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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Mbd2

Z-value: 0.57

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Transcription factors associated with Mbd2

Gene Symbol Gene ID Gene Info
ENSRNOG00000011853 methyl-CpG binding domain protein 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Mbd2rn6_v1_chr18_+_65814026_658140260.503.9e-01Click!

Activity profile of Mbd2 motif

Sorted Z-values of Mbd2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_78902063 0.35 ENSRNOT00000088469
protein phosphatase 2, regulatory subunit B, gamma
chr10_+_85301875 0.34 ENSRNOT00000080935
suppressor of cytokine signaling 7
chr6_-_109162267 0.27 ENSRNOT00000077518
NIMA-related kinase 9
chr1_-_267245636 0.24 ENSRNOT00000082799
SH3 and PX domains 2A
chr6_-_27190126 0.22 ENSRNOT00000068412
ENSRNOT00000013107
potassium two pore domain channel subfamily K member 3
chr3_-_164095878 0.22 ENSRNOT00000079414
beta-1,4-galactosyltransferase 5
chr16_+_19051965 0.21 ENSRNOT00000016399
solute carrier family 35, member E1
chr19_-_53688597 0.20 ENSRNOT00000074448
zinc finger CCHC-type containing 14
chr15_+_108908607 0.20 ENSRNOT00000089455
Zic family member 2
chr8_+_117486083 0.19 ENSRNOT00000027552
ENSRNOT00000088705
protein kinase cAMP-dependent type 2 regulatory subunit alpha
chr10_-_63952726 0.18 ENSRNOT00000090461
double C2 domain beta
chr10_+_62674561 0.16 ENSRNOT00000019946
ENSRNOT00000056110
ankyrin repeat domain 13B
chr10_-_90393317 0.16 ENSRNOT00000028563
family with sequence similarity 171, member A2
chrX_-_73778595 0.15 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
ring finger protein, LIM domain interacting
chr7_+_130498199 0.15 ENSRNOT00000092684
ENSRNOT00000092431
SH3 and multiple ankyrin repeat domains 3
chr9_+_82571269 0.14 ENSRNOT00000026941
SPEG complex locus
chr17_-_10208360 0.13 ENSRNOT00000087397
unc-5 netrin receptor A
chr19_+_23389375 0.13 ENSRNOT00000018629
spalt-like transcription factor 1
chr7_-_12085226 0.13 ENSRNOT00000088669
ENSRNOT00000079925
one cut domain, family member 3
chr6_+_54488038 0.12 ENSRNOT00000084661
ENSRNOT00000005637
sorting nexin 13
chr8_+_48805684 0.12 ENSRNOT00000064041
B-cell CLL/lymphoma 9-like
chr7_-_63045728 0.12 ENSRNOT00000039532
LEM domain containing 3
chr6_-_126582034 0.12 ENSRNOT00000010656
ENSRNOT00000080829
inositol-tetrakisphosphate 1-kinase
chr5_-_74366817 0.11 ENSRNOT00000076705
protein tyrosine phosphatase, non-receptor type 3
chr8_+_122197027 0.11 ENSRNOT00000013050
upstream binding protein 1 (LBP-1a)
chr10_+_43067299 0.10 ENSRNOT00000003447
polypeptide N-acetylgalactosaminyltransferase 10
chr1_-_164977633 0.10 ENSRNOT00000029629
ring finger protein 169
chr2_-_24923128 0.10 ENSRNOT00000044087
phosphodiesterase 8B
chr2_-_115891097 0.10 ENSRNOT00000013191
SKI-like proto-oncogene
chr10_-_109267500 0.09 ENSRNOT00000005977
centrosomal protein 131
chr3_-_83306781 0.09 ENSRNOT00000014088
tetratricopeptide repeat domain 17
chr7_-_140546908 0.09 ENSRNOT00000077502
lysine methyltransferase 2D
chr3_+_93495106 0.09 ENSRNOT00000029922
ENSRNOT00000085760
ankyrin repeat and BTB domain containing 2
chr12_-_47793534 0.09 ENSRNOT00000001588
family with sequence similarity 222, member A
chr7_+_25919867 0.09 ENSRNOT00000009625
ENSRNOT00000090153
RIC8 guanine nucleotide exchange factor B
chr10_-_82197848 0.09 ENSRNOT00000081307
calcium voltage-gated channel subunit alpha1 G
chr10_+_14035149 0.09 ENSRNOT00000065827
zinc finger protein 598
chr2_-_197935567 0.09 ENSRNOT00000085404
regulation of nuclear pre-mRNA domain containing 2
chr7_+_23403891 0.08 ENSRNOT00000037918
synapsin III
chr1_+_165724451 0.08 ENSRNOT00000025827
family with sequence similarity 168, member A
chr10_-_110182291 0.08 ENSRNOT00000015178
ENSRNOT00000054936
casein kinase 1, delta
chr18_-_63394690 0.08 ENSRNOT00000090078
ENSRNOT00000029431
centrosomal protein 76
chr1_+_80087684 0.08 ENSRNOT00000041215
echinoderm microtubule associated protein like 2
chr3_-_1924827 0.08 ENSRNOT00000006162
calcium voltage-gated channel subunit alpha1 B
chr1_-_198460126 0.08 ENSRNOT00000082940
ENSRNOT00000086019
MYC associated zinc finger protein
chr2_+_205783252 0.08 ENSRNOT00000025633
ENSRNOT00000025600
tripartite motif-containing 33
chr6_+_137997335 0.08 ENSRNOT00000006872
transmembrane protein 121
chr15_-_4022223 0.07 ENSRNOT00000081997
zinc finger, SWIM-type containing 8
chr7_-_141093924 0.07 ENSRNOT00000086276
NCK-associated protein 5-like
chr6_-_46631983 0.07 ENSRNOT00000045963
SRY box 11
chr5_+_58393233 0.06 ENSRNOT00000000142
DnaJ heat shock protein family (Hsp40) member B5
chr10_-_20818128 0.06 ENSRNOT00000011061
WW and C2 domain containing 1
chr10_-_82197520 0.06 ENSRNOT00000092024
calcium voltage-gated channel subunit alpha1 G
chr13_+_90532326 0.06 ENSRNOT00000008944
DDB1 and CUL4 associated factor 8
chr18_-_77322690 0.06 ENSRNOT00000058382
nuclear factor of activated T-cells 1
chr1_+_221644867 0.06 ENSRNOT00000054830
EH-domain containing 1
chr3_+_170550314 0.06 ENSRNOT00000006991
transcription factor AP-2 gamma
chr5_+_58393603 0.06 ENSRNOT00000080082
DnaJ heat shock protein family (Hsp40) member B5
chr4_-_115157263 0.06 ENSRNOT00000015296
tet methylcytosine dioxygenase 3
chr17_-_80320681 0.06 ENSRNOT00000023637
complement C1q like 3
chr1_+_221612584 0.05 ENSRNOT00000090100
autophagy related 2A
chr2_+_198231291 0.05 ENSRNOT00000078288
ENSRNOT00000046739
OTU deubiquitinase 7B
chr19_+_56054212 0.05 ENSRNOT00000022324
zinc finger protein (C2H2 type) 276
chr11_+_86512797 0.05 ENSRNOT00000051680
glycoprotein Ib platelet beta subunit
chr3_+_147772165 0.05 ENSRNOT00000008713
TBC1 domain family, member 20
chrX_-_15327684 0.05 ENSRNOT00000009794
proprotein convertase subtilisin/kexin type 1 inhibitor
chr17_-_75886523 0.05 ENSRNOT00000046266
USP6 N-terminal like
chr5_+_148193710 0.05 ENSRNOT00000088568
adhesion G protein-coupled receptor B2
chr1_-_221015929 0.05 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr1_+_251421596 0.05 ENSRNOT00000028143
phosphatase and tensin homolog
chrX_+_120859968 0.05 ENSRNOT00000085185
WD repeat domain 44
chr10_-_108196217 0.05 ENSRNOT00000075440
chromobox 4
chr5_+_156876706 0.04 ENSRNOT00000021864
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr5_+_135735825 0.04 ENSRNOT00000068267
zinc finger, SWIM-type containing 5
chr15_+_25933483 0.04 ENSRNOT00000018972
adaptor-related protein complex 5, mu 1 subunit
chr14_-_37871051 0.04 ENSRNOT00000003087
SLAIN motif family, member 2
chr2_+_43266739 0.04 ENSRNOT00000087031
mesoderm induction early response 1, family member 3
chr4_-_153028129 0.04 ENSRNOT00000074558
cat eye syndrome chromosome region, candidate 6
chr1_-_127599257 0.04 ENSRNOT00000018436
ankyrin repeat and SOCS box-containing 7
chr5_+_173183990 0.04 ENSRNOT00000068062
transmembrane protein 240
chr8_-_103554399 0.04 ENSRNOT00000079965
ENSRNOT00000089833
short transient receptor potential channel 1-like
chr10_+_91254058 0.04 ENSRNOT00000087218
ENSRNOT00000065373
formin-like 1
chr1_+_239398043 0.03 ENSRNOT00000087386
transmembrane protein 2
chr6_-_102196138 0.03 ENSRNOT00000014132
transmembrane protein 229B
chr5_+_144779681 0.03 ENSRNOT00000016493
dyslexia susceptibility 2-like
chr10_+_82800704 0.03 ENSRNOT00000089497
protein phosphatase 1, regulatory subunit 9B
chr14_+_83510278 0.03 ENSRNOT00000081161
POZ (BTB) and AT hook containing zinc finger 1
chr2_-_206274079 0.03 ENSRNOT00000056079
homeodomain interacting protein kinase 1
chr4_-_163119391 0.03 ENSRNOT00000086605
chromatin target of PRMT1-like 1
chr4_+_32373641 0.03 ENSRNOT00000076086
distal-less homeobox 6
chr5_+_136683592 0.03 ENSRNOT00000085527
solute carrier family 6 member 9
chr8_-_111850075 0.03 ENSRNOT00000082097
CDV3 homolog
chr5_+_150459713 0.03 ENSRNOT00000081681
ENSRNOT00000074251
TATA-box binding protein associated factor 12
chr7_+_120125633 0.03 ENSRNOT00000012480
SH3-domain binding protein 1
chr14_+_75852060 0.03 ENSRNOT00000075975
heparan sulfate-glucosamine 3-sulfotransferase 1
chr9_-_44786041 0.03 ENSRNOT00000067197
REV1, DNA directed polymerase
chr7_+_137680530 0.03 ENSRNOT00000006970
AT-rich interaction domain 2
chr3_+_108795235 0.03 ENSRNOT00000007028
sprouty-related, EVH1 domain containing 1
chr10_-_35800120 0.02 ENSRNOT00000004361
mastermind-like transcriptional coactivator 1
chr14_+_15059387 0.02 ENSRNOT00000002843
CCR4-NOT transcription complex, subunit 6-like
chr19_-_56054142 0.02 ENSRNOT00000051945
VPS9 domain containing 1
chr8_-_68966108 0.02 ENSRNOT00000012155
SMAD family member 6
chr5_+_60250546 0.02 ENSRNOT00000017707
zinc finger CCHC-type containing 7
chr3_-_163748996 0.02 ENSRNOT00000010633
staufen double-stranded RNA binding protein 1
chr1_-_72727112 0.02 ENSRNOT00000031172
BR serine/threonine kinase 1
chr16_-_18860086 0.02 ENSRNOT00000074814
SIN3 transcription regulator family member B
chr2_-_210088949 0.02 ENSRNOT00000070994
RNA binding motif protein 15
chr18_-_28495937 0.02 ENSRNOT00000027194
DnaJ heat shock protein family (Hsp40) member C18
chr2_-_84437084 0.02 ENSRNOT00000077598
ankyrin repeat domain 33B
chrX_+_120860178 0.02 ENSRNOT00000088661
WD repeat domain 44
chr10_-_95212111 0.02 ENSRNOT00000020795
karyopherin subunit alpha 2
chr10_+_56605140 0.01 ENSRNOT00000024079
PHD finger protein 23
chr3_+_114747410 0.01 ENSRNOT00000043414
spermatogenesis associated 5-like 1
chr6_+_2569013 0.01 ENSRNOT00000008988
atlastin GTPase 2
chr1_-_265798167 0.01 ENSRNOT00000079483
LIM domain binding 1
chr1_+_225140863 0.01 ENSRNOT00000027141
metastasis associated 1 family, member 2
chr2_+_218951141 0.01 ENSRNOT00000091001
exostosin-like glycosyltransferase 2
chr1_+_206900617 0.01 ENSRNOT00000054897
dedicator of cyto-kinesis 1
chr7_-_70969905 0.01 ENSRNOT00000057745
Ngfi-A binding protein 2
chr2_-_52531083 0.01 ENSRNOT00000089303
ENSRNOT00000021608
zinc finger protein 131
chr8_-_111850393 0.01 ENSRNOT00000044956
CDV3 homolog
chr17_+_72240802 0.01 ENSRNOT00000025993
ENSRNOT00000090453
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr3_-_176958880 0.01 ENSRNOT00000078661
zinc finger and BTB domain containing 46
chr10_-_84698886 0.01 ENSRNOT00000067542
nuclear factor, erythroid 2-like 1
chr4_-_62663200 0.01 ENSRNOT00000040969
CCR4-NOT transcription complex, subunit 4
chr8_-_48652064 0.01 ENSRNOT00000030745
ENSRNOT00000083490
C2CD2-like
chr5_+_166533181 0.01 ENSRNOT00000045063
calsyntenin 1
chr10_+_4957326 0.01 ENSRNOT00000003458
suppressor of cytokine signaling 1
chr2_-_218951030 0.01 ENSRNOT00000019172
solute carrier family 30 member 7
chr12_+_23473270 0.00 ENSRNOT00000001935
SH2B adaptor protein 2
chrX_-_15428518 0.00 ENSRNOT00000075774
proSAAS
chr8_+_115069095 0.00 ENSRNOT00000014770
dual specificity phosphatase 7
chr7_-_130408187 0.00 ENSRNOT00000015374
choline kinase beta
chr15_+_83707735 0.00 ENSRNOT00000057843
Kruppel-like factor 5
chr8_-_49025917 0.00 ENSRNOT00000078816
pleckstrin homology-like domain, family B, member 1
chr4_+_57715946 0.00 ENSRNOT00000079059
ENSRNOT00000034429
kelch domain containing 10

Network of associatons between targets according to the STRING database.

First level regulatory network of Mbd2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:1900095 random inactivation of X chromosome(GO:0060816) regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.2 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.0 0.1 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0 0.2 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.3 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.2 GO:1904717 regulation of AMPA glutamate receptor clustering(GO:1904717)
0.0 0.1 GO:0010045 response to nickel cation(GO:0010045)
0.0 0.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.3 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.0 0.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.1 GO:0035106 operant conditioning(GO:0035106)
0.0 0.1 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.1 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0 0.1 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 0.1 GO:0003357 noradrenergic neuron differentiation(GO:0003357)
0.0 0.1 GO:0072344 rescue of stalled ribosome(GO:0072344)
0.0 0.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.0 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.0 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.0 0.1 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.1 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0016266 O-glycan processing(GO:0016266)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.1 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 0.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.1 GO:0005042 netrin receptor activity(GO:0005042)
0.0 0.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.0 GO:0052743 inositol tetrakisphosphate phosphatase activity(GO:0052743)
0.0 0.1 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.1 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.0 0.1 GO:0051766 inositol trisphosphate kinase activity(GO:0051766)
0.0 0.0 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.2 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation