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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Lhx2_Hoxc5

Z-value: 0.88

Motif logo

Transcription factors associated with Lhx2_Hoxc5

Gene Symbol Gene ID Gene Info
ENSRNOG00000010551 LIM homeobox 2
ENSRNOG00000016598 homeo box C5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Hoxc5rn6_v1_chr7_+_144628120_144628120-0.266.8e-01Click!
Lhx2rn6_v1_chr3_+_22640545_22640604-0.256.8e-01Click!

Activity profile of Lhx2_Hoxc5 motif

Sorted Z-values of Lhx2_Hoxc5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chrM_+_9870 0.57 ENSRNOT00000044582
mitochondrially encoded NADH 4L dehydrogenase
chr5_+_6373583 0.54 ENSRNOT00000084749

chr8_-_104155775 0.48 ENSRNOT00000042885
60S ribosomal protein L31-like
chrM_+_11736 0.47 ENSRNOT00000048767
mitochondrially encoded NADH dehydrogenase 5
chr13_-_83457888 0.47 ENSRNOT00000076289
ENSRNOT00000004065
SFT2 domain containing 2
chr15_-_93765498 0.44 ENSRNOT00000093297
MYC binding protein 2, E3 ubiquitin protein ligase
chr1_+_15834779 0.39 ENSRNOT00000079069
ENSRNOT00000083012
BCL2-associated transcription factor 1
chr15_+_87722221 0.36 ENSRNOT00000082688
sciellin
chr1_+_61786900 0.35 ENSRNOT00000090287

chr13_+_91054974 0.35 ENSRNOT00000091089
C-reactive protein
chr2_-_149444548 0.33 ENSRNOT00000018600
purinergic receptor P2Y12
chr15_-_42794279 0.32 ENSRNOT00000023385
epoxide hydrolase 2
chr7_+_20262680 0.32 ENSRNOT00000046378
similar to hypothetical protein 4930509O22
chr1_+_252409268 0.32 ENSRNOT00000026219
lipase, family member M
chr6_+_86785771 0.32 ENSRNOT00000066702
pre-mRNA processing factor 39
chr7_-_116106368 0.31 ENSRNOT00000035678
lymphocyte antigen 6 complex, locus K
chr1_+_140998240 0.31 ENSRNOT00000023506
ENSRNOT00000090897
abhydrolase domain containing 2
chr2_+_23289374 0.30 ENSRNOT00000090666
ENSRNOT00000032783
dimethylglycine dehydrogenase
chr1_-_78180216 0.30 ENSRNOT00000071576
complement component 5a receptor 2
chr10_-_34242985 0.30 ENSRNOT00000046438
similar to novel protein
chr10_-_16752205 0.25 ENSRNOT00000079462
CREB3 regulatory factor
chrX_-_70460536 0.25 ENSRNOT00000076824
PDZ domain containing 11
chr13_+_96303703 0.25 ENSRNOT00000084718
ENSRNOT00000029723
EF-hand calcium binding domain 2
chr15_+_4240203 0.25 ENSRNOT00000010178
MSS51 mitochondrial translational activator
chr8_+_2604962 0.24 ENSRNOT00000009993
caspase 1
chrX_+_84064427 0.24 ENSRNOT00000046364
zinc finger protein 711
chrM_+_3904 0.23 ENSRNOT00000040993
mitochondrially encoded NADH dehydrogenase 2
chrX_+_14019961 0.23 ENSRNOT00000004785
synaptotagmin-like 5
chr1_+_72956026 0.22 ENSRNOT00000031462
retinol dehydrogenase 13
chr6_-_108660063 0.22 ENSRNOT00000006240
apoptosis resistant E3 ubiquitin protein ligase 1
chr17_-_52477575 0.22 ENSRNOT00000081290
GLI family zinc finger 3
chr15_+_36809361 0.22 ENSRNOT00000076667
poly (ADP-ribose) polymerase family, member 4
chr2_+_127489771 0.22 ENSRNOT00000093581
inturned planar cell polarity protein
chr17_-_84247038 0.22 ENSRNOT00000068553
nebulette
chr7_-_80457816 0.21 ENSRNOT00000039430

chr4_-_16654811 0.21 ENSRNOT00000008637
piccolo (presynaptic cytomatrix protein)
chr4_+_61814974 0.21 ENSRNOT00000074951
aldo-keto reductase family 1 member B10
chr11_+_38727048 0.20 ENSRNOT00000081537
zinc finger protein 260-like
chr3_-_90751055 0.20 ENSRNOT00000040741
LRRGT00091
chr2_+_187447501 0.20 ENSRNOT00000038589
IQ motif containing GTPase activating protein 3
chr6_+_76349362 0.20 ENSRNOT00000043224
aldolase 1 A retrogene 2
chr4_+_2053712 0.19 ENSRNOT00000045086
ring finger protein 32
chr4_-_165456677 0.19 ENSRNOT00000082207
killer cell lectin-like receptor, subfamily A, member 2
chr7_-_76035096 0.19 ENSRNOT00000072255

chr6_-_91581262 0.19 ENSRNOT00000034507

chr1_-_166919302 0.19 ENSRNOT00000026925
folate receptor beta
chr18_+_30487264 0.18 ENSRNOT00000040125
protocadherin beta 10
chr2_-_157035483 0.18 ENSRNOT00000076491
similar to RalA binding protein 1
chr17_+_45175121 0.18 ENSRNOT00000080417
NFKB activating protein-like
chr10_+_29289203 0.18 ENSRNOT00000067013
PWWP domain containing 2A
chr8_-_21492801 0.18 ENSRNOT00000077465
zinc finger protein 426
chr1_-_261179790 0.18 ENSRNOT00000074420
ENSRNOT00000072073
exosome component 1
chr1_-_38538987 0.18 ENSRNOT00000090406
ENSRNOT00000071275
zinc finger protein 728-like
chr3_-_25212049 0.17 ENSRNOT00000040023
LDL receptor related protein 1B
chr1_+_66959610 0.17 ENSRNOT00000072122
ENSRNOT00000045994
vomeronasal 1 receptor 48
chr2_-_34452895 0.17 ENSRNOT00000079385

chr2_+_118547190 0.17 ENSRNOT00000083676
ENSRNOT00000090301
ENSRNOT00000013410
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr2_+_66940057 0.16 ENSRNOT00000043050
cadherin 9
chr1_+_169145445 0.16 ENSRNOT00000034019
hypothetical protein LOC499219
chrM_+_9451 0.16 ENSRNOT00000041241
mitochondrially encoded NADH dehydrogenase 3
chr8_+_12355767 0.16 ENSRNOT00000068445
family with sequence similarity 76, member B
chr7_+_15785410 0.16 ENSRNOT00000082664
ENSRNOT00000073235
zinc finger protein 955A
chr13_-_67206688 0.16 ENSRNOT00000003630
ENSRNOT00000090693
phospholipase A2 group IVA
chr1_+_280103695 0.15 ENSRNOT00000065289
enolase family member 4
chrX_+_908044 0.15 ENSRNOT00000072087
zinc finger protein 300
chr20_-_13994794 0.15 ENSRNOT00000093466
gamma-glutamyltransferase 5
chr4_-_22424862 0.15 ENSRNOT00000082359
ATP binding cassette subfamily B member 1A
chr5_-_12172009 0.15 ENSRNOT00000061903
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
chr4_+_27509221 0.15 ENSRNOT00000067954
ankyrin repeat and IBR domain containing 1
chr4_+_88694583 0.15 ENSRNOT00000009202
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr7_+_141666111 0.15 ENSRNOT00000083250

chr5_+_24410863 0.15 ENSRNOT00000010591
tumor protein p53 inducible nuclear protein 1
chr16_-_81714346 0.15 ENSRNOT00000092552
lysosomal-associated membrane protein 1
chr15_+_33885106 0.14 ENSRNOT00000024483
dehydrogenase/reductase 2
chr8_-_96547568 0.14 ENSRNOT00000078343
similar to RIKEN cDNA 4930579C12 gene
chr7_+_91384187 0.14 ENSRNOT00000005828
UTP23, small subunit processome component
chr5_-_168734296 0.14 ENSRNOT00000066120
calmodulin binding transcription activator 1
chr9_+_30419001 0.14 ENSRNOT00000018116
collagen type IX alpha 1 chain
chrM_+_8599 0.14 ENSRNOT00000049683
mitochondrially encoded cytochrome C oxidase III
chr2_+_86891092 0.14 ENSRNOT00000077162
ENSRNOT00000083066
zinc finger protein 457-like
chr18_-_6587080 0.14 ENSRNOT00000040815
60S ribosomal protein L39
chr2_+_86996497 0.14 ENSRNOT00000042058
zinc finger protein 455
chr4_+_31229913 0.14 ENSRNOT00000077134
ENSRNOT00000087897
sterile alpha motif domain containing 9-like
chr16_+_22979444 0.14 ENSRNOT00000017822
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr10_+_36715565 0.14 ENSRNOT00000005048
CDC-like kinase 4
chr1_-_66237501 0.14 ENSRNOT00000073006
zinc finger protein 606
chr6_+_86823684 0.14 ENSRNOT00000086081
ENSRNOT00000006574
Fanconi anemia, complementation group M
chr4_+_147832136 0.13 ENSRNOT00000064603
rhodopsin
chr19_-_21970103 0.13 ENSRNOT00000074210

chr10_+_56445647 0.13 ENSRNOT00000056870
transmembrane protein 256
chr1_-_267463694 0.13 ENSRNOT00000084851
ENSRNOT00000016645
collagen type XVII alpha 1 chain
chr1_+_253221812 0.13 ENSRNOT00000085880
ENSRNOT00000054753
kinesin family member 20B
chr16_-_7412150 0.13 ENSRNOT00000047252
similar to ribosomal protein S24
chr8_+_96551245 0.13 ENSRNOT00000039850
BCL2-related protein A1
chr1_-_214202853 0.13 ENSRNOT00000022954
lamin tail domain containing 2
chr3_-_71798531 0.12 ENSRNOT00000088170
calcitonin receptor like receptor
chr14_+_38192446 0.12 ENSRNOT00000090242
nuclear transcription factor, X-box binding-like 1
chr9_-_95143092 0.12 ENSRNOT00000064171
ENSRNOT00000085325
ubiquitin specific peptidase 40
chr11_+_88095170 0.12 ENSRNOT00000041557
coiled-coil domain containing 116
chr12_-_20276121 0.12 ENSRNOT00000065873
similar to paired immunoglobin-like type 2 receptor beta
chr12_-_24775891 0.12 ENSRNOT00000074851
Williams Beuren syndrome chromosome region 27
chr7_+_78558701 0.12 ENSRNOT00000006393
regulating synaptic membrane exocytosis 2
chrX_-_158288109 0.12 ENSRNOT00000072527
PHD finger protein 6
chr19_-_37796089 0.12 ENSRNOT00000024891
RAN binding protein 10
chrX_+_156873849 0.12 ENSRNOT00000085410
Rho GTPase activating protein 4
chrM_+_7006 0.12 ENSRNOT00000043693
mitochondrially encoded cytochrome c oxidase II
chr1_+_128637049 0.12 ENSRNOT00000018639
tetratricopeptide repeat domain 23
chr2_+_86996798 0.12 ENSRNOT00000070821
zinc finger protein 455
chr6_+_18880737 0.12 ENSRNOT00000003432
alkB homolog 8, tRNA methyltransferase
chr2_+_184600721 0.12 ENSRNOT00000075823
glutamyl-tRNA amidotransferase subunit B
chr16_-_37177033 0.12 ENSRNOT00000014015
F-box protein 8
chr3_+_56125924 0.11 ENSRNOT00000011380
ubiquitin protein ligase E3 component n-recognin 3
chr4_+_127164453 0.11 ENSRNOT00000017889
kelch repeat and BTB domain containing 8
chr3_+_113918629 0.11 ENSRNOT00000078978
ENSRNOT00000037168
CTD small phosphatase like 2
chr14_-_45859908 0.11 ENSRNOT00000086994
phosphoglucomutase 2
chr13_-_47916185 0.11 ENSRNOT00000087793
dual specificity tyrosine phosphorylation regulated kinase 3
chr19_+_24655626 0.11 ENSRNOT00000086690

chr4_-_150520774 0.11 ENSRNOT00000009095
zinc finger protein 9
chr13_-_80775230 0.11 ENSRNOT00000091389
ENSRNOT00000004762
flavin containing monooxygenase 2
chr3_+_119561290 0.11 ENSRNOT00000015843
biliverdin reductase A
chr9_+_53013413 0.11 ENSRNOT00000005313
ankyrin and armadillo repeat containing
chr11_+_67101714 0.11 ENSRNOT00000078936
CD86 molecule
chr16_+_84465656 0.11 ENSRNOT00000043188
LRRGT00175
chr14_+_7949239 0.11 ENSRNOT00000044617
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4-like 1
chr20_+_1889652 0.11 ENSRNOT00000068508
ENSRNOT00000000996
olfactory receptor 1746
chrX_-_106607352 0.11 ENSRNOT00000082858

chr3_+_94530586 0.11 ENSRNOT00000067860
cleavage stimulation factor subunit 3
chrX_+_159081445 0.11 ENSRNOT00000056688

chr9_+_73378057 0.11 ENSRNOT00000043627
ENSRNOT00000045766
ENSRNOT00000092445
ENSRNOT00000037974
microtubule-associated protein 2
chr1_+_61382118 0.11 ENSRNOT00000050119
zinc finger protein 52
chr10_+_84966989 0.11 ENSRNOT00000013580
secernin 2
chr1_+_101603222 0.11 ENSRNOT00000033278
izumo sperm-egg fusion 1
chr7_+_132378273 0.10 ENSRNOT00000010990
hypothetical protein LOC690142
chr1_+_62133816 0.10 ENSRNOT00000034746
zinc finger protein 182-like
chr5_+_155934490 0.10 ENSRNOT00000077933
ubiquitin carboxyl-terminal hydrolase 48-like
chr14_+_113530470 0.10 ENSRNOT00000004919
polyribonucleotide nucleotidyltransferase 1
chr1_+_227240383 0.10 ENSRNOT00000074127
membrane spanning 4-domains A6E
chr4_-_162498052 0.10 ENSRNOT00000066349
chromobox homolog 3-like
chr2_-_60461458 0.10 ENSRNOT00000024285
BRX1, biogenesis of ribosomes
chr1_+_165237847 0.10 ENSRNOT00000022963
phosphoglucomutase 2-like 1
chr14_+_17228856 0.10 ENSRNOT00000003082
C-X-C motif chemokine ligand 9
chr5_+_36566783 0.10 ENSRNOT00000077650
F-box and leucine-rich repeat protein 4
chrM_+_7919 0.10 ENSRNOT00000046108
mitochondrially encoded ATP synthase 6
chr9_-_38495126 0.10 ENSRNOT00000016933
ENSRNOT00000090385
RAB23, member RAS oncogene family
chr1_-_235405831 0.10 ENSRNOT00000071578

chr12_-_1195591 0.10 ENSRNOT00000001446
StAR-related lipid transfer domain containing 13
chr8_+_79638696 0.10 ENSRNOT00000085959
dyslexia susceptibility 1 candidate 1
chr2_+_260444227 0.10 ENSRNOT00000064249
solute carrier family 44, member 5
chr7_-_140502441 0.10 ENSRNOT00000089544
lysine methyltransferase 2D
chr20_+_34258791 0.10 ENSRNOT00000000468
solute carrier family 35, member F1
chr1_-_67094567 0.10 ENSRNOT00000073583

chr15_+_62406873 0.10 ENSRNOT00000047572
olfactomedin 4
chr16_+_21399553 0.10 ENSRNOT00000034446
zinc finger protein 709-like
chr17_-_86657473 0.10 ENSRNOT00000078827

chr4_+_31333970 0.09 ENSRNOT00000064866
coiled-coil domain-containing protein 132-like
chr3_-_21669957 0.09 ENSRNOT00000012354
ENSRNOT00000078718
ring finger and CCCH-type domains 2
chr2_+_118910587 0.09 ENSRNOT00000065518
zinc finger protein 639
chr8_+_29714285 0.09 ENSRNOT00000042890
opioid binding protein/cell adhesion molecule-like
chr2_-_227890077 0.09 ENSRNOT00000021335
N-deacetylase and N-sulfotransferase 3
chr1_+_261180007 0.09 ENSRNOT00000072181
zinc finger, DHHC-type containing 16
chr6_-_108076186 0.09 ENSRNOT00000014814
family with sequence similarity 161, member B
chr8_-_49158971 0.09 ENSRNOT00000020573
lysine methyltransferase 2A
chr17_+_89951752 0.09 ENSRNOT00000057572
ENSRNOT00000091023
abl-interactor 1
chr12_+_6403940 0.09 ENSRNOT00000083484
beta 3-glucosyltransferase
chr8_-_96516975 0.09 ENSRNOT00000067996
similar to RIKEN cDNA 4930579C12 gene
chr2_-_122756842 0.09 ENSRNOT00000080181
coiled-coil domain containing 144B
chr14_-_66978499 0.09 ENSRNOT00000081601
slit guidance ligand 2
chr18_+_86116044 0.09 ENSRNOT00000058160
ENSRNOT00000076159
rotatin
chr9_+_12420368 0.09 ENSRNOT00000071620

chr3_-_133131192 0.09 ENSRNOT00000055630
taspase 1
chr15_-_28104206 0.09 ENSRNOT00000032536
angiogenin, ribonuclease A family, member 2
chr7_+_27174882 0.09 ENSRNOT00000051181
glycosyltransferase 8 domain containing 2
chr9_+_12475006 0.09 ENSRNOT00000079703
uncharacterized LOC100912293
chr1_-_88516129 0.09 ENSRNOT00000087232

chr14_+_108415068 0.09 ENSRNOT00000083763
pseudouridylate synthase 10
chr11_+_68633160 0.09 ENSRNOT00000063795
SEC22 homolog A, vesicle trafficking protein
chr17_+_23661429 0.09 ENSRNOT00000046523
phosphatase and actin regulator 1
chr10_-_52290657 0.09 ENSRNOT00000005293
mitogen activated protein kinase kinase 4
chr3_-_165700489 0.09 ENSRNOT00000017008
zinc finger protein 93
chr2_+_72006099 0.09 ENSRNOT00000034044
cadherin 12
chr12_+_19196611 0.09 ENSRNOT00000001801
alpha-2-glycoprotein 1, zinc-binding
chr5_+_25253010 0.09 ENSRNOT00000061333
RNA binding motif protein 12B
chr19_+_15081590 0.08 ENSRNOT00000024187
carboxylesterase 1F
chr2_-_219262901 0.08 ENSRNOT00000037068
G-protein coupled receptor 88
chr4_+_162281574 0.08 ENSRNOT00000087850
C-type lectin domain family 2, member D
chr1_+_99505677 0.08 ENSRNOT00000024645
zinc finger protein 719
chr8_-_12355091 0.08 ENSRNOT00000009318
centrosomal protein 57
chr9_-_1012450 0.08 ENSRNOT00000051449
ribosomal protein S20-like
chr4_-_176909075 0.08 ENSRNOT00000067489
ATP binding cassette subfamily C member 9
chr2_-_40386669 0.08 ENSRNOT00000014074
ELOVL fatty acid elongase 7
chr4_+_112662609 0.08 ENSRNOT00000009104
GC-rich sequence DNA-binding factor 2
chr1_+_164706276 0.08 ENSRNOT00000024311
olfactory receptor 36
chr5_-_164648328 0.08 ENSRNOT00000090811
zinc finger protein 933
chrX_-_70978952 0.08 ENSRNOT00000076910
solute carrier family 7 member 3
chr19_-_41567013 0.08 ENSRNOT00000022757
zinc finger protein 612
chr10_-_87521514 0.08 ENSRNOT00000084668
ENSRNOT00000071705
keratin associated protein 2-4-like
chr3_+_21764377 0.08 ENSRNOT00000063938
G protein-coupled receptor 21
chr14_-_18704059 0.08 ENSRNOT00000081455
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
chr12_-_21362205 0.08 ENSRNOT00000064787
paired immunoglobulin-like type 2 receptor beta-2
chr5_-_73552798 0.08 ENSRNOT00000022836
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx2_Hoxc5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0071623 negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:1900673 olefin metabolic process(GO:1900673)
0.1 0.3 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.1 0.3 GO:1902211 regulation of prolactin signaling pathway(GO:1902211)
0.1 0.2 GO:0009644 response to high light intensity(GO:0009644)
0.1 0.2 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
0.1 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.3 GO:0016095 polyprenol catabolic process(GO:0016095)
0.1 0.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.2 GO:0000962 mitochondrial mRNA catabolic process(GO:0000958) positive regulation of mitochondrial RNA catabolic process(GO:0000962)
0.1 0.2 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.1 0.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 0.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.2 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.0 0.1 GO:0072702 myofibroblast differentiation(GO:0036446) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) regulation of myofibroblast differentiation(GO:1904760)
0.0 0.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.2 GO:2001025 positive regulation of response to drug(GO:2001025)
0.0 0.1 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.5 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.0 0.2 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.1 GO:2000458 astrocyte chemotaxis(GO:0035700) regulation of astrocyte chemotaxis(GO:2000458)
0.0 0.1 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.1 GO:0072592 oxygen metabolic process(GO:0072592)
0.0 0.1 GO:0000105 histidine biosynthetic process(GO:0000105)
0.0 0.1 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.0 0.1 GO:1903564 regulation of protein localization to cilium(GO:1903564)
0.0 0.1 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.0 0.1 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 0.1 GO:2000688 positive regulation of rubidium ion transport(GO:2000682) positive regulation of rubidium ion transmembrane transporter activity(GO:2000688)
0.0 0.1 GO:0035722 monocyte extravasation(GO:0035696) interleukin-12-mediated signaling pathway(GO:0035722) interleukin-15-mediated signaling pathway(GO:0035723) cellular response to interleukin-12(GO:0071349) cellular response to interleukin-15(GO:0071350)
0.0 0.1 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.1 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0 0.1 GO:0006431 methionyl-tRNA aminoacylation(GO:0006431)
0.0 0.1 GO:0072709 cellular response to sorbitol(GO:0072709)
0.0 0.0 GO:0032053 ciliary basal body organization(GO:0032053)
0.0 0.1 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.0 0.2 GO:0009642 response to light intensity(GO:0009642)
0.0 1.3 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.0 0.1 GO:0007309 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
0.0 0.1 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.0 0.1 GO:0015884 folic acid transport(GO:0015884)
0.0 0.1 GO:0034085 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.0 0.1 GO:0045963 phospholipase C-activating serotonin receptor signaling pathway(GO:0007208) phospholipase D-activating G-protein coupled receptor signaling pathway(GO:0031583) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0 0.1 GO:1904428 negative regulation of tubulin deacetylation(GO:1904428)
0.0 0.1 GO:0060327 cytoplasmic actin-based contraction involved in cell motility(GO:0060327)
0.0 0.1 GO:0034626 fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.1 GO:0016056 rhodopsin mediated signaling pathway(GO:0016056)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.1 GO:1903401 L-lysine transmembrane transport(GO:1903401)
0.0 0.1 GO:0051030 snRNA transport(GO:0051030)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0 0.0 GO:0070814 hydrogen sulfide biosynthetic process(GO:0070814)
0.0 0.0 GO:0048382 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) mesendoderm development(GO:0048382) regulation of cardiac ventricle development(GO:1904412)
0.0 0.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.0 GO:0036334 epidermal stem cell homeostasis(GO:0036334)
0.0 0.0 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.0 0.0 GO:0000966 RNA 5'-end processing(GO:0000966)
0.0 0.0 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.1 GO:0035633 maintenance of blood-brain barrier(GO:0035633)
0.0 0.0 GO:0043179 rhythmic excitation(GO:0043179)
0.0 0.1 GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0 0.3 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.0 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)
0.0 0.1 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.0 0.0 GO:0010034 response to acetate(GO:0010034)
0.0 0.0 GO:0042125 protein glycosylation at cell surface(GO:0033575) protein galactosylation at cell surface(GO:0033580) protein galactosylation(GO:0042125)
0.0 0.1 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.0 0.0 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.0 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.1 GO:0034035 flavonoid metabolic process(GO:0009812) purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.1 GO:1901994 negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 0.0 GO:0060383 positive regulation of DNA strand elongation(GO:0060383)
0.0 0.1 GO:0002911 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.0 0.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.0 0.0 GO:0050828 regulation of liquid surface tension(GO:0050828)
0.0 0.1 GO:0014029 neural crest formation(GO:0014029)
0.0 0.4 GO:0035036 sperm-egg recognition(GO:0035036)
0.0 0.1 GO:0046878 positive regulation of saliva secretion(GO:0046878) positive regulation of glucocorticoid secretion(GO:2000851)
0.0 0.1 GO:0071409 cellular response to cycloheximide(GO:0071409)
0.0 0.1 GO:0010360 negative regulation of anion channel activity(GO:0010360)
0.0 0.1 GO:1902035 positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.0 0.0 GO:0000459 exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0 0.0 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168)
0.0 0.0 GO:0021629 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
0.0 0.0 GO:0001560 regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0 0.0 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 0.1 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.0 0.1 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.0 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
0.0 0.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.0 0.0 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0 0.0 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.1 GO:0042048 olfactory behavior(GO:0042048)
0.0 0.0 GO:0015680 intracellular copper ion transport(GO:0015680)
0.0 0.1 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.1 GO:0072161 mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012)
0.0 0.0 GO:0002084 protein depalmitoylation(GO:0002084)
0.0 0.1 GO:1904749 regulation of protein localization to nucleolus(GO:1904749)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0044317 rod spherule(GO:0044317)
0.1 0.2 GO:0045025 mitochondrial degradosome(GO:0045025)
0.1 0.3 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.1 0.2 GO:0061474 phagolysosome membrane(GO:0061474)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 1.5 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.2 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0 0.1 GO:0005846 nuclear cap binding complex(GO:0005846)
0.0 0.0 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 0.1 GO:0071821 FANCM-MHF complex(GO:0071821)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942) Ndc80 complex(GO:0031262)
0.0 0.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.1 GO:0071546 pi-body(GO:0071546)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.1 GO:0070761 pre-snoRNP complex(GO:0070761)
0.0 0.0 GO:1990423 RZZ complex(GO:1990423)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0001847 opsonin receptor activity(GO:0001847)
0.1 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 1.5 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 0.2 GO:0070401 NADP-retinol dehydrogenase activity(GO:0052650) NADP+ binding(GO:0070401)
0.0 0.1 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.0 0.1 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.2 GO:0032027 myosin light chain binding(GO:0032027)
0.0 0.2 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0008281 sulfonylurea receptor activity(GO:0008281)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.1 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 0.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.0 0.2 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.3 GO:0005542 folic acid binding(GO:0005542)
0.0 0.2 GO:0003840 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.0 GO:0000403 Y-form DNA binding(GO:0000403)
0.0 0.1 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0004825 methionine-tRNA ligase activity(GO:0004825)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.1 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.1 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.2 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.0 GO:0098603 selenol Se-methyltransferase activity(GO:0098603)
0.0 0.1 GO:0004982 N-formyl peptide receptor activity(GO:0004982)
0.0 0.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.2 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 0.1 GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding(GO:0071886)
0.0 0.1 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.1 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.1 GO:0000829 inositol heptakisphosphate kinase activity(GO:0000829)
0.0 0.1 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.1 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0 0.1 GO:0015189 L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.0 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0 0.1 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.1 GO:0034046 poly(G) binding(GO:0034046)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 0.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.0 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.2 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0 0.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.0 GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0 0.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.0 0.2 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.0 GO:0000405 bubble DNA binding(GO:0000405)
0.0 0.0 GO:0031714 C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.0 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.0 0.1 GO:0004708 MAP kinase kinase activity(GO:0004708)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.4 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.0 0.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.0 0.0 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling