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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Mecp2
Z-value: 2.57
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Transcription factors associated with Mecp2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mecp2 | rn6_v1_chrX_+_156655960_156655960 | 0.99 | 1.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Mecp2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.6 | GO:1904717 | regulation of AMPA glutamate receptor clustering(GO:1904717) |
| 1.1 | 3.2 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 0.4 | 3.2 | GO:0021942 | radial glia guided migration of Purkinje cell(GO:0021942) |
| 0.3 | 3.1 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.3 | 2.9 | GO:0045634 | regulation of melanocyte differentiation(GO:0045634) |
| 0.1 | 2.8 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 0.1 | 2.3 | GO:0006896 | Golgi to vacuole transport(GO:0006896) |
| 0.3 | 1.9 | GO:0043435 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.0 | 1.8 | GO:0006182 | cGMP biosynthetic process(GO:0006182) |
| 0.1 | 1.7 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 5.8 | GO:0060170 | ciliary membrane(GO:0060170) |
| 0.0 | 4.7 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.3 | 3.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 3.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 2.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.1 | 2.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 2.0 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.1 | 1.9 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 1.9 | GO:0030027 | lamellipodium(GO:0030027) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 9.0 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 6.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.1 | 4.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 4.3 | GO:0003724 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) |
| 0.0 | 4.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 3.3 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 3.2 | GO:0005249 | voltage-gated potassium channel activity(GO:0005249) |
| 0.1 | 3.0 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.1 | 2.9 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.9 | 2.6 | GO:0031826 | type 2A serotonin receptor binding(GO:0031826) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.5 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.1 | 4.0 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 3.8 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.1 | 3.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 2.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 2.6 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.1 | 1.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.8 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.3 | 3.0 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 2.7 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |
| 0.0 | 2.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 2.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 2.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.2 | 2.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.1 | 2.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 2.2 | REACTOME ERK MAPK TARGETS | Genes involved in ERK/MAPK targets |