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GSE49485: Hypoxia transcriptome sequencing of rat brain.
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Results for Lhx2_Hoxc5
Z-value: 0.88
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Transcription factors associated with Lhx2_Hoxc5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Hoxc5 | rn6_v1_chr7_+_144628120_144628120 | -0.26 | 6.8e-01 | Click! |
| Lhx2 | rn6_v1_chr3_+_22640545_22640604 | -0.25 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrM_+_9870 Show fit | 0.57 |
ENSRNOT00000044582
|
mitochondrially encoded NADH 4L dehydrogenase |
|
| chr5_+_6373583 Show fit | 0.54 |
ENSRNOT00000084749
|
|
|
| chr8_-_104155775 Show fit | 0.48 |
ENSRNOT00000042885
|
60S ribosomal protein L31-like |
|
| chrM_+_11736 Show fit | 0.47 |
ENSRNOT00000048767
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr13_-_83457888 Show fit | 0.47 |
ENSRNOT00000076289
ENSRNOT00000004065 |
SFT2 domain containing 2 |
|
| chr15_-_93765498 Show fit | 0.44 |
ENSRNOT00000093297
|
MYC binding protein 2, E3 ubiquitin protein ligase |
|
| chr1_+_15834779 Show fit | 0.39 |
ENSRNOT00000079069
ENSRNOT00000083012 |
BCL2-associated transcription factor 1 |
|
| chr15_+_87722221 Show fit | 0.36 |
ENSRNOT00000082688
|
sciellin |
|
| chr1_+_61786900 Show fit | 0.35 |
ENSRNOT00000090287
|
|
|
| chr13_+_91054974 Show fit | 0.35 |
ENSRNOT00000091089
|
C-reactive protein |
Network of associatons between targets according to the STRING database.
First level regulatory network of Lhx2_Hoxc5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
| 0.0 | 0.5 | GO:0021785 | branchiomotor neuron axon guidance(GO:0021785) |
| 0.1 | 0.4 | GO:0071623 | negative regulation of granulocyte chemotaxis(GO:0071623) negative regulation of neutrophil chemotaxis(GO:0090024) |
| 0.0 | 0.4 | GO:0035036 | sperm-egg recognition(GO:0035036) |
| 0.1 | 0.3 | GO:1904139 | microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139) |
| 0.1 | 0.3 | GO:1900673 | olefin metabolic process(GO:1900673) |
| 0.1 | 0.3 | GO:0006579 | amino-acid betaine catabolic process(GO:0006579) |
| 0.1 | 0.3 | GO:1902211 | regulation of prolactin signaling pathway(GO:1902211) |
| 0.1 | 0.3 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.3 | GO:0016095 | polyprenol catabolic process(GO:0016095) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.6 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.1 | 0.3 | GO:0072557 | IPAF inflammasome complex(GO:0072557) |
| 0.0 | 0.3 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 0.3 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 0.1 | 0.2 | GO:0044317 | rod spherule(GO:0044317) |
| 0.1 | 0.2 | GO:0045025 | mitochondrial degradosome(GO:0045025) |
| 0.1 | 0.2 | GO:0061474 | phagolysosome membrane(GO:0061474) |
| 0.0 | 0.2 | GO:0000243 | commitment complex(GO:0000243) |
| 0.0 | 0.2 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.5 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 0.3 | GO:0001847 | opsonin receptor activity(GO:0001847) |
| 0.1 | 0.3 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.0 | 0.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.0 | 0.3 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.2 | GO:0051870 | methotrexate binding(GO:0051870) |
| 0.1 | 0.2 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
| 0.0 | 0.2 | GO:0070401 | NADP-retinol dehydrogenase activity(GO:0052650) NADP+ binding(GO:0070401) |
| 0.0 | 0.2 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.0 | 0.3 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.0 | 0.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.0 | 0.2 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.0 | 0.1 | REACTOME OPSINS | Genes involved in Opsins |
| 0.0 | 0.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.0 | 0.0 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |