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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Mnx1_Lhx6_Lmx1a
Z-value: 0.67
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Transcription factors associated with Mnx1_Lhx6_Lmx1a
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lmx1a | rn6_v1_chr13_+_85918252_85918252 | 0.78 | 1.2e-01 | Click! |
| Lhx6 | rn6_v1_chr3_-_15433252_15433252 | -0.41 | 5.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_2174131 Show fit | 1.99 |
ENSRNOT00000001313
|
Purkinje cell protein 2 |
|
| chr10_-_88670430 Show fit | 1.51 |
ENSRNOT00000025547
|
hypocretin neuropeptide precursor |
|
| chr2_+_145174876 Show fit | 1.17 |
ENSRNOT00000040631
|
mab-21 like 1 |
|
| chr4_-_80395502 Show fit | 0.60 |
ENSRNOT00000014437
|
neuropeptide VF precursor |
|
| chr5_+_50381244 Show fit | 0.52 |
ENSRNOT00000012385
|
glycoprotein hormones, alpha polypeptide |
|
| chr7_-_28711761 Show fit | 0.47 |
ENSRNOT00000006249
|
PARP1 binding protein |
|
| chr14_+_4362717 Show fit | 0.32 |
ENSRNOT00000002887
|
BarH-like homeobox 2 |
|
| chr8_+_71914867 Show fit | 0.31 |
ENSRNOT00000023372
|
death-associated protein kinase 2 |
|
| chr12_-_17186679 Show fit | 0.30 |
ENSRNOT00000001730
|
UNC homeobox |
|
| chr2_-_185852759 Show fit | 0.25 |
ENSRNOT00000049461
|
mab-21 like 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mnx1_Lhx6_Lmx1a
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0016056 | rhodopsin mediated signaling pathway(GO:0016056) |
| 0.2 | 1.5 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.1 | 0.6 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 0.1 | 0.5 | GO:0046884 | follicle-stimulating hormone secretion(GO:0046884) |
| 0.0 | 0.5 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
| 0.1 | 0.3 | GO:2000422 | regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424) |
| 0.0 | 0.3 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
| 0.0 | 0.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.0 | 0.3 | GO:0010172 | embryonic body morphogenesis(GO:0010172) |
| 0.1 | 0.2 | GO:0014016 | neuroblast differentiation(GO:0014016) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 0.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.0 | 0.1 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 0.1 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 0.1 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 0.1 | GO:0071438 | invadopodium membrane(GO:0071438) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.1 | 0.2 | GO:0071886 | 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886) |
| 0.0 | 0.2 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
| 0.0 | 0.2 | GO:0001222 | transcription corepressor binding(GO:0001222) |
| 0.0 | 0.1 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.0 | 0.1 | GO:0015252 | hydrogen ion channel activity(GO:0015252) |
| 0.0 | 0.1 | GO:0016714 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714) |
| 0.0 | 0.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 0.1 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.0 | 0.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.0 | 0.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 0.2 | REACTOME SEROTONIN RECEPTORS | Genes involved in Serotonin receptors |