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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nfia
Z-value: 0.66
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Transcription factors associated with Nfia
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfia | rn6_v1_chr5_+_116421894_116421900 | -0.67 | 2.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_151709877 Show fit | 0.50 |
ENSRNOT00000080602
|
TMF1-regulated nuclear protein 1 |
|
| chr2_+_190003223 Show fit | 0.42 |
ENSRNOT00000015712
|
S100 calcium binding protein A5 |
|
| chr18_-_15540177 Show fit | 0.41 |
ENSRNOT00000022113
|
transthyretin |
|
| chr7_-_28711761 Show fit | 0.39 |
ENSRNOT00000006249
|
PARP1 binding protein |
|
| chr5_-_156811650 Show fit | 0.32 |
ENSRNOT00000068065
|
family with sequence similarity 43, member B |
|
| chr3_-_11417546 Show fit | 0.31 |
ENSRNOT00000018776
|
lipocalin 2 |
|
| chr1_-_215536980 Show fit | 0.30 |
ENSRNOT00000027344
|
interferon induced transmembrane protein 10 |
|
| chr17_-_13393243 Show fit | 0.29 |
ENSRNOT00000018252
|
growth arrest and DNA-damage-inducible, gamma |
|
| chr15_+_34452116 Show fit | 0.28 |
ENSRNOT00000027647
|
leukotriene B4 receptor |
|
| chr6_+_8886591 Show fit | 0.26 |
ENSRNOT00000091510
ENSRNOT00000089174 |
SIX homeobox 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfia
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0021696 | cerebellar cortex morphogenesis(GO:0021696) |
| 0.1 | 0.4 | GO:1902380 | positive regulation of mRNA cleavage(GO:0031439) positive regulation of endoribonuclease activity(GO:1902380) positive regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904722) |
| 0.1 | 0.4 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
| 0.0 | 0.4 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.4 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.3 | GO:0015688 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 0.3 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178) |
| 0.0 | 0.3 | GO:0061737 | leukotriene signaling pathway(GO:0061737) |
| 0.0 | 0.3 | GO:0060134 | prepulse inhibition(GO:0060134) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.0 | 0.3 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.2 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 0.1 | GO:0098574 | cytoplasmic side of lysosomal membrane(GO:0098574) |
| 0.0 | 0.1 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.0 | 0.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.1 | GO:0005968 | Rab-protein geranylgeranyltransferase complex(GO:0005968) |
| 0.0 | 0.1 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.0 | 0.1 | GO:0001405 | presequence translocase-associated import motor(GO:0001405) |
| 0.0 | 0.1 | GO:0097512 | cardiac myofibril(GO:0097512) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0031249 | denatured protein binding(GO:0031249) |
| 0.0 | 0.4 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.3 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.0 | 0.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.2 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.0 | 0.2 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.0 | 0.2 | GO:0005172 | vascular endothelial growth factor receptor binding(GO:0005172) |
| 0.0 | 0.2 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 0.0 | 0.2 | GO:0016929 | SUMO-specific protease activity(GO:0016929) |
| 0.0 | 0.2 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.3 | REACTOME EICOSANOID LIGAND BINDING RECEPTORS | Genes involved in Eicosanoid ligand-binding receptors |
| 0.0 | 0.2 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |