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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Msx1_Lhx9_Barx1_Rax_Dlx6

Z-value: 0.29

Motif logo

Transcription factors associated with Msx1_Lhx9_Barx1_Rax_Dlx6

Gene Symbol Gene ID Gene Info
ENSRNOG00000006876 msh homeobox 1
ENSRNOG00000010357 LIM homeobox 9
ENSRNOG00000016915 BARX homeobox 1
ENSRNOG00000016944 retina and anterior neural fold homeobox
ENSRNOG00000010822 distal-less homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Msx1rn6_v1_chr14_+_77712240_777122400.856.7e-02Click!
Lhx9rn6_v1_chr13_-_55878094_558780940.751.4e-01Click!
Barx1rn6_v1_chr17_-_14828329_14828329-0.682.1e-01Click!
Raxrn6_v1_chr18_-_61642056_616420560.395.2e-01Click!
Dlx6rn6_v1_chr4_+_32373641_32373641-0.375.4e-01Click!

Activity profile of Msx1_Lhx9_Barx1_Rax_Dlx6 motif

Sorted Z-values of Msx1_Lhx9_Barx1_Rax_Dlx6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_88670430 0.38 ENSRNOT00000025547
hypocretin neuropeptide precursor
chr6_+_8886591 0.30 ENSRNOT00000091510
ENSRNOT00000089174
SIX homeobox 3
chr12_-_2174131 0.10 ENSRNOT00000001313
Purkinje cell protein 2
chr4_-_80395502 0.10 ENSRNOT00000014437
neuropeptide VF precursor
chr2_+_210880777 0.09 ENSRNOT00000026237
G protein subunit alpha transducin 2
chr20_+_44680449 0.07 ENSRNOT00000000728
Traf3 interacting protein 2
chr2_+_145174876 0.07 ENSRNOT00000040631
mab-21 like 1
chr3_+_5709236 0.07 ENSRNOT00000061201
ENSRNOT00000070887
dopamine beta-hydroxylase
chr15_+_44441856 0.06 ENSRNOT00000018006
gonadotropin releasing hormone 1
chr2_-_235249571 0.05 ENSRNOT00000093631
ENSRNOT00000085096
retinal pigment epithelium derived rhodopsin homolog
chr3_-_165537940 0.05 ENSRNOT00000071119
ENSRNOT00000070964
spalt-like transcription factor 4
chr5_+_50381244 0.05 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr9_+_117795132 0.04 ENSRNOT00000086943
A-kinase anchor inhibitor 1
chr10_-_87232723 0.04 ENSRNOT00000015150
keratin 25
chr15_-_95514259 0.04 ENSRNOT00000038433
SLIT and NTRK-like family, member 6
chrX_+_118197217 0.04 ENSRNOT00000090922
5-hydroxytryptamine receptor 2C
chr1_+_101178104 0.04 ENSRNOT00000028072
parathyroid hormone 2
chr14_+_59611434 0.04 ENSRNOT00000065366
cholecystokinin A receptor
chr3_+_9403840 0.04 ENSRNOT00000071380
pyroglutamylated RFamide peptide
chr15_+_11298478 0.03 ENSRNOT00000007672
leucine rich repeat containing 3B
chr9_-_85243001 0.03 ENSRNOT00000020219
secretogranin II
chr6_-_77421286 0.03 ENSRNOT00000011453
NK2 homeobox 1
chr8_+_47674321 0.03 ENSRNOT00000026170
ENSRNOT00000078776
tripartite motif-containing 29
chr12_-_47142852 0.03 ENSRNOT00000001591
POP5 homolog, ribonuclease P/MRP subunit
chr1_-_48825364 0.03 ENSRNOT00000024213
1-acylglycerol-3-phosphate O-acyltransferase 4
chr8_+_71914867 0.02 ENSRNOT00000023372
death-associated protein kinase 2
chr2_+_198755262 0.02 ENSRNOT00000028807
RNA binding motif protein 8A
chr10_-_88172910 0.02 ENSRNOT00000046956
keratin 42
chr20_-_3728844 0.02 ENSRNOT00000074958
psoriasis susceptibility 1 candidate 2
chr12_-_45801842 0.02 ENSRNOT00000078837

chr2_-_219262901 0.02 ENSRNOT00000037068
G-protein coupled receptor 88
chr12_+_24978483 0.01 ENSRNOT00000040069
elastin
chr14_+_76732650 0.01 ENSRNOT00000088197
cytokine-dependent hematopoietic cell linker
chr3_+_45683993 0.01 ENSRNOT00000038983
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
chr17_+_11683862 0.01 ENSRNOT00000024766
msh homeobox 2
chr8_+_106449321 0.01 ENSRNOT00000018622
retinol binding protein 1
chr5_-_28131133 0.01 ENSRNOT00000067331
solute carrier family 26 member 7
chr11_-_32550539 0.01 ENSRNOT00000002715
regulator of calcineurin 1
chr4_+_6827429 0.01 ENSRNOT00000071737
Ras homolog enriched in brain
chr1_+_185863043 0.01 ENSRNOT00000079072
SRY box 6
chr16_+_63958645 0.01 ENSRNOT00000081522
ENSRNOT00000082355
ENSRNOT00000013991
neuregulin 1
chr6_-_125723732 0.01 ENSRNOT00000084815
fibulin 5
chr1_-_279277339 0.01 ENSRNOT00000023667
GDNF family receptor alpha 1
chr3_+_122544788 0.01 ENSRNOT00000063828
transglutaminase 3
chr3_-_171342646 0.01 ENSRNOT00000071853
prostate transmembrane protein, androgen induced 1
chr4_-_67610710 0.01 ENSRNOT00000039067
mitochondrial ribosomal protein S33
chr9_+_40817654 0.01 ENSRNOT00000037392

chr4_+_61924013 0.01 ENSRNOT00000090717
bisphosphoglycerate mutase
chr5_-_28130803 0.01 ENSRNOT00000093186
solute carrier family 26 member 7
chrX_+_6273733 0.01 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr1_+_105284753 0.01 ENSRNOT00000041950
solute carrier family 6 member 5
chr2_+_158097843 0.01 ENSRNOT00000016541
pentraxin 3
chr18_-_31109025 0.01 ENSRNOT00000026381
FCH and double SH3 domains 1
chr7_-_143228060 0.01 ENSRNOT00000088923
ENSRNOT00000012640
keratin 75
chr20_-_25826658 0.01 ENSRNOT00000057950
ENSRNOT00000084660
catenin alpha 3
chr2_+_239415046 0.01 ENSRNOT00000072196
CXXC finger protein 4
chr1_-_134871167 0.01 ENSRNOT00000076300
chromodomain helicase DNA binding protein 2
chr2_-_170301348 0.01 ENSRNOT00000088131
sucrase-isomaltase
chrM_+_7006 0.01 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr3_+_56766475 0.01 ENSRNOT00000078819
Sp5 transcription factor
chr7_+_35773928 0.01 ENSRNOT00000034639
centrosomal protein 83
chr18_+_81694808 0.00 ENSRNOT00000020446
cytochrome b5 type A
chr4_+_158088505 0.00 ENSRNOT00000026643
von Willebrand factor
chr8_-_40137390 0.00 ENSRNOT00000042717
pannexin 3
chr10_+_53740841 0.00 ENSRNOT00000004295
myosin heavy chain 2
chr13_+_49005405 0.00 ENSRNOT00000092560
ENSRNOT00000076457
LEM domain containing 1
chr4_-_4473307 0.00 ENSRNOT00000045773
dipeptidyl peptidase like 6
chr16_-_39476384 0.00 ENSRNOT00000092968
glycoprotein m6a
chr1_-_151106802 0.00 ENSRNOT00000021971
tyrosinase
chr6_-_71199110 0.00 ENSRNOT00000081883
protein kinase D1
chr5_-_12526962 0.00 ENSRNOT00000092104
suppression of tumorigenicity 18
chr13_+_79378733 0.00 ENSRNOT00000039221
tumor necrosis factor superfamily member 18
chr1_-_101819478 0.00 ENSRNOT00000056181
glutamate-rich WD repeat containing 1
chr2_+_240642847 0.00 ENSRNOT00000079694
ubiquitin-conjugating enzyme E2D 3
chr4_+_119225040 0.00 ENSRNOT00000012365
bone morphogenetic protein 10
chr11_-_60679555 0.00 ENSRNOT00000059735
coiled-coil domain containing 80

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx1_Lhx9_Barx1_Rax_Dlx6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0014016 neuroblast differentiation(GO:0014016)
0.1 0.4 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.0 GO:0031583 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.1 GO:2000354 regulation of ovarian follicle development(GO:2000354)
0.0 0.1 GO:0042420 dopamine catabolic process(GO:0042420)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0034774 secretory granule lumen(GO:0034774)
0.0 0.1 GO:1990005 granular vesicle(GO:1990005)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.0 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors