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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nfatc2
Z-value: 0.68
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Transcription factors associated with Nfatc2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc2 | rn6_v1_chr3_-_165360292_165360292 | -0.17 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_107760550 Show fit | 0.52 |
ENSRNOT00000077091
ENSRNOT00000051638 |
Meis homeobox 2 |
|
| chr7_-_130368819 Show fit | 0.34 |
ENSRNOT00000064328
|
synaptonemal complex central element protein 3 |
|
| chr1_-_15301998 Show fit | 0.32 |
ENSRNOT00000016400
|
solute carrier family 35, member D3 |
|
| chr15_+_10120206 Show fit | 0.31 |
ENSRNOT00000033048
|
retinoic acid receptor, beta |
|
| chr19_-_6031655 Show fit | 0.30 |
ENSRNOT00000092016
|
|
|
| chr15_+_50891127 Show fit | 0.29 |
ENSRNOT00000020728
|
stanniocalcin 1 |
|
| chr14_+_43694183 Show fit | 0.28 |
ENSRNOT00000046342
|
similar to ribosomal protein S23 |
|
| chr2_-_123851854 Show fit | 0.26 |
ENSRNOT00000023327
|
interleukin 2 |
|
| chr2_-_30127269 Show fit | 0.26 |
ENSRNOT00000023869
|
CART prepropeptide |
|
| chr17_-_89163113 Show fit | 0.24 |
ENSRNOT00000050445
|
ribosomal protein S19-like |
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfatc2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0042376 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.0 | 0.4 | GO:0060536 | cartilage morphogenesis(GO:0060536) |
| 0.0 | 0.4 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.1 | 0.3 | GO:0070093 | negative regulation of glucagon secretion(GO:0070093) |
| 0.1 | 0.3 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.0 | 0.3 | GO:0060591 | chondroblast differentiation(GO:0060591) |
| 0.0 | 0.3 | GO:0003406 | retinal pigment epithelium development(GO:0003406) |
| 0.0 | 0.3 | GO:0070863 | positive regulation of protein exit from endoplasmic reticulum(GO:0070863) |
| 0.1 | 0.2 | GO:0006480 | N-terminal protein amino acid methylation(GO:0006480) |
| 0.1 | 0.2 | GO:0060478 | acrosomal vesicle exocytosis(GO:0060478) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0000801 | central element(GO:0000801) |
| 0.1 | 0.2 | GO:0043511 | inhibin complex(GO:0043511) |
| 0.0 | 0.2 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.0 | 0.1 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.0 | 0.1 | GO:0044307 | dendritic branch(GO:0044307) |
| 0.0 | 0.1 | GO:1990769 | proximal neuron projection(GO:1990769) |
| 0.0 | 0.1 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 0.1 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 0.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.0 | 0.3 | GO:0003708 | retinoic acid receptor activity(GO:0003708) |
| 0.1 | 0.2 | GO:0086057 | voltage-gated calcium channel activity involved in bundle of His cell action potential(GO:0086057) |
| 0.1 | 0.2 | GO:0004698 | calcium-dependent protein kinase C activity(GO:0004698) |
| 0.1 | 0.2 | GO:0071885 | N-terminal protein N-methyltransferase activity(GO:0071885) |
| 0.1 | 0.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 0.2 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.0 | 0.2 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.2 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.1 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.0 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.0 | 0.0 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |