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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nfe2_Bach1_Mafk
Z-value: 0.62
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Transcription factors associated with Nfe2_Bach1_Mafk
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mafk | rn6_v1_chr12_-_16934706_16934706 | 0.50 | 3.9e-01 | Click! |
| Bach1 | rn6_v1_chr11_+_27364916_27364916 | 0.44 | 4.6e-01 | Click! |
| Nfe2 | rn6_v1_chr7_-_144880092_144880092 | -0.13 | 8.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_88551056 Show fit | 0.65 |
ENSRNOT00000032737
|
zinc finger protein 385C |
|
| chr12_-_2174131 Show fit | 0.45 |
ENSRNOT00000001313
|
Purkinje cell protein 2 |
|
| chr1_-_166943592 Show fit | 0.43 |
ENSRNOT00000026962
|
folate receptor 1 |
|
| chr7_+_59200918 Show fit | 0.34 |
ENSRNOT00000085073
|
protein tyrosine phosphatase, receptor type, R |
|
| chr11_+_87435185 Show fit | 0.32 |
ENSRNOT00000002558
|
purinergic receptor P2X 6 |
|
| chr19_-_37250919 Show fit | 0.25 |
ENSRNOT00000021015
|
exocyst complex component 3-like 1 |
|
| chr1_-_88881460 Show fit | 0.22 |
ENSRNOT00000028287
|
hematopoietic cell signal transducer |
|
| chr1_-_221917901 Show fit | 0.22 |
ENSRNOT00000092270
|
solute carrier family 22 member 12 |
|
| chr1_+_198690794 Show fit | 0.20 |
ENSRNOT00000023999
|
zinc finger protein 771 |
|
| chr17_-_53102342 Show fit | 0.17 |
ENSRNOT00000073834
|
proteasome subunit alpha 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfe2_Bach1_Mafk
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0060974 | cell migration involved in heart formation(GO:0060974) |
| 0.1 | 0.4 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.1 | 0.3 | GO:0038128 | ERBB2 signaling pathway(GO:0038128) |
| 0.0 | 0.3 | GO:0051601 | exocyst localization(GO:0051601) |
| 0.0 | 0.3 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.1 | 0.2 | GO:0000053 | argininosuccinate metabolic process(GO:0000053) |
| 0.0 | 0.2 | GO:0015747 | urate transport(GO:0015747) |
| 0.0 | 0.1 | GO:0009609 | response to symbiotic bacterium(GO:0009609) |
| 0.0 | 0.1 | GO:0097069 | cellular response to thyroxine stimulus(GO:0097069) |
| 0.0 | 0.1 | GO:2000468 | regulation of peroxidase activity(GO:2000468) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 0.3 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.3 | GO:0005639 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) |
| 0.0 | 0.3 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.2 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.1 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.1 | GO:0005927 | muscle tendon junction(GO:0005927) |
| 0.0 | 0.1 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.0 | 0.0 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.0 | 0.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.3 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.2 | GO:1901702 | urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702) |
| 0.0 | 0.2 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.1 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 0.1 | GO:0047025 | 3-oxoacyl-[acyl-carrier-protein] reductase (NADH) activity(GO:0047025) |
| 0.0 | 0.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.1 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.0 | 0.1 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 0.0 | 0.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |