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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Myf6
Z-value: 1.27
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Transcription factors associated with Myf6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Myf6 | rn6_v1_chr7_-_49741540_49741540 | 0.13 | 8.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_9037942 Show fit | 1.27 |
ENSRNOT00000036770
|
immediate early response 5-like |
|
| chr4_+_32373641 Show fit | 1.10 |
ENSRNOT00000076086
|
distal-less homeobox 6 |
|
| chr15_-_61947764 Show fit | 0.92 |
ENSRNOT00000017400
|
chondromodulin |
|
| chr7_-_143967484 Show fit | 0.92 |
ENSRNOT00000081758
|
Sp7 transcription factor |
|
| chr6_-_110904288 Show fit | 0.71 |
ENSRNOT00000014645
|
interferon regulatory factor 2 binding protein-like |
|
| chr10_-_90151042 Show fit | 0.63 |
ENSRNOT00000055187
|
histone deacetylase 5 |
|
| chr2_-_260596777 Show fit | 0.61 |
ENSRNOT00000009370
|
LIM homeobox 8 |
|
| chr20_+_8165307 Show fit | 0.55 |
ENSRNOT00000000637
|
Pim-1 proto-oncogene, serine/threonine kinase |
|
| chr15_+_50891127 Show fit | 0.55 |
ENSRNOT00000020728
|
stanniocalcin 1 |
|
| chr15_-_34198921 Show fit | 0.47 |
ENSRNOT00000024991
|
neural retina leucine zipper |
Network of associatons between targets according to the STRING database.
First level regulatory network of Myf6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.7 | GO:0001886 | endothelial cell morphogenesis(GO:0001886) |
| 0.3 | 1.0 | GO:1901662 | phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662) |
| 0.0 | 1.0 | GO:0060021 | palate development(GO:0060021) |
| 0.0 | 0.9 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.1 | 0.7 | GO:0046543 | development of secondary female sexual characteristics(GO:0046543) |
| 0.0 | 0.7 | GO:0021884 | forebrain neuron development(GO:0021884) |
| 0.1 | 0.6 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 0.1 | 0.6 | GO:2000615 | regulation of histone H3-K9 acetylation(GO:2000615) |
| 0.2 | 0.5 | GO:0007468 | regulation of rhodopsin gene expression(GO:0007468) |
| 0.1 | 0.4 | GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.6 | GO:0090571 | RNA polymerase II transcription repressor complex(GO:0090571) |
| 0.1 | 0.6 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
| 0.0 | 0.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.0 | 0.2 | GO:0044393 | TCR signalosome(GO:0036398) microspike(GO:0044393) |
| 0.0 | 0.2 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.0 | 0.2 | GO:0030915 | Smc5-Smc6 complex(GO:0030915) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.1 | 0.9 | GO:0017151 | DEAD/H-box RNA helicase binding(GO:0017151) |
| 0.2 | 0.6 | GO:0001226 | RNA polymerase II transcription corepressor binding(GO:0001226) |
| 0.0 | 0.6 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 0.5 | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen(GO:0016712) |
| 0.0 | 0.4 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.4 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.0 | 0.4 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.1 | 0.3 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 0.5 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.0 | 0.5 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.0 | 0.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 0.2 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 0.2 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.1 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 0.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 0.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 0.4 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.0 | 0.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.0 | 0.2 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.2 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.0 | 0.1 | REACTOME NOTCH HLH TRANSCRIPTION PATHWAY | Genes involved in Notch-HLH transcription pathway |
| 0.0 | 0.1 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.1 | REACTOME THE ACTIVATION OF ARYLSULFATASES | Genes involved in The activation of arylsulfatases |