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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Nkx1-1_Nkx1-2

Z-value: 0.28

Motif logo

Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
ENSRNOG00000005113 NK1 homeobox 1
ENSRNOG00000017006 NK1 homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Nkx1-2rn6_v1_chr1_-_204605552_2046055520.573.2e-01Click!

Activity profile of Nkx1-1_Nkx1-2 motif

Sorted Z-values of Nkx1-1_Nkx1-2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_35979193 0.20 ENSRNOT00000071104
transmembrane protein 132B
chr2_+_145174876 0.19 ENSRNOT00000040631
mab-21 like 1
chr5_-_168734296 0.16 ENSRNOT00000066120
calmodulin binding transcription activator 1
chrX_+_15113878 0.15 ENSRNOT00000007464
WD repeat domain 13
chr1_+_278557792 0.14 ENSRNOT00000023414
attractin like 1
chr10_+_103395511 0.11 ENSRNOT00000004256
G protein-coupled receptor, class C, group 5, member C
chr3_+_14889510 0.09 ENSRNOT00000080760
DAB2 interacting protein
chr9_+_10013854 0.08 ENSRNOT00000077653
ENSRNOT00000072033
KH-type splicing regulatory protein
chr19_+_45938915 0.07 ENSRNOT00000065508
MON1 homolog B, secretory trafficking associated
chr2_-_33025271 0.07 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr7_+_2752680 0.06 ENSRNOT00000033726
citrate synthase
chr4_+_88694583 0.06 ENSRNOT00000009202
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr3_-_120076788 0.06 ENSRNOT00000047158
potassium voltage-gated channel interacting protein 3
chr9_+_71915421 0.05 ENSRNOT00000020447
phosphoinositide kinase, FYVE-type zinc finger containing
chr11_-_51202703 0.05 ENSRNOT00000002719
ENSRNOT00000077220
Cbl proto-oncogene B
chr9_+_73418607 0.05 ENSRNOT00000092547
microtubule-associated protein 2
chr20_+_6211420 0.05 ENSRNOT00000000624
potassium channel tetramerization domain containing 20
chr17_+_63635086 0.05 ENSRNOT00000020634
disco-interacting protein 2 homolog C
chr1_+_282134981 0.05 ENSRNOT00000036203
nanos C2HC-type zinc finger 1
chr3_+_62648447 0.05 ENSRNOT00000002111
alkylglycerone phosphate synthase
chr8_+_32188617 0.05 ENSRNOT00000081145
zinc finger and BTB domain containing 44
chr1_-_64147251 0.05 ENSRNOT00000088502
CCR4-NOT transcription complex, subunit 3
chr10_+_103206014 0.05 ENSRNOT00000004081
tweety family member 2
chr2_-_196177775 0.04 ENSRNOT00000028553
zinc finger protein 687
chr1_-_215284548 0.04 ENSRNOT00000090375
cortactin
chr2_-_188718704 0.04 ENSRNOT00000028010
zinc finger and BTB domain containing 7B
chr12_+_49665282 0.04 ENSRNOT00000086397
G protein-coupled receptor kinase 3
chr1_+_141767940 0.04 ENSRNOT00000064034
zinc finger protein 710
chr17_-_22678253 0.04 ENSRNOT00000083122
LRRGT00112-like
chr16_-_10802512 0.04 ENSRNOT00000079554
bone morphogenetic protein receptor type 1A
chr20_+_12944786 0.03 ENSRNOT00000048218
pericentrin
chr1_-_100926335 0.03 ENSRNOT00000020304
adaptor-related protein complex 2, alpha 1 subunit
chr16_+_7035068 0.03 ENSRNOT00000024296
NIMA-related kinase 4
chr9_-_43022998 0.03 ENSRNOT00000063781
ENSRNOT00000089843
lectin, mannose-binding 2-like
chr7_-_12673659 0.03 ENSRNOT00000091650
ENSRNOT00000041277
ENSRNOT00000044865
polypyrimidine tract binding protein 1
chr1_+_15834779 0.03 ENSRNOT00000079069
ENSRNOT00000083012
BCL2-associated transcription factor 1
chr16_+_7035241 0.03 ENSRNOT00000084977
NIMA-related kinase 4
chr5_+_131380297 0.03 ENSRNOT00000010548
ATP/GTP binding protein-like 4
chr6_+_111076351 0.03 ENSRNOT00000089644
transmembrane protein 63c
chr17_-_87826421 0.03 ENSRNOT00000068156
Rho GTPase activating protein 21
chr2_+_148765412 0.03 ENSRNOT00000018248
ENSRNOT00000084662
selenoprotein T
chr8_-_21492801 0.03 ENSRNOT00000077465
zinc finger protein 426
chr1_-_198450047 0.03 ENSRNOT00000027360
major vault protein
chr10_-_65502936 0.03 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chr13_+_92569785 0.03 ENSRNOT00000082700
formin 2
chr17_-_78812111 0.02 ENSRNOT00000021506
DNA cross-link repair 1C
chr13_+_91054974 0.02 ENSRNOT00000091089
C-reactive protein
chr2_-_219458271 0.02 ENSRNOT00000064735
cell division cycle 14A
chr9_+_3896337 0.02 ENSRNOT00000079166
protein tyrosine phosphatase type IVA 1
chr14_+_82375181 0.02 ENSRNOT00000023904
family with sequence similarity 53, member A
chrX_+_73390903 0.02 ENSRNOT00000077002
zinc finger protein 449
chrX_+_140878216 0.02 ENSRNOT00000075840
ENSRNOT00000077026
Zic family member 3
chr7_-_91538673 0.02 ENSRNOT00000006209
RAD21 cohesin complex component
chr13_-_83457888 0.02 ENSRNOT00000076289
ENSRNOT00000004065
SFT2 domain containing 2
chr1_-_101819478 0.02 ENSRNOT00000056181
glutamate-rich WD repeat containing 1
chr4_+_158088505 0.02 ENSRNOT00000026643
von Willebrand factor
chr1_-_134867001 0.02 ENSRNOT00000090149
chromodomain helicase DNA binding protein 2
chr5_+_71742911 0.02 ENSRNOT00000047225
zinc finger protein 462
chr5_-_154222702 0.01 ENSRNOT00000080069
proline-rich nuclear receptor coactivator 2
chr7_+_71157664 0.01 ENSRNOT00000005919
short chain dehydrogenase/reductase family 9C, member 7
chr12_-_46493203 0.01 ENSRNOT00000057036
citron rho-interacting serine/threonine kinase
chr11_-_60882379 0.01 ENSRNOT00000002799
CD200 receptor 1
chr6_-_108660063 0.01 ENSRNOT00000006240
apoptosis resistant E3 ubiquitin protein ligase 1
chr8_+_70789256 0.01 ENSRNOT00000048302
caseinolytic mitochondrial matrix peptidase chaperone subunit
chr3_-_90751055 0.01 ENSRNOT00000040741
LRRGT00091
chr1_-_89007041 0.01 ENSRNOT00000032363
proline and serine rich 3
chr13_+_67611708 0.01 ENSRNOT00000063833
translocated promoter region, nuclear basket protein
chr1_-_134871167 0.01 ENSRNOT00000076300
chromodomain helicase DNA binding protein 2
chr8_-_78096302 0.01 ENSRNOT00000086185
ENSRNOT00000077999
myocardial zonula adherens protein
chr2_-_210088949 0.01 ENSRNOT00000070994
RNA binding motif protein 15
chr15_-_80713153 0.01 ENSRNOT00000063800
kelch-like family member 1
chr1_+_261180007 0.01 ENSRNOT00000072181
zinc finger, DHHC-type containing 16
chr12_-_12738620 0.01 ENSRNOT00000078603
ENSRNOT00000067021
PMS1 homolog 2, mismatch repair system component
chr6_+_18880737 0.01 ENSRNOT00000003432
alkB homolog 8, tRNA methyltransferase
chr20_-_13994794 0.01 ENSRNOT00000093466
gamma-glutamyltransferase 5
chr3_+_80081647 0.01 ENSRNOT00000057161
ADP-ribosylation factor GTPase activating protein 2
chr10_+_48569555 0.01 ENSRNOT00000003966
adenosine A2B receptor
chr5_+_36566783 0.01 ENSRNOT00000077650
F-box and leucine-rich repeat protein 4
chr5_+_144114012 0.01 ENSRNOT00000035597
serine/threonine kinase 40
chr1_-_127292090 0.01 ENSRNOT00000016959
leucine-rich repeat kinase 1
chr16_+_39144972 0.01 ENSRNOT00000086728
ADAM metallopeptidase domain 21
chr14_-_7863664 0.00 ENSRNOT00000061162
protein tyrosine phosphatase, non-receptor type 13
chr5_+_58995249 0.00 ENSRNOT00000023411
coiled-coil domain containing 107
chr2_-_149432106 0.00 ENSRNOT00000051027
purinergic receptor P2Y13
chr7_+_117055395 0.00 ENSRNOT00000091960
mitogen-activated protein kinase 15
chr6_-_44361908 0.00 ENSRNOT00000009491
inhibitor of DNA binding 2, HLH protein
chr1_-_80544825 0.00 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
RELB proto-oncogene, NF-kB subunit
chr4_+_14001761 0.00 ENSRNOT00000076519
CD36 molecule
chr1_+_88113445 0.00 ENSRNOT00000056955
gametogenetin
chr14_-_16903242 0.00 ENSRNOT00000003001
shroom family member 3
chr4_-_55011415 0.00 ENSRNOT00000056996
glutamate metabotropic receptor 8
chr14_+_81858737 0.00 ENSRNOT00000029784
ENSRNOT00000058068
ENSRNOT00000058067
DNA polymerase nu
chr14_-_113644779 0.00 ENSRNOT00000005306
cilia and flagella associated protein 36
chr18_+_4084228 0.00 ENSRNOT00000071392
calcium binding tyrosine phosphorylation regulated
chr4_-_88684415 0.00 ENSRNOT00000009001
similar to 40S ribosomal protein S7 (S8)
chr2_+_248398917 0.00 ENSRNOT00000045855
guanylate binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0019086 late viral transcription(GO:0019086)
0.0 0.1 GO:0036324 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324)
0.0 0.1 GO:0098749 cerebellar neuron development(GO:0098749)
0.0 0.0 GO:0046154 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
0.0 0.0 GO:0048382 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) mesendoderm development(GO:0048382) regulation of cardiac ventricle development(GO:1904412)
0.0 0.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:1990032 parallel fiber(GO:1990032)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 0.0 GO:0001069 regulatory region RNA binding(GO:0001069)