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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Mef2d_Mef2a

Z-value: 0.42

Motif logo

Transcription factors associated with Mef2d_Mef2a

Gene Symbol Gene ID Gene Info
ENSRNOG00000031778 myocyte enhancer factor 2D
ENSRNOG00000047756 myocyte enhancer factor 2a

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mef2drn6_v1_chr2_+_187512164_1875121640.612.7e-01Click!
Mef2arn6_v1_chr1_-_128287151_1282871510.444.6e-01Click!

Activity profile of Mef2d_Mef2a motif

Sorted Z-values of Mef2d_Mef2a motif

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_73827488 0.35 ENSRNOT00000064070
ankyrin 1
chr4_+_148782479 0.33 ENSRNOT00000018133
similar to hypothetical protein MGC6835
chr18_-_26211445 0.32 ENSRNOT00000027739
neuronal regeneration related protein
chr2_+_196334626 0.30 ENSRNOT00000050914
ENSRNOT00000028645
ENSRNOT00000090729
semaphorin 6C
chrX_-_40086870 0.23 ENSRNOT00000010027
small muscle protein, X-linked
chr3_-_170040953 0.19 ENSRNOT00000005866
cerebellin 4 precursor
chr16_+_72388880 0.19 ENSRNOT00000072459
similar to Protein C8orf4 (Thyroid cancer protein 1) (TC-1)
chr2_+_204512302 0.18 ENSRNOT00000021846
calsequestrin 2
chr1_-_25839198 0.18 ENSRNOT00000090388
ENSRNOT00000092757
ENSRNOT00000042072
triadin
chr2_-_45518502 0.15 ENSRNOT00000014627
heat shock protein family B (small) member 3
chr12_-_23841049 0.14 ENSRNOT00000031555
heat shock protein family B (small) member 1
chr10_-_56558487 0.13 ENSRNOT00000023256
solute carrier family 2 member 4
chr5_-_114014277 0.11 ENSRNOT00000011731
Jun proto-oncogene, AP-1 transcription factor subunit
chr3_+_150323116 0.11 ENSRNOT00000023429
ENSRNOT00000080485
RALY heterogeneous nuclear ribonucleoprotein
chr10_-_88670430 0.11 ENSRNOT00000025547
hypocretin neuropeptide precursor
chr1_-_199624783 0.10 ENSRNOT00000026908
cytochrome c oxidase subunit 6A2
chrX_+_71528988 0.10 ENSRNOT00000075963
O-linked N-acetylglucosamine (GlcNAc) transferase
chr1_+_101178104 0.10 ENSRNOT00000028072
parathyroid hormone 2
chr1_+_199449973 0.08 ENSRNOT00000029994
tripartite motif containing 72
chr4_+_153874852 0.08 ENSRNOT00000079744
solute carrier family 6 member 13
chr10_-_32471454 0.08 ENSRNOT00000003224
sarcoglycan, delta
chr1_-_264975132 0.08 ENSRNOT00000021748
ladybird homeobox 1
chr13_-_90710148 0.08 ENSRNOT00000010113
ENSRNOT00000080638
potassium voltage-gated channel subfamily J member 9
chr7_+_142912316 0.08 ENSRNOT00000010171
nuclear receptor subfamily 4, group A, member 1
chr1_+_238222521 0.07 ENSRNOT00000024000
aldehyde dehydrogenase 1 family, member A1
chrX_+_33895769 0.07 ENSRNOT00000085993
ENSRNOT00000079365
RALBP1 associated Eps domain containing protein 2
chr1_+_31531143 0.07 ENSRNOT00000034704
leucine rich repeat containing 14B
chr10_+_55687050 0.07 ENSRNOT00000057136
period circadian clock 1
chr3_+_58965552 0.07 ENSRNOT00000002068
mitogen-activated protein kinase kinase kinase 20
chr11_-_34526931 0.07 ENSRNOT00000002291
holocarboxylase synthetase
chr8_+_110982777 0.07 ENSRNOT00000010992
kyphoscoliosis peptidase
chr5_-_22769907 0.06 ENSRNOT00000047805
ENSRNOT00000076167
ENSRNOT00000076507
ENSRNOT00000076113
ENSRNOT00000083779
aspartate-beta-hydroxylase
chr10_+_63803309 0.06 ENSRNOT00000036666
myosin 1C
chr5_+_147257678 0.06 ENSRNOT00000066268
ring finger protein 19B
chr6_+_73553210 0.06 ENSRNOT00000006562
A-kinase anchoring protein 6
chr10_-_4257868 0.06 ENSRNOT00000035886
TNF receptor superfamily member 17
chr5_+_152533349 0.06 ENSRNOT00000067524
tripartite motif containing 63
chr8_+_117836701 0.05 ENSRNOT00000043345
plexin B1
chr3_+_161433410 0.05 ENSRNOT00000024657
solute carrier family 12 member 5
chr2_-_172361779 0.05 ENSRNOT00000085876
schwannomin interacting protein 1
chr4_-_81241152 0.05 ENSRNOT00000015325
ENSRNOT00000015152
heterogeneous nuclear ribonucleoprotein A2/B1
chr10_-_16046033 0.05 ENSRNOT00000089460
cytoplasmic polyadenylation element binding protein 4
chr2_-_247988462 0.05 ENSRNOT00000022387
PDZ and LIM domain 5
chr9_-_9702306 0.05 ENSRNOT00000082341
thyroid hormone receptor interactor 10
chr2_-_227411964 0.05 ENSRNOT00000019931
synaptopodin 2
chr4_-_179512471 0.04 ENSRNOT00000012588
KRAS proto-oncogene, GTPase
chr3_+_151126591 0.04 ENSRNOT00000025859
myosin heavy chain 7B
chr3_+_79940561 0.04 ENSRNOT00000016652
myosin binding protein C, cardiac
chr18_+_63203063 0.04 ENSRNOT00000024144
PRELI domain containing 3A
chr15_+_4064706 0.04 ENSRNOT00000011956
synaptopodin 2-like
chr13_-_90602365 0.04 ENSRNOT00000009344
calsequestrin 1
chr13_-_51076165 0.04 ENSRNOT00000004602
adenosine A1 receptor
chr18_+_32273770 0.04 ENSRNOT00000087408
fibroblast growth factor 1
chr7_+_142905758 0.04 ENSRNOT00000078663
nuclear receptor subfamily 4, group A, member 1
chr10_-_16045835 0.03 ENSRNOT00000064832
cytoplasmic polyadenylation element binding protein 4
chr13_-_99531959 0.03 ENSRNOT00000005059
WD repeat domain 26
chr3_+_56868167 0.03 ENSRNOT00000087134
glutamate decarboxylase 1
chr3_+_173955686 0.03 ENSRNOT00000088447
family with sequence similarity 217, member B
chr9_+_82571269 0.03 ENSRNOT00000026941
SPEG complex locus
chr2_+_219598162 0.03 ENSRNOT00000020297
leucine rich repeat containing 39
chr5_-_144274981 0.03 ENSRNOT00000065871
MAP7 domain containing 1
chr5_+_151776004 0.03 ENSRNOT00000009683
nuclear receptor subfamily 0, group B, member 2
chr8_-_55177818 0.03 ENSRNOT00000013960
heat shock protein family B (small) member 2
chr1_+_100299626 0.03 ENSRNOT00000092327
ENSRNOT00000044257
SH3 and multiple ankyrin repeat domains 1
chr16_-_74264142 0.03 ENSRNOT00000026067
dickkopf WNT signaling pathway inhibitor 4
chr2_-_104958034 0.03 ENSRNOT00000080699
glycogenin 1
chr9_+_82556573 0.03 ENSRNOT00000026860
desmin
chr2_-_33025271 0.03 ENSRNOT00000074941
microtubule associated serine/threonine kinase family member 4
chr3_+_111818150 0.02 ENSRNOT00000067181
jumonji domain containing 7
chr1_-_142164007 0.02 ENSRNOT00000078982
mannosidase, alpha, class 2A, member 2
chr3_-_5575136 0.02 ENSRNOT00000008034
solute carrier family 2 member 6
chr10_-_65502936 0.02 ENSRNOT00000089615
SPT6 homolog, histone chaperone
chr7_+_35309265 0.02 ENSRNOT00000080291
transmembrane and coiled-coil domain family 3
chr10_-_86688730 0.02 ENSRNOT00000055333
nuclear receptor subfamily 1, group D, member 1
chr2_+_93792601 0.02 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr8_+_130416355 0.02 ENSRNOT00000026234
kelch-like family member 40
chr12_+_17734133 0.02 ENSRNOT00000042117
platelet derived growth factor subunit A
chr17_+_57075218 0.02 ENSRNOT00000089536
cAMP responsive element modulator
chr2_+_198772937 0.02 ENSRNOT00000028812
integrin subunit alpha 10
chr13_+_52624878 0.02 ENSRNOT00000076054
ENSRNOT00000076299
troponin I1, slow skeletal type
chr4_-_100303047 0.02 ENSRNOT00000018170
ENSRNOT00000084782
methionine adenosyltransferase 2A
chr1_-_166912524 0.02 ENSRNOT00000092952
inositol polyphosphate phosphatase-like 1
chr16_+_49266903 0.02 ENSRNOT00000014704
solute carrier family 25 member 4
chr2_-_187854363 0.02 ENSRNOT00000092993
lamin A/C
chr2_+_212257225 0.02 ENSRNOT00000077883
vav guanine nucleotide exchange factor 3
chr10_+_90217924 0.02 ENSRNOT00000028388
ankyrin repeat and SOCS box-containing 16
chr1_-_56683731 0.02 ENSRNOT00000014552
thrombospondin 2
chr15_-_28314459 0.02 ENSRNOT00000042055
ENSRNOT00000040540
NDRG family member 2
chr9_-_97151832 0.02 ENSRNOT00000040169
ankyrin repeat and SOCS box-containing 18
chr4_+_71675383 0.02 ENSRNOT00000051265
chloride voltage-gated channel 1
chr14_+_63095720 0.02 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr5_-_150704117 0.02 ENSRNOT00000067455
sestrin 2
chr9_-_113504605 0.02 ENSRNOT00000067974
RAB31, member RAS oncogene family
chr6_-_136145837 0.02 ENSRNOT00000015122
creatine kinase B
chr1_-_142164263 0.02 ENSRNOT00000016281
mannosidase, alpha, class 2A, member 2
chr13_+_99136871 0.01 ENSRNOT00000078263
ENSRNOT00000004350
SDE2 telomere maintenance homolog
chr13_-_81214494 0.01 ENSRNOT00000004950
ENSRNOT00000082385
paired related homeobox 1
chr10_+_89459650 0.01 ENSRNOT00000028149
ENSRNOT00000077942
NBR1, autophagy cargo receptor
chr10_+_3218466 0.01 ENSRNOT00000093629
ENSRNOT00000093338
ENSRNOT00000077695
N-terminal asparagine amidase
chr11_-_90406797 0.01 ENSRNOT00000073049
snail family transcriptional repressor 2
chr17_-_43689311 0.01 ENSRNOT00000028779
histone cluster 1, H2bc-like 1
chr17_+_72218769 0.01 ENSRNOT00000041346
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr3_+_65816569 0.01 ENSRNOT00000079672
ubiquitin-conjugating enzyme E2E 3
chr10_-_70871066 0.01 ENSRNOT00000015139
C-C motif chemokine ligand 3
chr1_-_282170017 0.01 ENSRNOT00000066947
eukaryotic translation initiation factor 3, subunit A
chr2_-_198016898 0.01 ENSRNOT00000025523
carbonic anhydrase 14
chr3_+_5709236 0.01 ENSRNOT00000061201
ENSRNOT00000070887
dopamine beta-hydroxylase
chr10_+_86337728 0.01 ENSRNOT00000085408
titin-cap
chr2_-_197991198 0.01 ENSRNOT00000056322
circadian associated repressor of transcription
chr2_-_157759819 0.01 ENSRNOT00000015763
ENSRNOT00000016016
cyclin-L1-like
chr3_+_79918969 0.01 ENSRNOT00000016306
Spi-1 proto-oncogene
chr7_-_123767797 0.01 ENSRNOT00000012699
transcription factor 20
chr1_-_199270627 0.01 ENSRNOT00000026063
syntaxin 1B
chr2_-_178057157 0.01 ENSRNOT00000091135
Rap guanine nucleotide exchange factor 2
chr2_-_197991574 0.01 ENSRNOT00000085632
circadian associated repressor of transcription
chr3_+_122114108 0.01 ENSRNOT00000091935
signal-regulatory protein alpha
chr17_-_43614844 0.01 ENSRNOT00000023054
histone cluster 1 H1 family member a
chr20_+_13940877 0.01 ENSRNOT00000093587
calcineurin binding protein 1
chr2_+_198721724 0.01 ENSRNOT00000043535
ankyrin repeat domain 34A
chr4_+_83391283 0.01 ENSRNOT00000031365
cAMP responsive element binding protein 5
chr7_-_132143470 0.01 ENSRNOT00000038946
ENSRNOT00000044092
ENSRNOT00000066528
ENSRNOT00000045553
ENSRNOT00000046744
ENSRNOT00000055742
kinesin family member 21A
chr2_+_184230459 0.01 ENSRNOT00000074187

chr13_+_52662996 0.01 ENSRNOT00000047682
troponin T2, cardiac type
chr9_-_52238564 0.01 ENSRNOT00000005073
collagen type V alpha 2 chain
chr15_+_3996048 0.00 ENSRNOT00000078653
N-deacetylase and N-sulfotransferase 2
chr9_+_47536824 0.00 ENSRNOT00000049349
transmembrane protein 182
chr10_+_53740841 0.00 ENSRNOT00000004295
myosin heavy chain 2
chr4_-_50312608 0.00 ENSRNOT00000010019
Fez family zinc finger 1
chr1_+_21748261 0.00 ENSRNOT00000019519
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr5_+_173640780 0.00 ENSRNOT00000027476
PPARGC1 and ESRR induced regulator, muscle 1
chr13_-_77896697 0.00 ENSRNOT00000003452
tenascin N
chr14_-_17171580 0.00 ENSRNOT00000085525
ADP-ribosyltransferase 3
chrX_-_138972684 0.00 ENSRNOT00000040165
heparan sulfate 6-O-sulfotransferase 2
chr16_+_2537248 0.00 ENSRNOT00000017995
ankyrin repeat and SOCS box-containing 14
chr1_+_265904566 0.00 ENSRNOT00000086041
ENSRNOT00000036156
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr5_+_154598758 0.00 ENSRNOT00000015776
transcription elongation factor A3
chr10_+_82032656 0.00 ENSRNOT00000067751
ankyrin repeat domain 40
chr20_-_20713128 0.00 ENSRNOT00000000784
Rho-related BTB domain containing 1
chr7_+_144628120 0.00 ENSRNOT00000022247
homeo box C5
chr10_-_82785142 0.00 ENSRNOT00000005381
sarcoglycan, alpha
chr8_-_127782070 0.00 ENSRNOT00000045493
phospholipase C, delta 1
chr15_-_33250546 0.00 ENSRNOT00000017857
similar to RIKEN cDNA 4931414P19
chr5_-_152589719 0.00 ENSRNOT00000022522
exostosin-like glycosyltransferase 1
chr1_-_89488223 0.00 ENSRNOT00000028624
FXYD domain-containing ion transport regulator 1
chr7_-_14402010 0.00 ENSRNOT00000008303
widely-interspaced zinc finger motifs
chr7_-_107391184 0.00 ENSRNOT00000056793
transmembrane protein 71
chr14_+_83897117 0.00 ENSRNOT00000026569
MORC family CW-type zinc finger 2
chr20_-_31597830 0.00 ENSRNOT00000085877
collagen type XIII alpha 1 chain

Network of associatons between targets according to the STRING database.

First level regulatory network of Mef2d_Mef2a

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0090158 endoplasmic reticulum membrane organization(GO:0090158)
0.0 0.1 GO:1903544 cellular response to interleukin-11(GO:0071348) response to butyrate(GO:1903544)
0.0 0.2 GO:0071313 cellular response to caffeine(GO:0071313)
0.0 0.1 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
0.0 0.1 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.1 GO:0097167 circadian regulation of translation(GO:0097167)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.0 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 0.0 GO:0070256 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
0.0 0.3 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.1 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.2 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 0.3 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:0035976 AP1 complex(GO:0035976)
0.0 0.1 GO:0005927 muscle tendon junction(GO:0005927)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0097363 protein O-GlcNAc transferase activity(GO:0097363)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.0 GO:0019002 GMP binding(GO:0019002)