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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Nfatc1
Z-value: 1.07
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Transcription factors associated with Nfatc1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Nfatc1 | rn6_v1_chr18_-_77322690_77322690 | 0.59 | 2.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_137934484 Show fit | 0.75 |
ENSRNOT00000049046
|
hypothetical protein LOC317588 |
|
| chr20_-_22459025 Show fit | 0.66 |
ENSRNOT00000000792
|
early growth response 2 |
|
| chr13_+_29839867 Show fit | 0.60 |
ENSRNOT00000090623
|
|
|
| chr2_+_149899836 Show fit | 0.50 |
ENSRNOT00000086481
|
similar to hypothetical protein C130079G13 |
|
| chr13_+_41802697 Show fit | 0.47 |
ENSRNOT00000046719
|
LRRGT00155-like |
|
| chr1_-_4560789 Show fit | 0.46 |
ENSRNOT00000082415
|
androglobin |
|
| chr1_+_168668707 Show fit | 0.46 |
ENSRNOT00000015108
|
|
|
| chr17_+_48436720 Show fit | 0.44 |
ENSRNOT00000074309
|
|
|
| chr1_+_1545134 Show fit | 0.44 |
ENSRNOT00000044523
|
|
|
| chr2_-_112368557 Show fit | 0.44 |
ENSRNOT00000075017
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Nfatc1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0032197 | transposition, RNA-mediated(GO:0032197) |
| 0.1 | 0.6 | GO:0021593 | rhombomere morphogenesis(GO:0021593) |
| 0.1 | 0.5 | GO:0003383 | apical constriction(GO:0003383) |
| 0.0 | 0.4 | GO:0033085 | negative regulation of T cell differentiation in thymus(GO:0033085) negative regulation of thymocyte aggregation(GO:2000399) |
| 0.1 | 0.3 | GO:0090271 | positive regulation of fibroblast growth factor production(GO:0090271) |
| 0.1 | 0.3 | GO:2001013 | positive regulation of macrophage apoptotic process(GO:2000111) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013) |
| 0.1 | 0.3 | GO:0002337 | B-1a B cell differentiation(GO:0002337) |
| 0.1 | 0.3 | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) |
| 0.1 | 0.3 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.0 | 0.3 | GO:0035989 | tendon development(GO:0035989) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.5 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.3 | GO:0005592 | collagen type XI trimer(GO:0005592) |
| 0.0 | 0.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.0 | 0.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.2 | GO:0043511 | inhibin complex(GO:0043511) |
| 0.0 | 0.2 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 0.2 | GO:0072557 | IPAF inflammasome complex(GO:0072557) NLRP1 inflammasome complex(GO:0072558) AIM2 inflammasome complex(GO:0097169) |
| 0.0 | 0.2 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.0 | 0.2 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 0.2 | GO:0097539 | ciliary transition fiber(GO:0097539) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.5 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 0.3 | GO:0001225 | RNA polymerase II transcription coactivator binding(GO:0001225) |
| 0.1 | 0.3 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.1 | 0.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.0 | 0.3 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.0 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.0 | 0.6 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.0 | 0.5 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.1 | 0.3 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 0.3 | PID CONE PATHWAY | Visual signal transduction: Cones |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.4 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.0 | 0.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 0.3 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.3 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.0 | 0.2 | REACTOME GLYCOPROTEIN HORMONES | Genes involved in Glycoprotein hormones |
| 0.0 | 0.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.2 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.0 | 0.2 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 0.2 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |