbon dioxide(GO:0010037)
0.0	0.2	GO:0061365	positive regulation of triglyceride lipase activity(GO:0061365)
0.0	0.1	GO:0007468	regulation of rhodopsin gene expression(GO:0007468)
0.0	0.1	GO:2000777	positive regulation of oocyte maturation(GO:1900195) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
0.0	0.1	GO:0072086	specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268)
0.0	0.1	GO:1904158	axonemal central apparatus assembly(GO:1904158)
0.0	0.1	GO:0002238	response to molecule of fungal origin(GO:0002238)
0.0	0.1	GO:1904350	regulation of protein catabolic process in the vacuole(GO:1904350)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)

Showing 1 to 10 of 12 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	GO:1990716	axonemal central apparatus(GO:1990716)

Showing 1 to 1 of 1 entries

Gene overrepresentation in molecular function category:

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Total log-likelihood	Term	Description
0.6	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.3	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.1	GO:0042903	tubulin deacetylase activity(GO:0042903)
0.1	GO:0008430	selenium binding(GO:0008430)

Showing 1 to 4 of 4 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation

Showing 1 to 1 of 1 entries

Results for Nkx2-1

Z-value: 0.47

Motif logo

Transcription factors associated with Nkx2-1

Activity-expression correlation:

Activity profile of Nkx2-1 motif

Sorted Z-values of Nkx2-1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: