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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Lhx5_Lmx1b_Lhx1
Z-value: 0.57
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Transcription factors associated with Lhx5_Lmx1b_Lhx1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Lhx1 | rn6_v1_chr10_-_71849293_71849293 | -0.50 | 3.9e-01 | Click! |
| Lhx5 | rn6_v1_chr12_-_41671437_41671437 | -0.46 | 4.3e-01 | Click! |
| Lmx1b | rn6_v1_chr3_-_12686869_12686869 | -0.10 | 8.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_74679858 Show fit | 0.29 |
ENSRNOT00000003859
|
protein phosphatase, Mg2+/Mn2+ dependent, 1E |
|
| chr12_-_46493203 Show fit | 0.25 |
ENSRNOT00000057036
|
citron rho-interacting serine/threonine kinase |
|
| chr2_-_35870578 Show fit | 0.21 |
ENSRNOT00000066069
|
ring finger protein 180 |
|
| chr12_+_25435567 Show fit | 0.21 |
ENSRNOT00000092982
|
general transcription factor II I |
|
| chr16_+_46731403 Show fit | 0.21 |
ENSRNOT00000017624
|
teneurin transmembrane protein 3 |
|
| chr13_+_91054974 Show fit | 0.20 |
ENSRNOT00000091089
|
C-reactive protein |
|
| chr2_-_34452895 Show fit | 0.20 |
ENSRNOT00000079385
|
|
|
| chr1_-_190370499 Show fit | 0.20 |
ENSRNOT00000084389
|
|
|
| chr4_-_18396035 Show fit | 0.20 |
ENSRNOT00000034692
|
semaphorin 3A |
|
| chr2_+_190003223 Show fit | 0.18 |
ENSRNOT00000015712
|
S100 calcium binding protein A5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Lhx5_Lmx1b_Lhx1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.0 | 0.3 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 0.2 | GO:1901748 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.0 | 0.2 | GO:1903375 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375) |
| 0.0 | 0.2 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.0 | 0.2 | GO:1903527 | positive regulation of membrane tubulation(GO:1903527) |
| 0.0 | 0.2 | GO:0014886 | transition between slow and fast fiber(GO:0014886) |
| 0.0 | 0.2 | GO:0097264 | self proteolysis(GO:0097264) |
| 0.0 | 0.2 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.0 | 0.2 | GO:0043129 | surfactant homeostasis(GO:0043129) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.1 | GO:1990032 | parallel fiber(GO:1990032) |
| 0.0 | 0.1 | GO:0097444 | spine apparatus(GO:0097444) |
| 0.0 | 0.1 | GO:0032398 | MHC class Ib protein complex(GO:0032398) |
| 0.0 | 0.1 | GO:0044307 | germinal vesicle(GO:0042585) dendritic branch(GO:0044307) |
| 0.0 | 0.1 | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB(GO:0005944) |
| 0.0 | 0.1 | GO:0014801 | longitudinal sarcoplasmic reticulum(GO:0014801) |
| 0.0 | 0.1 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.0 | 0.1 | GO:0070847 | core mediator complex(GO:0070847) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.2 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374) |
| 0.0 | 0.2 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.0 | 0.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.1 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.0 | 0.1 | GO:0097363 | protein O-GlcNAc transferase activity(GO:0097363) |
| 0.0 | 0.1 | GO:0001642 | group III metabotropic glutamate receptor activity(GO:0001642) |
| 0.0 | 0.1 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.0 | 0.1 | GO:0031727 | CCR2 chemokine receptor binding(GO:0031727) |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.2 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 0.1 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |