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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Maz_Zfp281
Z-value: 1.66
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Transcription factors associated with Maz_Zfp281
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Maz | rn6_v1_chr1_-_198460126_198460126 | -0.32 | 6.0e-01 | Click! |
| Zfp281 | rn6_v1_chr13_+_53506925_53506925 | -0.20 | 7.5e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_88135410 Show fit | 1.27 |
ENSRNOT00000014180
|
carbonic anhydrase 3 |
|
| chr8_+_45797315 Show fit | 1.07 |
ENSRNOT00000059997
|
|
|
| chr6_+_135856218 Show fit | 1.04 |
ENSRNOT00000066715
|
similar to novel protein |
|
| chr1_-_220265772 Show fit | 1.02 |
ENSRNOT00000027119
|
neuronal PAS domain protein 4 |
|
| chr4_-_169999873 Show fit | 1.02 |
ENSRNOT00000011697
|
glutamate ionotropic receptor NMDA type subunit 2B |
|
| chr5_+_147476221 Show fit | 0.96 |
ENSRNOT00000010730
|
syncoilin, intermediate filament protein |
|
| chr2_-_250235435 Show fit | 0.95 |
ENSRNOT00000088618
|
LIM domain only 4 |
|
| chr1_-_80599572 Show fit | 0.95 |
ENSRNOT00000024832
|
apolipoprotein C4 |
|
| chr1_-_198559568 Show fit | 0.93 |
ENSRNOT00000023080
|
quinolinate phosphoribosyltransferase |
|
| chr3_+_58164931 Show fit | 0.91 |
ENSRNOT00000002078
|
distal-less homeobox 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Maz_Zfp281
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.8 | GO:0061193 | taste bud development(GO:0061193) |
| 0.5 | 1.6 | GO:0021882 | regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898) |
| 0.1 | 1.4 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.2 | 1.3 | GO:0071376 | response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376) |
| 0.4 | 1.2 | GO:1902748 | positive regulation of lens fiber cell differentiation(GO:1902748) |
| 0.2 | 1.2 | GO:1902336 | positive regulation of retinal ganglion cell axon guidance(GO:1902336) |
| 0.1 | 1.2 | GO:0045631 | regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980) |
| 0.2 | 1.0 | GO:0036166 | phenotypic switching(GO:0036166) |
| 0.2 | 1.0 | GO:0098989 | NMDA selective glutamate receptor signaling pathway(GO:0098989) |
| 0.2 | 1.0 | GO:0086048 | membrane depolarization during bundle of His cell action potential(GO:0086048) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 2.0 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.1 | 1.6 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 1.6 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 1.5 | GO:0098839 | postsynaptic density membrane(GO:0098839) |
| 0.1 | 1.5 | GO:0005685 | U1 snRNP(GO:0005685) |
| 0.0 | 1.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 1.4 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 1.0 | GO:0005861 | troponin complex(GO:0005861) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.6 | GO:0098811 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 2.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 1.7 | GO:0005169 | neurotrophin TRKB receptor binding(GO:0005169) |
| 0.0 | 1.6 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.0 | 1.6 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.0 | 1.6 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 1.3 | GO:0016151 | nickel cation binding(GO:0016151) |
| 0.3 | 1.2 | GO:0035614 | snRNA stem-loop binding(GO:0035614) |
| 0.1 | 1.2 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.1 | 1.2 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 2.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 2.4 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 1.6 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 1.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 1.2 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 1.2 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.0 | 1.2 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 1.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 1.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 1.2 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 0.1 | 1.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.1 | 1.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 1.1 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 1.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 1.0 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.1 | 1.0 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII | Genes involved in CREB phosphorylation through the activation of CaMKII |
| 0.1 | 1.0 | REACTOME SIGNALLING TO P38 VIA RIT AND RIN | Genes involved in Signalling to p38 via RIT and RIN |