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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Max_Mycn
Z-value: 1.30
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Transcription factors associated with Max_Mycn
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Mycn | rn6_v1_chr6_-_38228379_38228379 | -0.77 | 1.3e-01 | Click! |
| Max | rn6_v1_chr6_-_100011226_100011226 | -0.76 | 1.4e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_123119460 Show fit | 1.74 |
ENSRNOT00000028833
|
arginine vasopressin |
|
| chr2_-_197991198 Show fit | 1.11 |
ENSRNOT00000056322
|
circadian associated repressor of transcription |
|
| chr2_-_197991574 Show fit | 1.07 |
ENSRNOT00000085632
|
circadian associated repressor of transcription |
|
| chr2_-_260596777 Show fit | 1.01 |
ENSRNOT00000009370
|
LIM homeobox 8 |
|
| chr2_-_187668677 Show fit | 0.87 |
ENSRNOT00000056898
ENSRNOT00000092563 |
TSSK6 activating co-chaperone |
|
| chr17_-_9695292 Show fit | 0.70 |
ENSRNOT00000036162
|
proline rich 7 (synaptic) |
|
| chr1_+_33910912 Show fit | 0.69 |
ENSRNOT00000044690
|
iroquois homeobox 1 |
|
| chr9_-_16848503 Show fit | 0.67 |
ENSRNOT00000024815
|
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 |
|
| chr3_-_66417741 Show fit | 0.61 |
ENSRNOT00000007662
|
neuronal differentiation 1 |
|
| chr3_+_113415774 Show fit | 0.56 |
ENSRNOT00000056151
|
small EDRK-rich factor 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Max_Mycn
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.4 | 1.7 | GO:0002125 | maternal aggressive behavior(GO:0002125) |
| 0.1 | 1.0 | GO:0001731 | formation of translation preinitiation complex(GO:0001731) |
| 0.0 | 0.9 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.2 | 0.7 | GO:0072268 | specification of loop of Henle identity(GO:0072086) pattern specification involved in metanephros development(GO:0072268) |
| 0.1 | 0.7 | GO:0009162 | deoxyribonucleoside monophosphate metabolic process(GO:0009162) |
| 0.0 | 0.7 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.2 | 0.6 | GO:0070949 | regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949) |
| 0.1 | 0.6 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.1 | 0.6 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.8 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 0.0 | 2.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.0 | 1.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.3 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.1 | 0.9 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.1 | 0.8 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 0.8 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.1 | 0.8 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.1 | 0.6 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.1 | 0.6 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 2.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.6 | 1.7 | GO:0031893 | vasopressin receptor binding(GO:0031893) |
| 0.0 | 1.4 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.1 | 0.9 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 0.8 | GO:0045505 | dynein intermediate chain binding(GO:0045505) |
| 0.0 | 0.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 0.8 | GO:0016799 | hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799) |
| 0.0 | 0.8 | GO:0031369 | translation initiation factor binding(GO:0031369) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.8 | PID IL23 PATHWAY | IL23-mediated signaling events |
| 0.0 | 0.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 0.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 0.4 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.0 | 0.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.0 | 0.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.3 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.0 | 0.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.7 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.0 | 2.2 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.2 | 1.8 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.1 | 1.3 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.0 | 1.2 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.0 | 1.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.0 | 1.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.0 | 0.9 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.0 | 0.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |