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GSE49485: Hypoxia transcriptome sequencing of rat brain.

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Results for Lef1

Z-value: 0.39

Motif logo

Transcription factors associated with Lef1

Gene Symbol Gene ID Gene Info
ENSRNOG00000010121 lymphoid enhancer binding factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Lef1rn6_v1_chr2_+_236233239_2362332390.553.3e-01Click!

Activity profile of Lef1 motif

Sorted Z-values of Lef1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_+_28515025 0.17 ENSRNOT00000088033
ENSRNOT00000005317
ENSRNOT00000081141
DnaJ heat shock protein family (Hsp40) member C27
chr3_+_147585947 0.16 ENSRNOT00000006833
scratch family transcriptional repressor 2
chr16_-_74264142 0.16 ENSRNOT00000026067
dickkopf WNT signaling pathway inhibitor 4
chr7_-_93826665 0.16 ENSRNOT00000011344
TNF receptor superfamily member 11B
chr2_+_150756185 0.14 ENSRNOT00000088461
ENSRNOT00000036808
muscleblind-like splicing regulator 1
chr10_-_27179254 0.13 ENSRNOT00000004619
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr2_-_142686577 0.13 ENSRNOT00000014562
NHL repeat containing 3
chr3_+_47677720 0.12 ENSRNOT00000065340
T-box, brain, 1
chr11_+_9642365 0.12 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chr7_-_98098268 0.12 ENSRNOT00000010361
F-box protein 32
chr3_+_131351587 0.11 ENSRNOT00000010835
BTB domain containing 3
chr18_+_30900291 0.11 ENSRNOT00000060461
protocadherin gamma subfamily B, 7
chr10_-_83128297 0.11 ENSRNOT00000082160
lysine acetyltransferase 7
chr5_-_168734296 0.11 ENSRNOT00000066120
calmodulin binding transcription activator 1
chr3_+_59981959 0.11 ENSRNOT00000030460
Sp9 transcription factor
chr8_+_49418965 0.11 ENSRNOT00000021819
sodium voltage-gated channel beta subunit 2
chr9_+_14551758 0.10 ENSRNOT00000017157
nuclear transcription factor Y subunit alpha
chr14_+_2613406 0.10 ENSRNOT00000000083
transmembrane p24 trafficking protein 5
chr2_-_140618405 0.09 ENSRNOT00000017736
SET domain containing (lysine methyltransferase) 7
chr3_+_148541909 0.09 ENSRNOT00000012187
CCM2 like scaffolding protein
chr20_-_27208041 0.09 ENSRNOT00000084720
RUN and FYVE domain containing 2
chr13_+_34400170 0.09 ENSRNOT00000061516
ENSRNOT00000061515
ENSRNOT00000061513
ENSRNOT00000084506
ENSRNOT00000086641
cytoplasmic linker associated protein 1
chr5_-_79222687 0.09 ENSRNOT00000010516
AT-hook transcription factor
chr18_+_27424328 0.08 ENSRNOT00000033784
kinesin family member 20A
chr2_+_205783252 0.08 ENSRNOT00000025633
ENSRNOT00000025600
tripartite motif-containing 33
chr11_-_62451149 0.08 ENSRNOT00000093686
ENSRNOT00000081443
zinc finger and BTB domain containing 20
chr4_+_142453013 0.08 ENSRNOT00000056573

chr1_+_151439409 0.08 ENSRNOT00000022060
ENSRNOT00000050639
glutamate metabotropic receptor 5
chrX_-_26376467 0.08 ENSRNOT00000051655
ENSRNOT00000036502
Rho GTPase activating protein 6
chr2_+_238257031 0.07 ENSRNOT00000016066
integrator complex subunit 12
chr2_+_179952227 0.07 ENSRNOT00000015081
platelet derived growth factor C
chr2_-_165739874 0.07 ENSRNOT00000014384
karyopherin subunit alpha 4
chr18_+_14756684 0.07 ENSRNOT00000076085
ENSRNOT00000076129
microtubule-associated protein, RP/EB family, member 2
chr13_+_52976507 0.07 ENSRNOT00000090599
ENSRNOT00000011324
kinesin family member 21B
chr15_-_2966576 0.07 ENSRNOT00000070893
ENSRNOT00000017383
lysine acetyltransferase 6B
chr17_+_13670520 0.07 ENSRNOT00000019442
SHC adaptor protein 3
chr3_+_116899878 0.07 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr18_+_30909490 0.07 ENSRNOT00000026967
protocadherin gamma subfamily B, 8
chr1_-_131460473 0.07 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr2_+_142686724 0.07 ENSRNOT00000014614
proline and serine rich 1
chr6_+_147876237 0.06 ENSRNOT00000056649
transmembrane protein 196
chrX_+_156655960 0.06 ENSRNOT00000085723
methyl CpG binding protein 2
chr7_-_36408588 0.06 ENSRNOT00000063946
CASP2 and RIPK1 domain containing adaptor with death domain
chr8_+_118821729 0.06 ENSRNOT00000028409
SET domain containing 2
chr14_+_63095720 0.06 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr2_-_147693082 0.06 ENSRNOT00000022507
WW domain containing transcription regulator 1
chr1_-_198316882 0.06 ENSRNOT00000085304
ENSRNOT00000064985
TAO kinase 2
chr8_-_78397123 0.06 ENSRNOT00000087270
ENSRNOT00000084925
transcription factor 12
chr20_-_31597830 0.06 ENSRNOT00000085877
collagen type XIII alpha 1 chain
chr10_-_27179900 0.06 ENSRNOT00000082445
gamma-aminobutyric acid type A receptor gamma 2 subunit
chr6_+_99625306 0.06 ENSRNOT00000008573
pleckstrin homology and RhoGEF domain containing G3
chr3_-_43119159 0.06 ENSRNOT00000041394
nuclear receptor subfamily 4, group A, member 2
chr15_+_37171052 0.06 ENSRNOT00000011684
zinc finger MYM-type containing 2
chr8_-_73164620 0.06 ENSRNOT00000031988
talin 2
chr8_-_84506328 0.06 ENSRNOT00000064754
muscular LMNA-interacting protein
chr9_+_2202511 0.06 ENSRNOT00000017556
SATB homeobox 1
chr10_+_81913689 0.06 ENSRNOT00000003780
transducer of ErbB-2.1
chr5_+_4373626 0.06 ENSRNOT00000064946
EYA transcriptional coactivator and phosphatase 1
chr2_+_205553163 0.06 ENSRNOT00000039572
neuroblastoma RAS viral oncogene homolog
chr12_+_27155587 0.05 ENSRNOT00000044800

chr10_-_85574889 0.05 ENSRNOT00000072274
hypothetical protein LOC691153
chr8_-_36467627 0.05 ENSRNOT00000082346
family with sequence similarity 118, member B
chr13_+_71110064 0.05 ENSRNOT00000088329
regulator of G-protein signaling 8
chr3_+_56766475 0.05 ENSRNOT00000078819
Sp5 transcription factor
chr6_-_147172022 0.05 ENSRNOT00000080675
integrin subunit beta 8
chr13_-_73055631 0.05 ENSRNOT00000081892
xenotropic and polytropic retrovirus receptor 1
chr7_-_140546908 0.05 ENSRNOT00000077502
lysine methyltransferase 2D
chr9_+_19451630 0.05 ENSRNOT00000065048
ectonucleotide pyrophosphatase/phosphodiesterase 4
chrX_-_115175299 0.05 ENSRNOT00000074322
doublecortin
chr13_-_51076852 0.04 ENSRNOT00000078993
adenosine A1 receptor
chr9_+_49479023 0.04 ENSRNOT00000050922
ENSRNOT00000077111
POU class 3 homeobox 3
chr8_+_117620317 0.04 ENSRNOT00000084220
cadherin, EGF LAG seven-pass G-type receptor 3
chr15_+_105851542 0.04 ENSRNOT00000086959
RAS related protein 2a
chr12_-_47793534 0.04 ENSRNOT00000001588
family with sequence similarity 222, member A
chr5_+_122100099 0.04 ENSRNOT00000007738
phosphodiesterase 4B
chr17_-_51912496 0.04 ENSRNOT00000019272
inhibin beta A subunit
chr2_+_220432037 0.04 ENSRNOT00000021988
ferric-chelate reductase 1
chr8_+_63600663 0.04 ENSRNOT00000012644
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr8_+_59457018 0.04 ENSRNOT00000017900
iron responsive element binding protein 2
chr1_-_6970040 0.04 ENSRNOT00000016273
utrophin
chr20_-_31598118 0.04 ENSRNOT00000046537
collagen type XIII alpha 1 chain
chr17_+_23135985 0.04 ENSRNOT00000090794
neural precursor cell expressed, developmentally down-regulated 9
chr19_+_39543242 0.04 ENSRNOT00000018837
WW domain containing E3 ubiquitin protein ligase 2
chr10_+_88987558 0.04 ENSRNOT00000026878
hydroxysteroid (17-beta) dehydrogenase 1
chr2_+_196013799 0.04 ENSRNOT00000084023
pogo transposable element with ZNF domain
chr17_+_82065937 0.04 ENSRNOT00000051349
ADP-ribosylation factor like GTPase 5B
chr13_+_98924962 0.04 ENSRNOT00000074148
lin-9 DREAM MuvB core complex component
chr5_+_128083118 0.04 ENSRNOT00000079161
zinc finger CCHC-type containing 11
chr2_-_220535751 0.03 ENSRNOT00000089082
palmdelphin
chr15_+_3996048 0.03 ENSRNOT00000078653
N-deacetylase and N-sulfotransferase 2
chr17_-_84830185 0.03 ENSRNOT00000040697
SKI/DACH domain containing 1
chr5_-_144479306 0.03 ENSRNOT00000087697
argonaute 1, RISC catalytic component
chr13_-_52514875 0.03 ENSRNOT00000064758
neuron navigator 1
chr2_-_211001258 0.03 ENSRNOT00000037336
ataxin 7-like 2
chr1_-_134870255 0.03 ENSRNOT00000055829
chromodomain helicase DNA binding protein 2
chr9_-_38196273 0.03 ENSRNOT00000044452
dystonin
chr13_-_72063347 0.03 ENSRNOT00000090544
ENSRNOT00000003869
calcium voltage-gated channel subunit alpha1 E
chr11_-_31213787 0.03 ENSRNOT00000002800
PAX3 and PAX7 binding protein 1
chr13_-_81214494 0.03 ENSRNOT00000004950
ENSRNOT00000082385
paired related homeobox 1
chr10_-_74376270 0.03 ENSRNOT00000079311
glycerophosphodiester phosphodiesterase domain containing 1
chr13_-_84619023 0.03 ENSRNOT00000089827
ENSRNOT00000045056
pogo transposable element with KRAB domain
chr15_+_86243148 0.03 ENSRNOT00000084471
ENSRNOT00000090727
LIM domain 7
chr16_-_71203609 0.03 ENSRNOT00000088458
nuclear receptor binding SET domain protein 3
chr5_+_25168295 0.03 ENSRNOT00000020245
fibrinogen silencer binding protein
chr6_-_72596446 0.03 ENSRNOT00000008459
HECT domain E3 ubiquitin protein ligase 1
chr11_-_35697072 0.03 ENSRNOT00000039999
ERG, ETS transcription factor
chr5_-_139748489 0.03 ENSRNOT00000078741
nuclear transcription factor Y subunit gamma
chr1_-_218100272 0.03 ENSRNOT00000028411
ENSRNOT00000088588
cyclin D1
chr3_+_58164931 0.03 ENSRNOT00000002078
distal-less homeobox 1
chr13_-_111581018 0.03 ENSRNOT00000083072
ENSRNOT00000077981
SERTA domain containing 4
chr2_+_144861455 0.02 ENSRNOT00000093284
ENSRNOT00000019748
ENSRNOT00000072110
doublecortin-like kinase 1
chr1_-_221015929 0.02 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr8_-_14880644 0.02 ENSRNOT00000015977
FAT atypical cadherin 3
chr8_-_96132634 0.02 ENSRNOT00000041655
synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_149741312 0.02 ENSRNOT00000070854
high mobility group protein B1-like
chr8_+_111210811 0.02 ENSRNOT00000011347
angiomotin like 2
chr14_+_66598259 0.02 ENSRNOT00000049743
potassium voltage-gated channel interacting protein 4
chrX_-_32095867 0.02 ENSRNOT00000049947
ENSRNOT00000080730
angiotensin I converting enzyme 2
chr10_-_86004096 0.02 ENSRNOT00000091978
ENSRNOT00000066855
SH3 and cysteine rich domain 2
chr2_-_219458271 0.02 ENSRNOT00000064735
cell division cycle 14A
chr7_-_132984110 0.02 ENSRNOT00000046626
high mobility group box 1, pseudogene 3
chr15_-_41338284 0.02 ENSRNOT00000077225
TNF receptor superfamily member 19
chr18_-_27424090 0.02 ENSRNOT00000087968
bromodomain containing 8
chr9_-_61810417 0.02 ENSRNOT00000020910
raftlin family member 2
chr14_-_35652709 0.02 ENSRNOT00000003080
GS homeobox 2
chr3_-_51643140 0.02 ENSRNOT00000006646
sodium voltage-gated channel alpha subunit 3
chrX_+_9436707 0.02 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr13_-_91872954 0.02 ENSRNOT00000004613
ENSRNOT00000079263
cell adhesion molecule 3
chr8_+_118206698 0.02 ENSRNOT00000082607
ENSRNOT00000064140
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chrX_+_86126157 0.02 ENSRNOT00000006992
kelch-like family member 4
chr8_-_118182559 0.02 ENSRNOT00000084838
DExH-box helicase 30
chrX_-_4945944 0.02 ENSRNOT00000077238
lysine demethylase 6A
chr18_+_79773608 0.02 ENSRNOT00000088484
zinc finger protein 516
chr15_-_100303807 0.02 ENSRNOT00000041344
40S ribosomal protein S16-like
chr5_-_7874909 0.02 ENSRNOT00000064774
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr9_-_81772851 0.02 ENSRNOT00000032719
ubiquitin specific peptidase 37
chr10_+_94407559 0.02 ENSRNOT00000013046
DEAD-box helicase 42
chr10_-_89700283 0.01 ENSRNOT00000028213
ets variant 4
chr9_+_65279675 0.01 ENSRNOT00000019486
basic leucine zipper and W2 domains 1
chr9_+_46657575 0.01 ENSRNOT00000083322
mitogen-activated protein kinase kinase kinase kinase 4
chr6_-_147172813 0.01 ENSRNOT00000066545
integrin subunit beta 8
chr14_-_2474780 0.01 ENSRNOT00000074874
protein Dr1-like
chr6_+_73358112 0.01 ENSRNOT00000041373
Rho GTPase activating protein 5
chr6_-_22092346 0.01 ENSRNOT00000083128
ENSRNOT00000006830
baculoviral IAP repeat-containing 6
chr4_+_78240385 0.01 ENSRNOT00000011041
zinc finger protein 775
chr2_-_188660179 0.01 ENSRNOT00000027935
ephrin A4
chr3_-_107760550 0.01 ENSRNOT00000077091
ENSRNOT00000051638
Meis homeobox 2
chr13_-_95250235 0.01 ENSRNOT00000085648
AKT serine/threonine kinase 3
chr8_+_70630767 0.01 ENSRNOT00000051353
immunoglobulin superfamily, DCC subclass, member 3
chr4_+_179481263 0.01 ENSRNOT00000021284
electron transfer flavoprotein regulatory factor 1
chr2_-_57935334 0.01 ENSRNOT00000022319
ENSRNOT00000085599
ENSRNOT00000077790
ENSRNOT00000035821
solute carrier family 1 member 3
chr6_+_108820774 0.01 ENSRNOT00000089683
ENSRNOT00000080038
ENSRNOT00000006492
YLP motif containing 1
chr8_-_64268555 0.01 ENSRNOT00000013581
ENSRNOT00000084758
ariadne RBR E3 ubiquitin protein ligase 1
chr6_+_147876557 0.01 ENSRNOT00000080090
transmembrane protein 196
chr5_+_126976456 0.01 ENSRNOT00000014275
NDC1 transmembrane nucleoporin
chr6_-_107080524 0.01 ENSRNOT00000011662
zinc finger FYVE-type containing 1
chr2_-_139528162 0.01 ENSRNOT00000014317
solute carrier family 7 member 11
chr18_-_58097316 0.01 ENSRNOT00000088527

chr9_-_4447715 0.01 ENSRNOT00000061882
lysine acetyltransferase 2B
chr18_+_46148849 0.01 ENSRNOT00000026724
proline rich 16
chrX_-_18726732 0.00 ENSRNOT00000026214
ubiquilin 2
chr6_+_145546595 0.00 ENSRNOT00000007112
Rap guanine nucleotide exchange factor 5
chr10_+_89285855 0.00 ENSRNOT00000028033
glucose-6-phosphatase, catalytic subunit
chr14_-_44845218 0.00 ENSRNOT00000004003
kelch-like family member 5
chr14_-_2700977 0.00 ENSRNOT00000000086
metal response element binding transcription factor 2
chr3_+_8643936 0.00 ENSRNOT00000077797
SET nuclear proto-oncogene
chr10_-_87541851 0.00 ENSRNOT00000089610
similar to keratin associated protein 2-4
chrX_+_54266687 0.00 ENSRNOT00000058309
LRRGT00076-like
chr9_-_111213098 0.00 ENSRNOT00000087355
gypsy retrotransposon integrase 1
chr19_-_29016521 0.00 ENSRNOT00000049860
similar to spermatogenesis associated glutamate (E)-rich protein 4d
chr20_+_5262120 0.00 ENSRNOT00000000535
bromodomain containing 2
chr20_-_32258286 0.00 ENSRNOT00000082114
DExD-box helicase 50

Network of associatons between targets according to the STRING database.

First level regulatory network of Lef1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0042489 negative regulation of odontogenesis of dentin-containing tooth(GO:0042489)
0.0 0.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0 0.1 GO:0021836 chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.0 0.1 GO:0072720 response to dithiothreitol(GO:0072720)
0.0 0.1 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.2 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.1 GO:0099553 trans-synaptic signaling by lipid, modulating synaptic transmission(GO:0099552) trans-synaptic signaling by endocannabinoid, modulating synaptic transmission(GO:0099553)
0.0 0.1 GO:0060849 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.0 0.1 GO:1903860 negative regulation of dendrite extension(GO:1903860) negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.0 0.1 GO:0097198 histone H3-K36 trimethylation(GO:0097198)
0.0 0.1 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 0.0 GO:1900453 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900) negative regulation of circadian sleep/wake cycle, non-REM sleep(GO:0042323) negative regulation of mucus secretion(GO:0070256) negative regulation of long term synaptic depression(GO:1900453)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.1 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.1 GO:0046684 response to pyrethroid(GO:0046684)
0.0 0.1 GO:0051866 general adaptation syndrome(GO:0051866)
0.0 0.0 GO:0072021 ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0031592 centrosomal corona(GO:0031592)
0.0 0.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.0 GO:0043511 inhibin complex(GO:0043511)
0.0 0.0 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0001069 regulatory region RNA binding(GO:0001069)
0.0 0.1 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.0 0.2 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 0.1 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.1 GO:0045322 unmethylated CpG binding(GO:0045322)
0.0 0.0 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.0 0.0 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.0 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.0 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.0 GO:0030350 iron-responsive element binding(GO:0030350)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation