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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Meis2

Z-value: 0.39

Motif logo

Transcription factors associated with Meis2

Gene Symbol Gene ID Gene Info
ENSRNOG00000004730 Meis homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Meis2rn6_v1_chr3_-_107760550_1077605890.941.8e-02Click!

Activity profile of Meis2 motif

Sorted Z-values of Meis2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_52266100 0.27 ENSRNOT00000087532

chr11_-_88180542 0.17 ENSRNOT00000002539
yippee-like 1
chr2_-_178521038 0.16 ENSRNOT00000033107
relaxin/insulin-like family peptide receptor 1
chr7_+_20462081 0.16 ENSRNOT00000088383

chr13_+_113373578 0.14 ENSRNOT00000009900
plexin A2
chr5_+_8459660 0.13 ENSRNOT00000007491
carboxypeptidase A6
chr5_+_118574801 0.12 ENSRNOT00000035949
ubiquitin-conjugating enzyme E2U (putative)
chr11_+_45888221 0.11 ENSRNOT00000071932
ENSRNOT00000066008
ENSRNOT00000060802
leukemia NUP98 fusion partner 1
chr13_-_82129989 0.11 ENSRNOT00000078963

chr7_+_20262680 0.11 ENSRNOT00000046378
similar to hypothetical protein 4930509O22
chr9_-_73958480 0.11 ENSRNOT00000017838
myosin, light chain 1
chr1_+_220071811 0.11 ENSRNOT00000090642

chrX_+_45637415 0.10 ENSRNOT00000050544
similar to ferritin heavy polypeptide-like 17
chr7_-_70452675 0.10 ENSRNOT00000090498

chr3_-_102151489 0.08 ENSRNOT00000006349
anoctamin 3
chr9_-_49448168 0.08 ENSRNOT00000059478

chr10_-_110101872 0.08 ENSRNOT00000071893
coiled-coil domain containing 57
chr3_-_52998650 0.08 ENSRNOT00000009988
similar to 40S ribosomal protein S3
chr2_-_19808937 0.08 ENSRNOT00000044237
ATPase H+ transporting accessory protein 1 like
chr4_+_181315444 0.08 ENSRNOT00000044147
PPFIA binding protein 1
chr3_-_162035614 0.08 ENSRNOT00000047890
zinc finger protein 663
chr2_-_220838905 0.08 ENSRNOT00000078914

chr12_+_24148567 0.08 ENSRNOT00000077378
ENSRNOT00000045157
C-C motif chemokine ligand 24
chr8_-_115358046 0.08 ENSRNOT00000017607
glutamate metabotropic receptor 2
chr4_-_182844291 0.07 ENSRNOT00000064320
transmembrane and tetratricopeptide repeat containing 1
chr11_-_81444375 0.07 ENSRNOT00000058479
ENSRNOT00000078131
ENSRNOT00000080949
ENSRNOT00000080562
ENSRNOT00000084867
kininogen 1
chr13_+_101790865 0.07 ENSRNOT00000087784
TATA-box binding protein associated factor, RNA polymerase I subunit A
chr1_+_88875375 0.07 ENSRNOT00000028284
Tyro protein tyrosine kinase binding protein
chr9_+_27343853 0.07 ENSRNOT00000072794
transmembrane protein 14A
chr5_+_156613741 0.07 ENSRNOT00000076031
SH2 domain containing 5
chr18_+_47739140 0.07 ENSRNOT00000082760
synuclein, alpha interacting protein
chrX_-_10031167 0.07 ENSRNOT00000060988
G protein-coupled receptor 34
chr5_+_147476221 0.07 ENSRNOT00000010730
syncoilin, intermediate filament protein
chr5_-_105010857 0.07 ENSRNOT00000009749
perilipin 2
chr14_-_1461543 0.07 ENSRNOT00000075656
cytokine receptor-like factor 2
chr16_+_39909270 0.07 ENSRNOT00000081994
WD repeat domain 17
chrX_+_13117239 0.07 ENSRNOT00000088998

chr5_-_156105867 0.06 ENSRNOT00000078851
alkaline phosphatase, liver/bone/kidney
chr3_+_128155069 0.06 ENSRNOT00000051184
ENSRNOT00000006389
phospholipase C beta 1
chr2_+_240021152 0.06 ENSRNOT00000012473
tachykinin receptor 3
chr8_+_33239139 0.06 ENSRNOT00000011589
Rho GTPase activating protein 32
chr12_+_47074200 0.06 ENSRNOT00000014910
dynein light chain LC8-type 1
chr12_+_31530699 0.06 ENSRNOT00000033379
ENSRNOT00000067867
RIMS binding protein 2
chr8_+_119160731 0.06 ENSRNOT00000046745
ALS2 C-terminal like
chr10_-_76166251 0.06 ENSRNOT00000003251
ENSRNOT00000055683
A-kinase anchoring protein 1
chr1_-_82004538 0.06 ENSRNOT00000087572
POU class 2 homeobox 2
chr11_+_84745904 0.06 ENSRNOT00000002617
kelch-like family member 6
chr5_-_2982603 0.06 ENSRNOT00000045460
potassium voltage-gated channel subfamily B member 2
chr8_-_14292698 0.06 ENSRNOT00000073672

chr2_-_104461863 0.06 ENSRNOT00000016953
corticotropin releasing hormone
chr5_-_152589719 0.06 ENSRNOT00000022522
exostosin-like glycosyltransferase 1
chr20_+_28572242 0.06 ENSRNOT00000072485
SH3 domain containing ring finger 3
chr9_+_61738471 0.06 ENSRNOT00000090305

chr8_-_73194837 0.06 ENSRNOT00000024885
ENSRNOT00000081450
ENSRNOT00000064613
talin 2
chr3_+_72329967 0.06 ENSRNOT00000090256
solute carrier family 43, member 3
chr3_-_122946289 0.05 ENSRNOT00000055810
PC-esterase domain containing 1A
chr7_-_15821927 0.05 ENSRNOT00000050658
similar to zinc finger protein 101
chr1_+_15180328 0.05 ENSRNOT00000050656
interleukin 20 receptor subunit alpha
chr20_+_4576057 0.05 ENSRNOT00000081456
ENSRNOT00000085701
euchromatic histone lysine methyltransferase 2
chrX_+_72684329 0.05 ENSRNOT00000057644
DMRT-like family C1c1
chr5_-_74029238 0.05 ENSRNOT00000031432
ferric-chelate reductase 1-like
chr3_-_153321352 0.05 ENSRNOT00000064824
RB transcriptional corepressor like 1
chr1_+_91152635 0.05 ENSRNOT00000073438
dermokine-like
chr19_-_55490426 0.05 ENSRNOT00000081800
CBFA2/RUNX1 translocation partner 3
chr17_-_77261731 0.05 ENSRNOT00000066850
upper zone of growth plate and cartilage matrix associated
chr6_-_51297712 0.05 ENSRNOT00000082985
protein kinase cAMP-dependent type 2 regulatory subunit beta
chr18_+_56414488 0.05 ENSRNOT00000088988
colony stimulating factor 1 receptor
chr1_+_87045796 0.05 ENSRNOT00000027620
galectin 7
chr6_+_59757397 0.05 ENSRNOT00000047001

chr14_+_82350734 0.05 ENSRNOT00000023259
transmembrane protein 129
chr14_-_78377825 0.05 ENSRNOT00000068104

chr10_-_110585376 0.05 ENSRNOT00000054917
Rab40b, member RAS oncogene family
chr12_-_6341902 0.05 ENSRNOT00000001201
heat shock protein family H (Hsp110) member 1
chr14_+_104250617 0.05 ENSRNOT00000079874
sprouty-related, EVH1 domain containing 2
chr7_-_14369821 0.05 ENSRNOT00000008560
A-kinase anchoring protein 8 like
chr7_-_120744602 0.05 ENSRNOT00000018564
potassium voltage-gated channel subfamily J member 4
chr2_-_149432106 0.05 ENSRNOT00000051027
purinergic receptor P2Y13
chr2_-_186232292 0.05 ENSRNOT00000087088
doublecortin-like kinase 2
chr1_+_248195797 0.05 ENSRNOT00000066891
tumor protein D55-like
chr1_+_166534643 0.04 ENSRNOT00000026586
phosphodiesterase 2A
chr3_+_80555196 0.04 ENSRNOT00000067318
Rho GTPase activating protein 1
chrX_-_23187341 0.04 ENSRNOT00000000180
5'-aminolevulinate synthase 2
chr1_-_82003691 0.04 ENSRNOT00000084569
POU class 2 homeobox 2
chr3_+_58632476 0.04 ENSRNOT00000010630
Rap guanine nucleotide exchange factor 4
chrX_+_15114892 0.04 ENSRNOT00000078168
WD repeat domain 13
chr10_+_36715565 0.04 ENSRNOT00000005048
CDC-like kinase 4
chr10_+_105498728 0.04 ENSRNOT00000032163
sphingosine kinase 1
chr1_-_48686713 0.04 ENSRNOT00000091196

chr14_-_34115273 0.04 ENSRNOT00000032156
centrosomal protein 135
chr6_-_94834908 0.04 ENSRNOT00000006284
trans-L-3-hydroxyproline dehydratase
chr10_+_92667869 0.04 ENSRNOT00000082780
ENSRNOT00000073350
integrin subunit beta 3
chr5_+_50381244 0.04 ENSRNOT00000012385
glycoprotein hormones, alpha polypeptide
chr7_+_70697050 0.04 ENSRNOT00000045964
R3H domain containing 2
chr17_-_43626538 0.04 ENSRNOT00000074292
histone cluster 2, H3c2
chr11_-_38420032 0.04 ENSRNOT00000002209
ENSRNOT00000080681
C2 calcium-dependent domain containing 2
chr10_+_62191656 0.04 ENSRNOT00000029866
SET and MYND domain containing 4
chr4_-_109532234 0.04 ENSRNOT00000008665
regenerating family member 3 gamma
chr2_-_219628997 0.04 ENSRNOT00000064484
tRNA methyltransferase 13 homolog
chr5_-_48165317 0.04 ENSRNOT00000088179
ankyrin repeat domain 6
chr15_-_103340239 0.04 ENSRNOT00000067309
ENSRNOT00000088909
TDP-glucose 4,6-dehydratase
chr19_-_50220455 0.04 ENSRNOT00000079760
short chain dehydrogenase/reductase family 42E, member 1
chr19_+_14459450 0.04 ENSRNOT00000079257
zinc finger protein 82
chr1_+_191704311 0.04 ENSRNOT00000024057
sodium channel epithelial 1 gamma subunit
chr1_-_78626284 0.04 ENSRNOT00000052299
carcinoembryonic antigen-related cell adhesion molecule 3-like
chr4_-_119568736 0.04 ENSRNOT00000041234
aprataxin and PNKP like factor
chr11_+_46737892 0.04 ENSRNOT00000052182

chr16_-_6245644 0.04 ENSRNOT00000040759
calcium voltage-gated channel subunit alpha1 D
chr7_+_123482255 0.04 ENSRNOT00000064487
hypothetical protein LOC688613
chr1_+_141218095 0.04 ENSRNOT00000051411
similar to 6.8 kDa mitochondrial proteolipid
chr19_+_25143428 0.04 ENSRNOT00000007535
paralemmin 3
chr7_-_3170146 0.04 ENSRNOT00000036373
diacylglycerol kinase, alpha
chr13_+_104816371 0.04 ENSRNOT00000086497

chr13_-_37287458 0.04 ENSRNOT00000003391
insulin induced gene 2
chr17_-_14058642 0.04 ENSRNOT00000019489
nucleoredoxin-like 2
chr5_-_173680290 0.04 ENSRNOT00000027564
sterile alpha motif domain containing 11
chr12_+_41200718 0.04 ENSRNOT00000038426
ENSRNOT00000048450
ENSRNOT00000067176
2'-5' oligoadenylate synthetase 1A
chr10_-_58834538 0.04 ENSRNOT00000020043
solute carrier family 13 member 5
chr11_+_80358211 0.04 ENSRNOT00000002519
somatostatin
chr17_-_43675934 0.04 ENSRNOT00000081345
histone cluster 1 H1 family member t
chr12_+_660011 0.04 ENSRNOT00000040830
PDS5 cohesin associated factor B
chr9_-_40008680 0.04 ENSRNOT00000016578
KH RNA binding domain containing, signal transduction associated 2
chr3_+_36173002 0.04 ENSRNOT00000038906
LRRGT00012
chr14_-_5428757 0.04 ENSRNOT00000002897
leucine rich repeat containing 8 family, member B
chr3_-_123997277 0.04 ENSRNOT00000058238
similar to Proteasome subunit beta type 3 (Proteasome theta chain)
chr16_+_7336685 0.04 ENSRNOT00000025853
Brca1 associated protein 1
chr8_-_39551700 0.04 ENSRNOT00000091894
ENSRNOT00000076025
PBX/knotted 1 homeobox 2
chr6_-_132802206 0.03 ENSRNOT00000080163
ENSRNOT00000050350
tryptophanyl-tRNA synthetase
chr6_+_6908684 0.03 ENSRNOT00000079095
metastasis associated 1 family, member 3
chr1_-_88112683 0.03 ENSRNOT00000090615
sprouty-related, EVH1 domain containing 3
chr13_-_83202864 0.03 ENSRNOT00000003976
X-C motif chemokine ligand 1
chr8_+_56179816 0.03 ENSRNOT00000059078
Rho GTPase activating protein 20
chr7_-_57679795 0.03 ENSRNOT00000007461
thyrotropin-releasing hormone degrading enzyme
chr4_-_116786391 0.03 ENSRNOT00000086297
ENSRNOT00000091490
exocyst complex component 6B
chr1_-_199655147 0.03 ENSRNOT00000026979
zinc finger protein 239-like
chr8_-_55696601 0.03 ENSRNOT00000016127
RGD1562914
chr4_+_88423412 0.03 ENSRNOT00000040163
vomeronasal 1 receptor 88
chr17_+_2690062 0.03 ENSRNOT00000024937
olfactory receptor 1653
chr2_+_147006830 0.03 ENSRNOT00000080780

chr1_+_72756809 0.03 ENSRNOT00000082423
protein phosphatase 6, regulatory subunit 1
chr5_+_145079803 0.03 ENSRNOT00000084202
splicing factor proline and glutamine rich
chr2_+_183674522 0.03 ENSRNOT00000014433
transmembrane protein 154
chr4_+_22859622 0.03 ENSRNOT00000073501
ENSRNOT00000068410
ADAM metallopeptidase domain 22
chrX_-_45419817 0.03 ENSRNOT00000087509
prostaglandin E synthase 3-like 1
chr18_+_30387937 0.03 ENSRNOT00000027210
protocadherin beta 4
chr8_+_119228612 0.03 ENSRNOT00000078439
ENSRNOT00000043737
leucine rich repeat containing 2
chr7_-_107223047 0.03 ENSRNOT00000007250
ENSRNOT00000084875
leucine rich repeat containing 6
chr6_-_108976489 0.03 ENSRNOT00000007350
ribosomal protein S6 kinase-like 1
chr2_+_211337271 0.03 ENSRNOT00000045155
cytochrome c oxidase subunit 6B1
chr8_-_62616828 0.03 ENSRNOT00000068340
AT-rich interaction domain 3B
chr5_+_149047681 0.03 ENSRNOT00000015198
lysosomal protein transmembrane 5
chr4_+_81311490 0.03 ENSRNOT00000016265
sorting nexin 10
chr17_+_87274944 0.03 ENSRNOT00000073718
enhancer trap locus 4
chr10_-_11935382 0.03 ENSRNOT00000010059
zinc finger protein 174
chrX_+_77143892 0.03 ENSRNOT00000085227
ATPase copper transporting alpha
chr3_-_160573978 0.03 ENSRNOT00000018386
WAP four-disulfide core domain 5
chr2_-_227411964 0.03 ENSRNOT00000019931
synaptopodin 2
chr3_-_51297852 0.03 ENSRNOT00000001607
cordon-bleu WH2 repeat protein-like 1
chr15_-_70399924 0.03 ENSRNOT00000087940
diaphanous-related formin 3
chr1_-_142615673 0.03 ENSRNOT00000018021
IQ motif containing GTPase activating protein 1
chr5_-_59543101 0.03 ENSRNOT00000019532
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr3_+_7686503 0.03 ENSRNOT00000017984
senataxin
chr1_-_217620420 0.03 ENSRNOT00000092783
cortactin
chr8_-_107656861 0.03 ENSRNOT00000050374
muscle RAS oncogene homolog
chrX_+_984798 0.03 ENSRNOT00000073016
zinc finger protein 182
chr3_+_156642464 0.03 ENSRNOT00000085354
topoisomerase (DNA) I
chr5_+_145145983 0.03 ENSRNOT00000079732
zinc finger MYM-type containing 6
chr1_-_195096694 0.03 ENSRNOT00000088874
SNRPN upstream reading frame
chr1_+_61314070 0.03 ENSRNOT00000077642
zinc finger protein 54
chr1_-_261051498 0.03 ENSRNOT00000071417
Rho GTPase activating protein 19
chr2_-_173542284 0.03 ENSRNOT00000013111
zinc finger, B-box domain containing
chr20_-_30748784 0.03 ENSRNOT00000084391
sphingosine-1-phosphate lyase 1
chr3_+_100768637 0.03 ENSRNOT00000083542
brain-derived neurotrophic factor
chr8_-_33121002 0.03 ENSRNOT00000047211
LRRGT00010-like
chr5_-_57008795 0.03 ENSRNOT00000090891
ENSRNOT00000046463
aprataxin
chr7_-_34951644 0.03 ENSRNOT00000030015
vezatin, adherens junctions transmembrane protein
chr14_+_17531398 0.03 ENSRNOT00000050038
cyclin dependent kinase like 2
chr1_-_81295442 0.03 ENSRNOT00000030900
immunity related GTPase cinema
chr7_-_8060373 0.03 ENSRNOT00000071699
olfactory receptor 798
chr10_+_15183803 0.03 ENSRNOT00000039777
F-box and leucine-rich repeat protein 16
chr7_+_143874734 0.03 ENSRNOT00000093277
predicted gene 9918
chr4_+_145653602 0.03 ENSRNOT00000038964
TatD DNase domain containing 2
chr5_+_56797502 0.03 ENSRNOT00000067992
transmembrane protein 215
chr7_-_105592804 0.03 ENSRNOT00000006789
adenylate cyclase 8
chr4_+_120671489 0.03 ENSRNOT00000029125
monoglyceride lipase
chr3_-_113231790 0.03 ENSRNOT00000019025
tumor protein p53 binding protein 1
chr3_+_28627084 0.03 ENSRNOT00000049884
Rho GTPase activating protein 15
chr6_-_55001464 0.03 ENSRNOT00000006618
aryl hydrocarbon receptor
chr16_-_71237118 0.03 ENSRNOT00000066974
nuclear receptor binding SET domain protein 3
chr9_+_81518176 0.02 ENSRNOT00000078317
ENSRNOT00000019265
ENSRNOT00000088246
ENSRNOT00000084682
actin related protein 2/3 complex, subunit 2
chr15_-_51967806 0.02 ENSRNOT00000012993
ENSRNOT00000084166
ENSRNOT00000091826
ENSRNOT00000082505
protein phosphatase 3 catalytic subunit gamma
chr11_+_38727048 0.02 ENSRNOT00000081537
zinc finger protein 260-like
chr1_-_116567189 0.02 ENSRNOT00000048996
protein BEX1-like
chr7_-_115045802 0.02 ENSRNOT00000040236
ENSRNOT00000071818
maestro heat-like repeat family member 5
chr1_+_161922141 0.02 ENSRNOT00000078300
ENSRNOT00000015784
asparaginyl-tRNA synthetase 2 (mitochondrial)(putative)
chr11_+_34557679 0.02 ENSRNOT00000002289
ripply transcriptional repressor 3
chr2_-_259150479 0.02 ENSRNOT00000085892

chrX_+_28072826 0.02 ENSRNOT00000039796
FERM and PDZ domain containing 4
chr3_+_150574473 0.02 ENSRNOT00000023905
agouti signaling protein
chr17_+_76306585 0.02 ENSRNOT00000065978
dehydrogenase E1 and transketolase domain containing 1
chr3_-_147143576 0.02 ENSRNOT00000091811
ENSRNOT00000012727
syntaphilin

Network of associatons between targets according to the STRING database.

First level regulatory network of Meis2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0002380 immunoglobulin secretion involved in immune response(GO:0002380)
0.0 0.1 GO:1901423 response to benzene(GO:1901423)
0.0 0.1 GO:0071529 cementum mineralization(GO:0071529)
0.0 0.1 GO:0071350 monocyte extravasation(GO:0035696) interleukin-12-mediated signaling pathway(GO:0035722) interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-12(GO:0071349) cellular response to interleukin-15(GO:0071350)
0.0 0.1 GO:0071314 cellular response to cocaine(GO:0071314)
0.0 0.0 GO:2000410 regulation of thymocyte migration(GO:2000410)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.1 GO:0060174 limb bud formation(GO:0060174)
0.0 0.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.0 GO:2000474 adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) regulation of opioid receptor signaling pathway(GO:2000474)
0.0 0.1 GO:0061590 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0 0.1 GO:1903575 cornified envelope assembly(GO:1903575)
0.0 0.0 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.0 0.0 GO:0071422 succinate transport(GO:0015744) succinate transmembrane transport(GO:0071422)
0.0 0.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 0.1 GO:0097338 response to antipsychotic drug(GO:0097332) response to clozapine(GO:0097338)
0.0 0.1 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0033503 HULC complex(GO:0033503)
0.0 0.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.0 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.1 GO:0004995 tachykinin receptor activity(GO:0004995)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.0 0.0 GO:0008481 sphinganine kinase activity(GO:0008481)
0.0 0.1 GO:0051431 corticotropin-releasing hormone receptor 2 binding(GO:0051431)
0.0 0.0 GO:0015141 succinate transmembrane transporter activity(GO:0015141)
0.0 0.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.0 GO:0036004 GAF domain binding(GO:0036004)
0.0 0.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions