ISMARA results: Neurod2_Bhlha15_Bhlhe22

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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.78

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Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1

Gene Symbol	Gene ID	Gene Info
Neurod2 NCBI RGD Ensembl	ENSRNOG00000028417	Neurod2
Bhlha15 NCBI RGD Ensembl	ENSRNOG00000025164	basic helix-loop-helix family, member a15
Bhlhe22 NCBI RGD Ensembl	ENSRNOG00000021745	basic helix-loop-helix family, member e22
Olig1 NCBI RGD Ensembl	ENSRNOG00000028648	oligodendrocyte transcription factor 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Bhlhe22	rn6_v1_chr2_+_102685513_102685513	0.69	1.9e-01	Click!
Bhlha15	rn6_v1_chr12_-_12407561_12407561	-0.67	2.2e-01	Click!
Olig1	rn6_v1_chr11_+_31428358_31428358	-0.03	9.6e-01	Click!

Activity profile of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

Sorted Z-values of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_66417741 Show fit	0.56	ENSRNOT00000007662	Neurod1 NCBI RGD Ensembl Show fit	neuronal differentiation 1
chr10_-_63952726 Show fit	0.55	ENSRNOT00000090461	Doc2b NCBI RGD Ensembl Show fit	double C2 domain beta
chr2_+_196334626 Show fit	0.53	ENSRNOT00000050914 ENSRNOT00000028645 ENSRNOT00000090729	Sema6c NCBI RGD Ensembl Show fit	semaphorin 6C
chr10_-_56530842 Show fit	0.51	ENSRNOT00000077451	AABR07029863.3 NCBI RGD Ensembl Show fit
chr8_-_63750531 Show fit	0.47	ENSRNOT00000009496	Neo1 NCBI RGD Ensembl Show fit	neogenin 1
chr7_-_114848414 Show fit	0.47	ENSRNOT00000032620	Slc45a4 NCBI RGD Ensembl Show fit	solute carrier family 45, member 4
chr3_+_145764932 Show fit	0.47	ENSRNOT00000075257	AABR07054264.1 NCBI RGD Ensembl Show fit
chr2_-_177924970 Show fit	0.40	ENSRNOT00000029340	Rapgef2 NCBI RGD Ensembl Show fit	Rap guanine nucleotide exchange factor 2
chr7_-_117978787 Show fit	0.37	ENSRNOT00000074262	Zfp647 NCBI RGD Ensembl Show fit	zinc finger protein 647
chr3_-_145810834 Show fit	0.34	ENSRNOT00000075429	LOC102555217 NCBI RGD Ensembl Show fit	zinc finger protein 120-like

Showing 1 to 10 of 169 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0035120	post-embryonic appendage morphogenesis(GO:0035120) post-embryonic limb morphogenesis(GO:0035127) post-embryonic forelimb morphogenesis(GO:0035128) telomeric repeat-containing RNA transcription(GO:0097393) telomeric repeat-containing RNA transcription from RNA pol II promoter(GO:0097394) regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901580) negative regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901581) positive regulation of telomeric RNA transcription from RNA pol II promoter(GO:1901582)
0.1	0.6	GO:0060729	intestinal epithelial structure maintenance(GO:0060729)
0.2	0.5	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.5	GO:0031340	positive regulation of vesicle fusion(GO:0031340)
0.0	0.5	GO:0048681	negative regulation of axon regeneration(GO:0048681)
0.1	0.4	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.4	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.1	0.3	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1	0.3	GO:0044806	G-quadruplex DNA unwinding(GO:0044806)
0.0	0.3	GO:0002087	regulation of respiratory gaseous exchange by neurological system process(GO:0002087)

Showing 1 to 10 of 41 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.8	GO:0031201	SNARE complex(GO:0031201)
0.2	0.6	GO:1990421	subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.1	0.4	GO:0042825	TAP complex(GO:0042825)
0.0	0.3	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.3	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0008275	gamma-tubulin small complex(GO:0008275)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0044305	calyx of Held(GO:0044305)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)

Showing 1 to 10 of 13 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0015616	DNA translocase activity(GO:0015616)
0.0	0.6	GO:0070888	E-box binding(GO:0070888)
0.2	0.5	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.5	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.5	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.4	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.1	0.4	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.4	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.1	0.3	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.2	GO:0004874	aryl hydrocarbon receptor activity(GO:0004874)

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 1 of 1 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Total log-likelihood	Term	Description
0.6	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.4	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis

Showing 1 to 5 of 5 entries

Results for Neurod2_Bhlha15_Bhlhe22_Olig1

Z-value: 0.78

Motif logo

Transcription factors associated with Neurod2_Bhlha15_Bhlhe22_Olig1

Activity-expression correlation:

Activity profile of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

Sorted Z-values of Neurod2_Bhlha15_Bhlhe22_Olig1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Neurod2_Bhlha15_Bhlhe22_Olig1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: