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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Mnt
Z-value: 0.76
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Transcription factors associated with Mnt
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mnt | rn6_v1_chr10_+_61685241_61685241 | -0.43 | 4.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123119460 Show fit | 1.05 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr2_-_197991198 Show fit | 0.73 |
ENSRNOT00000056322
|
circadian associated repressor of transcription |
|
| chr2_-_197991574 Show fit | 0.70 |
ENSRNOT00000085632
|
circadian associated repressor of transcription |
|
| chr17_-_9695292 Show fit | 0.63 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr2_-_187160373 Show fit | 0.53 |
ENSRNOT00000018961
|
neurotrophic receptor tyrosine kinase 1 |
|
| chr7_-_13751271 Show fit | 0.45 |
ENSRNOT00000009931
|
solute carrier family 1 member 6 |
|
| chr14_+_4362717 Show fit | 0.44 |
ENSRNOT00000002887
|
BarH-like homeobox 2 |
|
| chr1_+_33910912 Show fit | 0.35 |
ENSRNOT00000044690
|
iroquois homeobox 1 |
|
| chr11_-_36479868 Show fit | 0.35 |
ENSRNOT00000075762
|
non-histone chromosomal protein HMG-14-like |
|
| chr16_+_49462889 Show fit | 0.32 |
ENSRNOT00000039909
|
ankyrin repeat domain 37 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mnt
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.4 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.3 | 1.0 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 0.5 | GO:0061368 | behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368) |
| 0.1 | 0.4 | GO:0072268 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.0 | 0.4 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.1 | 0.3 | GO:0060764 | cell-cell signaling involved in mammary gland development(GO:0060764) |
| 0.1 | 0.3 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.1 | 0.3 | GO:0032763 | regulation of mast cell cytokine production(GO:0032763) |
| 0.1 | 0.3 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 0.1 | 0.3 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.3 | GO:0097413 | Lewy body(GO:0097413) |
| 0.0 | 0.3 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.2 | GO:0005785 | signal recognition particle receptor complex(GO:0005785) |
| 0.0 | 0.2 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.0 | 0.2 | GO:0000506 | glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506) |
| 0.0 | 0.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.2 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.1 | GO:0031510 | SUMO activating enzyme complex(GO:0031510) |
| 0.0 | 0.1 | GO:0061474 | phagolysosome membrane(GO:0061474) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.3 | 1.0 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.1 | 0.5 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.0 | 0.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 0.3 | GO:0071535 | RING-like zinc finger domain binding(GO:0071535) |
| 0.0 | 0.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.3 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.1 | 0.2 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
| 0.1 | 0.2 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.1 | 0.2 | GO:0031871 | proteinase activated receptor binding(GO:0031871) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.2 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 0.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 0.5 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 0.5 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.0 | 0.3 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 0.0 | 0.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.0 | 0.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 0.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.0 | 0.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.0 | 0.2 | REACTOME PURINE CATABOLISM | Genes involved in Purine catabolism |